LOCUS       NM_144685               2446 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens homeodomain interacting protein kinase 4 (HIPK4),
            mRNA.
ACCESSION   NM_144685
VERSION     NM_144685.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2446)
  AUTHORS   Liu,X., Zang,C., Wu,Y., Meng,R., Chen,Y., Jiang,T., Wang,C.,
            Yang,X., Guo,Y., Situ,C., Hu,Z., Zhang,J. and Guo,X.
  TITLE     Homeodomain-interacting protein kinase HIPK4 regulates
            phosphorylation of manchette protein RIMBP3 during spermiogenesis
  JOURNAL   J Biol Chem 298 (9), 102327 (2022)
   PUBMED   35931115
  REMARK    GeneRIF: Homeodomain-interacting protein kinase HIPK4 regulates
            phosphorylation of manchette protein RIMBP3 during spermiogenesis.
REFERENCE   3  (bases 1 to 2446)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 2446)
  AUTHORS   Larribere,L., Galach,M., Novak,D., Arevalo,K., Volz,H.C.,
            Stark,H.J., Boukamp,P., Boutros,M. and Utikal,J.
  TITLE     An RNAi Screen Reveals an Essential Role for HIPK4 in Human Skin
            Epithelial Differentiation from iPSCs
  JOURNAL   Stem Cell Reports 9 (4), 1234-1245 (2017)
   PUBMED   28966120
  REMARK    GeneRIF: loss of HIPK4 expression improves early skin epithelial
            differentiation accompanied by an increase in K8 and K18
            expression, and improves late keratinocyte differentiation with an
            increase of epidermal identity
REFERENCE   5  (bases 1 to 2446)
  AUTHORS   van der Laden,J., Soppa,U. and Becker,W.
  TITLE     Effect of tyrosine autophosphorylation on catalytic activity and
            subcellular localisation of homeodomain-interacting protein kinases
            (HIPK)
  JOURNAL   Cell Commun Signal 13, 3 (2015)
   PUBMED   25630557
  REMARK    GeneRIF: Analysis of these mutants revealed that HIPK1, HIPK2 and
            HIPK3 but not HIPK4 are capable of autophosphorylating on other
            tyrosines
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2446)
  AUTHORS   Schmitz,M.L., Rodriguez-Gil,A. and Hornung,J.
  TITLE     Integration of stress signals by homeodomain interacting protein
            kinases
  JOURNAL   Biol Chem 395 (4), 375-386 (2014)
   PUBMED   24225127
  REMARK    Review article
REFERENCE   7  (bases 1 to 2446)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   8  (bases 1 to 2446)
  AUTHORS   He,Q., Shi,J., Sun,H., An,J., Huang,Y. and Sheikh,M.S.
  TITLE     Characterization of Human Homeodomain-interacting Protein Kinase 4
            (HIPK4) as a Unique Member of the HIPK Family
  JOURNAL   Mol Cell Pharmacol 2 (2), 61-68 (2010)
   PUBMED   20508833
REFERENCE   9  (bases 1 to 2446)
  AUTHORS   Arai,S., Matsushita,A., Du,K., Yagi,K., Okazaki,Y. and Kurokawa,R.
  TITLE     Novel homeodomain-interacting protein kinase family member, HIPK4,
            phosphorylates human p53 at serine 9
  JOURNAL   FEBS Lett 581 (29), 5649-5657 (2007)
   PUBMED   18022393
  REMARK    GeneRIF: homeodomain interacting protein kinase 4 could
            phosphorylate human p53 protein at serine 9, both in vitro and in
            vivo
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292228.1 and BC034501.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_144685.4.
            
            Summary: This gene encodes a member of the homeodomain interacting
            protein kinase (HIPK) family of proteins. While other members of
            this family are found throughout vertebrates, this member is
            present only in mammals. Compared to other members of this family,
            the encoded protein lacks a nuclear localization signal and a
            C-terminal autoinhibitory domain. The encoded protein exhibits
            kinase activity and may phosphorylate the tumor suppressor protein
            p53. [provided by RefSeq, Jul 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034501.2, AK292228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291823.3/ ENSP00000291823.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2020              AK292228.1         2-2021
            2021-2446           BC034501.2         2027-2452
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2446
                     /gene="HIPK4"
                     /note="homeodomain interacting protein kinase 4"
                     /db_xref="GeneID:147746"
                     /db_xref="HGNC:HGNC:19007"
                     /db_xref="MIM:611712"
     exon            1..744
                     /gene="HIPK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..2130
                     /gene="HIPK4"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="homeodomain-interacting protein kinase 4"
                     /protein_id="NP_653286.2"
                     /db_xref="CCDS:CCDS12555.1"
                     /db_xref="GeneID:147746"
                     /db_xref="HGNC:HGNC:19007"
                     /db_xref="MIM:611712"
                     /translation="MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKN
                     DAYRNRIIKNELKLLHCMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKE
                     NNFAPLPARHIRTVTLQVLTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFG
                     SASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGN
                     NEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVR
                     PLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHE
                     RISPSAALRHPFVSMQQLRSAHETTHYYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPY
                     YCLAEEKEAAGMGSVAGSSPFFREEKAPGMQRAIDQLDDLSLQEAGHGLWGETCTNAV
                     SDMMVPLKAAITGHHVPDSGPEPILAFYSSRLAGRHKARKPPAGSKSDSNFSNLIRLS
                     QVSPEDDRPCRGSSWEEGEHLGASAEPLAILQRDEDGPNIDNMTMEAERPDPELFDPS
                     SCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHGPPRGATSFLQHVTGHH"
     exon            745..1101
                     /gene="HIPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1947
                     /gene="HIPK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2446
                     /gene="HIPK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2428..2433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIPK4"
                     /note="hexamer: AATATA"
     polyA_site      2446
                     /gene="HIPK4"
                     /note="major polyA site"
ORIGIN      
        1 actcaacagc gctggaaccc attcggtggg gcctggggcc cctcatccca agccaggagg
       61 gtttctgggg aggggtgcag cccctggcag actgacagtg tggcctgggg gtttgggggt
      121 gccagggaag caggggccaa cctcatagga ggagacacga gtgcggttct ctttccccca
      181 ctggggggcc tgctgtgtca gcagccaggc gggaggcctg ggcggcagag ccagtggtac
      241 aggggcctgg gcagggcggt gtctggcagc agcggcacca tgtccaccat ccagtcggag
      301 actgactgct acgacatcat cgaggtcttg ggcaagggga ccttcgggga ggtagccaag
      361 ggctggcggc ggagcacggg cgagatggtg gccatcaaga tcctcaagaa tgacgcctac
      421 cgcaaccgca tcatcaagaa cgagctgaag ctgctgcact gcatgcgagg cctagaccct
      481 gaagaggccc acgtcatccg cttccttgag ttcttccatg acgccctcaa gttctacctg
      541 gtctttgagc tgctggagca aaaccttttc gagttccaga aggagaacaa cttcgcgccc
      601 ctccccgccc gccacatccg tacagtcacc ctgcaggtgc tcacagccct ggcccggctc
      661 aaggagctgg ctatcatcca cgctgatctc aagcctgaga acatcatgct ggtggaccag
      721 acccgctgcc ccttcagggt caaggtgatt gacttcggat ccgccagcat tttcagcgag
      781 gtgcgctacg tgaaggagcc atacatccag tcgcgcttct accgggcccc tgagatcctg
      841 ctggggctgc ccttctgcga gaaggtggac gtgtggtccc tgggctgcgt catggctgag
      901 ctgcacctgg gctggcctct ctaccccggc aacaacgagt acgaccaggt gcgctacatc
      961 tgcgaaaccc agggcctgcc caagccacac ctgttgcacg ccgcctgcaa ggcccaccac
     1021 ttcttcaagc gcaaccccca ccctgacgct gccaacccct ggcagctcaa gtcctcggct
     1081 gactacctgg ccgagacgaa ggtgcgccca ttggagcgcc gcaagtatat gctcaagtcg
     1141 ttggaccaga ttgagacagt gaatggtggc agtgtggcca gtcggctaac cttccctgac
     1201 cgggaggcgc tggcggagca cgccgacctc aagagcatgg tggagctgat caagcgcatg
     1261 ctgacctggg agtcacacga acgcatcagc cccagtgctg ccctgcgcca ccccttcgtg
     1321 tccatgcagc agctgcgcag tgcccacgag accacccact actaccagct ctcgctgcgc
     1381 agctaccgcc tctcgctgca agtggagggg aagcccccca cgcccgtcgt ggccgcagaa
     1441 gatgggaccc cctactactg tctggctgag gagaaggagg ctgcgggtat gggcagtgtg
     1501 gccggcagca gccccttctt ccgagaggag aaggcaccag gtatgcaaag agccatcgac
     1561 cagctggatg acctgagtct gcaggaggct gggcatgggc tgtggggtga gacctgcacc
     1621 aatgcggtct ccgacatgat ggtccccctc aaggcagcca tcactggcca ccatgtgccc
     1681 gactcgggcc ctgagcccat cctggccttc tacagcagcc gcctggcagg ccgccacaag
     1741 gcccgcaagc cacctgcggg ttccaagtcc gactccaact tcagcaacct cattcggctg
     1801 agccaggtct cgcctgagga tgacaggccc tgccggggca gcagctggga ggaaggagag
     1861 catctcgggg cctctgctga gccactggcc atcctgcagc gagatgagga tgggcccaac
     1921 attgacaaca tgaccatgga agctgagagg ccagaccctg agctcttcga ccccagcagc
     1981 tgtcctggag aatggctgag tgagccagac tgcaccctgg agagcgtcag gggcccacgg
     2041 gctcaggggc tcccaccccg ccgctcccac cagcatggtc caccccgggg ggccaccagc
     2101 ttcctccagc atgtcaccgg gcaccactga tggtgattcc acccctgccc atcactgggg
     2161 gctgcgctag ctgggctggc attccctccc aacctgaact gctcctcaga gccatctcct
     2221 gaacccacaa attattctta cagaaagata gttatccaga aattctcatt ccccgtctgc
     2281 ggtgcggtgc gtgcctgcac acctctccta aacacagcag ggctttggag tctggcccat
     2341 gctccttggc cagaaggaca gcaggaaagg gggctgcacc ccgctggccc tgcgctcgcc
     2401 cttggccctg ctgcctctgt ctatttcaat atagaactgt tcagca
//
