LOCUS       NM_006734               9697 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens HIVEP zinc finger 2 (HIVEP2), mRNA.
ACCESSION   NM_006734
VERSION     NM_006734.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9697)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 9697)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 9697)
  AUTHORS   Murphy,C.E., Lawther,A.J., Webster,M.J., Asai,M., Kondo,Y.,
            Matsumoto,M., Walker,A.K. and Weickert,C.S.
  TITLE     Nuclear factor kappa B activation appears weaker in schizophrenia
            patients with high brain cytokines than in non-schizophrenic
            controls with high brain cytokines
  JOURNAL   J Neuroinflammation 17 (1), 215 (2020)
   PUBMED   32680547
  REMARK    GeneRIF: Nuclear factor kappa B activation appears weaker in
            schizophrenia patients with high brain cytokines than in
            non-schizophrenic controls with high brain cytokines.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9697)
  AUTHORS   Zhao,J., Chen,C., Bell,R.L., Qing,H. and Lin,Z.
  TITLE     Identification of HIVEP2 as a dopaminergic transcription factor
            related to substance use disorders in rats and humans
  JOURNAL   Transl Psychiatry 9 (1), 247 (2019)
   PUBMED   31586043
  REMARK    GeneRIF: HIVEP2-mediated transcriptional mechanisms are implicated
            in dopaminergic pathophysiology of substance use disorder.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9697)
  AUTHORS   Goldsmith,H., Wells,A., Sa,M.J.N., Williams,M., Heussler,H.,
            Buckman,M., Pfundt,R., de Vries,B.B.A. and Goel,H.
  TITLE     Expanding the phenotype of intellectual disability caused by HIVEP2
            variants
  JOURNAL   Am J Med Genet A 179 (9), 1872-1877 (2019)
   PUBMED   31207095
  REMARK    GeneRIF: We describe the phenotype and genotype of two additional
            patients with novel de novo pathogenic HIVEP2 variants, who have
            previously unreported features, including hyperphagia and
            Angelman-like features.
REFERENCE   6  (bases 1 to 9697)
  AUTHORS   Dorflinger,U., Pscherer,A., Moser,M., Rummele,P., Schule,R. and
            Buettner,R.
  TITLE     Activation of somatostatin receptor II expression by transcription
            factors MIBP1 and SEF-2 in the murine brain
  JOURNAL   Mol Cell Biol 19 (5), 3736-3747 (1999)
   PUBMED   10207097
REFERENCE   7  (bases 1 to 9697)
  AUTHORS   van 't Veer,L.J., Lutz,P.M., Isselbacher,K.J. and Bernards,R.
  TITLE     Structure and expression of major histocompatibility
            complex-binding protein 2, a 275-kDa zinc finger protein that binds
            to an enhancer of major histocompatibility complex class I genes
  JOURNAL   Proc Natl Acad Sci U S A 89 (19), 8971-8975 (1992)
   PUBMED   1409593
REFERENCE   8  (bases 1 to 9697)
  AUTHORS   Sudo,T., Ozawa,K., Soeda,E.I., Nomura,N. and Ishii,S.
  TITLE     Mapping of the human gene for the human immunodeficiency virus type
            1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24
  JOURNAL   Genomics 12 (1), 167-170 (1992)
   PUBMED   1733857
REFERENCE   9  (bases 1 to 9697)
  AUTHORS   Nomura,N., Zhao,M.J., Nagase,T., Maekawa,T., Ishizaki,R., Tabata,S.
            and Ishii,S.
  TITLE     HIV-EP2, a new member of the gene family encoding the human
            immunodeficiency virus type 1 enhancer-binding protein. Comparison
            with HIV-EP1/PRDII-BF1/MBP-1
  JOURNAL   J Biol Chem 266 (13), 8590-8594 (1991)
   PUBMED   2022670
REFERENCE   10 (bases 1 to 9697)
  AUTHORS   Rustgi,A.K., Van 't Veer,L.J. and Bernards,R.
  TITLE     Two genes encode factors with NF-kappa B- and H2TF1-like
            DNA-binding properties
  JOURNAL   Proc Natl Acad Sci U S A 87 (22), 8707-8710 (1990)
   PUBMED   2247438
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR936782.1, AW197846.1,
            AA465317.1, X65644.1, DA216380.1, AL023584.1 and AA041301.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006734.3.
            
            Summary: This gene encodes a member of a family of closely related,
            large, zinc finger-containing transcription factors. The encoded
            protein regulates transcription by binding to regulatory regions of
            various cellular and viral genes that maybe involved in growth,
            development and metastasis. The protein contains the ZAS domain
            comprised of two widely separated regions of zinc finger motifs, a
            stretch of highly acidic amino acids and a serine/threonine-rich
            sequence. [provided by RefSeq, Nov 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: X65644.1, DQ231041.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367603.8/ ENSP00000356575.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               CR936782.1         27-129
            104-412             AW197846.1         87-395
            413-570             CR936782.1         439-596
            571-912             AA465317.1         63-404              c
            913-1311            CR936782.1         939-1337
            1312-3525           X65644.1           771-2984
            3526-4280           CR936782.1         3552-4306
            4281-5330           X65644.1           3740-4789
            5331-5744           DA216380.1         154-567
            5745-6210           CR936782.1         5770-6235
            6211-6989           X65644.1           5670-6448
            6990-7637           CR936782.1         7015-7662
            7638-9125           X65644.1           7097-8584
            9126-9565           AL023584.1         12247-12686         c
            9566-9697           AA041301.1         11-142              c
FEATURES             Location/Qualifiers
     source          1..9697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.2"
     gene            1..9697
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /note="HIVEP zinc finger 2"
                     /db_xref="GeneID:3097"
                     /db_xref="HGNC:HGNC:4921"
                     /db_xref="MIM:143054"
     exon            1..78
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /inference="alignment:Splign:2.1.0"
     exon            79..191
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /inference="alignment:Splign:2.1.0"
     exon            192..286
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /inference="alignment:Splign:2.1.0"
     exon            287..331
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /inference="alignment:Splign:2.1.0"
     exon            332..5905
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /inference="alignment:Splign:2.1.0"
     CDS             719..8059
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /note="Schnurri-2; c-myc intron binding protein 1; MHC
                     binding protein-2; human immunodeficiency virus type I
                     enhancer binding protein 2"
                     /codon_start=1
                     /product="transcription factor HIVEP2"
                     /protein_id="NP_006725.3"
                     /db_xref="CCDS:CCDS43510.1"
                     /db_xref="GeneID:3097"
                     /db_xref="HGNC:HGNC:4921"
                     /db_xref="MIM:143054"
                     /translation="MDTGDTALGQKATSRSGETDKASGRWRQEQSAVIKMSTFGSHEG
                     QRQPQIEPEQIGNTASAQLFGSGKLASPSEVVQQVAEKQYPPHRPSPYSCQHSLSFPQ
                     HSLPQGVMHSTKPHQSLEGPPWLFPGPLPSVASEDLFPFPIHGHSGGYPRKKISSLNP
                     AYSQYSQKSIEQAEEAHKKEHKPKKPGKYICPYCSRACAKPSVLKKHIRSHTGERPYP
                     CIPCGFSFKTKSNLYKHRKSHAHAIKAGLVPFTESAVSKLDLEAGFIDVEAEIHSDGE
                     QSTDTDEESSLFAEASDKMSPGPPIPLDIASRGGYHGSLEESLGGPMKVPILIIPKSG
                     IPLPNESSQYIGPDMLPNPSLNTKADDSHTVKQKLALRLSEKKGQDSEPSLNLLSPHS
                     KGSTDSGYFSRSESAEQQISPPNTNAKSYEEIIFGKYCRLSPRNALSVTTTSQERAAM
                     GRKGIMEPLPHVNTRLDVKMFEDPVSQLIPSKGDVDPSQTSMLKSTKFNSESRQPQII
                     PSSIRNEGKLYPANFQGSNPVLLEAPVDSSPLIRSNSVPTSSATNLTIPPSLRGSHSF
                     DERMTGSDDVFYPGTVGIPPQRMLRRQAAFELPSVQEGHVEVEHHGRMLKGISSSSLK
                     EKKLSPGDRVGYDYDVCRKPYKKWEDSETPKQNYRDISCLSSLKHGGEYFMDPVVPLQ
                     GVPSMFGTTCENRKRRKEKSVGDEEDTPMICSSIVSTPVGIMASDYDPKLQMQEGVRS
                     GFAMAGHENLSHGHTERFDPCRPQLQPGSPSLVSEESPSAIDSDKMSDLGGRKPPGNV
                     ISVIQHTNSLSRPNSFERSESAELVACTQDKAPSPSETCDSEISEAPVSPEWAPPGDG
                     AESGGKPSPSQQVQQQSYHTQPRLVRQHNIQVPEIRVTEEPDKPEKEKEAQSKEPEKP
                     VEEFQWPQRSETLSQLPAEKLPPKKKRLRLADMEHSSGESSFESTGTGLSRSPSQESN
                     LSHSSSFSMSFEREETSKLSALPKQDEFGKHSEFLTVPAGSYSLSVPGHHHQKEMRRC
                     SSEQMPCPHPAEVPEVRSKSFDYGNLSHAPVSGAAASTVSPSRERKKCFLVRQASFSG
                     SPEISQGEVGMDQSVKQEQLEHLHAGLRSGWHHGPPAVLPPLQQEDPGKQVAGPCPPL
                     SSGPLHLAQPQIMHMDSQESLRNPLIQPTSYMTSKHLPEQPHLFPHQETIPFSPIQNA
                     LFQFQYPTVCMVHLPAQQPPWWQAHFPHPFAQHPQKSYGKPSFQTEIHSSYPLEHVAE
                     HTGKKPAEYAHTKEQTYPCYSGASGLHPKNLLPKFPSDQSSKSTETPSEQVLQEDFAS
                     ANAGSLQSLPGTVVPVRIQTHVPSYGSVMYTSISQILGQNSPAIVICKVDENMTQRTL
                     VTNAAMQGIGFNIAQVLGQHAGLEKYPIWKAPQTLPLGLESSIPLCLPSTSDSVATLG
                     GSKRMLSPASSLELFMETKQQKRVKEEKMYGQIVEELSAVELTNSDIKKDLSRPQKPQ
                     LVRQGCASEPKDGLQSGSSSFSSLSPSSSQDYPSVSPSSREPFLPSKEMLSGSRAPLP
                     GQKSSGPSESKESSDELDIDETASDMSMSPQSSSLPAGDGQLEEEGKGHKRPVGMLVR
                     MASAPSGNVADSTLLLTDMADFQQILQFPSLRTTTTVSWCFLNYTKPNYVQQATFKSS
                     VYASWCISSCNPNPSGLNTKTTLALLRSKQKITAEIYTLAAMHRPGTGKLTSSSAWKQ
                     FTQMKPDASFLFGSKLERKLVGNILKERGKGDIHGDKDIGSKQTEPIRIKIFEGGYKS
                     NEDYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYVCKLCNFAFKTKGNL
                     TKHMKSKAHMKKCLELGVSMTSVDDTETEEAENLEDLHKAAEKHSMSSISTDHQFSDA
                     EESDGEDGDDNDDDDEDEDDFDDQGDLTPKTRSRSTSPQPPRFSSLPVNVGAVPHGVP
                     SDSSLGHSSLISYLVTLPSIRVTQLMTPSDSCEDTQMTEYQRLFQSKSTDSEPDKDRL
                     DIPSCMDEECMLPSEPSSSPRDFSPSSHHSSPGYDSSPCRDNSPKRYLIPKGDLSPRR
                     HLSPRRDLSPMRHLSPRKEAALRREMSQRDVSPRRHLSPRRPVSPGKDITARRDLSPR
                     RERRYMTTIRAPSPRRALYHNPPLSMGQYLQAEPIVLGPPNLRRGLPQVPYFSLYGDQ
                     EGAYEHPGSSLFPEGPNDYVFSHLPLHSQQQVRAPIPMVPVGGIQMVHSMPPALSSLH
                     PSPTLPLPMEGFEEKKGASGESFSKDPYVLSKQHEKRGPHALQSSGPPSTPSSPRLLM
                     KQSTSEDSLNATEREQEENIQTCTKAIASLRIATEEAALLGPDQPARVQEPHQNPLGS
                     AHVSIRHFSRPEPGQPCTSATHPDLHDGEKDNFGTSQTPLAHSTFYSKSCVDDKQLDF
                     HSSKELSSSTEESKDPSSEKSQLH"
     exon            5906..6060
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /inference="alignment:Splign:2.1.0"
     exon            6061..6236
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /inference="alignment:Splign:2.1.0"
     exon            6237..6338
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /inference="alignment:Splign:2.1.0"
     exon            6339..7234
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /inference="alignment:Splign:2.1.0"
     exon            7235..9697
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8887..8892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /note="hexamer: ATTAAA"
     polyA_site      8912
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
     regulatory      9675..9680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /note="hexamer: AATAAA"
     polyA_site      9697
                     /gene="HIVEP2"
                     /gene_synonym="HIV-EP2; MBP-2; MIBP1; MRD43; SHN2; ZAS2;
                     ZNF40B"
                     /note="major polyA site"
ORIGIN      
        1 actaatgagc gacgtgcacc ggcgcgcacg gcccggccac cgctgcggct gcggcggccg
       61 gcggcggccc gttgtcaggt ggagcctttg aattttttaa aagaccatag taatcagatc
      121 tacttgaaaa attaagtgaa ttgatttggt tggaatgctc ttttaccgat gctttaacat
      181 acagccacta gattcccaga agttgtgcat gagttcctgt gaggagagtt ggcatcttgg
      241 aaatcaaaga cggttgtgat gcagtttttt gatatgagga taacaggaag cgtcaggaca
      301 atcatgccca taagaactct aaactgttca gatcatttta tcttagtgaa actggcaatt
      361 gaactttgct ctagttgatg ggcaaaattt ctcctagact attcatcatc ccaatttcat
      421 cctagttgaa aattttcaaa tgccataaga aatctttata gatttgcact tagcttttgg
      481 atggacgttt ctacaatgga gagaactgtg ttatagccct ggtccaagga cattactagc
      541 taatgcccat cgactgtggt gtgcgtgtgg aaggttccaa agagaaggag caatcagcaa
      601 gtttgcagac accctggaac atggaagcaa ccaagcttta agaagcacag ctttggagac
      661 actccatgag tctgcactgc tttcagggga actagcactt aagaccttgt gtaacaaaat
      721 ggacactggg gacacagctc taggacaaaa agctacctca aggtctggag aaactgataa
      781 agcatcaggt agatggagac aggaacaatc agctgttatt aagatgagca cttttggcag
      841 tcatgaagga cagcggcaac cacaaataga gcctgagcaa atcggaaaca cagcatcagc
      901 acaactgttt ggttctggga aactggcctc ccctagtgaa gtggtgcagc aagtcgcaga
      961 gaagcaatat ccaccgcatc gtccgagtcc ttactcatgc caacactcac tctctttccc
     1021 tcagcactca ttgccacagg gggtcatgca cagcaccaag ccacatcaga gcctcgaagg
     1081 tcctccgtgg cttttccctg gccctttgcc atccgttgcc tctgaggact tatttccttt
     1141 tcctatacat ggccacagtg gtggttatcc tagaaaaaag atttcaagtc tgaaccctgc
     1201 ttatagccaa tactcccaga aaagtattga acaggcagaa gaggctcaca agaaagagca
     1261 caaacccaaa aagcctggca agtacatttg cccttactgc agcagagcgt gtgccaaacc
     1321 tagtgtactg aaaaaacaca tcaggtccca tactggggag cggccatatc catgtatacc
     1381 ttgtggtttc tctttcaaga caaagagcaa tttgtacaag cacaggaagt cacatgccca
     1441 tgcaattaag gcaggattag tacctttcac agagtcagct gtatctaaat tggacctaga
     1501 ggctggtttt attgatgtag aagcagaaat acattcagat ggtgaacaga gtacagacac
     1561 agatgaggag agttctttat ttgccgaggc ttctgacaaa atgagtcctg gtccacccat
     1621 cccactggac attgccagca gaggcggcta tcatgggtca ttggaagaat cattgggagg
     1681 tccaatgaag gtgccgattt tgattatccc taaaagtggg attcctctcc ctaatgaaag
     1741 ctctcagtat attggccctg atatgctacc aaatccatct ttaaatacta aggctgatga
     1801 ttcgcacaca gtcaaacaga aacttgcact aagactgtca gagaaaaaag gacaagattc
     1861 tgagccatcg ctcaaccttc tgagcccgca cagtaaagga agcactgatt ctggttactt
     1921 ttctcgctca gaaagtgctg agcagcaaat aagccctccc aacacaaatg caaagtctta
     1981 tgaagaaatc atctttggaa aatactgtcg gcttagtccg agaaatgcac tcagtgttac
     2041 aaccacaagt caggagcgtg ccgcaatggg taggaagggc ataatggaac cattacctca
     2101 cgttaacacc aggttagatg tcaagatgtt tgaagatcct gtttcacagc tgatcccaag
     2161 caagggagat gtcgacccca gtcaaacgag catgctgaaa tccactaagt tcaacagtga
     2221 gtccagacaa ccccagatta ttccatcatc tatcaggaac gaaggaaaac tttatccagc
     2281 aaacttccaa ggcagcaacc cggttctctt agaagctcct gtagactctt caccccttat
     2341 tagaagcaac tcagtgccaa cttcttcagc aactaatcta actattcctc cttctttgag
     2401 aggaagtcac tcatttgatg aaaggatgac tggttccgac gatgtattct atccagggac
     2461 cgtgggcata ccccctcagc gcatgctaag aagacaagcg gcatttgagc tgccttcggt
     2521 acaggagggc cacgtggaag tcgagcacca tggcaggatg ttgaagggta tcagcagttc
     2581 atccctgaag gaaaagaaat tgtctcctgg ggacagggtt gggtatgact atgatgtctg
     2641 tcggaaaccc tataagaagt gggaggactc tgaaacacca aagcaaaact acagggacat
     2701 ttcctgcttg agttctttaa agcatggtgg agaatatttc atggatcccg tggtgccatt
     2761 gcagggagta ccaagcatgt ttggaactac ctgtgaaaac aggaaacgcc ggaaagagaa
     2821 gagcgtaggg gatgaagagg acacgcccat gatctgcagc agcattgtaa gcactcctgt
     2881 gggcatcatg gcttccgatt atgaccccaa actgcagatg caggaaggag tcaggagtgg
     2941 atttgccatg gctggacacg aaaacctttc tcatggtcac acggaacgct ttgacccatg
     3001 tcggccccaa ctgcagcctg gaagtccatc tcttgtgtca gaggagtcac cttcagccat
     3061 tgattcagac aagatgtcag acctaggggg caggaaacct cctggaaatg tgatttctgt
     3121 gattcagcac accaactcac tgagccgacc caattcattt gaaaggtctg agtcagccga
     3181 acttgtggct tgcacacagg ataaagcccc ttccccttca gagacttgtg acagtgagat
     3241 ttcagaagcc ccagtgagtc ctgagtgggc tccacctggg gatggtgcag aaagtggggg
     3301 gaaaccctct ccatctcagc aggtgcagca gcagtcctat cacacacagc ccaggctagt
     3361 tcggcaacac aacatccagg ttcctgagat tcgagtgacc gaggagcctg ataaacctga
     3421 gaaggagaag gaagcccaga gcaaagagcc agagaagcct gtggaagaat ttcagtggcc
     3481 ccagagaagt gagacccttt cccagctccc cgcggagaag ttgccaccca aaaagaagcg
     3541 tctgcgactt gcagatatgg agcactcctc aggggagtcc agctttgaat ccacaggcac
     3601 aggcctctcc cgcagcccca gccaagaaag caacttgtcc cacagctcca gtttctccat
     3661 gtcttttgaa agagaagaaa ccagtaagct ttctgcactt cctaagcagg atgagtttgg
     3721 gaagcattca gagtttctga ctgtccctgc tggttcatac tcattgtctg tcccaggcca
     3781 tcaccaccag aaagagatgc gacgctgctc atcagagcag atgccttgtc ctcacccagc
     3841 ggaagtccca gaagttcgga gcaaatcatt tgattatggg aatctgtccc atgctcctgt
     3901 gtcgggagca gcagcctcca cggtatcacc gtccagggag aggaagaaat gctttctggt
     3961 gcggcaagct tccttcagtg gctccccaga aatctcccag ggcgaggttg gcatggatca
     4021 gagcgtgaag caagagcagc tggagcacct gcatgctggc ctccggtccg ggtggcacca
     4081 tggcccgcct gctgtgctgc ctcctcttca gcaagaggac ccagggaagc aggtggcggg
     4141 tccttgtccc ccgctgagct cggggccact gcacctggcc cagccacaga tcatgcacat
     4201 ggacagtcag gaatctttga gaaatccctt gatccaacca acatcctata tgacaagcaa
     4261 gcacttacct gaacagccac acttatttcc acatcaagag acaattccat tttctccaat
     4321 ccagaatgcc ttgtttcagt ttcagtatcc tacagtttgt atggttcatt taccagctca
     4381 gcagcctccc tggtggcagg cacatttccc acatcccttt gctcagcacc ctcagaagag
     4441 ctatggcaag ccctcttttc agacagaaat ccattcgagc tatcccttag agcatgtggc
     4501 agagcacact ggaaagaaac ctgctgagta tgcacacacg aaagagcaga cctacccatg
     4561 ttattcagga gcatcagggc tacacccaaa gaaccttctt ccaaagtttc catcagacca
     4621 gagcagtaag tcaactgaaa cgccctctga gcaggttctt caagaagatt ttgcctcggc
     4681 aaatgctggg tctttgcagt ccctcccagg aacagtggtt cctgttcgga tccagacgca
     4741 cgtaccatcc tatggaagtg tcatgtacac aagcatttct cagatacttg ggcagaatag
     4801 ccctgccatt gtcatatgca aagtcgatga gaatatgacc caaaggacac tggtcaccaa
     4861 cgcagccatg caagggatag gattcaacat tgcccaggtg ctggggcagc atgcgggctt
     4921 ggagaagtac cccatttgga aagcacctca gactttgccc ctcggcttag aatcctccat
     4981 ccccttgtgt ttaccttcca cctctgacag cgtggccacc ctgggaggta gcaagcgaat
     5041 gctttctcca gccagtagct tggagctctt catggaaacc aagcagcaga aaagggtcaa
     5101 agaagaaaag atgtacggac agattgtgga ggagcttagt gctgtggagc tgaccaactc
     5161 agacatcaaa aaggacctct cccgccccca gaaaccccag ctggttcgac aaggatgtgc
     5221 ttctgagcca aaagatggct tgcagtcagg gtcatcttcc ttctcctcgc tgtcgccctc
     5281 ctcatctcaa gactatcctt ctgttagccc gtcttccagg gagccattcc tgcccagcaa
     5341 ggagatgctt tccggttccc gggcaccact tccggggcag aagtccagtg ggccttctga
     5401 aagcaaagaa tcttcagatg aattagatat cgatgagacg gcatcggaca tgagcatgag
     5461 cccacagagt tcttcattac cagcaggaga tggtcagctg gaagaggaag ggaagggcca
     5521 caagcggcct gttggcatgc tggtccgcat ggcctctgcc cccagcggga acgtggcaga
     5581 ctcaactctt cttctcacgg acatggcaga tttccagcag attcttcagt tccccagtct
     5641 gcggacaaca actactgtga gttggtgctt cttgaattat acaaaaccca attatgtgca
     5701 acaggccacc ttcaaatcct cggtttatgc ttcatggtgc attagttcct gtaatccaaa
     5761 cccatcagga ttgaacacca agaccacgct ggctcttctg aggtccaagc aaaaaatcac
     5821 tgcagaaatt tatactctgg ctgctatgca taggcctgga accggcaagc ttacatcatc
     5881 aagtgcttgg aagcagttta ctcagatgaa acctgatgcg tcctttttat ttggcagcaa
     5941 actagaaagg aaactagtgg gaaatatctt aaaggaaaga gggaaaggag atattcatgg
     6001 agataaagat attggatcca aacaaactga gccaatccga attaaaatat ttgaaggagg
     6061 gtacaaatcg aatgaagatt atgtatatgt cagaggacgt ggccggggaa agtacatttg
     6121 tgaagaatgt gggattcgct gtaagaagcc aagcatgctc aaaaaacaca tccgtaccca
     6181 tactgatgtt cggccttatg tatgcaagtt atgtaacttt gccttcaaaa cgaaaggaaa
     6241 cctaacgaag catatgaaat ctaaagcaca catgaaaaaa tgcctggaat tgggagtctc
     6301 aatgacatcg gtggatgata cagaaactga ggaagcagaa aatttggaag atttgcacaa
     6361 agcagcagag aagcatagca tgtccagcat ttcaactgat catcagttct ccgatgctga
     6421 ggaatcagat ggtgaggatg gagatgataa tgatgatgat gatgaagatg aagatgactt
     6481 tgacgaccag ggagatttaa caccaaaaac aagatcaaga agcaccagtc ctcagcctcc
     6541 tagattctcc tccttgcctg tgaatgttgg cgccgtaccc cacggggttc cttcagatag
     6601 ttccctggga cattcttcgt tgatcagcta tttggttact ttgccaagta ttcgagttac
     6661 tcagcttatg acacccagtg attcatgtga agatacccag atgacagaat accagaggct
     6721 attccagagc aaaagtacgg actcagaacc agacaaagac agattggaca tacctagttg
     6781 tatggatgag gagtgcatgc taccttcaga gccaagctcc tctcccaggg acttctcacc
     6841 ctcaagccac cattcctctc caggatatga ttcttcaccc tgtcgagata attcaccaaa
     6901 gaggtatctg atacccaaag gagatttatc tcccaggaga catttatcac ctaggagaga
     6961 tctgtcaccc atgagacatc tttcaccaag aaaggaagct gcattgagaa gagagatgtc
     7021 ccaaagagat gtttcaccaa gaaggcattt gtctccaagg aggccagtgt ctcctgggaa
     7081 agatatcaca gcaagaagag acctctctcc tagaagagag agaagataca tgaccacaat
     7141 aagagcgcca tctcccagaa gggctttata ccataaccca ccattgtcca tgggacagta
     7201 tttgcaagca gagccaattg tattggggcc tcctaattta agaagaggat tacctcaggt
     7261 tccttacttc agtctctatg gagaccaaga aggtgcttat gaacatccag gctccagcct
     7321 tttccctgag ggtcctaatg actatgtctt cagtcatctt ccactccact ctcagcaaca
     7381 agtgcgagcc cctatcccca tggtgcccgt tggtgggatc cagatggttc actccatgcc
     7441 gccagccctt tccagtttac atccttcacc cacattgccc ctgccaatgg agggctttga
     7501 ggagaagaaa ggcgcgtcag gggagtcctt ctccaaggac ccctatgtgc tttctaagca
     7561 gcatgagaag cgaggtcctc acgctttgca gtcatctggt ccacctagca ctccctcctc
     7621 tcctcggctg ttgatgaaac agagcacttc ggaagacagc ctaaacgcaa cagagcggga
     7681 acaggaggaa aatatacaga cttgtacaaa agccattgcc tctctccgga ttgccacgga
     7741 agaggcagct ctgctcgggc cagatcagcc agcgcgggtg caggagcccc accagaaccc
     7801 cctgggaagt gcacatgtta gcattagaca ctttagtaga cctgagccag gtcagccctg
     7861 tacctcagcc acccaccctg acttgcatga tggtgaaaag gacaattttg gtacatcaca
     7921 gactccatta gctcactcca cgttttacag caagagttgt gtggatgaca agcagttgga
     7981 ctttcacagc agcaaggaat tatcttcaag cacagaggaa agcaaagatc cttcatcaga
     8041 aaagagtcag ctacattgat ctatgatgca tggagacttt catttccaca ttttcccatt
     8101 tttttgtttt tgtttttcta gaaatggagg taatccagtt tatagcatgc ctgtcctaag
     8161 ttacagtagt ttgctattat atatactttt gttatatcaa aagaattagg taaattaaca
     8221 agtcatcatg agcctgacca aaacaaaatt tgaaattaac ctattgggtc tggtactttt
     8281 aaaattgtac agatgtttgt gccttttctt tactttgctt atattcttat aagcattttt
     8341 tagcagtaat ttgtacatat tttagaattt gtgtatctgc tttgtaataa atgtaatttc
     8401 tttccttttt tggacacttg gatctaaatg atgtaaagca aaacagcatc aatatatatg
     8461 tgaggttgca ctaaaacata tttttatatg attaaaactg aacagctttt atgtacagct
     8521 ctgattctgt aatactaata tttatttact ttgtttcata aattgtacat tttttcttaa
     8581 tgttgtggat tgcttttcta tgtgaagcat gggatttact gttgcgtaac tagaacaaaa
     8641 atgtacattg taaacaagat atttaaacta gagtatctta ttctgcactt atgcattagt
     8701 taaaaaaaga taaaggatgt atcagtcagt tcttaactct tgtatatttt tttgtctctt
     8761 gtttgctgga ttgactataa cttaagtgct gattgtgatt ttaaaatgat agtaccgtaa
     8821 agcattaaag taaacaatgt gctattgtga gttttttcaa agctttataa atcagttata
     8881 aataatatta aaagtatttg gtcttatgtg aacatgttga tctatatact catctaaaaa
     8941 tatgggaaaa cattccaccc catgtaaata tgtacaagtg catcactggt acaattttat
     9001 gtaactcagt tggacactag gttgccacag acctatgcta ggtgtcttta aaaaattaag
     9061 gtgacaaagc acatgggact gtgtagagct tggttatcgg ccggcccggt ggcttggcag
     9121 gcagtgctgt gcgctgctca tggagaagac ctgggcttag caatctcctt agttcttgct
     9181 acacaggatg gtgactggaa ctaaggctac acagagggtc gcacttggac tctgagggtt
     9241 gggtgtggaa gggggaaaag gagatggaga cctgctcccc agctcttcct gtcagccggt
     9301 ttacatggga acagggttaa catctgtgtt aggggaggtc accttaccct ttttcatagg
     9361 ggaagagtgt cacactcctg gctatctcag ggggaatggg gaaaagaatc tttcaagggc
     9421 aaagaactcg tgggaggatg tctgttgtat gtaatactca caatggcttt tggttagtgt
     9481 tgaaggtggg aagagcattt gtaggtccag aagagtgaaa gagagggagg ggtgcagcaa
     9541 catgtgcaca ggcacgcaca tgtgtgcacg cacacataca atctgggtta tctttgtgct
     9601 atatagtgga ttataattct gtgaaaccaa gtttgtatat tgaattacat taaggagtgt
     9661 tctttaaaaa gagaaataaa tatacaatta catgctt
//
