LOCUS       NM_024503              12617 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens HIVEP zinc finger 3 (HIVEP3), transcript variant 1,
            mRNA.
ACCESSION   NM_024503
VERSION     NM_024503.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12617)
  AUTHORS   Tang,Y., Xu,G., Hu,B. and Zhu,Y.
  TITLE     HIVEP3 as a potential prognostic factor promotes the development of
            acute myeloid leukemia
  JOURNAL   Growth Factors 41 (1), 43-56 (2023)
   PUBMED   36571205
  REMARK    GeneRIF: HIVEP3 as a potential prognostic factor promotes the
            development of acute myeloid leukemia.
REFERENCE   2  (bases 1 to 12617)
  AUTHORS   Zhang,X., Zhang,X., Liu,K., Li,W., Wang,J., Liu,P. and Ma,W.
  TITLE     HIVEP3 cooperates with ferroptosis gene signatures to confer
            adverse prognosis in acute myeloid leukemia
  JOURNAL   Cancer Med 11 (24), 5050-5065 (2022)
   PUBMED   35535739
  REMARK    GeneRIF: HIVEP3 cooperates with ferroptosis gene signatures to
            confer adverse prognosis in acute myeloid leukemia.
REFERENCE   3  (bases 1 to 12617)
  AUTHORS   Soini,L., Leysen,S., Crabbe,T., Davis,J. and Ottmann,C.
  TITLE     The identification and structural analysis of potential 14-3-3
            interaction sites on the bone regulator protein Schnurri-3
  JOURNAL   Acta Crystallogr F Struct Biol Commun 77 (Pt 8), 254-261 (2021)
   PUBMED   34341191
  REMARK    GeneRIF: The identification and structural analysis of potential
            14-3-3 interaction sites on the bone regulator protein Schnurri-3.
REFERENCE   4  (bases 1 to 12617)
  AUTHORS   Lavocat,F., Osta,B. and Miossec,P.
  TITLE     Increased sensitivity of rheumatoid synoviocytes to Schnurri-3
            expression in TNF-alpha and IL-17A induced osteoblastic
            differentiation
  JOURNAL   Bone 87, 89-96 (2016)
   PUBMED   27072520
  REMARK    GeneRIF: rheumatoid arthritis-fibroblast-like synoviocytes were
            more sensitive to the synergistic increase of Schnurri-3
            expression.
REFERENCE   5  (bases 1 to 12617)
  AUTHORS   Chung,S.A., Brown,E.E., Williams,A.H., Ramos,P.S., Berthier,C.C.,
            Bhangale,T., Alarcon-Riquelme,M.E., Behrens,T.W., Criswell,L.A.,
            Graham,D.C., Demirci,F.Y., Edberg,J.C., Gaffney,P.M., Harley,J.B.,
            Jacob,C.O., Kamboh,M.I., Kelly,J.A., Manzi,S., Moser-Sivils,K.L.,
            Russell,L.P., Petri,M., Tsao,B.P., Vyse,T.J., Zidovetzki,R.,
            Kretzler,M., Kimberly,R.P., Freedman,B.I., Graham,R.R. and
            Langefeld,C.D.
  CONSRTM   International Consortium for Systemic Lupus Erythematosus Genetics
  TITLE     Lupus nephritis susceptibility loci in women with systemic lupus
            erythematosus
  JOURNAL   J Am Soc Nephrol 25 (12), 2859-2870 (2014)
   PUBMED   24925725
REFERENCE   6  (bases 1 to 12617)
  AUTHORS   Qin,H., Wang,J., Liang,Y., Taniguchi,Y., Tanigaki,K. and Han,H.
  TITLE     RING1 inhibits transactivation of RBP-J by Notch through
            interaction with LIM protein KyoT2
  JOURNAL   Nucleic Acids Res 32 (4), 1492-1501 (2004)
   PUBMED   14999091
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 12617)
  AUTHORS   Oukka,M., Wein,M.N. and Glimcher,L.H.
  TITLE     Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in
            T cells
  JOURNAL   J Exp Med 199 (1), 15-24 (2004)
   PUBMED   14707112
  REMARK    GeneRIF: Overexpression of KRC in transformed and primary T cells
            leads to increased IL-2 production.
REFERENCE   8  (bases 1 to 12617)
  AUTHORS   Oukka,M., Kim,S.T., Lugo,G., Sun,J., Wu,L.C. and Glimcher,L.H.
  TITLE     A mammalian homolog of Drosophila schnurri, KRC, regulates TNF
            receptor-driven responses and interacts with TRAF2
  JOURNAL   Mol Cell 9 (1), 121-131 (2002)
   PUBMED   11804591
REFERENCE   9  (bases 1 to 12617)
  AUTHORS   Hicar,M.D., Liu,Y., Allen,C.E. and Wu,L.C.
  TITLE     Structure of the human zinc finger protein HIVEP3: molecular
            cloning, expression, exon-intron structure, and comparison with
            paralogous genes HIVEP1 and HIVEP2
  JOURNAL   Genomics 71 (1), 89-100 (2001)
   PUBMED   11161801
REFERENCE   10 (bases 1 to 12617)
  AUTHORS   Rustgi,A.K., Van 't Veer,L.J. and Bernards,R.
  TITLE     Two genes encode factors with NF-kappa B- and H2TF1-like
            DNA-binding properties
  JOURNAL   Proc Natl Acad Sci U S A 87 (22), 8707-8710 (1990)
   PUBMED   2247438
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105268.2, BC152563.1,
            AF278765.1, AL445933.32 and AI082114.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024503.4.
            
            Summary: This gene encodes a member of the human immunodeficiency
            virus type 1 enhancer-binding protein family. Members of this
            protein family contain multiple zinc finger and acid-rich (ZAS)
            domains and serine-threonine rich regions. This protein acts as a
            transcription factor and is able to regulate nuclear factor
            kappaB-mediated transcription by binding the kappaB motif in target
            genes. This protein also binds the recombination signal sequence
            that flanks the V, D, and J regions of immunoglobulin and T-cell
            receptors. Alternate splicing results in both coding and non-coding
            transcript variants. [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF278765.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529, SAMEA2159931
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372583.6/ ENSP00000361664.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC105268.2         96160-96374
            216-432             BC152563.1         1-217
            433-992             AF278765.1         11-570
            993-5881            AL445933.32        145623-150511       c
            5882-7045           AF278765.1         5460-6623
            7046-7636           AL445933.32        78291-78881         c
            7637-8123           AF278765.1         7215-7701
            8124-12246          AL445933.32        72132-76254         c
            12247-12617         AI082114.1         7-377               c
FEATURES             Location/Qualifiers
     source          1..12617
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..12617
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /note="HIVEP zinc finger 3"
                     /db_xref="GeneID:59269"
                     /db_xref="HGNC:HGNC:13561"
                     /db_xref="MIM:606649"
     exon            1..510
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /inference="alignment:Splign:2.1.0"
     exon            511..590
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /inference="alignment:Splign:2.1.0"
     exon            591..789
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /inference="alignment:Splign:2.1.0"
     exon            790..6371
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /inference="alignment:Splign:2.1.0"
     CDS             1311..8531
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /note="isoform a is encoded by transcript variant 1;
                     transcription factor HIVEP3; kappa-binding protein 1; zinc
                     finger protein ZAS3; kappa-B and V(D)J recombination
                     signal sequences-binding protein; ZAS family, member 3;
                     human immunodeficiency virus type I enhancer binding
                     protein 3"
                     /codon_start=1
                     /product="transcription factor HIVEP3 isoform a"
                     /protein_id="NP_078779.2"
                     /db_xref="CCDS:CCDS463.1"
                     /db_xref="GeneID:59269"
                     /db_xref="HGNC:HGNC:13561"
                     /db_xref="MIM:606649"
                     /translation="MDPEQSVKGTKKAEGSPRKRLTKGEAIQTSVSSSVPYPGSGTAA
                     TQESPAQELLAPQPFPGPSSVLREGSQEKTGQQQKPPKRPPIEASVHISQLPQHPLTP
                     AFMSPGKPEHLLEGSTWQLVDPMRPGPSGSFVAPGLHPQSQLLPSHASIIPPEDLPGV
                     PKVFVPRPSQVSLKPTEEAHKKERKPQKPGKYICQYCSRPCAKPSVLQKHIRSHTGER
                     PYPCGPCGFSFKTKSNLYKHRKSHAHRIKAGLASGMGGEMYPHGLEMERIPGEEFEEP
                     TEGESTDSEEETSATSGHPAELSPRPKQPLLSSGLYSSGSHSSSHERCSLSQSSTAQS
                     LEDPPPFVEPSSEHPLSHKPEDTHTIKQKLALRLSERKKVIDEQAFLSPGSKGSTESG
                     YFSRSESAEQQVSPPNTNAKSYAEIIFGKCGRIGQRTAMLTATSTQPLLPLSTEDKPS
                     LVPLSVPRTQVIEHITKLITINEAVVDTSEIDSVKPRRSSLSRRSSMESPKSSLYREP
                     LSSHSEKTKPEQSLLSLQHPPSTAPPVPLLRSHSMPSAACTISTPHHPFRGSYSFDDH
                     ITDSEALSHSSHVFTSHPRMLKRQPAIELPLGGEYSSEEPGPSSKDTASKPSDEVEPK
                     ESELTKKTKKGLKTKGVIYECNICGARYKKRDNYEAHKKYYCSELQIAKPISAGTHTS
                     PEAEKSQIEHEPWSQMMHYKLGTTLELTPLRKRRKEKSLGDEEEPPAFESTKSQFGSP
                     GPSDAARNLPLESTKSPAEPSKSVPSLEGPTGFQPRTPKPGSGSESGKERRTTSKEIS
                     VIQHTSSFEKSDSLEQPSGLEGEDKPLAQFPSPPPAPHGRSAHSLQPKLVRQPNIQVP
                     EILVTEEPDRPDTEPEPPPKEPEKTEEFQWPQRSQTLAQLPAEKLPPKKKRLRLAEMA
                     QSSGESSFESSVPLSRSPSQESNVSLSGSSRSASFERDDHGKAEAPSPSSDMRPKPLG
                     THMLTVPSHHPHAREMRRSASEQSPNVSHSAHMTETRSKSFDYGSLSLTGPSAPAPVA
                     PPARVAPPERRKCFLVRQASLSRPPESELEVAPKGRQESEEPQPSSSKPSAKSSLSQI
                     SSAATSHGGPPGGKGPGQDRPPLGPTVPYTEALQVFHHPVAQTPLHEKPYLPPPVSLF
                     SFQHLVQHEPGQSPEFFSTQAMSSLLSSPYSMPPLPPSLFQAPPLPLQPTVLHPGQLH
                     LPQLMPHPANIPFRQPPSFLPMPYPTSSALSSGFFLPLQSQFALQLPGDVESHLPQIK
                     TSLAPLATGSAGLSPSTEYSSDIRLPPVAPPASSSAPTSAPPLALPACPDTMVSLVVP
                     VRVQTNMPSYGSAMYTTLSQILVTQSQGSSATVALPKFEEPPSKGTTVCGADVHEVGP
                     GPSGLSEEQSRAFPTPYLRVPVTLPERKGTSLSSESILSLEGSSSTAGGSKRVLSPAG
                     SLELTMETQQQKRVKEEEASKADEKLELVKPCSVVLTSTEDGKRPEKSHLGNQGQGRR
                     ELEMLSSLSSDPSDTKEIPPLPHPALSHGTAPGSEALKEYPQPSGKPHRRGLTPLSVK
                     KEDSKEQPDLPSLAPPSSLPLSETSSRPAKSQEGTDSKKVLQFPSLHTTTNVSWCYLN
                     YIKPNHIQHADRRSSVYAGWCISLYNPNLPGVSTKAALSLLRSKQKVSKETYTMATAP
                     HPEAGRLVPSSSRKPRMTEVHLPSLVSPEGQKDLARVEKEEERRGEPEEDAPASQRGE
                     PARIKIFEGGYKSNEEYVYVRGRGRGKYVCEECGIRCKKPSMLKKHIRTHTDVRPYVC
                     KHCHFAFKTKGNLTKHMKSKAHSKKCQETGVLEELEAEEGTSDDLFQDSEGREGSEAV
                     EEHQFSDLEDSDSDSDLDEDEDEDEEESQDELSRPSSEAPPPGPPHALRADSSPILGP
                     QPPDAPASGTEATRGSSVSEAERLTASSCSMSSQSMPGLPWLGPAPLGSVEKDTGSAL
                     SYKPVSPRRPWSPSKEAGSRPPLARKHSLTKNDSSPQRCSPAREPQASAPSPPGLHVD
                     PGRGMGALPCGSPRLQLSPLTLCPLGRELAPRAHVLSKLEGTTDPGLPRYSPTRRWSP
                     GQAESPPRSAPPGKWALAGPGSPSAGEHGPGLGLDPRVLFPPAPLPHKLLSRSPETCA
                     SPWQKAESRSPSCSPGPAHPLSSRPFSALHDFHGHILARTEENIFSHLPLHSQHLTRA
                     PCPLIPIGGIQMVQARPGAHPTLLPGPTAAWVSGFSGGGSDLTGAREAQERGRWSPTE
                     SSSASVSPVAKVSKFTLSSELEGGDYPKERERTGGGPGRPPDWTPHGTGAPAEPTPTH
                     SPCTPPDTLPRPPQGRRAAQSWSPRLESPRAPTNPEPSATPPLDRSSSVGCLAEASAR
                     FPARTRNLSGEPRTRQDSPKPSGSGEPRAHPHQPEDRVPPNA"
     exon            6372..6517
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /inference="alignment:Splign:2.1.0"
     exon            6518..6693
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /inference="alignment:Splign:2.1.0"
     exon            6694..6780
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /inference="alignment:Splign:2.1.0"
     exon            6781..7715
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /inference="alignment:Splign:2.1.0"
     exon            7716..12617
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12045..12050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /note="hexamer: AATAAA"
     polyA_site      12067
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /note="major polyA site"
     regulatory      12594..12599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /note="hexamer: AATAAA"
     polyA_site      12617
                     /gene="HIVEP3"
                     /gene_synonym="KBP-1; KBP1; KRC; Schnurri-3; SHN3; ZAS3;
                     ZNF40C"
                     /note="major polyA site"
ORIGIN      
        1 ggtctggact cctagtggaa aagacaagcg aggcatgggt tggctctgga ttcagaaaac
       61 agctgctgat tagattctgt gtctgcaggc tgaatttatt ccgtgttttt cagcagcacg
      121 aattcaagag ggatgcttct gtttgggttt ctgatcgtga tttatattta ttcagaggaa
      181 taacagaggg tggatctgtt cccggcgcga gcatgctcac aaccagccga ctctcccatt
      241 atccagctgc ctagtttggt gcttcaatgt acatggctat tccgtgtgca tatgtgtgta
      301 tacaaacacg catgcatgcc tggatggaca tacgtatgca caggttattt tttaaggaca
      361 attctttcaa taaggtcttt accccttact tgaaacaggt gttcatgaaa aaaatgcaca
      421 aaatcctgcc tggccggaat aattcatgaa gaaggggctg gatccgtggg tcagagaaca
      481 caggaccagt ttgccatccc aaggccgaag gcctccctcc aacacagttc tccaagctct
      541 agaaatctct gacacatctt gaccatgaga ccacggctgg tttttggcag gattcgaggc
      601 acaaacccag cagcctcaac ctagttcatg gaggagcctc gcggggtcct ggccaagcaa
      661 gcccgcccct ctggtgggaa gagcggcgcc taggtggagg gtggctgccg taggagtgga
      721 catgaatgct ggctttcaga gagaacagcg tttcagtttt ggtcatcgga agtggtgcct
      781 tcagcacaga agaagagcgt gatttctcct ccaaggccgt tgatctccaa cccagaacta
      841 aaggggagaa gagccacccc cagcatccag cgtggcatct cttgtgccag gaccagggat
      901 gactgggcca tggacacaga tgtctccaac cttcaaccgt ttgcatagca cacgggggac
      961 tcgtgggggc cacctgccac tgccagctga aacaatacaa tggcaatact gacatccttc
     1021 atgacgtttt cccgacagac attcaggcag aaagtgctgg tgcgttttct gtctgcaaag
     1081 tagagggcca tgcctcacca atagaatagc gtgggccctg atgacctgct ccgagtccac
     1141 tcacagccag tgacacttgc aaaaaactcc caaagccgtc ttgggtttgg ctcccacagc
     1201 tcttgaccaa tgtggccaaa gctggacacc tccttgggac actgggatta ttcataaatg
     1261 cagcccgccc tgactctccc tgaatagcat ctgaagtctt tgtgaaggtc atggatcctg
     1321 aacaaagtgt caagggcacc aagaaggctg agggaagtcc ccggaagcgg ctgaccaaag
     1381 gagaggccat tcagaccagt gtttcttcca gcgtcccata cccaggcagc ggcacagctg
     1441 ccacccaaga gagccccgcc caagagctct tagccccgca gcccttcccg ggcccctcat
     1501 cagttcttag ggaaggctct caggagaaaa cgggccagca gcagaagccc cccaaaaggc
     1561 cccccatcga agcatccgtc cacatctcac agcttccgca gcaccctctg acaccagcat
     1621 tcatgtcgcc tggcaaacct gagcatctcc tggaggggtc cacatggcaa ctggttgacc
     1681 ccatgagacc tggaccctct ggctccttcg tggcccctgg gctccatcct cagagccagc
     1741 tccttccttc ccacgcttcc atcattcccc ccgaggacct tcctggagtc cccaaagtct
     1801 tcgtgcctcg tccttcccag gtctccttga agcccacaga agaggcacac aagaaggaga
     1861 ggaagcccca gaagccaggc aagtacatct gccagtactg cagccggccc tgtgccaagc
     1921 ccagcgtgct ccagaagcac attcgctcac acacaggtga gaggccctac ccctgcggcc
     1981 cctgtggctt ctccttcaag accaagagta atctctacaa gcacaggaag tcccatgccc
     2041 accgcatcaa agcaggcctg gcctcaggca tgggtggcga gatgtaccca catgggctgg
     2101 agatggagcg gatccctggg gaagagtttg aggagcccac tgagggagaa agcacagatt
     2161 ctgaagagga gactagtgcc acctctggtc accctgcaga gctctcccca agacccaagc
     2221 agccccttct ctccagcggg ctatacagct ctgggagcca cagttccagc cacgaacgct
     2281 gttccctgtc ccagtccagc acagcccagt cactcgaaga cccccctcca tttgtggaac
     2341 cctcatctga gcaccccctg agccataaac ctgaagacac ccacacgatt aagcagaagc
     2401 tggccctccg cttaagcgag aggaagaagg tgatcgatga gcaggcgttt ctgagcccag
     2461 gcagcaaagg gagtactgag tctgggtatt tctctcgctc cgagagtgca gagcagcagg
     2521 tcagcccccc aaacaccaac gccaagtcct acgctgagat catctttggc aagtgtgggc
     2581 gaataggaca gcggaccgcc atgctgacag ccacctccac ccagcccctc ctgcccctgt
     2641 ccaccgaaga caagcccagc ctggtgcctt tgtctgtacc ccggacgcag gtgatcgagc
     2701 acatcacgaa gctcatcacc atcaacgagg ccgtggtgga caccagcgag atcgacagcg
     2761 tgaagccaag gcggagctca ctgtccaggc gcagcagcat ggagtcccca aaatccagcc
     2821 tctaccggga gcccctgtca tcccacagtg agaaaaccaa gcctgaacaa tcactgctga
     2881 gcctccagca cccgcccagt accgcccccc ctgtgcctct cctgagaagc cactcaatgc
     2941 cttctgccgc ctgcactatc agcacccccc accacccctt ccgaggtagc tactccttcg
     3001 atgaccatat caccgactcc gaagccctga gccacagcag tcacgtgttt acctcccacc
     3061 cccggatgct gaagcgccag ccggcaatcg aattaccttt gggaggggaa tacagttctg
     3121 aggagcctgg cccaagcagc aaagacacag cctccaagcc ctcggacgaa gtggaaccca
     3181 aggaaagcga gcttaccaaa aagaccaaga agggtttgaa aacaaaaggg gtgatctacg
     3241 aatgtaacat atgtggtgct cggtacaaga aaagggataa ctacgaagcc cacaaaaaat
     3301 actactgctc agagcttcag atcgcaaagc ccatctctgc aggcacccac acatctccag
     3361 aagctgaaaa gagtcagatt gagcatgagc cgtggtccca aatgatgcat tacaaactgg
     3421 gaaccaccct ggaactcact ccactgagga agaggaggaa agagaagagc cttggggacg
     3481 aggaagagcc acctgccttt gagtccacaa aaagtcagtt tggcagcccc gggccatctg
     3541 atgctgctcg gaaccttccc ctggagtcca ccaagtcacc agcagaacca agtaaatcag
     3601 tgccctcctt ggagggaccc acgggcttcc agccaaggac tcccaagcca gggtccggtt
     3661 cagaatcagg gaaggagagg agaacaacgt ccaaagaaat ttctgtcatc cagcacacca
     3721 gctcctttga gaaatctgat tctctcgagc agccgagtgg cttggaaggg gaagacaaac
     3781 ctctggccca gttcccatca cccccacctg ccccacacgg acgctctgct cactccctgc
     3841 agcctaagtt ggtccgccag cccaacattc aggttcctga gatcctagta actgaggagc
     3901 ctgaccggcc ggacacagag ccagagccgc cccctaagga acctgagaag actgaggagt
     3961 tccaatggcc ccagcgcagc cagacacttg cccagctccc agctgagaag ctgccaccca
     4021 aaaagaagag gttgcgcctg gcagagatgg cccaatcatc aggggagtcc agcttcgagt
     4081 cctctgtgcc tctgtctcgc agcccgagcc aggaaagcaa tgtctctttg agtgggtcca
     4141 gccgctcagc ctcgtttgag agggatgacc atgggaaagc cgaggccccc agtccctcat
     4201 ctgacatgcg ccccaaaccc ctgggcaccc acatgttgac tgtccccagc caccacccac
     4261 atgcccgaga gatgcggagg tcagcctcag agcagagccc caacgtttcc cattctgccc
     4321 acatgaccga gacacgcagc aaatcctttg actatggcag cttgtccttg acaggccctt
     4381 ctgctccagc cccagtggct ccaccagcgc gggtggcccc gccagagaga agaaaatgct
     4441 tcttggtgag acaggcctct ctgagcaggc ctccagaatc tgagttggag gttgccccca
     4501 agggaagaca ggagagcgaa gaaccacagc cctcatccag taaaccctct gccaaaagct
     4561 cattgtccca gatttcctct gcggccacct cacatggtgg acccccggga ggcaagggcc
     4621 cagggcagga caggccccca ttggggccca ctgtgcccta cacagaagca ctgcaagtgt
     4681 tccaccaccc cgttgcccag acacccctgc atgagaagcc atacctgccc ccaccagtct
     4741 cccttttctc cttccagcat ctcgtgcagc atgagccagg acagtctcca gaattcttct
     4801 ccacccaggc catgtccagc ctcctgtcct caccatactc catgccccca cttcctccct
     4861 ccttatttca agccccaccg cttcctctcc agcctactgt tctgcaccca ggccaactcc
     4921 atctccccca gctcatgcct cacccagcca acatcccctt caggcagccc ccttccttcc
     4981 tccccatgcc atacccgacc tcctcagcac tgtcttctgg gtttttcctg cctctgcaat
     5041 cccagtttgc acttcagctc cctggtgatg tggaaagcca tctgccccag atcaaaacca
     5101 gcctggcccc actggcaaca ggaagtgctg gcctctcccc cagcacagag tacagcagtg
     5161 acatccggct accccctgtg gctcccccag ccagctcctc agcacctaca tcagctcctc
     5221 cactggccct gcctgcctgt ccagacacca tggtgtccct ggttgtgcct gtccgtgttc
     5281 agaccaatat gccgtcctat gggagcgcaa tgtacaccac cctttcccag atcttggtca
     5341 cccagtccca aggcagctca gcaactgtgg cacttcccaa gtttgaggaa cccccatcaa
     5401 aggggacgac tgtatgtggt gcagatgtgc atgaggttgg gcccggccct tctgggttaa
     5461 gtgaagagca aagcagagct ttcccaactc catacctgag agtgcctgtg acattacctg
     5521 aaagaaaagg cacttccctg tcatcagaga gtatcttgag cctggagggg agttcatcaa
     5581 cagcaggggg aagcaaacgt gtcctttcac cagctggcag ccttgaactt accatggaaa
     5641 cccagcagca aaaaagagtg aaggaggagg aggcttccaa ggcagatgaa aaacttgagc
     5701 tggtaaaacc atgcagtgtg gtccttacca gcaccgagga tgggaagagg ccagagaaat
     5761 cccacttagg caaccagggc caaggcagga gggagctaga aatgctgtcc agcctgtcct
     5821 cagatccatc tgacacaaag gaaattcctc ccctccctca ccctgcattg tcccatggga
     5881 cagccccagg ctcagaagct ttgaaggaat atccccagcc atctggcaaa cctcaccgaa
     5941 gagggttgac cccactgagc gtgaagaaag aagattccaa ggaacaacct gatctcccct
     6001 ccttggcacc tccgagctct ctgcctctgt cagaaacgtc ctccagacca gccaagtcac
     6061 aagaaggtac ggactcaaag aaggtactgc agttccccag cctccacaca accactaatg
     6121 tcagttggtg ctatttaaac tacattaagc caaatcacat ccagcatgca gataggaggt
     6181 cctctgttta cgctggttgg tgcataagtt tgtacaaccc caaccttccg ggggtttcca
     6241 ctaaagctgc tttgtccctc ctgaggtcta agcagaaagt gagcaaagag acatacacca
     6301 tggccacagc tccgcatcct gaggcaggaa ggcttgtgcc atccagctcc cgcaagcccc
     6361 gcatgacaga ggttcacctc ccttcactgg tttccccgga aggccagaaa gatctagcta
     6421 gagtggagaa ggaagaagag aggagagggg agccggagga ggatgctcct gcctcccaga
     6481 gaggggagcc ggcgaggatc aaaatcttcg aaggagggta caaatcaaac gaagagtatg
     6541 tatatgtgcg aggccgcggc cgagggaaat atgtttgtga ggagtgtgga attcgctgca
     6601 agaagcccag catgctgaag aaacacatcc gcacccacac tgacgtccgg ccctatgtgt
     6661 gcaagcactg tcactttgct tttaaaacca aagggaatct gactaagcac atgaagtcga
     6721 aggcccacag caaaaagtgc caagagacag gggtgctgga ggagctggaa gccgaagaag
     6781 gaaccagtga cgacctgttc caggactcgg aaggacgaga gggttcagag gctgtggagg
     6841 agcaccagtt ttcggacctg gaggactcgg actcagactc agacctggac gaagacgagg
     6901 atgaggatga ggaggagagc caggatgagc tgtccagacc atcctcagag gcgcccccgc
     6961 ctggcccacc acatgcactg cgggcagact cctcacccat cctgggccct cagcccccag
     7021 atgcccccgc ctctggcacg gaggctacac gaggcagctc ggtctcggaa gctgagcgcc
     7081 tgacagccag cagctgctcc atgtccagcc agagcatgcc gggcctcccc tggctgggac
     7141 cggcccctct gggctctgtg gagaaagaca caggctcagc cttgagctac aagcctgtgt
     7201 ccccaagaag accgtggtcc ccaagcaaag aagcaggcag ccgtccacca ctagcccgca
     7261 aacactcgct aaccaaaaac gactcatctc cccagcgatg ctccccggcc cgagaaccac
     7321 aggcctcagc cccaagccca cctggcctgc acgtggaccc aggaaggggc atgggcgctc
     7381 tcccttgtgg gtctccaaga cttcagctgt ctcctctcac cctctgcccc ctgggaagag
     7441 aactggcccc tcgagcacat gtgctctcca aactcgaggg taccaccgac ccaggcctcc
     7501 ccagatactc gcccaccagg agatggtctc caggtcaggc cgagtcacca ccacggtcag
     7561 cgccgccagg gaagtgggcc ttggctgggc cgggcagccc ctcagcgggg gagcatggcc
     7621 caggcttggg gctggaccca cgggttctct tcccgcccgc gcctctacct cacaagctcc
     7681 tcagcagaag cccagagacc tgcgcctccc cgtggcagaa ggccgagtcc cgaagtccct
     7741 cctgctcacc cggccctgct catcctctct cctcccgacc cttctccgcc ctccatgact
     7801 tccacggcca catcctggcc cggacagagg agaacatctt cagccacctg cctctgcact
     7861 cccagcactt gacccgtgcc ccatgtccct tgattcccat cggtgggatc cagatggtgc
     7921 aggcccggcc aggagcccac cccaccctgc tgccagggcc caccgcagcc tgggtcagtg
     7981 gcttctccgg gggtggcagc gacctgacag gggcccggga ggcccaggag cgaggccgct
     8041 ggagtcccac tgagagctcg tcagcctccg tgtcgcctgt ggctaaggtc tccaaattca
     8101 cactctcctc agagctggag ggcggggact accccaagga gagggagagg accggcggag
     8161 gcccgggcag gcctcctgac tggacacccc atgggaccgg ggcacctgca gagcccacac
     8221 ccacgcacag cccctgcacc ccacccgaca ccttgccccg gccgccccag ggacgccggg
     8281 cagcgcagtc ctggagcccc cgcttggagt ccccgcgtgc accgaccaac cccgagcctt
     8341 ctgccacccc gccgctggac cgcagcagct ctgtgggctg cctggcagag gcctctgccc
     8401 gcttcccagc ccggacgagg aacctctccg gggaacccag gaccaggcag gactccccca
     8461 agccctcagg aagtggggag cccagggcac atccacatca gcctgaggac agggttcccc
     8521 ccaacgctta gcctctctcc aactgcttca gcatctggct tccagtgtcc agcaacagac
     8581 gtttccagcc actttcctcg aatcatccca cttcctcagc cccatctgtc cctccgtcca
     8641 ggagctctca cggccccatc tgttgtacct tcccatgtat gcagttacct gtgccttttt
     8701 ctacaccttt tgttgcttaa aaagaaacaa aacaaatcac atacatacat ttaaaaaaaa
     8761 aacaacaacc cacgaggagt ctgaggctgt gaatagttta tggttttggg gaaaggctga
     8821 tggtgaagcc tcctgaccct ccccgctgtg gttggcagcc acccacccca gaggctggca
     8881 gagggaaagg ggtacactga gggagaaagg aaaaggaaac ttcaaacaat atagaattaa
     8941 atgtaaaagg aagcactcct gtgtacagat gcgatcaagg ttcctgttta ttgccacttc
     9001 acccccctgc ccagctcgta gccacccctc tctgccagca gaaaggccag tgtccccagg
     9061 cagaggggca caaacacagg caggtgaccc ccacccaggc cccagcaggc aggcccagaa
     9121 aaactaatct tttccttttt tttttttttt tttttttttg caagaaaata aaatgatact
     9181 tttcctagga tttcaacaca aaataatagg tgcaggtaga aggaggaggg ctggctcccc
     9241 aagggctcct ggatactctg gtagtctgag tcatgggccc atcctggcac tccacaggtg
     9301 ggcaggccac cccacccacg cacccccact ccagacacct cccttctgca ccccaccctg
     9361 gccccctggg ctggggaagg agccctgact gtccgtccct ggctcccaag cccctgaccg
     9421 aggcctcact ctcctgttgc ctcctctgtt ctaaaaccac caaaccaccc acaaaggcag
     9481 aagtggcagg gcccgagccc tagcggccgt tcctgagact gggttttggg ttttgtttca
     9541 tcttggtccc tggggtacaa gggagcctgt tcccctcatg gctgggtttt tccagttctc
     9601 cacagcagag gtttgcgggg aactgtttca ggaccacttt gccacaggac cgtttccccc
     9661 cgtccctgcc cctgtctcca ctaccccaag gaaataccca caactgtggc tggtggatac
     9721 ggcctggacc tgtttgctgt cttacacctc ttttttaaaa agagagagga tggtgtttga
     9781 tacttcaccc agccaccaca gattcttttg acctagagga tttttgaatt gtcctaactc
     9841 gttggaattc tccaaagcaa tcagtgtgag ccagtgcctc ttccttaccc acatctctac
     9901 tttcaagaag ctgccctgca tttcctgggg caaaactcta ctttgtaaga aaaataatag
     9961 gaccagaaat ttaaatccca aattgaacta tggaacttga actctagcgt gttcgcccca
    10021 actgggagag gtgagctttt tcccagtgtt tcagaactga ttttctttac tttctacaag
    10081 ggagggcagc acagggacta cggttgaggc ccgtgaaggc tgggtttgat gccaccctat
    10141 acagagcagg gacctctctg gctaatcccc agtcctcagc caggctgtgt gaatcaagtg
    10201 cctgccccag ggctcttgag ctattgaagc tgcttgggta caggacacag taggtgggga
    10261 gggttaagac ccttctgtga gttccctgtg cggggctgta cttgcctctt ccaattcgtg
    10321 gcctttccct gcttggtccc tactagacag acaaaccagc cacagtccag cctgcagcca
    10381 gaccaccttg ttcactcatt ctcctttgcc tcagagctaa gacaaaaatg agacagaagg
    10441 cagggctccc tgggagtcca ctgtgctcca gggttctggg gaatcagggt tagccagcag
    10501 ctcctggctg cttccctcag agactagggc tctcatcctc cccaagagaa gcagcaagcc
    10561 cagcctggac cacactgtcc atattgctgg acagtggcct gacagaaagt gactcctcca
    10621 agtcccagga ggccagggct tttctcatcc ttgcctttca gccctaaccc atgggactgc
    10681 ccacggattg gagacttcaa gggctgaggt ctgggagctg cataaagggc attgcttcag
    10741 cccaggttag aaatctgcct gggcaagctc ttcctgcccc agacctacaa agcagcagac
    10801 cgggggctct ggtggactag cccctgacat tggtgggggg ccccacacca ctccacccca
    10861 ccctgccttc cagctctcct gggcattttt ctccctgtac tcaaacagcc tacccaccca
    10921 aggtttcctc cctgggcagc ctagcaatga acagtgcagc cggcagggca gaggcccggc
    10981 agtcaccggg cccgtcaggc tcaggcagag aagccacagg ggccaggagt cactggagac
    11041 tatttctaaa tgatgggggt aaatgcacaa atagaatctc accaaagggc tgcctccaca
    11101 ttgatgccgt gcccagaggg acagaaccaa tgccaccagc ctgggtatat gtcactgggc
    11161 acagctctaa ccccctcctc cggactctag tcccgctcct ctgcgcacag agcccccagc
    11221 ccacaggtac accttcatga tttggagaaa gacgctcgcc ccatgcacgc cctcctctgg
    11281 gccttctgcc ctgctcccag tcacttccaa gcttcctgtt tgcctgtgat gttattgtgc
    11341 ctgttgaggg aagcagcaga ggaggcagtg gctgacttgg cacagatgcc tgctacgtgc
    11401 tctgttgaaa tgcgcggggt ggccattcct cggtacagac tagtcctggt ccttgggtgt
    11461 gggcagtggg ggaggaacca actggtcgag gtttcagagc caaaccttgc ctttggttgg
    11521 tgagtccttg ccccccaggc ctgcgctcca cgatgccttt cacccttggc aatctcaggg
    11581 ccatcctggg tagtaacccc actcctctct gctcccgccc gcacctgtgg ctctcactct
    11641 gggctcaacc cctgcaaccc tccaggagcc cgacagcagc cagctgcctg cactgtcgcc
    11701 tccgtaagct ccaacttcca gacccagaag tccctctgct tccctctgtt ggaaaaagcc
    11761 taaaagaatt agcttccaga ttcctctagc ccctgctcca ttcccaccca gtccttctga
    11821 agaggaatga gcaatacatc tgagctggat ttctctctag tcctttctcc agacaaatcc
    11881 ttcttaaagc aaaagtcctg gctgagcacc tgtccttggg gaccgatctg ccgtgtgacc
    11941 aggggaagaa agttcccgaa agcctgttcc accaattctg cttctgtgtt gtgaatccag
    12001 tctgctttcc attagaaaac cgcttcggca cttatggtca ctttaataaa tctagtatgt
    12061 aaaaaaagaa agaaagaaaa gaaacagaaa aaagaaacgt gcaggcaaat gtaaaataca
    12121 atgctctctg taagataaat atttgccttt ttttctaaaa ggtgtacgta ttctgtatgt
    12181 gaaattgtct gtagaaagtt tctatgttct taaatggcaa tacattccaa aaattgtact
    12241 gtagatatgt acagcaaccg cactgggatg gggtagtttt gcctgtaatt ttatttaaac
    12301 tccagtttcc acacttgcat cttgcaatgt tggtatggta tatatcagtg caaaagaaaa
    12361 aacaaaacag aaacaaacaa aaaaaaaaaa caaaaatcca cgcaggtcta aagcacagag
    12421 tctgacgtac aaaaggaaaa atgctcagta ttgatgtgtg tgacctttgt tgtaaattac
    12481 atctgtactg tgaatgagaa gtttttacaa gtataataat tgcctttatt acagctctgg
    12541 ctgagtgttc agcctgagga tattttttaa aaaaaaaaga attagcatgt tggaataaat
    12601 ttgaaaatcc caacata
//
