LOCUS       NM_003609               2560 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens HIRA interacting protein 3 (HIRIP3), transcript
            variant 1, mRNA.
ACCESSION   NM_003609
VERSION     NM_003609.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Ignatyeva,M., Patel,A.K.M., Ibrahim,A., Albiheyri,R.S., Zari,A.T.,
            Bahieldin,A., Bronner,C., Sabir,J.S.M. and Hamiche,A.
  TITLE     Identification and Characterization of HIRIP3 as a Histone H2A
            Chaperone
  JOURNAL   Cells 13 (3), 273 (2024)
   PUBMED   38334665
  REMARK    GeneRIF: Identification and Characterization of HIRIP3 as a Histone
            H2A Chaperone.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2560)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 2560)
  AUTHORS   Kim,J.E., Tannenbaum,S.R. and White,F.M.
  TITLE     Global phosphoproteome of HT-29 human colon adenocarcinoma cells
  JOURNAL   J Proteome Res 4 (4), 1339-1346 (2005)
   PUBMED   16083285
REFERENCE   8  (bases 1 to 2560)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 2560)
  AUTHORS   Lorain,S., Quivy,J.P., Monier-Gavelle,F., Scamps,C., Lecluse,Y.,
            Almouzni,G. and Lipinski,M.
  TITLE     Core histones and HIRIP3, a novel histone-binding protein, directly
            interact with WD repeat protein HIRA
  JOURNAL   Mol Cell Biol 18 (9), 5546-5556 (1998)
   PUBMED   9710638
REFERENCE   10 (bases 1 to 2560)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000588.2, Z25386.1,
            BU629222.1 and BX101682.1.
            
            On May 17, 2019 this sequence version replaced NM_003609.4.
            
            Summary: The HIRA protein shares sequence similarity with Hir1p and
            Hir2p, the two corepressors of histone gene transcription
            characterized in the yeast, Saccharomyces cerevisiae. The
            structural features of the HIRA protein suggest that it may
            function as part of a multiprotein complex. Several cDNAs encoding
            HIRA-interacting proteins, or HIRIPs, have been identified. In
            vitro, the protein encoded by this gene binds HIRA, as well as H2B
            and H3 core histones, indicating that a complex containing
            HIRA-HIRIP3 could function in some aspects of chromatin and histone
            metabolism. Alternatively spliced transcript variants encoding
            distinct isoforms have been found for this gene.[provided by
            RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.104665.1,
                                           SRR3476690.866475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279392.8/ ENSP00000279392.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1895              BC000588.2         450-2344
            1896-2004           Z25386.1           79-187
            2005-2011           BU629222.1         568-574             c
            2012-2560           BX101682.1         1-549
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2560
                     /gene="HIRIP3"
                     /note="HIRA interacting protein 3"
                     /db_xref="GeneID:8479"
                     /db_xref="HGNC:HGNC:4917"
                     /db_xref="MIM:603365"
     exon            1..77
                     /gene="HIRIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1683
                     /gene="HIRIP3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="HIRA-interacting protein 3 isoform 1"
                     /protein_id="NP_003600.2"
                     /db_xref="CCDS:CCDS10664.1"
                     /db_xref="GeneID:8479"
                     /db_xref="HGNC:HGNC:4917"
                     /db_xref="MIM:603365"
                     /translation="MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEP
                     EEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESES
                     GSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESS
                     EEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTK
                     SLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSC
                     KQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSE
                     DEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSR
                     KGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLGSCC
                     SHKERLSILRAELEALGMKGTPSLGKCRALKEQREEAAEVASLDVANIISGSGRPRRR
                     TAWNPLGEAAPPGELYRRTLDSDEERPRPAPPDWSHMRGIISSDGESN"
     exon            78..198
                     /gene="HIRIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            199..313
                     /gene="HIRIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            314..1251
                     /gene="HIRIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1420
                     /gene="HIRIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1519
                     /gene="HIRIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..2560
                     /gene="HIRIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIRIP3"
                     /note="hexamer: AATAAA"
     polyA_site      1895
                     /gene="HIRIP3"
                     /note="major polyA site"
     regulatory      2536..2541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIRIP3"
                     /note="hexamer: AATAAA"
     polyA_site      2560
                     /gene="HIRIP3"
ORIGIN      
        1 gggttgagca aaatggcgcg ggagaaggag atgcaggagt tcacccgtag cttcttccga
       61 ggccgcccgg acctcagcac gcttacgcat tccatcgtgc ggcggaggta cttagctcac
      121 tcgggccgca gccacctgga gcccgaggag aagcaggcac tgaagcggct ggtggaggag
      181 gagctgctga agatgcaggt ggatgaagcc gcttccaggg aagacaaact ggaccttacc
      241 aagaagggca agaggcctcc caccccttgt agcgacccgg agagaaaaag gttccgcttc
      301 aattcagagt cggagtccgg ctctgaagcc tccagcccag actactttgg acccccagca
      361 aagaatgggg tggcagcaga agtcagccca gccaaagagg agaatccaag gcgagcctca
      421 aaggcagttg aggagagcag tgatgaggaa cggcagaggg acctgcccgc acagagggga
      481 gaggagagca gtgaggagga ggaaaagggg tacaagggga agactaggaa gaaacctgtg
      541 gtaaagaagc aggcaccagg caaggcctca gtcagtagga agcaggccag ggaagaaagt
      601 gaggagagcg aggcagaacc cgttcagagg acagcaaaga aggtggaggg aaataaagga
      661 actaaaagcc tgaaggaaag tgaacaggag agtgaagagg agatcctagc ccagaagaaa
      721 gagcagagag aggaggaagt ggaggaggaa gagaaagaag aggatgagga aaagggggat
      781 tggaaaccca gaaccaggag caatggccgg agaaagtcag ctagggagga gaggagctgt
      841 aagcagaaaa gccaggcaaa gaggctcttg ggagactcag acagcgagga agagcagaaa
      901 gaggcagcca gcagtgggga tgacagtggg agagatagag aacccccagt gcagaggaag
      961 agtgaggaca ggacccagct taagggtggg aagaggttga gtggaagcag cgaggacgag
     1021 gaagacagtg ggaaggggga acccacagct aaaggctcta gaaagatggc cagactgggc
     1081 agcaccagtg gtgaggaaag tgacttggag agggaggtaa gtgacagcga ggcaggggga
     1141 ggcccccagg gggagaggaa gaaccgctct tccaagaaga gctccaggaa aggcaggaca
     1201 cgaagctcct cttcctcctc agatggaagt ccagaggcca aaggagggaa ggctggctca
     1261 ggtcgccgtg gagaggacca cccggctgtg atgaggctga agcgctacat tcgggcctgt
     1321 ggtgcccatc gaaactacaa gaagctgttg ggctcctgtt gctcacacaa ggagcgcctg
     1381 agtatcctcc gggcagaact ggaagcgcta ggcatgaagg gtaccccttc cctagggaag
     1441 tgtcgggccc tgaaggagca gagggaggag gcagctgagg tggcctcctt ggatgttgcg
     1501 aacatcatca gtggctcggg ccggccacgc agacgtacag cctggaaccc tttaggagaa
     1561 gcagcacccc caggggagct gtaccgacgg accctggact cagatgaaga gcggccccgt
     1621 cccgcacccc cagactggtc acatatgcgt ggcatcatca gcagtgatgg cgagagtaac
     1681 tgagctctgc cacccccagg agggaccctt gatacatgta caaagcatac atagcacccc
     1741 ttgccctgtg tctgtggaac agaagcagct tccttcagag aagactgcag ctcccaagga
     1801 cacaagctgt tgggatgcta cttctcagct tcacgctgtc cctttaaggt gtttattttt
     1861 taagactcaa taaaggagtg tttttaatca cctcatcaaa tttggtcccc cattctcacc
     1921 tcctgtattt tgggccagga aactgagcag tagtcactgc ctccacctcc tcccctggcc
     1981 tggttccctt taatttcccc cgggttcctg gaagaagtcc ctgcctccag accctgtcat
     2041 ccaacagcca ccagaccctt ttggagaagg gtgtgtggct cctgtgctgc ccgcctaccc
     2101 cgtggcccct ctgcttttag cctagtctga taacctaatg cccacttggg agagggatag
     2161 aatgacttga gggcagccag tgcttaagcc ttctccctta tgcaaacagc cactttgtcc
     2221 atgggctgtt agcctcaaag gggtggggaa aagcccatac ctcctgggcc agtcctagcc
     2281 ctctaggcct ctggctacag gcccagcctc tgcagtcaca tgaggtctcc actgaactct
     2341 ggctgctgag gcttgcggga agattcgtga gcatggagct gcctggggtc tgtgtgggag
     2401 gcaaacctaa gaatctttga agtcaaagca aagaaaacga attagaggtc aaggggttga
     2461 agaccacctt tgagatccga gatctggtca cacctaaagt cattaaaatc actgaaatgt
     2521 ttagatacac agcccaataa attctcttta taaaacacaa
//
