LOCUS       NM_018410               3157 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Holliday junction recognition protein (HJURP),
            transcript variant 1, mRNA.
ACCESSION   NM_018410
VERSION     NM_018410.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3157)
  AUTHORS   Liu,Y., Liu,S., Jing,R., Li,C., Guo,Y., Cai,Z., Xi,P., Dai,P.,
            Jia,L., Zhu,H. and Zhang,X.
  TITLE     Identification of ASF1A and HJURP by global H3-H4 histone chaperone
            analysis as a prognostic two-gene model in hepatocellular carcinoma
  JOURNAL   Sci Rep 14 (1), 7666 (2024)
   PUBMED   38561384
  REMARK    GeneRIF: Identification of ASF1A and HJURP by global H3-H4 histone
            chaperone analysis as a prognostic two-gene model in hepatocellular
            carcinoma.
            Erratum:[Sci Rep. 2024 Sep 5;14(1):20726. doi:
            10.1038/s41598-024-71753-0.. PMID: 39251799]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3157)
  AUTHORS   Serafim,R.B., Cardoso,C., Storti,C.B., da Silva,P., Qi,H.,
            Parasuram,R., Navegante,G., Peron,J.P.S., Silva,W.A. Jr.,
            Espreafico,E.M., Paco-Larson,M.L., Price,B.D. and Valente,V.
  TITLE     HJURP is recruited to double-strand break sites and facilitates DNA
            repair by promoting chromatin reorganization
  JOURNAL   Oncogene 43 (11), 804-820 (2024)
   PUBMED   38279062
  REMARK    GeneRIF: HJURP is recruited to double-strand break sites and
            facilitates DNA repair by promoting chromatin reorganization.
REFERENCE   3  (bases 1 to 3157)
  AUTHORS   Zhang,M., Wang,Z., Yang,G., Han,L. and Wang,X.
  TITLE     NFE2L1 restrains ferroptosis by transcriptionally regulating HJURP
            and participates in the progress of oral squamous cell carcinoma
  JOURNAL   J Bioenerg Biomembr 55 (6), 467-478 (2023)
   PUBMED   37848756
  REMARK    GeneRIF: NFE2L1 restrains ferroptosis by transcriptionally
            regulating HJURP and participates in the progress of oral squamous
            cell carcinoma.
REFERENCE   4  (bases 1 to 3157)
  AUTHORS   Zhang,Y., Zhang,W., Sun,L., Yue,Y., Shen,D., Tian,B., Du,M.,
            Dong,M., Liu,Y. and Zhang,D.
  TITLE     HJURP inhibits proliferation of ovarian cancer cells by regulating
            CENP-A/CENP-N
  JOURNAL   Bull Cancer 109 (10), 1007-1016 (2022)
   PUBMED   35940943
  REMARK    GeneRIF: HJURP inhibits proliferation of ovarian cancer cells by
            regulating CENP-A/CENP-N.
REFERENCE   5  (bases 1 to 3157)
  AUTHORS   Mao,M., Jia,Y., Chen,Y., Yang,J., Xu,L., Zhang,X., Zhou,J., Li,Z.,
            Chen,C., Ju,S. and Wang,L.
  TITLE     HJURP regulates cell proliferation and chemo-resistance via
            YAP1/NDRG1 transcriptional axis in triple-negative breast cancer
  JOURNAL   Cell Death Dis 13 (4), 396 (2022)
   PUBMED   35459269
  REMARK    GeneRIF: HJURP regulates cell proliferation and chemo-resistance
            via YAP1/NDRG1 transcriptional axis in triple-negative breast
            cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3157)
  AUTHORS   Dunleavy,E.M., Roche,D., Tagami,H., Lacoste,N., Ray-Gallet,D.,
            Nakamura,Y., Daigo,Y., Nakatani,Y. and Almouzni-Pettinotti,G.
  TITLE     HJURP is a cell-cycle-dependent maintenance and deposition factor
            of CENP-A at centromeres
  JOURNAL   Cell 137 (3), 485-497 (2009)
   PUBMED   19410545
  REMARK    GeneRIF: HJURP is a key factor for CENP-A deposition and
            maintenance at centromeres
REFERENCE   7  (bases 1 to 3157)
  AUTHORS   Foltz,D.R., Jansen,L.E., Bailey,A.O., Yates,J.R. 3rd, Bassett,E.A.,
            Wood,S., Black,B.E. and Cleveland,D.W.
  TITLE     Centromere-specific assembly of CENP-a nucleosomes is mediated by
            HJURP
  JOURNAL   Cell 137 (3), 472-484 (2009)
   PUBMED   19410544
  REMARK    GeneRIF: HJURP is a possible cell-cycle-regulated CENP-A-specific
            histone chaperone required for centromeric chromatin assembly
REFERENCE   8  (bases 1 to 3157)
  AUTHORS   Kato,T., Sato,N., Hayama,S., Yamabuki,T., Ito,T., Miyamoto,M.,
            Kondo,S., Nakamura,Y. and Daigo,Y.
  TITLE     Activation of Holliday junction recognizing protein involved in the
            chromosomal stability and immortality of cancer cells
  JOURNAL   Cancer Res 67 (18), 8544-8553 (2007)
   PUBMED   17823411
REFERENCE   9  (bases 1 to 3157)
  AUTHORS   Foltz,D.R., Jansen,L.E., Black,B.E., Bailey,A.O., Yates,J.R. 3rd
            and Cleveland,D.W.
  TITLE     The human CENP-A centromeric nucleosome-associated complex
  JOURNAL   Nat Cell Biol 8 (5), 458-469 (2006)
   PUBMED   16622419
  REMARK    GeneRIF: hFLEG1 is associated with the CENP-A centromeric
            nucleosome
REFERENCE   10 (bases 1 to 3157)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB101211.1, DB022872.1, BM838206.1, DN998761.1, CA441903.1,
            CF619091.1 and DB319863.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018410.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074809.1, BC001940.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000411486.7/ ENSP00000414109.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AB101211.1         33-292
            261-522             DB022872.1         290-551
            523-670             BM838206.1         521-668
            671-1085            DN998761.1         254-668
            1086-2478           AB101211.1         1118-2510
            2479-3019           CA441903.1         16-556              c
            3020-3031           CF619091.1         333-344
            3032-3157           DB319863.1         2-127               c
FEATURES             Location/Qualifiers
     source          1..3157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.1"
     gene            1..3157
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /note="Holliday junction recognition protein"
                     /db_xref="GeneID:55355"
                     /db_xref="HGNC:HGNC:25444"
                     /db_xref="MIM:612667"
     exon            1..152
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2282
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /note="isoform a is encoded by transcript variant 1; fetal
                     liver expressing gene 1; up-regulated in lung cancer 9;
                     14-3-3-associated AKT substrate; fetal liver-expressing
                     gene 1 protein"
                     /codon_start=1
                     /product="Holliday junction recognition protein isoform a"
                     /protein_id="NP_060880.3"
                     /db_xref="CCDS:CCDS33406.1"
                     /db_xref="GeneID:55355"
                     /db_xref="HGNC:HGNC:25444"
                     /db_xref="MIM:612667"
                     /translation="MLGTLRAMEGEDVEDDQLLQKLRASRRRFQRRMQRLIEKYNQPF
                     EDTPVVQMATLTYETPQGLRIWGGRLIKERNEGEIQDSSMKPADRTDGSVQAAAWGPE
                     LPSHRTVLGADSKSGEVDATSDQEESVAWALAPAVPQSPLKNELRRKYLTQVDILLQG
                     AEYFECAGNRAGRDVRVTPLPSLASPAVPAPGYCSRISRKSPGDPAKPASSPREWDPL
                     HPSSTDMALVPRNDSLSLQETSSSSFLSSQPFEDDDICNVTISDLYAGMLHSMSRLLS
                     TKPSSIISTKTFIMQNWNSRRRHRYKSRMNKTYCKGARRSQRSSKENFIPCSEPVKGT
                     GALRDCKNVLDVSCRKTGLKLEKAFLEVNRPQIHKLDPSWKERKVTPSKYSSLIYFDS
                     SATYNLDEENRFRTLKWLISPVKIVSRPTIRQGHGENRQREIEIRFDQLHREYCLSPR
                     NQPRRMCLPDSWAMNMYRGGPASPGGLQGLETRRLSLPSSKAKAKSLSEAFENLGKRS
                     LEAGRCLPKSDSSSSLPKTNPTHSATRPQQTSDLHVQGNSSGIFRKSVSPSKTLSVPD
                     KEVPGHGRNRYDEIKEEFDKLHQKYCLKSPGQMTVPLCIGVSTDKASMEVRYQTEGFL
                     GKLNPDPHFQGFQKLPSSPLGCRKSLLGSTAIEAPSSTCVARAITRDGTRDHQFPAKR
                     PRLSEPQGSGRQGNSLGASDGVDNTVRPGDQGSSSQPNSEERGENTSYRMEEKSDFML
                     EKLETKSV"
     exon            153..219
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /inference="alignment:Splign:2.1.0"
     exon            220..275
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /inference="alignment:Splign:2.1.0"
     exon            276..372
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /inference="alignment:Splign:2.1.0"
     exon            373..437
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /inference="alignment:Splign:2.1.0"
     exon            438..530
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /inference="alignment:Splign:2.1.0"
     exon            531..609
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /inference="alignment:Splign:2.1.0"
     exon            610..2206
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..3157
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2458..2463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /note="hexamer: AATAAA"
     polyA_site      2478
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /note="major polyA site"
     regulatory      3110..3115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /note="hexamer: AATACA"
     polyA_site      3128
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
     regulatory      3135..3140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
                     /note="hexamer: AGTAAA"
     polyA_site      3157
                     /gene="HJURP"
                     /gene_synonym="FAKTS; hFLEG1; URLC9"
ORIGIN      
        1 agtccgggtt ggcgcttggg tactggctgg gtccgatgct gggtacgctg cgcgccatgg
       61 agggcgagga cgtggaagac gaccagctgc tgcagaagct cagggccagt cgccgccgct
      121 tccagaggcg catgcagcgg ctgatagaga agtacaacca gcccttcgag gacaccccgg
      181 tggtgcaaat ggccacgctg acctacgaga cgccacaggg attgagaatt tggggtggaa
      241 gactaataaa ggaaagaaac gaaggagaga tccaggactc ctccatgaag cccgcggaca
      301 ggacagatgg ctccgtgcaa gctgcagcct ggggtcctga gcttccctcg caccgcacag
      361 tcctgggagc cgattcaaaa agcggtgagg tcgatgccac gtcagaccag gaagagtcag
      421 ttgcttgggc cttagcacct gcagtgcctc aaagcccttt gaaaaatgaa ttaagaagga
      481 aatacttgac ccaagtggat atactgctac aaggtgcaga gtattttgag tgtgcaggta
      541 acagagctgg aagggatgta cgtgtgactc cgctgccttc actggcctca cctgccgtgc
      601 ctgcccccgg atactgcagt cgtatctcca gaaagagtcc tggtgaccca gcgaaaccag
      661 cttcatctcc cagagaatgg gatcctttgc atccttcctc cacagacatg gccttagtac
      721 ctagaaatga cagcctctcc ctacaagaga ccagtagcag cagcttctta agcagccagc
      781 cctttgaaga tgatgacatt tgcaatgtga ccatcagtga cctgtacgca gggatgctgc
      841 actccatgag ccggctgttg agcacaaagc catcaagcat catctccacc aaaacgttca
      901 tcatgcaaaa ctggaactcc aggaggaggc acagatataa gagcaggatg aacaaaacat
      961 attgcaaagg agccagacgt tctcagagga gctccaagga gaacttcata ccctgctctg
     1021 agcctgtgaa agggacaggg gcattaagag attgcaagaa cgtattagat gtttcttgcc
     1081 gtaagacagg tttaaaattg gaaaaagctt ttcttgaagt caacagaccc caaatccata
     1141 agttagatcc aagttggaag gagcgcaaag tgacaccctc gaagtattct tccttgattt
     1201 acttcgactc cagtgcaaca tataatcttg atgaggaaaa tagatttagg acattaaaat
     1261 ggttaatttc tcctgtaaaa atagtttcca gaccaacaat acgacagggc catggagaga
     1321 accgtcagag ggagattgaa atccgatttg atcagcttca tcgggaatat tgcctgagtc
     1381 ccaggaacca gcctcgccgg atgtgcctcc cggactcctg ggccatgaac atgtacagag
     1441 ggggtcctgc gagtcctggt ggccttcagg gcttagaaac ccgcaggctg agtttacctt
     1501 ccagcaaagc aaaagcaaaa agtttaagtg aggcttttga aaacctaggc aaaagatctc
     1561 tggaagcagg taggtgcctg cccaagagcg attcatcttc atcacttcca aagaccaacc
     1621 ccacacacag cgcaactcgc ccgcagcaga catctgacct tcacgttcag ggaaatagtt
     1681 ctggaatatt tagaaagtca gtgtcaccca gcaaaactct ttcagtccca gataaagaag
     1741 tgccaggcca cggaaggaat cgttacgatg aaattaaaga agaatttgac aagcttcatc
     1801 aaaagtattg cctcaaatct cctgggcaga tgacagtgcc tttatgtatt ggagtgtcta
     1861 cagataaagc aagtatggaa gttcgatatc aaacagaagg cttcttagga aaattaaatc
     1921 cagaccctca cttccagggt ttccagaagt tgccatcatc acccctgggg tgcagaaaaa
     1981 gtctactggg ctcaactgca attgaggctc cttcatctac atgtgttgct cgtgccatca
     2041 cgagggatgg cacgagggac catcagttcc ctgcaaaaag acccaggcta tcagaacccc
     2101 agggctccgg acgccagggc aattccctgg gtgcctcaga tggggtggac aacaccgtca
     2161 gaccgggaga ccagggcagc tcttcacagc ccaactcaga agagagagga gagaacacgt
     2221 cttacaggat ggaagagaaa agtgatttca tgctagaaaa attggaaact aaaagtgtgt
     2281 agctaggtta tttcggagtg ttatttatct tcccacttgc tctctgtttg tatttttgtt
     2341 ttgtttttga ttcttgagac tgtgaggact tggttgactt ctctgccctt aaagtaaata
     2401 ttagtgaaat tggttccatc agagataacc tcgagttctt ggtgtagaaa ttatgtgaat
     2461 aaagttgctc aattagaatt tttagggttc tctttgatag gcctgttttt ctgatgtgtg
     2521 tgtttttttt gggggggggt tatttgtttg tttgtttgtt tgtttgtttg tttttgagac
     2581 agtctctctc tatcgcccag gctggagtgc ggtggcacaa tcttggctca ctgcaacttc
     2641 cgcctcccgg gttcaagcga ttcttctgcc tcagcctccc gagtagctgg gattacaggc
     2701 gcgcgccacc acgcctggct aatttttgta gttttagtag agacggggtt tcaccatatt
     2761 gaccaggctg gtctcgagct cctggcctcg tgatccatct gcctcggcct cccaaagtgc
     2821 tgggattata ggcgtgagcc actgctccca gccgtgtgtt cttttttaaa tttagatatg
     2881 tccagagaat cctctctcct gtttcccatt tcattcgaga atattgtttg cttgtgagac
     2941 gtaagttcga gccctgcatg caatgaccct tgaaggaaaa taaacagtcc tggtggtccc
     3001 agacgctcct gcagccacag cgcctgtgac tcctcatgat tcttactgaa gctgttgatg
     3061 acaggatatc atggtgacgt ttttgtaatg aaatatttca catattcaga atacattggt
     3121 gaaactcatg ctggagtaaa tagttaatat atggcca
//
