LOCUS       NM_002114               9053 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens HIVEP zinc finger 1 (HIVEP1), mRNA.
ACCESSION   NM_002114 XM_005249041
VERSION     NM_002114.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9053)
  AUTHORS   Hsu,K.W., Wang,A.M., Ping,Y.H., Huang,K.H., Huang,T.T., Lee,H.C.,
            Lo,S.S., Chi,C.W. and Yeh,T.S.
  TITLE     Downregulation of tumor suppressor MBP-1 by microRNA-363 in gastric
            carcinogenesis
  JOURNAL   Carcinogenesis 35 (1), 208-217 (2014)
   PUBMED   23975832
  REMARK    GeneRIF: Downregulation of tumor suppressor MBP-1 by microRNA-363
            in gastric carcinogenesis.
REFERENCE   2  (bases 1 to 9053)
  AUTHORS   Blandin,G., Marchand,S., Charton,K., Daniele,N., Gicquel,E.,
            Boucheteil,J.B., Bentaib,A., Barrault,L., Stockholm,D., Bartoli,M.
            and Richard,I.
  TITLE     A human skeletal muscle interactome centered on proteins involved
            in muscular dystrophies: LGMD interactome
  JOURNAL   Skelet Muscle 3 (1), 3 (2013)
   PUBMED   23414517
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9053)
  AUTHORS   Kahle,J.J., Gulbahce,N., Shaw,C.A., Lim,J., Hill,D.E.,
            Barabasi,A.L. and Zoghbi,H.Y.
  TITLE     Comparison of an expanded ataxia interactome with patient medical
            records reveals a relationship between macular degeneration and
            ataxia
  JOURNAL   Hum Mol Genet 20 (3), 510-527 (2011)
   PUBMED   21078624
REFERENCE   4  (bases 1 to 9053)
  AUTHORS   McClay,J.L., Adkins,D.E., Aberg,K., Stroup,S., Perkins,D.O.,
            Vladimirov,V.I., Lieberman,J.A., Sullivan,P.F. and van den
            Oord,E.J.
  TITLE     Genome-wide pharmacogenomic analysis of response to treatment with
            antipsychotics
  JOURNAL   Mol Psychiatry 16 (1), 76-85 (2011)
   PUBMED   19721433
REFERENCE   5  (bases 1 to 9053)
  AUTHORS   Yu,B., Mitchell,G.A. and Richter,A.
  TITLE     Cirhin up-regulates a canonical NF-kappaB element through strong
            interaction with Cirip/HIVEP1
  JOURNAL   Exp Cell Res 315 (18), 3086-3098 (2009)
   PUBMED   19732766
REFERENCE   6  (bases 1 to 9053)
  AUTHORS   Omichinski,J.G., Clore,G.M., Robien,M., Sakaguchi,K., Appella,E.
            and Gronenborn,A.M.
  TITLE     High-resolution solution structure of the double Cys2His2 zinc
            finger from the human enhancer binding protein MBP-1
  JOURNAL   Biochemistry 31 (16), 3907-3917 (1992)
   PUBMED   1567844
REFERENCE   7  (bases 1 to 9053)
  AUTHORS   Muchardt,C., Seeler,J.S., Nirula,A., Shurland,D.L. and Gaynor,R.B.
  TITLE     Regulation of human immunodeficiency virus enhancer function by
            PRDII-BF1 and c-rel gene products
  JOURNAL   J Virol 66 (1), 244-250 (1992)
   PUBMED   1727488
REFERENCE   8  (bases 1 to 9053)
  AUTHORS   Gaynor,R.B., Muchardt,C., Diep,A., Mohandas,T.K., Sparkes,R.S. and
            Lusis,A.J.
  TITLE     Localization of the zinc finger DNA-binding protein
            HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24
  JOURNAL   Genomics 9 (4), 758-761 (1991)
   PUBMED   2037300
REFERENCE   9  (bases 1 to 9053)
  AUTHORS   Nakamura,T., Donovan,D.M., Hamada,K., Sax,C.M., Norman,B.,
            Flanagan,J.R., Ozato,K., Westphal,H. and Piatigorsky,J.
  TITLE     Regulation of the mouse alpha A-crystallin gene: isolation of a
            cDNA encoding a protein that binds to a cis sequence motif shared
            with the major histocompatibility complex class I gene and other
            genes
  JOURNAL   Mol Cell Biol 10 (7), 3700-3708 (1990)
   PUBMED   1694016
REFERENCE   10 (bases 1 to 9053)
  AUTHORS   Fan,C.M. and Maniatis,T.
  TITLE     A DNA-binding protein containing two widely separated zinc finger
            motifs that recognize the same DNA sequence
  JOURNAL   Genes Dev 4 (1), 29-42 (1990)
   PUBMED   2106471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157373.23, AI033710.1, BC140816.1, AL391828.10 and AA563642.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002114.3.
            
            Summary: This gene encodes a transcription factor belonging to the
            ZAS family, members of which are large proteins that contain a ZAS
            domain - a modular protein structure consisting of a pair of C2H2
            zinc fingers with an acidic-rich region and a serine/threonine-rich
            sequence. These proteins bind specifically to the DNA sequence
            motif, GGGACTTTCC, found in the enhancer elements of several viral
            promoters, including human immunodeficiency virus (HIV), and to
            related sequences found in the enhancer elements of a number of
            cellular promoters. This protein binds to this sequence motif,
            suggesting a role in the transcriptional regulation of both viral
            and cellular genes. [provided by RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X51435.1, BC140816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379388.7/ ENSP00000368698.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AL157373.23        46272-46450
            180-246             AI033710.1         1-67
            247-4916            BC140816.1         1-4670
            4917-4917           AL391828.10        64567-64567
            4918-8678           BC140816.1         4672-8432
            8679-9053           AA563642.1         1-375               c
FEATURES             Location/Qualifiers
     source          1..9053
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.1"
     gene            1..9053
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /note="HIVEP zinc finger 1"
                     /db_xref="GeneID:3096"
                     /db_xref="HGNC:HGNC:4920"
                     /db_xref="MIM:194540"
     exon            1..255
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /inference="alignment:Splign:2.1.0"
     exon            256..398
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..8515
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /note="major histocompatibility complex binding protein 1;
                     positive regulatory domain II binding factor 1; cirhin
                     interaction protein; gate keeper of apoptosis-activating
                     protein; human immunodeficiency virus type I enhancer
                     binding protein 1"
                     /codon_start=1
                     /product="zinc finger protein 40"
                     /protein_id="NP_002105.3"
                     /db_xref="CCDS:CCDS43426.1"
                     /db_xref="GeneID:3096"
                     /db_xref="HGNC:HGNC:4920"
                     /db_xref="MIM:194540"
                     /translation="MPRTKQIHPRNLRDKIEEAQKELNGAEVSKKEILQAGVKGTSES
                     LKGVKRKKIVAENHLKKIPKSPLRNPLQAKHKQNTEESSFAVLHSASESHKKQNYIPV
                     KNGKQFTKQNGETPGIIAEASKSEESVSPKKPLFLQQPSELRRWRSEGADPAKFSDLD
                     EQCDSSSLSSKTRTDNSECISSHCGTTSPSYTNTAFDVLLKAMEPELSTLSQKGSPCA
                     IKTEKLRPNKTARSPPKLKNSSMDAPNQTSQELVAESQSSCTSYTVHMSAAQKNEQGA
                     MQSASHLYHQHEHFVPKSNQHNQQLPGCSGFTGSLTNLQNQENAKLEQVYNIAVTSSV
                     GLTSPSSRSQVTPQNQQMDSASPLSISPANSTQSPPMPIYNSTHVASVVNQSVEQMCN
                     LLLKDQKPKKQGKYICEYCNRACAKPSVLLKHIRSHTGERPYPCVTCGFSFKTKSNLY
                     KHKKSHAHTIKLGLVLQPDAGGLFLSHESPKALSIHSDVEDSGESEEEGATDERQHDL
                     GAMELQPVHIIKRMSNAETLLKSSFTPSSPENVIGDFLLQDRSAESQAVTELPKVVVH
                     HVTVSPLRTDSPKAMDPKPELSSAQKQKDLQVTNVQPLSANMSQGGVSRLETNENSHQ
                     KGDMNPLEGKQDSHVGTVHAQLQRQQATDYSQEQQGKLLSPRSLGSTDSGYFSRSESA
                     DQTVSPPTPFARRLPSTEQDSGRSNGPSAALVTTSTPSALPTGEKALLLPGQMRPPLA
                     TKTLEERISKLISDNEALVDDKQLDSVKPRRTSLSRRGSIDSPKSYIFKDSFQFDLKP
                     VGRRTSSSSDIPKSPFTPTEKSKQVFLLSVPSLDCLPITRSNSMPTTGYSAVPANIIP
                     PPHPLRGSQSFDDKIGAFYDDVFVSGPNAPVPQSGHPRTLVRQAAIEDSSANESHVLG
                     TGQSLDESHQGCHAAGEAMSVRSKALAQGPHIEKKKSHQGRGTMFECETCRNRYRKLE
                     NFENHKKFYCSELHGPKTKVAMREPEHSPVPGGLQPQILHYRVAGSSGIWEQTPQIRK
                     RRKMKSVGDDEELQQNESGTSPKSSEGLQFQNALGCNPSLPKHNVTIRSDQQHKNIQL
                     QNSHIHLVARGPEQTMDPKLSTIMEQQISSAAQDKIELQRHGTGISVIQHTNSLSRPN
                     SFDKPEPFERASPVSFQELNRTGKSGSLKVIGISQEESHPSRDGSHPHQLALSDALRG
                     ELQESSRKSPSERHVLGQPSRLVRQHNIQVPEILVTEEPDRDLEAQCHDQEKSEKFSW
                     PQRSETLSKLPTEKLPPKKKRLRLAEIEHSSTESSFDSTLSRSLSRESSLSHTSSFSA
                     SLDIEDVSKTEASPKIDFLNKAEFLMIPAGLNTLNVPGCHREMRRTASEQINCTQTSM
                     EVSDLRSKSFDCGSITPPQTTPLTELQPPSSPSRVGVTGHVPLLERRRGPLVRQISLN
                     IAPDSHLSPVHPTSFQNTALPSVNAVPYQGPQLTSTSLAEFSANTLHSQTQVKDLQAE
                     TSNSSSTNVFPVQQLCDINLLNQIHAPPSHQSTQLSLQVSTQGSKPDKNSVLSGSSKS
                     EDCFAPKYQLHCQVFTSGPSCSSNPVHSLPNQVISDPVGTDHCVTSATLPTKLIDSMS
                     NSHPLLPPELRPLGSQVQKVPSSFMLPIRLQSSVPAYCFATLTSLPQILVTQDLPNQP
                     ICQTNHSVVPISEEQNSVPTLQKGHQNALPNPEKEFLCENVFSEMSQNSSLSESLPIT
                     QKISVGRLSPQQESSASSKRMLSPANSLDIAMEKHQKRAKDENGAVCATDVRPLEALS
                     SRVNEASKQKKPILVRQVCTTEPLDGVMLEKDVFSQPEISNEAVNLTNVLPADNSSTG
                     CSKFVVIEPISELQEFENIKSSTSLTLTVRSSPAPSENTHISPLKCTDNNQERKSPGV
                     KNQGDKVNIQEQSQQPVTSLSLFNIKDTQQLAFPSLKTTTNFTWCYLLRQKSLHLPQK
                     DQKTSAYTDWTVSASNPNPLGLPTKVALALLNSKQNTGKSLYCQAITTHSKSDLLVYS
                     SKWKSSLSKRALGNQKSTVVEFSNKDASEINSEQDKENSLIKSEPRRIKIFDGGYKSN
                     EEYVYVRGRGRGKYICEECGIRCKKPSMLKKHIRTHTDVRPYHCTYCNFSFKTKGNLT
                     KHMKSKAHSKKCVDLGVSVGLIDEQDTEESDEKQRFSYERSGYDLEESDGPDEDDNEN
                     EDDDEDSQAESVLSATPSVTASPQHLPSRSSLQDPVSTDEDVRITDCFSGVHTDPMDV
                     LPRALLTRMTVLSTAQSDYNRKTLSPGKARQRAARDENDTIPSVDTSRSPCHQMSVDY
                     PESEEILRSSMAGKAVAITQSPSSVRLPPAAAEHSPQTAAGMPSVASPHPDPQEQKQQ
                     ITLQPTPGLPSPHTHLFSHLPLHSQQQSRTPYNMVPVGGIHVVPAGLTYSTFVPLQAG
                     PVQLTIPAVSVVHRTLGTHRNTVTEVSGTTNPAGVAELSSVVPCIPIGQIRVPGLQNL
                     STPGLQSLPSLSMETVNIVGLANTNMAPQVHPPGLALNAVGLQVLTANPSSQSSPAPQ
                     AHIPGLQILNIALPTLIPSVSQVAVDAQGAPEMPASQSKACETQPKQTSVASANQVSR
                     TESPQGLPTVQRENAKKVLNPPAPAGDHARLDGLSKMDTEKAASANHVKPKPELTSIQ
                     GQPASTSQPLLKAHSEVFTKPSGQQTLSPDRQVPRPTALPRRQPTVHFSDVSSDDDED
                     RLVIAT"
     exon            399..452
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /inference="alignment:Splign:2.1.0"
     exon            453..6433
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /inference="alignment:Splign:2.1.0"
     exon            6434..6567
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /inference="alignment:Splign:2.1.0"
     exon            6568..6743
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /inference="alignment:Splign:2.1.0"
     exon            6744..6845
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /inference="alignment:Splign:2.1.0"
     exon            6846..7336
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /inference="alignment:Splign:2.1.0"
     exon            7337..9053
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9029..9034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /note="hexamer: AGTAAA"
     polyA_site      9053
                     /gene="HIVEP1"
                     /gene_synonym="CIRIP; CRYBP1; GAAP; MBP-1; PRDII-BF1;
                     Schnurri-1; ZAS1; ZNF40; ZNF40A"
                     /note="major polyA site"
ORIGIN      
        1 gccagtcgcc ggccttcagc gtggcggctg ctgggcggcg gcagggtggc ggacggagcg
       61 ggggaccggg gagcggcggc cgccggagga ggttatgttt gtgtttgggg ttgtcaagtg
      121 aaggagggat cccaggcgcc gccgccgccg ccgcgcgggg gtcgcggaga tcccgagccg
      181 cggccgccgc catcagcagc gcagctccag ggccggctgc agcggcagcg gctccgccgg
      241 gcgtcctggc agcagcacat ggattaattg atgtatgttg agtttatgga gctgcctttt
      301 ggtggcttgc tttatctgca gtttttaaga agaaaaagaa ggccctgagt caaagaagat
      361 gcctcgaact aaacaaattc atcccagaaa tctaagagac aaaattgaag aagcacaaaa
      421 agaacttaat ggggcagaag tttcaaaaaa agaaatctta caggctggtg ttaaaggaac
      481 ttcggaatcc cttaaaggtg tgaaacgcaa aaagatcgta gctgagaatc acctgaaaaa
      541 aataccaaaa tccccactga gaaatcctct tcaggcaaaa cataaacaaa atacagaaga
      601 gtcatctttc gccgttcttc atagtgcttc ggagtctcac aagaaacaga attatattcc
      661 tgtaaaaaat gggaagcagt ttaccaaaca aaatggagaa acacctggaa taattgctga
      721 agcctcaaaa tctgaagaat ctgtctcccc aaagaagccc ttgtttctgc agcaaccatc
      781 tgaactgcgt agatggagat ccgaaggcgc tgatcctgcc aaattcagtg acctcgatga
      841 acaatgtgac tcaagttcct tgtcaagtaa aaccaggact gacaatagcg aatgcatctc
      901 ttctcattgt ggcactacgt ccccctccta tacaaacact gcattcgatg tcttactgaa
      961 agcaatggag ccagaactga gcaccttgtc acaaaagggc tcaccttgtg caattaagac
     1021 agaaaaactg aggccaaata aaactgcacg ttcccctccc aaattaaaaa acagttcaat
     1081 ggatgcccca aatcagactt cacaggaatt ggttgctgaa tcacagtctt cttgtacctc
     1141 atacacagtc catatgtctg ctgctcagaa gaatgagcaa ggggcaatgc agtcagcttc
     1201 tcatttgtat catcaacatg aacactttgt tcccaaatcc aaccaacata atcaacagct
     1261 tccggggtgt tcaggtttca caggatcact gacaaatctg caaaatcaag agaatgccaa
     1321 acttgaacag gtttataata tagcagtgac atcatctgta ggcctaactt caccttccag
     1381 tagatctcag gttactcctc aaaaccagca aatggattct gcttcacctt tgtcaataag
     1441 tccggctaat tctacacagt cgccccccat gccaatctat aattcaactc atgttgcctc
     1501 tgttgttaat caaagcgtag agcaaatgtg caatcttctt ctgaaagatc agaagccaaa
     1561 aaaacaagga aaatatattt gtgagtattg caatagagca tgtgcaaagc ctagtgtgct
     1621 tttaaagcat atccgctccc acactggaga gcgaccctat ccctgtgtga cttgtggatt
     1681 ttcatttaag actaaaagta atctgtataa gcacaagaaa tcccacgcac atactatcaa
     1741 actgggtctt gtcttgcaac cagatgctgg tggcttgttc ttgtcccacg agtcccccaa
     1801 agcacttagt attcattcag acgtagaaga cagtggggag agcgaggagg aaggcgccac
     1861 tgatgagaga cagcatgacc tgggcgccat ggagctgcag cctgtgcaca taataaagag
     1921 gatgtcaaat gctgaaactt tactaaaatc aagcttcact ccaagcagtc cagaaaatgt
     1981 gataggtgac tttttgctac aggacagatc tgcagaatca caagctgtga cagagttacc
     2041 gaaagttgtg gtccaccatg tcactgtgtc ccccttaaga actgacagtc caaaggccat
     2101 ggatcccaag cctgaacttt ctagtgcaca aaagcagaag gaccttcagg tgacaaacgt
     2161 acagccactt tcagccaaca tgtcccaggg tggagtctcc aggttggaga ctaatgagaa
     2221 ttcccaccag aaaggcgaca tgaatccact ggaaggaaag caagactctc acgtaggaac
     2281 ggtacacgcc cagctacaaa ggcagcaggc taccgattac tcccaagagc agcaaggaaa
     2341 gctcctgagt cctcgaagtt taggaagtac ggattctggt tacttttcac gttctgaaag
     2401 tgccgatcaa acagtgagtc caccaactcc ctttgccaga aggttaccca gcacagaaca
     2461 agactctgga aggagtaacg gaccctctgc agctcttgtc accacgtcaa caccctctgc
     2521 tttgcccaca ggggaaaagg cattgctttt accaggtcag atgcgcccac ctttggccac
     2581 aaaaacactt gaggagcgga tatcgaagct tatctcagac aatgaagctt tggtagatga
     2641 caagcaactg gatagtgtga agccgcggag aacctcactg tcaagacgag gaagcattga
     2701 ttcccccaaa tcatacatat ttaaagattc tttccagttt gatttaaaac cagtgggacg
     2761 gagaacaagt tcaagctctg atataccgaa gtcacctttc acccctactg aaaaatcaaa
     2821 gcaagtgttt cttctgtctg taccttcact tgactgttta cctatcacaa gaagtaattc
     2881 catgccgacc acaggttatt cagcagtacc tgcaaatata atacctcctc ctcatccact
     2941 aagaggaagt cagtcatttg atgacaaaat tggcgctttc tatgatgatg tctttgtatc
     3001 gggacctaac gctcctgtgc cccagagtgg gcatccccgt acacttgtga gacaagcagc
     3061 catagaagac tcttcagcaa atgaaagtca tgttcttggt actggacagt ccctggatga
     3121 gagccaccaa ggatgccatg ctgctggtga agccatgtca gtgaggagca aggcactggc
     3181 acaaggccca catatagaaa aaaagaagtc tcatcaaggg cgagggacaa tgtttgagtg
     3241 tgaaacttgt agaaacaggt ataggaaact ggaaaatttt gaaaatcata agaaatttta
     3301 ctgttctgag ttacatggac caaaaacaaa ggtagccatg agagaacctg agcacagccc
     3361 tgtgcccggc ggtctgcagc ctcagattct acactacaga gtcgctgggt cctccggcat
     3421 ctgggaacag acgccccaga taagaaaaag gaggaaaatg aaaagtgttg gggatgatga
     3481 agaacttcag caaaatgaaa gtggaacatc tccaaaaagt tctgaaggcc ttcagtttca
     3541 gaatgctctg ggctgtaatc ccagtttgcc taaacataat gttaccataa gaagtgacca
     3601 gcagcataaa aatatacagt tgcaaaactc ccatattcac cttgttgcca ggggccctga
     3661 gcagaccatg gatcccaagc tgtcgaccat catggaacaa cagataagtt cagcagccca
     3721 ggacaagata gaactgcaga gacacggaac tggaatctct gtcatccagc acaccaactc
     3781 cctgagcagg cccaactcat ttgacaagcc tgagcctttt gaaagagcct ccccagtttc
     3841 tttccaggag ctgaatagaa cggggaagtc cgggtctcta aaagtgatag gaatctccca
     3901 agaggaaagt cacccttctc gggacgggtc tcatcctcac cagcttgcac tatcagacgc
     3961 tctcagagga gaacttcagg aaagctccag aaagagtcca agtgaacgac atgtgttagg
     4021 acagccctca agacttgtcc ggcagcacaa catccaagtt ccagagattt tggtcacaga
     4081 agaaccagat cgagacctgg aagctcaatg ccatgatcaa gaaaagtcag agaagttcag
     4141 ttggccccag cgtagtgaaa ccttgtcaaa attgccaaca gagaaactgc cacccaaaaa
     4201 gaaaaggctc cgtctggctg agatagaaca ttcctcaaca gaatcgagct ttgattccac
     4261 tctctccagg agtctaagta gggagagcag tttatctcac acttcaagtt tctcagcctc
     4321 tttagacata gaggacgttt ctaaaacgga ggcttccccc aaaatcgatt ttctaaataa
     4381 agccgagttt cttatgattc cagctggctt gaatactctg aatgttcctg gatgtcaccg
     4441 ggaaatgagg cgtactgcat cagaacagat taattgcacg caaacgtcaa tggaggtctc
     4501 tgatctcaga agcaaatcat tcgattgtgg aagcatcacc ccaccccaga caacaccact
     4561 tactgaattg cagcctccat cttcaccttc tcgagtggga gtgactgggc atgtgcctct
     4621 cttagaaaga aggagaggcc cactggtacg gcaaatatct ttaaacatag ccccagatag
     4681 tcatctgtct cctgtacacc caacatcttt ccaaaatact gctcttccca gtgtgaatgc
     4741 agtgccatat caggggcctc agctcactag tacatcttta gctgagtttt ctgcaaatac
     4801 tttgcactct cagactcagg ttaaggatct gcaggcagaa acatcaaact ccagctctac
     4861 caacgttttt cctgttcaac agctctgtga tatcaatttg ttaaatcaaa tccatgcacc
     4921 gcctagccac cagagcacac agctatctct gcaagtgtct acgcagggta gcaagccaga
     4981 taaaaattct gttttatctg ggtcttctaa aagtgaggat tgctttgctc ccaaatacca
     5041 attgcattgt caggttttca cttcaggccc atcttgctct tctaatcctg tgcattcttt
     5101 gccaaatcaa gttatttcag atccagttgg aacagatcat tgtgtgacat cagcaacatt
     5161 accaaccaaa ttaattgaca gcatgtctaa ttcgcatcct ctgctaccac cagagctcag
     5221 gccccttgga agtcaggtgc agaaggtgcc atcatcattc atgctgccca tacgcctgca
     5281 gagtagtgtt cctgcttact gttttgctac actcacatcc ctgccacaaa tactagtgac
     5341 ccaagatctg cccaatcagc caatttgcca gactaatcat agtgtagtgc caatcagtga
     5401 agaacaaaat tctgtgccaa cattacaaaa aggtcatcag aatgctttgc caaacccaga
     5461 gaaggaattt ctatgtgaaa atgttttttc agagatgagc caaaattctt ctctatcaga
     5521 atccttgccc ataactcaga aaatatctgt tggtcgactt tcccctcaac aagaatcttc
     5581 agcttcgagt aaaaggatgc tttccccagc aaatagttta gacattgcca tggaaaagca
     5641 ccagaagcgg gccaaagatg aaaatggagc tgtttgtgca acagacgtga gacctttaga
     5701 ggctttgagt tcgagagtta atgaagctag taaacagaag aagcctattt tagtgagaca
     5761 ggtttgtact acagagcccc tggacggtgt gatgttggaa aaggatgttt tttctcaacc
     5821 tgaaattagt aatgaggctg ttaatttgac aaatgtttta ccagctgata attcatcaac
     5881 aggatgctct aaatttgtcg ttatagaacc tataagtgaa ttgcaggaat ttgaaaacat
     5941 caagtcatcc acatcattaa ctcttacagt tcgaagttca cctgctcctt cagaaaatac
     6001 tcatatttct cctttgaaat gtacagacaa taaccaagaa aggaagtctc caggggttaa
     6061 aaatcaaggt gacaaagtga acatccaaga gcaaagtcaa cagccagtca cttctctttc
     6121 attgtttaac atcaaggaca cccagcagct ggctttccct agcctgaaaa ctacaaccaa
     6181 ctttacatgg tgttatctct taaggcagaa gtcgttgcat ttgcctcaga aggaccagaa
     6241 aacttcagcc tatactgatt ggacagtaag cgccagtaat ccaaatccac tcggtttgcc
     6301 cacaaaagtt gcacttgctc tccttaattc aaaacagaac actggaaaat cactatactg
     6361 tcaagcaata actacccatt ccaagtcaga cttattggtc tattcaagca agtggaaaag
     6421 cagcttaagc aagagagcat taggtaatca aaagtccaca gtagttgaat tcagcaataa
     6481 agatgcctct gaaattaaca gtgagcaaga taaagaaaat tccttaatca aaagtgaacc
     6541 aagaagaatt aaaatatttg atggaggata taagtcaaat gaagagtatg tatatgtccg
     6601 aggcagggga agaggaaaat acatttgtga agaatgtgga atacgttgta agaaacctag
     6661 catgttaaag aaacacatac gaacccatac agatgtccgc ccctaccact gcacttactg
     6721 taacttctcc tttaagacta aaggaaatct gacaaaacac atgaagtcca aggcacatag
     6781 caagaaatgt gtggatttag gcgtctcagt aggtttaata gatgaacagg atacagaaga
     6841 atcagatgaa aaacagagat tcagttatga gcgatctgga tatgatcttg aagaatctga
     6901 tggcccagat gaggatgaca atgaaaatga agacgatgat gaggacagcc aggctgaatc
     6961 agtcctgtca gccacaccct cagtcacagc tagcccgcag caccttccat ctagaagtag
     7021 ccttcaggac cctgtgagta ctgacgagga tgtcaggatc accgattgct tttctggggt
     7081 acacacggac ccaatggacg ttctgcccag ggcgctgctc accagaatga ctgtcctgag
     7141 cacagcacag tctgactaca ataggaagac actctctccg gggaaggcca ggcagcgtgc
     7201 tgcgagagat gaaaacgaca caattccgtc tgtagacact tccaggtccc cgtgtcatca
     7261 gatgtctgtg gactaccctg agtcagaaga aattctgaga agttctatgg caggaaaagc
     7321 tgttgctata acacagagcc catcatctgt aagacttcct cctgctgcag ctgagcacag
     7381 cccccagaca gcagcgggga tgccttctgt ggcctcacca catcctgacc ctcaagaaca
     7441 gaagcagcaa ataactctac agccgactcc aggcttgcct tctccccaca ctcatttgtt
     7501 tagccacctt cctttgcatt cccagcagca atcgaggaca ccttataata tggttccagt
     7561 tggggggatc catgtggtac ctgctggcct cacatactcc acgtttgtgc cccttcaggc
     7621 tggaccagtg cagctcacga tccctgctgt cagtgtcgtt cacagaactt tgggtactca
     7681 taggaatacg gtcacagaag tgtctggcac tacaaaccct gctggagtgg ctgaattaag
     7741 cagtgttgtg ccatgtattc ctatcggcca aatccgcgtg ccaggccttc agaacctaag
     7801 taccccaggc ttgcagtcac tcccctcgtt aagcatggaa accgtcaata ttgtaggcct
     7861 agccaataca aatatggccc cacaagtcca tccaccagga ctggctctga atgctgtcgg
     7921 actgcaggtt ctgactgcaa acccttcatc acaaagcagc cccgcccctc aggcacacat
     7981 tccaggtctc cagatcttga acatagcatt gcccacctta atcccctcag tcagtcaagt
     8041 agccgttgat gcacagggag ctccagaaat gccagcttcc caaagcaaag catgcgagac
     8101 acaacccaag cagacttctg tagccagcgc aaaccaggtc agcaggaccg agtctcctca
     8161 ggggttacct acagtccagc gggaaaatgc aaaaaaagtt ctgaatccac ctgcccctgc
     8221 aggtgaccat gcaaggcttg atggcctgag taaaatggac acagagaagg ctgcctcggc
     8281 aaatcacgtg aagcccaagc ctgaactcac ttccatacag ggccaaccag cgtccacgtc
     8341 acaacctctg ctgaaggcac attctgaagt ttttacaaag ccctcaggcc agcagactct
     8401 ctctccagac agacaggttc ccaggcccac agcactaccg cggaggcagc ccactgtgca
     8461 cttcagcgac gtgagcagcg atgatgacga ggacaggctt gtgatagcaa cctgatggat
     8521 tttatttttt atttgctttt tttttatata acacttaaag gtttctttga aaaccctcct
     8581 ttccttaaag cacatttttc tgacataaac tcatgactaa tctttgtgca atcatgaact
     8641 tttgaccaat aattgttgtt ttgtgtcagc tccagccatt tttgtacatg ttgtatagac
     8701 aattgtgcct tttaggagct ttatgtttag aaactgtaca gattgttgaa tatctatata
     8761 cataaaaata tattatatat gtatatgaaa accaggtagt tatttgtgtt tagtaaggaa
     8821 aacctgtcaa ataaatcaaa tgattaaatt atatgttcca ctgttgaata taaattttat
     8881 ggctatgggg cagagtttct gtgtataaat tagtatgtaa actccatatt tattgtattc
     8941 atattagtct ttgaaaatgg gtctgtcctc cttgtgtaag acagtaactt tacacttcag
     9001 acagattttc tgtgttatga aatgtttcag taaaatattg tttactgact tta
//
