LOCUS       XM_047425139            3748 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens hexokinase 1 (HK1), transcript variant X4,
            mRNA.
ACCESSION   XM_047425139
VERSION     XM_047425139.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000010.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3748
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
     gene            1..3748
                     /gene="HK1"
                     /gene_synonym="hexokinase; HK; HK1-ta; HK1-tb; HK1-tc;
                     HKD; HKI; HMSNR; HXK1; NEDVIBA; NMSR; RP79"
                     /note="hexokinase 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 1 mRNA, 103 ESTs, 2087
                     long SRA reads, 24 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     20 samples with support for all annotated introns"
                     /db_xref="GeneID:3098"
                     /db_xref="HGNC:HGNC:4922"
                     /db_xref="MIM:142600"
     CDS             290..3001
                     /gene="HK1"
                     /gene_synonym="hexokinase; HK; HK1-ta; HK1-tb; HK1-tc;
                     HKD; HKI; HMSNR; HXK1; NEDVIBA; NMSR; RP79"
                     /codon_start=1
                     /product="hexokinase-1 isoform X2"
                     /protein_id="XP_047281095.1"
                     /db_xref="GeneID:3098"
                     /db_xref="HGNC:HGNC:4922"
                     /db_xref="MIM:142600"
                     /translation="MACAPEKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPT
                     ATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVHMESEVYDTPE
                     NIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKR
                     FKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGT
                     GTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGK
                     QLFEKMVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKNKEG
                     LHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRL
                     RTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLA
                     EQHRQIEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDG
                     TENGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVS
                     CISDFLDYMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLR
                     DAIKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMV
                     EGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIV
                     RNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNST
                     CDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPH
                     FSRIMHQTVKELSPKCNVSFLLSEDGSGKGAALITAVGVRLRTEASS"
ORIGIN      
        1 attactggag gcctcccgcc cagcacagga gccacccaac ctggcccagg agccaccacg
       61 tggtgcctcc tagggctcct gggcacacaa agggcccaga gggcatggct cctgtacccc
      121 tggcactcac ggtctagctg gcggtgtgga ccatgcatgt gtccctgcaa cgcccaggaa
      181 agacacacac cacgaagtgt ctcccaggca gatcgactcc tacatagtga acacctaagg
      241 ccgaggggat gctgaggaga ggagtggacg gtgtggggtg gggcggatca tggcatgtgc
      301 tcctgagaag attgacaagt atctctatgc catgcggctc tccgatgaaa ctctcataga
      361 tatcatgact cgcttcagga aggagatgaa gaatggcctc tcccgggatt ttaatccaac
      421 agccacagtc aagatgttgc caacattcgt aaggtccatt cctgatggct ctgaaaaggg
      481 agatttcatt gccctggatc ttggtgggtc ttcctttcga attctgcggg tgcaagtgaa
      541 tcatgagaaa aaccagaatg ttcacatgga gtccgaggtt tatgacaccc cagagaacat
      601 cgtgcacggc agtggaagcc agctttttga tcatgttgct gagtgcctgg gagatttcat
      661 ggagaaaagg aagatcaagg acaagaagtt acctgtggga ttcacgtttt cttttccttg
      721 ccaacaatcc aaaatagatg aggccatcct gatcacctgg acaaagcgat ttaaagcgag
      781 cggagtggaa ggagcagatg tggtcaaact gcttaacaaa gccatcaaaa agcgagggga
      841 ctatgatgcc aacatcgtag ctgtggtgaa tgacacagtg ggcaccatga tgacctgtgg
      901 ctatgacgac cagcactgtg aagtcggcct gatcatcggc actggcacca atgcttgcta
      961 catggaggaa ctgaggcaca ttgatctggt ggaaggagac gaggggagga tgtgtatcaa
     1021 tacagaatgg ggagcctttg gagacgatgg atcattagaa gacatccgga cagagtttga
     1081 cagggagata gaccggggat ccctcaaccc tggaaaacag ctgtttgaga agatggtcag
     1141 tggcatgtac ttgggagagc tggttcgact gatcctagtc aagatggcca aggagggcct
     1201 cttatttgaa gggcggatca ccccggagct gctcacccga gggaagttta acaccagtga
     1261 tgtgtcagcc atcgaaaaga ataaggaagg cctccacaat gccaaagaaa tcctgacccg
     1321 cctgggagtg gagccgtccg atgatgactg tgtctcagtc cagcacgttt gcaccattgt
     1381 ctcatttcgc tcagccaact tggtggctgc cacactgggc gccatcttga accgcctgcg
     1441 tgataacaag ggcacaccca ggctgcggac cacggttggt gtcgacggat ctctttacaa
     1501 gacgcaccca cagtattccc ggcgtttcca caagactcta aggcgcttgg tgccagactc
     1561 cgatgtgcgc ttcctcctct cggagagtgg cagcggcaag ggggctgcca tggtgacggc
     1621 ggtggcctac cgcttggccg agcagcaccg gcagatagag gagaccctgg ctcatttcca
     1681 cctcaccaag gacatgctgc tggaggtgaa gaagaggatg cgggccgaga tggagctggg
     1741 gctgaggaag cagacgcaca acaatgccgt ggttaagatg ctgccctcct tcgtccggag
     1801 aactcccgac gggaccgaga atggtgactt cttggccctg gatcttggag gaaccaattt
     1861 ccgtgtgctg ctggtgaaaa tccgtagtgg gaaaaagaga acggtggaaa tgcacaacaa
     1921 gatctacgcc attcctattg aaatcatgca gggcactggg gaagagctgt ttgatcacat
     1981 tgtctcctgc atctctgact tcttggacta catggggatc aaaggcccca ggatgcctct
     2041 gggcttcacg ttctcatttc cctgccagca gacgagtctg gacgcgggaa tcttgatcac
     2101 gtggacaaag ggttttaagg caacagactg cgtgggccac gatgtagtca ccttactaag
     2161 ggatgcgata aaaaggagag aggaatttga cctggacgtg gtggctgtgg tcaacgacac
     2221 agtgggcacc atgatgacct gtgcttatga ggagcccacc tgtgaggttg gactcattgt
     2281 tgggaccggc agcaatgcct gctacatgga ggagatgaag aacgtggaga tggtggaggg
     2341 ggaccagggg cagatgtgca tcaacatgga gtggggggcc tttggggaca acgggtgtct
     2401 ggatgatatc aggacacact acgacagact ggtggacgaa tattccctaa atgctgggaa
     2461 acaaaggtat gagaagatga tcagtggtat gtacctgggt gaaatcgtcc gcaacatctt
     2521 aatcgacttc accaagaagg gattcctctt ccgagggcag atctctgaga cgctgaagac
     2581 ccggggcatc tttgagacca agtttctctc tcagatcgag agtgaccgat tagcactgct
     2641 ccaggtccgg gctatcctcc agcagctagg tctgaatagc acctgcgatg acagtatcct
     2701 cgtcaagaca gtgtgcgggg tggtgtccag gagggccgca cagctgtgtg gcgcaggcat
     2761 ggctgcggtt gtggataaga tccgcgagaa cagaggactg gaccgtctga atgtgactgt
     2821 gggagtggac gggacactct acaagcttca tccacacttc tccagaatca tgcaccagac
     2881 ggtgaaggaa ctgtcaccaa aatgtaacgt gtccttcctc ctgtctgagg atggcagcgg
     2941 caagggggcc gccctcatca cggccgtggg cgtgcggtta cgcacagagg caagcagcta
     3001 agagtccggg atccccagcc tactgcctct ccagcacttc tctcttcaag cggcgacccc
     3061 ctaccctccc agcgagttgc gctgggagac gctggcgcca gggcctgccg gcgcggggag
     3121 gaaagcaaaa tccaactaat ggtatatatt gtagggtaca gaatagagcg tgtgctgttg
     3181 ataatatctc tcacccggat ccctcctcac ttgccctgcc actttgcatg gtttgatttt
     3241 gacctggtcc cccacgtgtg aagtgtagtg gcatccattt ctaatgtatg cattcatcca
     3301 acagagttat ttattggctg gagatggaaa atcacaccac ctgacaggcc ttctgggcct
     3361 ccaaagccca tccttggggt tccccctccc tgtgtgaaat gtattatcac cagcagacac
     3421 tgccgggcct ccctcccggg ggcactgcct gaaggcgagt gtgggcatag cattagctgc
     3481 ttcctcccct cctggcaccc actgtggcct ggcatcgcat cgtggtgtgt caatgccaca
     3541 aaatcgtgtg tccgtggaac cagtcctagc cgcgtgtgac agtcttgcat tctgtttgtc
     3601 tcgtgggggg aggtggacag tcctgcggaa atgtgtcttg tctccatttg gataaaagga
     3661 accaaccaac aaacaatgcc atcactggaa tttcccaccg ctttgtgagc cgtgtcgtat
     3721 gacctagtaa actttgtacc aattcaaa
//
