LOCUS       NM_005734               7614 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens homeodomain interacting protein kinase 3 (HIPK3),
            transcript variant 1, mRNA.
ACCESSION   NM_005734
VERSION     NM_005734.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7614)
  AUTHORS   Wu,Y., Huang,J., Liu,L., Zhang,X., Zhang,W. and Li,Q.
  TITLE     CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia
            via CPT1A-mediated fatty acid oxidation
  JOURNAL   J Mol Med (Berl) 102 (8), 1037-1049 (2024)
   PUBMED   38904677
  REMARK    GeneRIF: CircHIPK3/miR-124 affects angiogenesis in early-onset
            preeclampsia via CPT1A-mediated fatty acid oxidation.
REFERENCE   2  (bases 1 to 7614)
  AUTHORS   Wu,Q.N., Qi,J., Liu,Z.K., Luo,X.J., Yu,K., Lu,Y.X., Wang,Y.,
            Jin,Y., Liu,J., Huang,L.Y., Zeng,Z.L., Zheng,Y., Xu,R.H. and
            Liu,Z.X.
  TITLE     HIPK3 maintains sensitivity to platinum drugs and prevents disease
            progression in gastric cancer
  JOURNAL   Cancer Lett 584, 216643 (2024)
   PUBMED   38246220
  REMARK    GeneRIF: HIPK3 maintains sensitivity to platinum drugs and prevents
            disease progression in gastric cancer.
REFERENCE   3  (bases 1 to 7614)
  AUTHORS   Mon,A.M., Intuyod,K., Klungsaeng,S., Jusakul,A., Pongking,T.,
            Lert-Itthiporn,W., Luvira,V., Pairojkul,C., Plengsuriyakarn,T.,
            Na-Bangchang,K., Pinlaor,S. and Pinlaor,P.
  TITLE     Overexpression of microRNA-205-5p promotes cholangiocarcinoma
            growth by reducing expression of homeodomain-interacting protein
            kinase 3
  JOURNAL   Sci Rep 13 (1), 22444 (2023)
   PUBMED   38105269
  REMARK    GeneRIF: Overexpression of microRNA-205-5p promotes
            cholangiocarcinoma growth by reducing expression of
            homeodomain-interacting protein kinase 3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7614)
  AUTHORS   Feng,S., Qi,Y., Xiao,Z., Chen,H., Liu,S., Luo,H., Wu,H. and
            Zhang,W.
  TITLE     CircHIPK3 relieves vascular calcification via mediating
            SIRT1/PGC-1alpha/MFN2 pathway by interacting with FUS
  JOURNAL   BMC Cardiovasc Disord 23 (1), 583 (2023)
   PUBMED   38012555
  REMARK    GeneRIF: CircHIPK3 relieves vascular calcification via mediating
            SIRT1/PGC-1alpha/MFN2 pathway by interacting with FUS.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7614)
  AUTHORS   Jiang,J., Gao,H., Zhou,W., Cai,H., Liao,L. and Wang,C.
  TITLE     Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes
            mellitus by regulating glutathione peroxidase 4 DNA methylation
  JOURNAL   J Gene Med 25 (9), e3526 (2023)
   PUBMED   37253602
  REMARK    GeneRIF: Circular RNA HIPK3 facilitates ferroptosis in gestational
            diabetes mellitus by regulating glutathione peroxidase 4 DNA
            methylation.
REFERENCE   6  (bases 1 to 7614)
  AUTHORS   Scaffidi,C., Volkland,J., Blomberg,I., Hoffmann,I., Krammer,P.H.
            and Peter,M.E.
  TITLE     Phosphorylation of FADD/ MORT1 at serine 194 and association with a
            70-kDa cell cycle-regulated protein kinase
  JOURNAL   J Immunol 164 (3), 1236-1242 (2000)
   PUBMED   10640736
REFERENCE   7  (bases 1 to 7614)
  AUTHORS   Nupponen,N.N. and Visakorpi,T.
  TITLE     Assignment of the protein kinase homolog of YAK1 (HIPK3) to human
            chromosome band 11p13 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (1-2), 102-103 (1999)
   PUBMED   10640824
REFERENCE   8  (bases 1 to 7614)
  AUTHORS   Kim,Y.H., Choi,C.Y., Lee,S.J., Conti,M.A. and Kim,Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
REFERENCE   9  (bases 1 to 7614)
  AUTHORS   Moilanen,A.M., Karvonen,U., Poukka,H., Janne,O.A. and Palvimo,J.J.
  TITLE     Activation of androgen receptor function by a novel nuclear protein
            kinase
  JOURNAL   Mol Biol Cell 9 (9), 2527-2543 (1998)
   PUBMED   9725910
REFERENCE   10 (bases 1 to 7614)
  AUTHORS   Begley,D.A., Berkenpas,M.B., Sampson,K.E. and Abraham,I.
  TITLE     Identification and sequence of human PKY, a putative kinase with
            increased expression in multidrug-resistant cells, with homology to
            yeast protein kinase Yak1
  JOURNAL   Gene 200 (1-2), 35-43 (1997)
   PUBMED   9373137
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY053621.1, DR000092.1, Y09306.1, AF004849.1, AL122015.17 and
            BX117467.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005734.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.144149.1,
                                           SRR1660809.112552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303296.9/ ENSP00000304226.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               HY053621.1         60-300
            242-679             DR000092.1         1-438
            680-1394            Y09306.1           221-935
            1395-4159           AF004849.1         893-3657
            4160-7309           AL122015.17        31791-34940         c
            7310-7614           BX117467.1         12-316              c
FEATURES             Location/Qualifiers
     source          1..7614
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..7614
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /note="homeodomain interacting protein kinase 3"
                     /db_xref="GeneID:10114"
                     /db_xref="HGNC:HGNC:4915"
                     /db_xref="MIM:604424"
     exon            1..509
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..1608
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             512..4159
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; ANPK;
                     FIST; homolog of protein kinase YAK1; fas-interacting
                     serine/threonine-protein kinase; androgen
                     receptor-interacting nuclear protein kinase"
                     /codon_start=1
                     /product="homeodomain-interacting protein kinase 3 isoform
                     1"
                     /protein_id="NP_005725.3"
                     /db_xref="CCDS:CCDS7884.1"
                     /db_xref="GeneID:10114"
                     /db_xref="HGNC:HGNC:4915"
                     /db_xref="MIM:604424"
                     /translation="MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTY
                     VNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQA
                     HVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGN
                     PVTVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRG
                     TNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFE
                     MLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPV
                     RQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAEL
                     FLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLE
                     EHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLI
                     DADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSL
                     LRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQTL
                     IICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRTQQM
                     LVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLS
                     APQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTN
                     IPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQT
                     IIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSP
                     DSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVED
                     THENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGR
                     LNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSN
                     PFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPM
                     LQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPL
                     SPTKLSQYPYM"
     exon            1609..1732
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1852
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1939
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2124
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2284
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2408
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2530
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2655
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2817
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2880
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3177
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3318
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3554
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3682
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..7614
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7590..7595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /note="hexamer: ATTAAA"
     regulatory      7595..7600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /note="hexamer: AATATA"
     polyA_site      7609
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
     polyA_site      7614
                     /gene="HIPK3"
                     /gene_synonym="DYRK6; FIST3; PKY; YAK1"
                     /note="major polyA site"
ORIGIN      
        1 ggtggcagct gcctcagtga cgactgccgg catcgcggcg acctgaggag atcaagccgc
       61 aggccccgcc gtcgccacca ctcccgccag tcttccttct ccgctcccgg ccggggcgtc
      121 aggaatgggc cccaatcgcc gtgggccccg caccctgcgt cgcccgtagg ccccagtagc
      181 cggaggccga ccggcctccc actacccctc gccctagcca agccgtcccc accccaaatc
      241 cccgggaagg aagatgaggg agacgggccc ggcgcttagc agccagagca gcagcagcag
      301 cagcagcggt cgggggaggg tgtttcgccg tttcctctca gccgccagga caagatggca
      361 gcggccgcgg agaggggctg agcccgggct gggtggtgcc gcctgctgaa gcgcctggct
      421 cccggtcccc ggcacggccc tgcgccccac cccggacatg ctcagggctg cggccgcccg
      481 aagaggagag agcgcgggcc tctaggaagg tatggcctca caagtcttgg tctacccacc
      541 atatgtttat caaactcagt caagtgcctt ttgtagtgtg aagaaactca aagtagagcc
      601 aagcagttgt gtattccagg aaagaaacta tccacggacc tatgtgaatg gtagaaactt
      661 tggaaattct catcctccca ctaagggtag tgcttttcag acaaagatac catttaatag
      721 acctcgagga cacaactttt cattgcagac aagtgctgtt gttttgaaaa acactgcagg
      781 tgctacaaag gtcatagcag ctcaggcaca gcaagctcac gtgcaggcac ctcagattgg
      841 ggcgtggcga aacagattgc atttcctaga aggcccccag cgatgtggat tgaagcgcaa
      901 gagtgaggag ttggataatc atagcagcgc aatgcagatt gtcgatgaat tgtccatact
      961 tcctgcaatg ttgcaaacca acatgggaaa tccagtgaca gttgtgacag ctaccacagg
     1021 atcaaaacag aattgtacca ctggagaagg tgactatcag ttagtacagc atgaagtctt
     1081 atgctccatg aaaaatactt acgaagtcct tgattttctt ggtcgaggca cgtttggcca
     1141 ggtagttaaa tgctggaaaa gagggacaaa tgaaattgta gcaatcaaaa ttttgaagaa
     1201 tcatccttct tatgcccgtc aaggtcaaat agaagtgagc atattagcaa ggctcagtac
     1261 tgaaaatgct gatgaatata actttgtacg agcttatgaa tgctttcagc accgtaacca
     1321 tacttgttta gtctttgaga tgctggaaca aaacttgtat gactttctga aacaaaataa
     1381 atttagtccc ctgccactaa aagtgattcg gcccattctt caacaagtgg ccactgcact
     1441 gaaaaaattg aaaagtcttg gtttaattca tgctgatctc aagccagaga atattatgtt
     1501 ggtggatcct gttcggcagc cttacagggt taaagtaata gactttgggt cggccagtca
     1561 tgtatcaaag actgtttgtt caacatatct acaatctcgg tactacagag ctccagagat
     1621 tatattgggg ttgccatttt gtgaagccat agacatgtgg tcattgggat gtgtgattgc
     1681 agaattattt cttggatggc cgctctaccc aggagccttg gagtatgatc agattcgata
     1741 catttctcag actcaaggtt tgccaggaga acagttgtta aatgtgggta ctaaatccac
     1801 aagatttttt tgcaaagaaa cagatatgtc tcattctggt tggagattaa agacattgga
     1861 agagcatgag gcagagacag gaatgaagtc taaagaagcc agaaaataca ttttcaacag
     1921 tctggatgat gtagcgcatg tgaacacagt gatggatttg gaaggaagtg atcttttggc
     1981 tgagaaagct gatagaagag aatttgttag tctgttgaag aaaatgttgc tgattgatgc
     2041 agatttaaga attactccag ctgagaccct gaaccatcct tttgttaata tgaaacatct
     2101 tctagatttc cctcatagca accatgtaaa gtcctgtttt catattatgg atatttgtaa
     2161 gtcccaccta aattcatgtg acacaaataa tcacaacaaa acttcacttt taagaccagt
     2221 tgcttcaagc agtactgcta cactgactgc aaattttact aaaatcggaa cattaagaag
     2281 tcaggcattg accacatctg ctcattcagt tgtgcaccat ggaatacctc tgcaggcagg
     2341 aactgctcag tttggttgtg gtgatgcttt tcagcagaca ttgattatct gtcccccagc
     2401 tattcaaggt attcctgcaa cacatggtaa acccaccagt tattcaataa gggtagataa
     2461 tacagttcca cttgtaactc aggccccagc tgtgcagcca ctacagatcc gaccaggagt
     2521 tctttctcag acgtggtctg gtagaacaca gcagatgctg gtgcctgcct ggcaacaggt
     2581 gacacccctg gctcctgcta ctactacact aacttctgag agtgtggctg gttcacacag
     2641 gcttggagac tgggggaaga tgatttcatg cagcaatcat tataactcag tgatgccgca
     2701 gcctcttctg accaatcaga taactttatc tgcccctcag ccagttagtg tggggattgc
     2761 acatgttgtc tggcctcagc ctgccactac caagaaaaat aaacagtgcc agaacagagg
     2821 tattttggta aaactaatgg aatgggagcc aggaagagag gaaataaatg ctttcagttg
     2881 gagtaattca ttacagaata ccaatatccc acattcagca tttatttctc caaagataat
     2941 taatgggaaa gatgtcgagg aagtaagttg tatagaaaca caggacaatc agaactcaga
     3001 aggagaggca agaaattgct gtgaaacatc tatcagacag gactctgatt catcagtttc
     3061 agacaaacag cggcaaacca tcattattgc cgactccccg agtcctgcag tgagtgtcat
     3121 cactatcagc agtgacactg atgaggaaga gacttcccag agacattcac tcagagaatg
     3181 taaaggtagt ctagattgtg aagcttgcca gagcactttg aatattgatc ggatgtgttc
     3241 attaagtagt cctgatagta ctctgagtac cagctcctca gggcagtcca gcccatcccc
     3301 ctgcaagaga ccgaatagta tgtcagatga agagcaagaa agtagttgtg atacggtgga
     3361 tggctctccg acatctgact cttccgggca tgacagtcca tttgcagaga gcacttttgt
     3421 ggaggacact catgaaaaca cagaattggt atcctctgct gacacagaaa ccaagccagc
     3481 tgtctgttct gttgtggtgc caccagtgga actagaaaat ggcttaaatg ccgatgagca
     3541 tatggcaaac acagattcta tatgccagcc attaataaaa ggacgatctg cccctggaag
     3601 attaaaccag ccttctgcag tgggtactcg tcagcaaaaa ttgacatcag cattccagca
     3661 gcagcatttg aacttcagtc aggttcagca ctttggatct gggcatcaag agtggaatgg
     3721 aaactttggg cacagaagac agcaagctta tattcctact agtgttacca gtaatccatt
     3781 cactctttct catggaagtc ccaatcacac agcagtgcat gcccacctgg ctggaaatac
     3841 acacctcgga ggacagccta ctctacttcc atacccatca tcagccaccc tcagtagtgc
     3901 tgcaccagtg gcccacctgt tagcctctcc gtgtacctca agacctatgt tacagcatcc
     3961 aacttataat atctcccatc ccagtggcat agttcaccaa gtcccagtgg gcttaaatcc
     4021 ccgtctgtta ccatccccaa ccattcatca gactcagtac aaaccaatct tcccaccaca
     4081 ttcttacatt gcagcatcac ctgcatatac tggatttcca ctgagtccaa caaaactcag
     4141 ccagtatcca tatatgtgaa aaacagtata ttggggaagc tcaatgatac aaacatttga
     4201 ttaaaaataa aaacatggta tttaatatta gccatggcac aagaaaatta tttttgaatc
     4261 atgtagactt gggtgcaatt taaacaactt tgagctttaa aaactcactt ttgatgtgtt
     4321 ttgcacattt ggtataactt gtctttggtc atgttatctt cttatgtagt aactctagac
     4381 aggtgactta tgggagcaga agtccagttt tgctcctgct attttttata aattgccttc
     4441 taactagtgc aagacacgtc tacatttggg aagccattct gtgtacagac ttagagcaac
     4501 agatgcacat atgtcagaat tacagcatac aagtgaattg tattatccgt gtcttagtgt
     4561 ataaatgttg ggtcacttac ctaagaaatt gagctattgt tctttacatt tgcatgtgtc
     4621 ttttgcatgg gcaaaatgtt gcctagactt tgctcttaaa tgttgttcta ataatctcag
     4681 ctgcattgta aaccgttcct acacatagtg ccttaaatat ttgaggttgt taatgttatt
     4741 acctatatat aaatgttgag gactgcagca cttaaaattc agacctacta tttagtttcc
     4801 ttttgatagc gtaatgttca tttttgtttt tgtgtggtat gatttcaggt agtagctgtt
     4861 tttttcctta ttaagagggc agcatgtttg ctatagctga attctgctgt ctgatttttc
     4921 agaatgatct agcttcaaga aaagcaagca gttagtagtg cttaagaaaa attgattcag
     4981 tatctaatgg atagttgata actgtcacag cacagcattt tatatactgt taagtgaaac
     5041 tgcaatacaa tctaagttta ttttgagagt gtttgctgta taattggact taataaaatg
     5101 tttagaggta cagtaggcat gactttgggt agataataaa atgcaaaatg ctcattgatt
     5161 catgatgtgg ttttatctta gcttgggcaa accatgcagt atttaataaa tagtagcaga
     5221 acttttacta ttgaagcttg aaaagatgtg agttctttgt gtgcaatttt tgatttatgc
     5281 atgtgagagg gttttttttt tttttaagta tttttacatt gcagtacttg ttttgcttgt
     5341 tggtgatgtt tgcttattta atacattccg tcagggacag aaattacatg cttttttttc
     5401 tttctaggaa gtgtgttgag ttcccccctt ccccgacatt tttttctttt ttgggtggtg
     5461 gtgatggtag tggttatgtc tgtttaaatg aagttgcttt tacagcacca aagacttaat
     5521 catccatttc ctatataaag gtagctactt tttgcataga cctcaagtat attgtagtgt
     5581 aaaggtggaa tttaaggaaa ggtattaaat tgaggctgtg ttttagctta caggcaagta
     5641 ataaattgta tcatttatct tgaatgtatc atagataagc tgctatataa cgattgccac
     5701 ttcagatagc tgtgaaatta ggtgattaac tagttgttat ttagccttct aatttctgta
     5761 taagtctaat tacatgaata gaaattgggg ttttgatttt ttactttgct tttctgtttg
     5821 gagtgtcatt gtaactactg tattgtaaat ggtggaaaat aattgcattt gttactttgg
     5881 ggtgtgttat ttgcatcagt attttatctc tattaatgtt tgtgctcatc actgcatatt
     5941 aaaaaaactt ggatgtatca gtgtaactta attttttatt ttcatactgg cattgtagac
     6001 acttgagaaa gctgtatctt gcaggcttga cttaactttt ttccttaaaa atctggaata
     6061 taatcttaca gcatttactg gaataaacag tacaaagcat tggagtgtaa aactctagat
     6121 gttttggatt tacagcgttt ctttgataaa tgaattgtat accactagta cagctctagt
     6181 acagcgttca caataagcta ataatggata agttttcttc actccattaa cacaagcagt
     6241 gttttattta ataatcatca atgaaataaa tgtgcctgaa attgatttta aaaattacag
     6301 tattagatca taaagtaaaa accagcagta catttttagt cacactgaaa atgaaggact
     6361 taattttccc cacaagtttc agtgttttta gtaattaatt ctatgcattt tatacaaata
     6421 gaaatatata tatataaaaa attaaatgtt taaaaaggag tagcctaaga ttaatttaaa
     6481 agattattta cagatgacac atttatgggg tcactattta agtaaatttg ctgccctcca
     6541 cagccttcta attttattta tatgttccag cagattatta ggatctgctt acttcttagg
     6601 aaagaatcaa tgctggcaac acattgtttc agaaacacca agtgcaaagg attgattgta
     6661 tcacaacagg tacaaaactg acagagtttt ctttttgttt agggccatgt ttactaccct
     6721 gaaatgttgt attttttgtc tttaatttcc aagacttaaa gcagtcttgt taaattgaca
     6781 taaatggtaa acttcaacat tttcataata cagtattaat gtttgataaa ggtatatccc
     6841 agttaactac actgctcttt aattgcaatc atgggcattt taatgtattt taaaataaat
     6901 ttcaaaattc tgctaaattc ttaatttagc atattgacaa agtaatctgg atttatacct
     6961 tttaaaaacc attttgacca gttttcttcg gttttaatgc tttcttaaat aaaacactgc
     7021 atgatttcca agttgcatat ttgcatacta ttttaatttg caaaatgttt tttaaatcaa
     7081 atatcctgat atttagttgt tttttttttc ctccagcgtg tttaattaaa tatgttactg
     7141 tattagcaaa acattttcat ttttaaaatc tgctaatttt aaacttggac tgtgttaagt
     7201 aaaagttaaa tcatacactg caaggtgtag gaagatttgt tttaatgaat ccaatgatac
     7261 agatttgatt actaagtttg aactgttaat tgtttaacaa ttttagactt gtggctttct
     7321 ttctttggtt tatttgtttt tgcttttact cctatgctac actagtttgc catgtagcaa
     7381 ttgcactgtg caatattaca ataaggactg ggaaaatttt atggatgtaa tgtctattac
     7441 ggtttgcgat agtatttctc tctagttctc agtgatttaa atgtgaccaa gccttctgta
     7501 ctttgtcaca aaaagcgggt tttccaggtg actattttgg tgagtgtcaa aataagaatt
     7561 tatggtgtat tactgtcgat tcactttgaa ttaaaatata tatattgcag caaa
//
