LOCUS       NM_025130               3653 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA.
ACCESSION   NM_025130
VERSION     NM_025130.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3653)
  AUTHORS   Pang,Q., Huang,S., Wang,H. and Cao,J.
  TITLE     HKDC1 promotes autophagy and proliferation in pancreatic
            adenocarcinoma through interaction with PARP1 and
            poly(ADP-ribosyl)ation
  JOURNAL   Cell Signal 124, 111474 (2024)
   PUBMED   39424110
  REMARK    GeneRIF: HKDC1 promotes autophagy and proliferation in pancreatic
            adenocarcinoma through interaction with PARP1 and
            poly(ADP-ribosyl)ation.
REFERENCE   2  (bases 1 to 3653)
  AUTHORS   Shi,F., Jiang,J., Wang,B., Hong,L., Zhang,Y., Meng,Y., Zhang,X.,
            Gong,L., Lin,J. and Diao,H.
  TITLE     Hepatitis B virus X protein promotes tumor glycolysis by
            downregulating lncRNA OIP5-AS1/HKDC1 in HCC
  JOURNAL   Cell Signal 119, 111183 (2024)
   PUBMED   38636768
  REMARK    GeneRIF: Hepatitis B virus X protein promotes tumor glycolysis by
            downregulating lncRNA OIP5-AS1/HKDC1 in HCC.
REFERENCE   3  (bases 1 to 3653)
  AUTHORS   Chen,H.Y., Li,X.N., Yang,L., Ye,C.X., Chen,Z.L. and Wang,Z.J.
  TITLE     CircVMP1 promotes glycolysis and disease progression by
            upregulating HKDC1 in colorectal cancer
  JOURNAL   Environ Toxicol 39 (3), 1617-1630 (2024)
   PUBMED   38009649
  REMARK    GeneRIF: CircVMP1 promotes glycolysis and disease progression by
            upregulating HKDC1 in colorectal cancer.
REFERENCE   4  (bases 1 to 3653)
  AUTHORS   Zhang,Y., Wang,M., Ye,L., Shen,S., Zhang,Y., Qian,X., Zhang,T.,
            Yuan,M., Ye,Z., Cai,J., Meng,X., Qiu,S., Liu,S., Liu,R., Jia,W.,
            Yang,X., Zhang,H., Zhong,X. and Gao,P.
  TITLE     HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by
            coupling cytoskeleton to STAT1 activation and PD-L1 expression
  JOURNAL   Nat Commun 15 (1), 1314 (2024)
   PUBMED   38351096
  REMARK    GeneRIF: HKDC1 promotes tumor immune evasion in hepatocellular
            carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1
            expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3653)
  AUTHORS   Hu,J., Xia,F., Chen,C. and Zhao,D.
  TITLE     HKDC1 in Gastric Cancer: A New Diagnostic, Prognostic Biomarker,
            and Novel Therapeutic Target
  JOURNAL   Ann Clin Lab Sci 53 (5), 726-737 (2023)
   PUBMED   37945018
  REMARK    GeneRIF: HKDC1 in Gastric Cancer: A New Diagnostic, Prognostic
            Biomarker, and Novel Therapeutic Target.
REFERENCE   6  (bases 1 to 3653)
  AUTHORS   Guo,C., Ludvik,A.E., Arlotto,M.E., Hayes,M.G., Armstrong,L.L.,
            Scholtens,D.M., Brown,C.D., Newgard,C.B., Becker,T.C., Layden,B.T.,
            Lowe,W.L. and Reddy,T.E.
  TITLE     Coordinated regulatory variation associated with gestational
            hyperglycaemia regulates expression of the novel hexokinase HKDC1
  JOURNAL   Nat Commun 6, 6069 (2015)
   PUBMED   25648650
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3653)
  AUTHORS   Hayes,M.G., Urbanek,M., Hivert,M.F., Armstrong,L.L., Morrison,J.,
            Guo,C., Lowe,L.P., Scheftner,D.A., Pluzhnikov,A., Levine,D.M.,
            McHugh,C.P., Ackerman,C.M., Bouchard,L., Brisson,D., Layden,B.T.,
            Mirel,D., Doheny,K.F., Leya,M.V., Lown-Hecht,R.N., Dyer,A.R.,
            Metzger,B.E., Reddy,T.E., Cox,N.J. and Lowe,W.L. Jr.
  CONSRTM   HAPO Study Cooperative Research Group
  TITLE     Identification of HKDC1 and BACE2 as genes influencing glycemic
            traits during pregnancy through genome-wide association studies
  JOURNAL   Diabetes 62 (9), 3282-3291 (2013)
   PUBMED   23903356
  REMARK    GeneRIF: Data identified two novel genome-wide significant
            associations: 2-h plasma glucose and HKDC1, and fasting C-peptide
            and BACE2.
            Erratum:[Diabetes. 2013 Oct;62(10):3641]
REFERENCE   8  (bases 1 to 3653)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3653)
  AUTHORS   Neale,B.M., Medland,S., Ripke,S., Anney,R.J., Asherson,P.,
            Buitelaar,J., Franke,B., Gill,M., Kent,L., Holmans,P.,
            Middleton,F., Thapar,A., Lesch,K.P., Faraone,S.V., Daly,M.,
            Nguyen,T.T., Schafer,H., Steinhausen,H.C., Reif,A., Renner,T.J.,
            Romanos,M., Romanos,J., Warnke,A., Walitza,S., Freitag,C.,
            Meyer,J., Palmason,H., Rothenberger,A., Hawi,Z., Sergeant,J.,
            Roeyers,H., Mick,E. and Biederman,J.
  CONSRTM   IMAGE II Consortium Group
  TITLE     Case-control genome-wide association study of
            attention-deficit/hyperactivity disorder
  JOURNAL   J Am Acad Child Adolesc Psychiatry 49 (9), 906-920 (2010)
   PUBMED   20732627
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 3653)
  AUTHORS   Irwin,D.M. and Tan,H.
  TITLE     Molecular evolution of the vertebrate hexokinase gene family:
            Identification of a conserved fifth vertebrate hexokinase gene
  JOURNAL   Comp Biochem Physiol Part D Genomics Proteomics 3 (1), 96-107
            (2008)
   PUBMED   20483211
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL596223.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_025130.3.
            
            Summary: This gene encodes a member of the hexokinase protein
            family. The encoded protein is involved in glucose metabolism, and
            reduced expression may be associated with gestational diabetes
            mellitus. High expression of this gene may also be associated with
            poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095086.1, AK291024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354624.6/ ENSP00000346643.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AL596223.3         51433-51599
            168-330             AL596223.3         58308-58470
            331-479             AL596223.3         63865-64013
            480-599             AL596223.3         64115-64234
            600-695             AL596223.3         70143-70238
            696-795             AL596223.3         71753-71852
            796-979             AL596223.3         74283-74466
            980-1135            AL596223.3         77180-77335
            1136-1369           AL596223.3         78461-78694
            1370-1674           AL596223.3         79525-79829
            1675-1820           AL596223.3         81391-81536
            1821-1940           AL596223.3         81634-81753
            1941-2036           AL596223.3         88137-88232
            2037-2136           AL596223.3         88428-88527
            2137-2320           AL596223.3         89877-90060
            2321-2476           AL596223.3         92240-92395
            2477-2710           AL596223.3         96686-96919
            2711-3653           AL596223.3         97711-98653
FEATURES             Location/Qualifiers
     source          1..3653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..3653
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /note="hexokinase domain containing 1"
                     /db_xref="GeneID:80201"
                     /db_xref="HGNC:HGNC:23302"
                     /db_xref="MIM:617221"
     exon            1..167
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2858
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /EC_number="2.7.1.1"
                     /note="putative hexokinase HKDC1; hexokinase
                     domain-containing protein 1"
                     /codon_start=1
                     /product="hexokinase HKDC1"
                     /protein_id="NP_079406.4"
                     /db_xref="CCDS:CCDS7288.1"
                     /db_xref="GeneID:80201"
                     /db_xref="HGNC:HGNC:23302"
                     /db_xref="MIM:617221"
                     /translation="MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFR
                     AEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGK
                     RHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQ
                     TKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCA
                     YDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTE
                     FDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLLFGGEKSSALHTKGKI
                     ETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVSFRSANLCAAALAA
                     ILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCDVRFLLSESGST
                     KGAAMVTAVASRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLAT
                     VRMLPTYVCGLPDGTEKGKFLALDLGGTNFRVLLVKIRSGRRSVRMYNKIFAIPLEIM
                     QGTGEELFDHIVQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKA
                     TDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSN
                     MCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDIWTRYDTEVDEGSLNPGKQRY
                     EKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQ
                     VRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRIT
                     VGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGAALITAVAKRLQQAQ
                     KEN"
     exon            168..330
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            331..479
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            480..599
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            600..695
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            696..795
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            796..979
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1135
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1369
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1674
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1820
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1940
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2036
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..2136
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2320
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2476
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2710
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..3653
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3626..3631
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /note="hexamer: AATAAA"
     polyA_site      3653
                     /gene="HKDC1"
                     /gene_synonym="RP92"
                     /note="major polyA site"
ORIGIN      
        1 aggtctgcca gcctggactg gaagcgtgca acactccaga gtcgtaggag tgaacactgc
       61 acaggaatct ctgcccatct caggagaaac caaacttggg gaaaatgttt gcggtccact
      121 tgatggcatt ttacttcagc aagctgaagg aggaccagat caagaaggtg gacaggttcc
      181 tgtatcacat gcggctctcc gatgacaccc ttttggacat catgaggcgg ttccgggctg
      241 agatggagaa gggcctggca aaggacacca accccacggc tgcagtgaag atgttgccca
      301 ccttcgtcag ggccattccc gatggttccg aaaatgggga gttcctttcc ctggatctcg
      361 gagggtccaa gttccgagtg ctgaaggtgc aagtcgctga agaggggaag cgacacgtgc
      421 agatggagag tcagttctac ccaacgccca atgaaatcat ccgcgggaac ggcacagagc
      481 tgtttgaata tgtagctgac tgtctggcag atttcatgaa gaccaaagat ttaaagcata
      541 agaaattgcc ccttggccta actttttctt tcccctgtcg acagactaaa ctggaagagg
      601 gtgtcctact ttcgtggaca aaaaagttta aggcacgagg agttcaggac acggatgtgg
      661 tgagccgtct gaccaaagcc atgagaagac acaaggacat ggacgtggac atcctggccc
      721 tggtcaatga caccgtgggg accatgatga cctgtgccta tgacgacccc tactgcgaag
      781 ttggtgtcat catcggaact ggcaccaatg cgtgttacat ggaggacatg agcaacattg
      841 acctggtgga gggcgacgag ggcaggatgt gcatcaacac agagtggggg gccttcgggg
      901 acgacggggc cctggaggac attcgcactg agttcgacag ggagctggac ctcggctctc
      961 tcaacccagg aaagcaactg ttcgagaaga tgatcagtgg cctgtacctg ggggagcttg
     1021 tcaggcttat cttgctgaag atggccaagg ctggcctcct gtttggtggt gagaaatctt
     1081 ctgctctcca cactaagggc aagatcgaaa cacggcacgt ggctgccatg gagaagtata
     1141 aagaaggcct tgctaataca agagagatcc tggtggacct gggtctggaa ccgtctgagg
     1201 ctgactgcat tgccgtccag catgtctgta ccatcgtctc cttccgctcg gccaatctct
     1261 gtgcagcagc tctggcggcc atcctgacac gcctccggga gaacaagaag gtggaacggc
     1321 tccggaccac agtgggcatg gacggcaccc tctacaagat acaccctcag tacccaaaac
     1381 gcctgcacaa ggtggtgagg aaactggtcc caagctgtga tgtccgcttc ctcctgtcag
     1441 agagtggcag caccaagggg gccgccatgg tgaccgcggt ggcctcccgc gtgcaggccc
     1501 agcggaagca gatcgacagg gtgctggctt tgttccagct gacccgagag cagctcgtgg
     1561 acgtgcaggc caagatgcgg gctgagctgg agtatgggct gaagaagaag agccacgggc
     1621 tggccacggt caggatgctg cccacctacg tctgcgggct gccggacggc acagagaaag
     1681 gaaagtttct cgccctggat cttgggggaa ccaacttccg ggtcctcctg gtgaagatca
     1741 gaagtggacg gaggtcagtg cgaatgtaca acaagatctt cgccatcccc ctggagatca
     1801 tgcagggcac tggtgaggag ctctttgatc acattgtgca gtgcatcgcc gacttcctgg
     1861 actacatggg cctcaaggga gcctccctac ctttgggctt cacattctca tttccctgca
     1921 ggcagatgag cattgacaag ggaacactca tagggtggac caaaggtttc aaggccactg
     1981 actgtgaagg ggaggacgtg gtggacatgc tcagggaagc catcaagagg agaaacgagt
     2041 ttgacctgga cattgttgca gtcgtgaatg atacagtggg gaccatgatg acctgtggct
     2101 atgaagatcc taattgtgag attggcctga ttgcaggaac aggcagcaac atgtgctaca
     2161 tggaggacat gaggaacatc gagatggtgg aggggggtga agggaagatg tgcatcaata
     2221 cagagtgggg aggatttgga gacaatggct gcatagatga catctggacc cgatacgaca
     2281 cggaggtgga tgaggggtcc ttgaatcctg gcaagcagag atacgagaaa atgaccagtg
     2341 ggatgtactt gggggagatt gtgcggcaga tcctgatcga cctgaccaag cagggtctcc
     2401 tcttccgagg gcagatttca gagcgtctcc ggaccagggg catcttcgaa accaagttcc
     2461 tgtcccagat cgaaagcgat cggctggccc ttctccaggt caggaggatt ctgcagcagc
     2521 tgggcctgga cagcacgtgt gaggacagca tcgtggtgaa ggaggtgtgc ggagccgtgt
     2581 cccggcgggc ggcccagctc tgcggtgctg gcctggccgc tatagtggaa aaaaggagag
     2641 aagaccaggg gctagagcac ctgaggatca ctgtgggtgt ggacggcacc ctgtacaagc
     2701 tgcaccctca cttttctaga atattgcagg aaactgtgaa ggaactagcc cctcgatgtg
     2761 atgtgacatt catgctgtca gaagatggca gtggaaaagg ggcagcactg atcactgctg
     2821 tggccaagag gttacagcag gcacagaagg agaactagga acccctggga ttggacctga
     2881 tgcatcttgg atactgaaca gcttttcctc tggcagatca gttggtcaga gaccaatggg
     2941 caccctcctg gctgacctca ccttctggat ggccgaaaga gaaccccagg ttctcgggta
     3001 ctcttagtat cttgtactgg atttgcagtg acattacatg acatctctat ttggtatatt
     3061 tgggccaaaa tgggccaact tatgaaatca aagtgtctgt cctgagagat cccctttcaa
     3121 cacattgttc aggtgaggct tgagctgtca attctctatg gctttcagtc ttgtggctgc
     3181 gggacttgga aatatataga atctgcccat gtggctggca ggctgtttcc ccattgggat
     3241 gcttaagcca tctcttatag gggattggac cctgtacttg tggatgaaca ttggagagca
     3301 agaggaactc acgttatgaa ctagggggat ctcatctaac ttgtccttaa cttgccatgt
     3361 tgacttcaaa cctattaaga gaacaaagac tttgaagtat ccagccccag ggtgcagaga
     3421 ggttgattgc cagggagcac tgcaggaatc attgcatgct taaagcgagt tatgtcagca
     3481 ccctgtagga ttttgttcct tattaagtgt gtgccatgtg gtggggtgct gtctggggca
     3541 tctgtttttc attttgcctg tggtttgtgt tgcaggtgtt gatagttgtt ttaaggattg
     3601 ttaggtatag gaaatccagt aaattaataa aaaaattttg attttccaat aaa
//
