LOCUS       NM_003325               4053 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens histone cell cycle regulator (HIRA), mRNA.
ACCESSION   NM_003325
VERSION     NM_003325.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4053)
  AUTHORS   Dasgupta,N., Lei,X., Shi,C.H., Arnold,R., Teneche,M.G.,
            Miller,K.N., Rajesh,A., Davis,A., Anschau,V., Campos,A.R.,
            Gilson,R., Havas,A., Yin,S., Chua,Z.M., Liu,T., Proulx,J.,
            Alcaraz,M., Rather,M.I., Baeza,J., Schultz,D.C., Yip,K.Y.,
            Berger,S.L. and Adams,P.D.
  TITLE     Histone chaperone HIRA, promyelocytic leukemia protein, and
            p62/SQSTM1 coordinate to regulate inflammation during cell
            senescence
  JOURNAL   Mol Cell 84 (17), 3271-3287 (2024)
   PUBMED   39178863
  REMARK    GeneRIF: Histone chaperone HIRA, promyelocytic leukemia protein,
            and p62/SQSTM1 coordinate to regulate inflammation during cell
            senescence.
REFERENCE   2  (bases 1 to 4053)
  AUTHORS   Nagagaki,Y., Kozakura,Y., Mahandaran,T., Fumoto,Y., Nakato,R.,
            Shirahige,K. and Ishikawa,F.
  TITLE     Histone H3.3 chaperone HIRA renders stress-responsive genes poised
            for prospective lethal stresses in acquired tolerance
  JOURNAL   Genes Cells 29 (9), 722-734 (2024)
   PUBMED   38977420
  REMARK    GeneRIF: Histone H3.3 chaperone HIRA renders stress-responsive
            genes poised for prospective lethal stresses in acquired tolerance.
REFERENCE   3  (bases 1 to 4053)
  AUTHORS   Javanshir,E., Ebrahimi,Z.J., Mirzohreh,S.T., Ghaffari,S.,
            Banisefid,E., Alamdari,N.M. and Roshanravan,N.
  TITLE     Disparity of gene expression in coronary artery disease: insights
            from MEIS1, HIRA, and Myocardin
  JOURNAL   Mol Biol Rep 51 (1), 712 (2024)
   PUBMED   38824221
  REMARK    GeneRIF: Disparity of gene expression in coronary artery disease:
            insights from MEIS1, HIRA, and Myocardin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4053)
  AUTHORS   Morozov,V.M., Riva,A., Sarwar,S., Kim,W.J., Li,J., Zhou,L.,
            Licht,J.D., Daaka,Y. and Ishov,A.M.
  TITLE     HIRA-mediated loading of histone variant H3.3 controls
            androgen-induced transcription by regulation of AR/BRD4 complex
            assembly at enhancers
  JOURNAL   Nucleic Acids Res 51 (19), 10194-10217 (2023)
   PUBMED   37638746
  REMARK    GeneRIF: HIRA-mediated loading of histone variant H3.3 controls
            androgen-induced transcription by regulation of AR/BRD4 complex
            assembly at enhancers.
REFERENCE   5  (bases 1 to 4053)
  AUTHORS   Kleijwegt,C., Bressac,F., Seurre,C., Bouchereau,W., Cohen,C.,
            Texier,P., Simonet,T., Schaeffer,L., Lomonte,P. and Corpet,A.
  TITLE     Interplay between PML NBs and HIRA for H3.3 dynamics following type
            I interferon stimulus
  JOURNAL   Elife 12, e80156 (2023)
   PUBMED   37227756
  REMARK    GeneRIF: Interplay between PML NBs and HIRA for H3.3 dynamics
            following type I interferon stimulus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4053)
  AUTHORS   Lorain,S., Quivy,J.P., Monier-Gavelle,F., Scamps,C., Lecluse,Y.,
            Almouzni,G. and Lipinski,M.
  TITLE     Core histones and HIRIP3, a novel histone-binding protein, directly
            interact with WD repeat protein HIRA
  JOURNAL   Mol Cell Biol 18 (9), 5546-5556 (1998)
   PUBMED   9710638
REFERENCE   7  (bases 1 to 4053)
  AUTHORS   Llevadot,R., Scambler,P., Estivill,X. and Pritchard,M.
  TITLE     Genomic organization of TUPLE1/HIRA: a gene implicated in DiGeorge
            syndrome
  JOURNAL   Mamm Genome 7 (12), 911-914 (1996)
   PUBMED   8995764
REFERENCE   8  (bases 1 to 4053)
  AUTHORS   Lorain,S., Demczuk,S., Lamour,V., Toth,S., Aurias,A., Roe,B.A. and
            Lipinski,M.
  TITLE     Structural Organization of the WD repeat protein-encoding gene HIRA
            in the DiGeorge syndrome critical region of human chromosome 22
  JOURNAL   Genome Res 6 (1), 43-50 (1996)
   PUBMED   8681138
REFERENCE   9  (bases 1 to 4053)
  AUTHORS   Lamour,V., Lecluse,Y., Desmaze,C., Spector,M., Bodescot,M.,
            Aurias,A., Osley,M.A. and Lipinski,M.
  TITLE     A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional
            repressors cloned from the DiGeorge syndrome critical region
  JOURNAL   Hum Mol Genet 4 (5), 791-799 (1995)
   PUBMED   7633437
REFERENCE   10 (bases 1 to 4053)
  AUTHORS   Halford,S., Wadey,R., Roberts,C., Daw,S.C., Whiting,J.A.,
            O'Donnell,H., Dunham,I., Bentley,D., Lindsay,E., Baldini,A. et al.
  TITLE     Isolation of a putative transcriptional regulator from the region
            of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and
            familial congenital heart disease
  JOURNAL   Hum Mol Genet 2 (12), 2099-2107 (1993)
   PUBMED   8111380
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC000079.1, AC000092.1 and
            AC000085.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_003325.3.
            
            Summary: This gene encodes a histone chaperone that preferentially
            places the variant histone H3.3 in nucleosomes. Orthologs of this
            gene in yeast, flies, and plants are necessary for the formation of
            transcriptionally silent heterochomatin. This gene plays an
            important role in the formation of the senescence-associated
            heterochromatin foci. These foci likely mediate the irreversible
            cell cycle changes that occur in senescent cells. It is considered
            the primary candidate gene in some haploinsufficiency syndromes
            such as DiGeorge syndrome, and insufficient production of the gene
            may disrupt normal embryonic development. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039835.1, X89887.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263208.5/ ENSP00000263208.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               AC000079.1         35552-35845         c
            295-357             AC000079.1         14828-14890         c
            358-468             AC000079.1         12595-12705         c
            469-559             AC000079.1         11296-11386         c
            560-654             AC000079.1         9898-9992           c
            655-750             AC000079.1         2104-2199           c
            751-911             AC000092.1         37739-37899         c
            912-1079            AC000092.1         35294-35461         c
            1080-1193           AC000092.1         33053-33166         c
            1194-1264           AC000092.1         29436-29506         c
            1265-1370           AC000092.1         28663-28768         c
            1371-1586           AC000092.1         26473-26688         c
            1587-1672           AC000092.1         24572-24657         c
            1673-1870           AC000092.1         18821-19018         c
            1871-2032           AC000092.1         16583-16744         c
            2033-2237           AC000092.1         2679-2883           c
            2238-2342           AC000092.1         2189-2293           c
            2343-2491           AC000092.1         288-436             c
            2492-2653           AC000085.5         97961-98122         c
            2654-2712           AC000085.5         97301-97359         c
            2713-2818           AC000085.5         96831-96936         c
            2819-2941           AC000085.5         95067-95189         c
            2942-3105           AC000085.5         94427-94590         c
            3106-3194           AC000085.5         92429-92517         c
            3195-4053           AC000085.5         71769-72627         c
FEATURES             Location/Qualifiers
     source          1..4053
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..4053
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /note="histone cell cycle regulator"
                     /db_xref="GeneID:7290"
                     /db_xref="HGNC:HGNC:4916"
                     /db_xref="MIM:600237"
     exon            1..294
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..3311
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /note="TUP1-like enhancer of split protein 1; DiGeorge
                     critical region gene 1; HIR histone cell cycle regulation
                     defective homolog A; histone regulator A"
                     /codon_start=1
                     /product="protein HIRA"
                     /protein_id="NP_003316.3"
                     /db_xref="CCDS:CCDS13759.1"
                     /db_xref="GeneID:7290"
                     /db_xref="HGNC:HGNC:4916"
                     /db_xref="MIM:600237"
                     /translation="MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWN
                     MSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATY
                     IGPSTVFGSSGKLANVEQWRCVSILRNHSGDVMDVAWSPHDAWLASCSVDNTVVIWNA
                     VKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDE
                     CGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKF
                     NPKIFKKKQKNGSSAKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDI
                     SWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLS
                     TAVIENPEMLKYQRRQQQQQLDQKSAATREMGSATSVAGVVNGESLEDIRKNLLKKQV
                     ETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSGSLAGTMLSSHSSPQLLPLDSST
                     PNSFGASKPCTEPVVAASARPAGDSVNKDSMNATSTPAALSPSVLTTPSKIEPMKAFD
                     SRFTERSKATPGAPALTSMTPTAVERLKEQNLVKELRPRDLLESSSDSDEKVPLAKAS
                     SLSKRKLELEVETVEKKKKGRPRKDSRLMPVSLSVQSPAALTAEKEAMCLSAPALALK
                     LPIPSPQRAFTLQVSSDPSMYIEVENEVTVVGGVKLSRLKCNREGKEWETVLTSRILT
                     AAGSCDVVCVACEKRMLSVFSTCGRRLLSPILLPSPISTLHCTGSYVMALTAAATLSV
                     WDVHRQVVVVKEESLHSILAGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTWNL
                     VSDKQDSLAQCADFRSSLPSQDAMLCSGPLAIIQGRTSNSGRQAARLFSVPHVVQQET
                     TLAYLENQVAAALTLQSSHEYRHWLLVYARYLVNEGFEYRLREICKDLLGPVHYSTGS
                     QWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK"
     exon            295..357
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            358..468
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..559
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..654
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..750
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..911
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1079
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1193
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1264
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1370
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1586
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1672
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1870
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2032
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2237
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2342
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2491
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..2653
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2712
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2818
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2941
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3105
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..3194
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..4053
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4030..4035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /note="hexamer: AATGAA"
     polyA_site      4053
                     /gene="HIRA"
                     /gene_synonym="DGCR1; TUP1; TUPLE1"
                     /note="major polyA site"
ORIGIN      
        1 gttgcccggg agccgcctga ggaggagcgg cgcaggggat gcggctgtgg tggcggcggc
       61 ggcggccgag cgcgggtggc ggctgtggcg gcggaggggg gcgcgggccg gcgatggcgc
      121 ggcggccctg agggcgcggg gcgggcggcg gccggagggc gggtggcgcg ggaggaagcg
      181 gcggcggtgg ctccatggcc cgggcgcgct gagggacccg gcgctcgcct cagcccggcg
      241 gcggcggcgg ccgaacaatg aagctcctga agccgacctg ggtcaaccac aatggcaagc
      301 cgattttttc agttgatatt caccctgacg ggaccaagtt cgcaactgga ggacaagggc
      361 aggattctgg gaaggttgtg atctggaata tgtctccagt cctccaggag gatgacgaga
      421 aggatgaaaa tattcccaag atgctttgcc agatggacaa tcacttagca tgtgtgaact
      481 gtgtgcggtg gtcaaacagt gggatgtatt tagcttctgg gggagatgac aaactgatta
      541 tggtgtggaa gcgggctacg tacatcggcc ccagcaccgt gttcggctcc agtggtaagc
      601 ttgccaatgt ggagcagtgg cggtgtgtct ctatcctccg gaatcattca ggcgatgtga
      661 tggatgtagc atggtctccc cacgatgcct ggctagcctc atgcagcgtg gataacactg
      721 tcgtcatctg gaatgctgta aagttcccag aaattctagc tactctgaga ggtcattctg
      781 gcttggtcaa agggttgaca tgggaccctg ttggtaaata catagcttct caagctgatg
      841 accgcagcct aaaggtgtgg aggacgctgg actggcagtt ggagaccagc atcaccaagc
      901 cttttgatga gtgtggagga acgacccatg tgttgcggct cagctggtca cctgatgggc
      961 attacctggt gtctgcccat gccatgaaca actcaggccc cactgcccag atcatcgaac
     1021 gggagggatg gaagaccaac atggactttg ttgggcaccg gaaagctgtg actgtcgtga
     1081 aattcaaccc aaaaatcttc aaaaagaagc agaagaatgg gagttctgcg aagcctagct
     1141 gcccgtactg ctgctgtgct gttggcagca aggaccgctc gctttctgtc tggctcacat
     1201 gtctgaaacg gccgctggtg gtcatccatg aactgtttga caaatccatc atggatattt
     1261 cctggactct gaatgggctg ggcatcttgg tatgctctat ggacggctct gtggcattcc
     1321 tcgacttctc ccaggatgag cttggcgatc ccctgagcga ggaggagaag agccgcattc
     1381 accagtccac ctatggcaag agcctagcca tcatgaccga ggcccagctc tccacagccg
     1441 tcattgagaa ccctgagatg ctcaagtacc agcgaaggca gcagcagcag cagctggacc
     1501 agaagagtgc tgcgaccagg gagatgggct cagccacctc agtcgcaggc gttgtcaacg
     1561 gggagagtct tgaagatatc aggaagaatc ttttgaagaa acaagttgag actcggacag
     1621 cagatggccg gagaagaatc acgcctctct gcatagcaca gctggacact ggggacttct
     1681 ccacggcatt ctttaacagc atccccctct cgggctccct ggcgggcacc atgctctctt
     1741 ctcatagcag tccacagcta ctgccactgg actccagtac ccctaactcc ttcggcgcct
     1801 cgaagccttg cacagagcct gtggtggctg ccagtgccag acctgcaggc gattctgtca
     1861 ataaagacag tatgaatgct acctctactc ctgctgcatt gtcaccttct gtgttaacga
     1921 ccccgtccaa gatcgaaccc atgaaagcgt ttgactcccg gttcacagag cggtccaaag
     1981 ccacaccagg tgctcctgcc ctgaccagca tgactccgac agctgtggaa aggttaaaag
     2041 agcagaacct tgtgaaagag ctgaggcccc gagacctcct ggagagcagc agtgacagcg
     2101 atgagaaagt ccctttggct aaggcttcct cactgtccaa gcgaaaactt gagcttgagg
     2161 tagagacagt agagaagaag aagaaagggc ggcctcggaa ggactctcgt ctcatgcctg
     2221 tgtctctgtc tgtccagtct ccagctgccc taaccgcaga gaaggaggcc atgtgtctgt
     2281 ctgcaccagc acttgcactg aagctgccaa ttccaagccc ccagagagca ttcaccctcc
     2341 aggtcagctc cgatccttcc atgtacattg aggtggagaa tgaagtgaca gtggtggggg
     2401 gcgtgaagct gagccgcctg aagtgcaacc gggaagggaa ggagtgggag acggtactca
     2461 ccagccggat cctcactgct gcgggcagct gtgacgtggt gtgtgtcgcc tgtgaaaaaa
     2521 ggatgctgtc agtgttctcc acctgtggtc gccgtctcct ctctcccatc ctcctgccat
     2581 ccccgatctc tactttgcat tgcacaggct cctacgtcat ggcgctcacc gctgcagcca
     2641 cactctctgt ctgggatgtt cacagacagg tggttgtggt gaaagaagag tctctacact
     2701 ccatcctggc aggaagtgat atgacggtat cacagatctt gctgacgcag catggaatcc
     2761 cagtaatgaa cctgtccgat gggaaggcgt actgctttaa tccgtcactt tccacatgga
     2821 acctggtttc tgacaagcag gactcactgg ctcagtgtgc agactttagg agcagcctgc
     2881 catcccagga cgccatgctg tgctcaggac cgttagccat aatccagggc cgcacctcca
     2941 actcgggaag gcaggctgcc cggctcttct ccgtgcctca tgtggtgcag caagagacca
     3001 ccctggccta cctagagaac caggtggcag cagcactcac cctgcagtcc agccacgagt
     3061 accgccattg gctcctcgtc tacgcacggt acctcgtaaa cgaagggttt gaataccgac
     3121 ttcgagaaat atgcaaggac ttactgggtc cggttcacta ctccactgga agccagtggg
     3181 agtcaacagt agtgggtctg cggaagaggg agctgctgaa ggagctgcta ccagtcatcg
     3241 ggcagaacct ccgattccag cgcctcttca ccgagtgtca ggaacagctc gacatcctga
     3301 gggacaagta gcctgcccca gcctgccctg gctgcagcaa gggcagggcc acactctcgc
     3361 cgctgatgac atgcaggacc gcctctcacc tgaccaggct gtagggggag gagacactgg
     3421 caggagatgt gctgtcctgc accagcgcca gcccagctcc ctgggcagat gtgccctgtg
     3481 tcctgggtct gacattgcct caggaggggg aagctcatcc ctccctccaa gcccccgatg
     3541 cggagctagg gctggagctc tgcccaggtg ccctggggcc agcaaggcag tcccaggcct
     3601 gccgtctcca gcacggcccc aaggtggaca ctagcccctg ctgctgcagg caccatgctg
     3661 cttcagcagt gacgattgag ccatttgtga gagagaatcc ggaagcgtta ggtattacag
     3721 cagactgacc taagacctat gtaaaaggaa agctgttcca acacacggac tatttttgta
     3781 ctagaatttg ctaacttgta atattgaatt tcctttggcc gataatcagg atttccctat
     3841 aagtcacttg gacattggtc acttgtagga aatttaaact ctaattatga cagctacact
     3901 gaaaaataat tgtactgaaa ttaacttgtc tatcttcatt tggttttaat ttttaaatgt
     3961 ttgtaaaaag agactgtttt gggggaatgg ggcaaagggg tgggcgattt cttttgtaag
     4021 tgtaaaataa atgaacacgc attgaatacc aaa
//
