LOCUS       NM_022740              15329 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens homeodomain interacting protein kinase 2 (HIPK2),
            transcript variant 1, mRNA.
ACCESSION   NM_022740 NM_014075
VERSION     NM_022740.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15329)
  AUTHORS   Zeng,X., Tang,J., Zhang,Q., Wang,C., Qi,J., Wei,Y., Xu,J., Yang,K.,
            Zhou,Z., Wu,H., Luo,J., Jiang,Y., Song,Z., Wu,J. and Wu,J.
  TITLE     CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of
            Colitis and Colorectal Cancer through Promoting TAZ Translation
  JOURNAL   Adv Sci (Weinh) 11 (34), e2401588 (2024)
   PUBMED   38981023
  REMARK    GeneRIF: CircHIPK2 Contributes Cell Growth in Intestinal Epithelial
            of Colitis and Colorectal Cancer through Promoting TAZ Translation.
REFERENCE   2  (bases 1 to 15329)
  AUTHORS   Lun,J., Zhang,Y., Yu,M., Zhai,W., Zhu,L., Liu,H., Guo,J., Zhang,G.,
            Qiu,W. and Fang,J.
  TITLE     Circular RNA circHIPK2 inhibits colon cancer cells through
            miR-373-3p/RGMA axis
  JOURNAL   Cancer Lett 593, 216957 (2024)
   PUBMED   38762192
  REMARK    GeneRIF: Circular RNA circHIPK2 inhibits colon cancer cells through
            miR-373-3p/RGMA axis.
REFERENCE   3  (bases 1 to 15329)
  AUTHORS   Fu,M., Chen,Y. and Shi,X.
  TITLE     ZC3H13 Accelerates Keloid Formation by Mediating N6-methyladenosine
            Modification of HIPK2
  JOURNAL   Biochem Genet 62 (3), 1857-1871 (2024)
   PUBMED   37752292
  REMARK    GeneRIF: ZC3H13 Accelerates Keloid Formation by Mediating
            N[6]-methyladenosine Modification of HIPK2.
REFERENCE   4  (bases 1 to 15329)
  AUTHORS   Su,W., Ye,Z., Wang,G., Huang,H. and Fang,Y.
  TITLE     Circ_0008410 contributes to fibroblast-like synoviocytes
            dysfunction by regulating miR-149-5p/HIPK2 axis
  JOURNAL   Microbiol Immunol 68 (3), 100-110 (2024)
   PUBMED   38129937
  REMARK    GeneRIF: Circ_0008410 contributes to fibroblast-like synoviocytes
            dysfunction by regulating miR-149-5p/HIPK2 axis.
REFERENCE   5  (bases 1 to 15329)
  AUTHORS   Yu,X., Fan,Z., Yang,T., Li,H., Shi,Y., Ye,L. and Huang,R.
  TITLE     Plasma circRNA HIPK2 as a putative biomarker for the diagnosis and
            prediction of therapeutic effects in major depressive disorder
  JOURNAL   Clin Chim Acta 552, 117694 (2024)
   PUBMED   38065380
  REMARK    GeneRIF: Plasma circRNA HIPK2 as a putative biomarker for the
            diagnosis and prediction of therapeutic effects in major depressive
            disorder.
REFERENCE   6  (bases 1 to 15329)
  AUTHORS   Hofmann,T.G., Mincheva,A., Lichter,P., Droge,W. and Schmitz,M.L.
  TITLE     Human homeodomain-interacting protein kinase-2 (HIPK2) is a member
            of the DYRK family of protein kinases and maps to chromosome
            7q32-q34
  JOURNAL   Biochimie 82 (12), 1123-1127 (2000)
   PUBMED   11120354
REFERENCE   7  (bases 1 to 15329)
  AUTHORS   Li,X., Wang,Y., Debatin,K.M. and Hug,H.
  TITLE     The serine/threonine kinase HIPK2 interacts with TRADD, but not
            with CD95 or TNF-R1 in 293T cells
  JOURNAL   Biochem Biophys Res Commun 277 (2), 513-517 (2000)
   PUBMED   11032752
REFERENCE   8  (bases 1 to 15329)
  AUTHORS   Choi,C.Y., Kim,Y.H., Kwon,H.J. and Kim,Y.
  TITLE     The homeodomain protein NK-3 recruits Groucho and a histone
            deacetylase complex to repress transcription
  JOURNAL   J Biol Chem 274 (47), 33194-33197 (1999)
   PUBMED   10559189
REFERENCE   9  (bases 1 to 15329)
  AUTHORS   Kim,Y.H., Choi,C.Y. and Kim,Y.
  TITLE     Covalent modification of the homeodomain-interacting protein kinase
            2 (HIPK2) by the ubiquitin-like protein SUMO-1
  JOURNAL   Proc Natl Acad Sci U S A 96 (22), 12350-12355 (1999)
   PUBMED   10535925
REFERENCE   10 (bases 1 to 15329)
  AUTHORS   Kim,Y.H., Choi,C.Y., Lee,S.J., Conti,M.A. and Kim,Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006021.2, AI580907.1, AF326592.1, AF208291.1, AC005531.2 and
            CK818532.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022740.4.
            
            Summary: This gene encodes a conserved serine/threonine kinase that
            is a member of the homeodomain-interacting protein kinase family.
            The encoded protein interacts with homeodomain transcription
            factors and many other transcription factors such as p53, and can
            function as both a corepressor and a coactivator depending on the
            transcription factor and its subcellular localization. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) encodes the full-length
            isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF208291.1, SRR11853567.28118.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406875.8/ ENSP00000385571.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC006021.2         62137-62240
            105-220             AI580907.1         1-116
            221-1073            AF326592.1         1-853
            1074-4131           AF208291.1         807-3864
            4132-14812          AC005531.2         133591-144271       c
            14813-15329         CK818532.1         21-537              c
FEATURES             Location/Qualifiers
     source          1..15329
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..15329
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /note="homeodomain interacting protein kinase 2"
                     /db_xref="GeneID:28996"
                     /db_xref="HGNC:HGNC:14402"
                     /db_xref="MIM:606868"
     exon            1..394
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     CDS             376..3972
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hHIPk2"
                     /codon_start=1
                     /product="homeodomain-interacting protein kinase 2 isoform
                     1"
                     /protein_id="NP_073577.3"
                     /db_xref="CCDS:CCDS75667.1"
                     /db_xref="GeneID:28996"
                     /db_xref="HGNC:HGNC:14402"
                     /db_xref="MIM:606868"
                     /translation="MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGY
                     GSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTS
                     VTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASG
                     ATVATATTSTATSKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWK
                     RGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHKNHTCLV
                     FEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVD
                     PSRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIA
                     ELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT
                     PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKML
                     TIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICKRRVNMYDTVNQSKT
                     PFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSA
                     ASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENA
                     VPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPE
                     TMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTST
                     TSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVT
                     CGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKN
                     VISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPL
                     KTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGP
                     HFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLA
                     AAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPV
                     SMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI"
     exon            395..1478
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1602
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1722
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1809
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1994
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2157
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2365
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2487
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2630
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2810
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            2811..3092
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3340
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3501
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..15329
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15306..15311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /note="hexamer: ATTAAA"
     polyA_site      15329
                     /gene="HIPK2"
                     /gene_synonym="PRO0593"
                     /note="major polyA site"
ORIGIN      
        1 atgctgagct gagccccgcc ggccctggcc gcgcgctgcc cccggctccc gcccctccgc
       61 ggatccgctc gggggccgcg gccgctcggc gcctcggcct cggccgctcc gcccgcccgg
      121 ccgccccgag ccccgagccc cgagcccccc gcgccgggcc cgggcggcag cggcggcggc
      181 ggcggcggcg gcgcgcccgg ccccctcccc cggcgccggc cacgggaggc ggtgatgcgg
      241 gcgcgggcgg cctcggctgc gccgagagcg gagacacagg ctcaagatgg cagattccga
      301 ctgaggctgg gggggccgag ctcgcgcgcc gctttcccgt ccccgttgcc atgaaccgcg
      361 gacaccccgg ccccgatggc ccccgtgtac gaaggtatgg cctcacatgt gcaagttttc
      421 tcccctcaca cccttcaatc aagtgccttc tgtagtgtga agaaactgaa aatagagccg
      481 agttccaact gggacatgac tgggtacggc tcccacagca aagtgtatag ccagagcaag
      541 aacatccccc tgtcgcagcc agccaccaca accgtcagca cctccttgcc ggtcccaaac
      601 ccaagcctac cttacgagca gaccatcgtc ttcccaggaa gcaccgggca catcgtggtc
      661 acctcagcaa gcagcacttc tgtcaccggg caagtcctcg gcggaccaca caacctaatg
      721 cgtcgaagca ctgtgagcct ccttgatacc taccaaaaat gtggactcaa gcgtaagagc
      781 gaggagatcg agaacacaag cagcgtgcag atcatcgagg agcatccacc catgattcag
      841 aataatgcaa gcggggccac tgtcgccact gccaccacgt ctactgccac ctccaaaaac
      901 agcggctcca acagcgaggg cgactatcag ctggtgcagc atgaggtgct gtgctccatg
      961 accaacacct acgaggtctt agagttcttg ggccgaggga cgtttgggca agtggtcaag
     1021 tgctggaaac ggggcaccaa tgagatcgta gccatcaaga tcctgaagaa ccacccatcc
     1081 tatgcccgac aaggtcagat tgaagtgagc atcctggccc ggttgagcac ggagagtgcc
     1141 gatgactata acttcgtccg ggcctacgaa tgcttccagc acaagaacca cacgtgcttg
     1201 gtcttcgaga tgttggagca gaacctctat gactttctga agcaaaacaa gtttagcccc
     1261 ttgcccctca aatacattcg cccagttctc cagcaggtag ccacagccct gatgaaactc
     1321 aaaagcctag gtcttatcca cgctgacctc aaaccagaaa acatcatgct ggtggatcca
     1381 tctagacaac catacagagt caaggtcatc gactttggtt cagccagcca cgtctccaag
     1441 gctgtgtgct ccacctactt gcagtccaga tattacaggg cccctgagat catccttggt
     1501 ttaccatttt gtgaggcaat tgacatgtgg tccctgggct gtgttattgc agaattgttc
     1561 ctgggttggc cgttatatcc aggagcttcg gagtatgatc agattcggta tatttcacaa
     1621 acacagggtt tgcctgctga atatttatta agcgccggga caaagacaac taggtttttc
     1681 aaccgtgaca cggactcacc atatcctttg tggagactga agacaccaga tgaccatgaa
     1741 gcagagacag ggattaagtc aaaagaagca agaaagtaca ttttcaactg tttagatgat
     1801 atggcccagg tgaacatgac gacagatttg gaagggagcg acatgttggt agaaaaggct
     1861 gaccggcggg agttcattga cctgttgaag aagatgctga ccattgatgc tgacaagaga
     1921 atcactccaa tcgaaaccct gaaccatccc tttgtcacca tgacacactt actcgatttt
     1981 ccccacagca cacacgtcaa atcatgtttc cagaacatgg agatctgcaa gcgtcgggtg
     2041 aatatgtatg acacggtgaa ccagagcaaa acccctttca tcacgcacgt ggcccccagc
     2101 acgtccacca acctgaccat gacctttaac aaccagctga ccactgtcca caaccaggct
     2161 ccctcctcta ccagtgccac tatttcctta gccaatcccg aagtctccat actaaactac
     2221 ccatctacac tctaccagcc ctcagcggca tccatggctg cagtggccca gcggagcatg
     2281 cccctgcaga caggaacagc ccagatttgt gcccggcctg acccgttcca gcaagctctc
     2341 atcgtgtgtc cccccggctt ccaaggcttg caggcctctc cctctaagca cgctggctac
     2401 tcggtgcgaa tggaaaatgc agttcccatc gtcactcaag ccccaggagc tcagcctctt
     2461 cagatccaac caggtctgct tgcccagcag gcttggccaa gtgggaccca gcagatcctg
     2521 cttcccccag catggcagca actgactgga gtggccaccc acacatcagt gcagcatgcc
     2581 accgtgattc ccgagaccat ggcaggcacc cagcagctgg cggactggag aaatacgcat
     2641 gctcacggaa gccattataa tcccatcatg cagcagcctg cactattgac cggtcatgtg
     2701 acccttccag cagcacagcc cttaaatgtg ggtgtggccc acgtgatgcg gcagcagcca
     2761 accagcacca cctcctcccg gaagagtaag cagcaccagt catctgtgag aaatgtctcc
     2821 acctgtgagg tgtcctcctc tcaggccatc agctccccac agcgatccaa gcgtgtcaag
     2881 gagaacacac ctccccgctg tgccatggtg cacagtagcc cggcctgcag cacctcggtc
     2941 acctgtgggt ggggcgacgt ggcctccagc accacccggg aacggcagcg gcagacaatt
     3001 gtcattcccg acactcccag ccccacggtc agcgtcatca ccatcagcag tgacacggac
     3061 gaggaggagg aacagaaaca cgcccccacc agcactgtct ccaagcaaag aaaaaacgtc
     3121 atcagctgtg tcacagtcca cgactccccc tactccgact cctccagcaa caccagcccc
     3181 tactccgtgc agcagcgtgc tgggcacaac aatgccaatg cctttgacac caaggggagc
     3241 ctggagaatc actgcacggg gaacccccga accatcatcg tgccacccct gaaaacccag
     3301 gccagcgaag tattggtgga gtgtgatagc ctggtgccag tcaacaccag tcaccactcg
     3361 tcctcctaca agtccaagtc ctccagcaac gtgacctcca ccagcggtca ctcttcaggg
     3421 agctcatctg gagccatcac ctaccggcag cagcggccgg gcccccactt ccagcagcag
     3481 cagccactca atctcagcca ggctcagcag cacatcacca cggaccgcac tgggagccac
     3541 cgaaggcagc aggcctacat cactcccacc atggcccagg ctccgtactc cttcccgcac
     3601 aacagcccca gccacggcac tgtgcacccg catctggctg cagccgctgc cgctgcccac
     3661 ctccccaccc agccccacct ctacacctac actgcgccgg cggccctggg ctccaccggc
     3721 accgtggccc acctggtggc ctcgcaaggc tctgcgcgcc acaccgtgca gcacactgcc
     3781 tacccagcca gcatcgtcca ccaggtcccc gtgagcatgg gcccccgggt cctgccctcg
     3841 cccaccatcc acccgagtca gtatccagcc caatttgccc accagaccta catcagcgcc
     3901 tcgccagcct ccaccgtcta cactggatac ccactgagcc ccgccaaggt caaccagtac
     3961 ccttacatat aaacactgga ggggagggag ggagggaggg agggagagaa tggcccgagg
     4021 gaggagggag agaaggaggg aggcgctcct gggaccgtgg gcgctggcct tttatactga
     4081 agatgccgca cacaaacaat gcaaacgggg caggggcggg gggggggggg ggggcagagg
     4141 gcagggggac gggtcgggac accagtgaaa cttgaaccgg gaagtgggag gacgtagagc
     4201 agagaagaga acatttttaa aaggaaggga ttaaagaggg tgggaaatct atggttttta
     4261 ttttaaaaaa gaaaaaggaa aaaaaaaaag tcaataacaa aaaacccagc tcaagaaccc
     4321 attctacgcc aaactggaaa ggagaagaga gcaacaggaa gattccagaa acggggggcc
     4381 ccagtttttg aagaacttta tgaacttttc aaagattatt ttcatatggc agcaagtgat
     4441 acggaagact gctgtcaggg acacctgata tggaaatcaa atagattttt aattaattga
     4501 acataagatt tagggatttt tccagaactc gaaagggtca acagccctcc agaatgtcgg
     4561 gctgcagcct gaggaggctg atgtttggag ctggtgtggg attggcgaag cccagtccgg
     4621 gctccctagt caggaaagac gggggacggc caggctgctg gaaggccccc gggggcgcgg
     4681 ggcgagtttt ctttttctga gcactctgga taaatcccta agcaacgttg tttctcaaat
     4741 gtcattaata atgtgtgttg caaactttag gtttttttct tttctgaaaa tgtattttct
     4801 ctttgaatcc acccctagtc gcgtagcgta gggctagcgg tcgtcacaga caccctagta
     4861 gaatgtagca ctcagcaccc ttgtctccta ccttgtgttc aactccaatg ataccaatag
     4921 aatattcctc aatgtaattg cacaaaaaaa agcgatataa cataggcatg taaccaatgt
     4981 ggcggtgcag gtgtgcgggt gagcgagcac gtgtgggtgt gcacgcgccg ccctccccgc
     5041 gtggccctcg gcgccgccac cctagctggc gcagtcttga cactgcatcc ttccctccta
     5101 gtgccttacc gagcgacaga cgcggcgtga gggtttactt ccactggtac tccaagaaac
     5161 tgaggctagt cagacacaat ctcagctctt ctgttgtgct gttgtaacag tttacgctgg
     5221 cctttttttt ttctttttct ttttcttttt aaaatgttaa tgcccgttgt ctttcctggg
     5281 ctgtttgcta gcggaaggat gccagggaag ccagcaggag ctaggagaga gtccgtggat
     5341 ctcgaaagaa atatgggaga cagatgcccg gcgggtgcgt ctggagatgg ggacggcggg
     5401 agttgagttg tggcagtagt tgagttgtaa tttgtgggcg gaggcccaga gagactcccc
     5461 acccttcacc cctgccccac tctgtcccca gttccgccat ttgtgaggcc agaggtttcc
     5521 ggactgttgg cctcgccagg cagccgtctc ccgccccagg cggcatcccc cagtccctcc
     5581 cgcctccacg agagcctgga gctctcagcc tcgcccgggg ctccactctc tcctccggct
     5641 ccctgggctg ttttgctcta acgatcttgc cagatccctc cctctgtaga caaccaccaa
     5701 cctctgtttg ctgttgaatt ctctcctcac attacccagg tctgctcaag acatgatttt
     5761 ggttttggtt tctgagggtt ctagtgggca gaaggttgga gggacactta tgagggtggc
     5821 cgggggtctg acgctgcact ttggaaaaac tcacacagtt gaatttccaa agaaatctgc
     5881 cctttgccct ctttgcacct ttgatacatt ctggaagttt tctcaggctt tggacacttc
     5941 tggggatgga ggtgtggaga agtggggagt tccctctctt catagtaaat aactctgaaa
     6001 tatgtgaatg tgaatggcag gagaatctgg ccaaggatgg ggccgaaaag ggtggttcta
     6061 attgtttgct tctgatgttg agtctttagc tgaccccaca ggcaggtttc caaggtgcaa
     6121 agagatcttt cccgagtcag cggccccatc ctcatcctcc ctccctttac ttcctcactg
     6181 tgcagtctcc ctcaaggatc tactgtgaaa ggtgtgtttg tagtgatatc caacctaact
     6241 cagtaacgaa gtcgttactt agctcttagc tgtgaaataa ctctggaaac ttccccaccc
     6301 caaccataaa ttcttactta taaagaaaca ggtccccaaa ctggaaacag cttagtccag
     6361 gcctcagcga gaaggaagga caccatgact gctccatgct gggcacagcc gggcagtctt
     6421 gccaagtgcc tgctggaggc tgtgccggca agaggcctgc agcaaggaga ttcccttccc
     6481 tcgggccatt atcaatactg tctttatctg gaggtgggga agcgcagccc tctgagacag
     6541 caggacaatg gtcagttcag agagggtgag ggcagcaaac gcttcagagg acacagaagc
     6601 cagaggaccc ccccccgccc cacagctggg tcagcctgga aaatccatct attagggact
     6661 ttttggcagc cagatggcag caatagccca ttaggtctca tcccgagttc caagtcttgg
     6721 ctgcaaatga gcctcagttc gccttactgg agagcacccc cagattcctg ggcacagttc
     6781 atttccagcc ctttctagat ctgatctttt agggggaaag acagcttaaa atgttctttt
     6841 cattttaaag aaaattattc tgtctgctta agttggaggc tacttactct ttcacctgac
     6901 attttctttc cttttattct tccagatcag gaatgaaatt tccatgctgc tcataaagat
     6961 aatattattg tactaattat ttttattacc attgtaatta tgatcattat gttgatattt
     7021 tagtcagggt tttaaatgca catttattcc aagtatcttt gtgttttctc tttaatattt
     7081 aaacttattc tctctgtgag tatataagta gactggaggg acatccagat gtccagtttt
     7141 gtcaggcaaa aaaaaaaagg aaagacttag gaagtaggaa aattgtttct gtcatctcta
     7201 tcccaacaag agacgtcaag aaagatccac cacagaacaa aagtttaaag aagaatcaaa
     7261 gccttgattg ggcttctgac aacatggtca ccatcaaggt tgtcattttc tagatcccag
     7321 aggcctggga tgcgacgtca ggtggcatct catgggctcg gggaatgtcg agtcactgac
     7381 tgtccagccc ttagccagct tctctcccac atcctcagag ctctcctgtg cttctgaaat
     7441 ctgttaacta aatctttggc ttgcctctgg tatttaagca agaaaattcc ctcccagagg
     7501 tgaccccatc cgcttcccca caatccatcc ttttgccatc ggcgcacctg gggcgtggct
     7561 taggttcttc aatgcaggga catttgcccc ctcccagaag ctgctgggca cagtgaggtg
     7621 gcgtaagagt gactggcagg tggtaccttc cccaggaaat ttcaccacac cacccagttc
     7681 ctcagcctgc cccctccccc tgtgatgcat gcccccagca cccaattcta gccagctgga
     7741 agtgggtgga gggacagcag gaggccagag aaaccctgaa caaagctggg cggctgctca
     7801 ggcatcacag gctgcacccc ctctgaaagc atccccactg ggctccggcc acatcttcag
     7861 tgcactgtgc tgtgtgcgct gggtgctcac acgctgtccc cagacccaca aagtgctagg
     7921 ccccagttga agaaaggggt gaaatagcca gcttcaccga agggaaggga agggaagtat
     7981 tgggcgatgc cagccccaca gacgctcagc aaacattagt gcacattctc ctagtcctca
     8041 cccaatggcc tcctctaccc ccatgcatgg agctgccaca tcagaagccc caagagaagc
     8101 tccctgcagg agaggccagc tccctggatg cccaattgca tacctggccg aatctgccat
     8161 tgagtcacct tagcaaatag gctgctgtca ctaggaccaa gctctcaagc agagggatgc
     8221 caacctagtc cttacttagc ccacgaatca tctagagcat cctctagtct tttgtgggct
     8281 ccctccttcc catttgaaga gacattgttc agaggaagag gggaagattt gaaatgtcag
     8341 gtcacggagg agtgtttaac tggagcctgg tgaaccgcag ggcaatttgc ttctgctcac
     8401 tgggttctga ctggcccgtc tggacgtggg cccccatgtc tctgtgctta gggcctcttc
     8461 atgatgtttt ggatgtttcc aagggaagtg ggtgagcaga tcaaggggtg ggagagtcga
     8521 ggcttgatgc cagttaatac tgtgaagtgg agcgtgcggt cagtggaatt cagaggaaaa
     8581 agaagggttg gagcaaagcg gcattcatct cctggactgt tagcctttct agtcttcctg
     8641 gtggctgagg tgttcacggg ctgggggagc cagctgacct ttgtcctctt caacctagaa
     8701 gactcagccc gcccagacac caacgtgtga gacggatgga catcaggaag ggaaggggag
     8761 attagcccaa ctgctgacag aacgatttcc cttggttgga ccttgggaat ggcaaacact
     8821 catattggaa caagcttggg gtggaagatt taggccgtgt gagcatgtgt gagtgagtgg
     8881 aacaaacttt cttggaaact ggagggagga gatgaggagg cttcgggaag tattactgat
     8941 ggctcatggt tgagagagcg acgtggggac ccagctcgcc ccagcttttg tcccaggttc
     9001 tctttgtctg atgctgaggg cagggtgggg tgtgggacca ccactcttgt tggcctgtca
     9061 agtagaccct aggacagaaa atggaaagaa ggaaatggct cggtgctctc aactagcaga
     9121 gagaattgag gagaggtaag ggttccttct gcaggccagc ctgggactcc acagcgccag
     9181 caggagtgac ttggccacaa gacattccag ccccagggac tttgcaggct tcattccctg
     9241 tctgtgtctt ttccttctgg tgtgttttac agacttctga tggggaagct tcaaacttga
     9301 gcaggccaga gatgtcctta ccaaattgga aaggaaggtg aaactgttcc tttctttagc
     9361 caaagaaccc ttctcaaaga cgcctccaga aatggacaaa atggccttcc cttcgttcct
     9421 ttccaggcaa taatgacatc attagtgatg caattctatt tgtctttctc tttcctctct
     9481 gtcctttttt ttaaaaaaaa aaaatgcatt tatttcaaaa ctgtgctatt cttttaagag
     9541 gagtggaggt gaccccttcg atgctgctgc tatcgggaga caaggtgcca taccaatacg
     9601 tgggcttgac taatcccagg ccaccatggg agagagcaaa gcagggctgc caggagttca
     9661 gttgcatcaa gggcgtagag cacgcggggg ctgggctcgg aatagcagta cttttccact
     9721 ttgatgcctt agaactctca cttctcatct ccacagacca gactcagtaa aatctcaggc
     9781 cactagagaa tggaaggcgg tgaaacagga tttaaatgca aaaaaaacct attggaggct
     9841 tttggcaccg tggctcacta gagggaccca gcatagtaga ggtttctctt gttgcagctt
     9901 ctgaaaagtt caaaaaagaa ctccaggccg ttcttccctc aaacccagtg agagtttgca
     9961 gagaagtgcc ccctgcaggg ctcccgtccc agaacaccag caccagagag ggtcttcccg
    10021 atgccccccg ctggacttgc ccaagcctct gggagcccct catctcagat ccctgtgttg
    10081 aacatgacac tgactgtccc ttatttgtta aaatttgcaa tatctctcaa gtaaataata
    10141 gccaacattt gttgaatgct ttcatgactc ccgggctaag gcctttatga gcgttgtctc
    10201 aaggggcccc aacagccatc ccacagggag ggggataaca gcccccattt atagataagg
    10261 gagctgaccg gatgctctga gaagtggcag gtgttgaagg aaggataaag cagtgatggg
    10321 ccagaatccc caaggttccc ttttttgttc atcaggccct tcctgagatg tgatttttaa
    10381 tcttttaact ttttttaatt aatagcaatg cgtggcctca tatttctatg aaccatttag
    10441 tgatactccc gcttcctgca tgccacacac tgtgctggga attgctcatg ggttgtcctg
    10501 tttcatcttc tccgtagccc tgtgagatcg gcaatattag tccccctaca gccaaggaaa
    10561 ctgcccagag ccacacaact cttgaggggc gaggagggct tgaacctgag tctgcccagc
    10621 tccagaactg agcttgcagc cattagccac agctgtctcc tgcatgtctg agcaaagaaa
    10681 ggcctttaca cagcatcacc ctgtgccatc ccatgcaccg tgggactcag ctaaaggact
    10741 gtgcaaagag ggggctcctg agttggattt aggcaaaagg ggcagaattc gtttgatttt
    10801 tagagaaaat ctctggagag tttcttttga ttcatagaat tccttttaga tttctttcca
    10861 gcataccaac tagctttagt agtgctgcta caaccagctc ttataagtaa gagtgaaaaa
    10921 gtattctttt cttctttaaa aaataagttt ttcttgctta tagttaattc tagaaaggca
    10981 atactaaagg tatatatttt tttcaaaatg ctatttttta ctgcacttga taattatcct
    11041 gacagctctg atctctgtaa tagattcact cttcagctct gggcagaacc agaggcaggg
    11101 ttcacaccaa atttgtaaat accatatgtg ggtctggtgt ccaggaactt ttttctttct
    11161 gttaaaaaaa agaaaaaaaa aagaaaaaaa aaaagaagta gaggtggaag aaagacaaga
    11221 cttagaggaa caaaagaatg ttttcttttg agatactctt ctcaaagaaa tagcaacaat
    11281 tgtataaaca ggaaaaccag ccagctttca tgataaaagg aaggcgtgtc tcttgccctg
    11341 gtatgagatt aacagaaata cagatgcatt tttattttga ttgaaagatg gtgagaatgt
    11401 agaaatgctt aggactagat ttttaatttt ttaaaataac tattatcatt tattatgaaa
    11461 tatttgttca gttgttttga gtgggtttct tgttcctttt ttcatttaaa accttctttg
    11521 ttgactggct ccaggcttgt ttgcctaaat tcttaggtag tttacacaag ttctagaatc
    11581 ttttagaact ttaactccat tggaagcaaa cctaactaat cggagtttga gatcctggtt
    11641 ggtttcaata ggtattctgg aattctggca gaacacctaa agattttttt tttttttaga
    11701 aggttttaga tacattatct tacacaaact gtgacctaat ggcaataatt acctcaaatg
    11761 tgggcattca tcctggtttt agcctttttt gaaatcatgt agccagcttg atcttggaat
    11821 ttaaagacta tgaattctct gtgggctgaa aataatgatt acttcatacc cccggtcatc
    11881 gttgcttaag tgaattctga aaatagctca tctttacaac aaaaattaaa ccaaggaaga
    11941 gattattctt tgtgtgttgt actcaaatgc gatgttcaaa tgcacatgtt aagtatatat
    12001 gtttttagct actgtaaaat gctgttagcc ttctaagcta tcaaaacagt cacattttaa
    12061 atgagtaaac taaacaattg actgtggata cttaagcata tttctggcta cgttttatag
    12121 ttaaagtgtt ttatagttta catttagact ggtacttttt aaagaaaagt tctgtttata
    12181 actgacatcc gcaaacccca gtgaatgcct cttagttgga ggttgtgtct cccccaaggc
    12241 aagtgtgttg tcccagactc ttctgtagtc cagcatgcgc acttccctct ggattattac
    12301 tttccacgtg aactcaagag aacatgaaag gcaatccaga tggagggaaa aggtgtgagt
    12361 ccgcagcccg ggccagatgc gaaggtctca tgcgtgtcgt ctaaacactt gtcttcaagg
    12421 ccttctctct gacatcttgg aagagtcatt gagaacagat aacctggttc attgattttt
    12481 gtcttgattt gaatatttaa cttattaata gatccactga tttccaggca ccaggcagta
    12541 gaagagactg ggattcaggt gaccatgaag gcacagctgc tacttctggg ccgggggtga
    12601 tattttgatc agcgttttgt aggggaggac catatacccc tattcccatg gtcgctggct
    12661 gggttttcca tatatctgct gtcatttatt cgttttcccc ttaaaagcaa aatcaatgta
    12721 aaaggctatg tttacgtttt actcattgtc cagcttagac tcaaagtcta gttcggtggg
    12781 agggggacct tagcatcctc tcagagatgg tcagggctga gcaggaggag gcagagacag
    12841 aggggcagct cagcctggtc cattgagacc cactctaaac agacatcata tttggaacaa
    12901 gaagatgctt cgagacagga atgggcccca ctgtcatgca gaaacagact gggggaatgg
    12961 cagtttccct gagtcttggt ttcttttatg ttttctcttg tgccaccacc aaactgcaga
    13021 ggacctgctg tgacctaaag ggcattcctt tagcagataa gaccttgaaa actgcaaaac
    13081 acctgggacc agggagcttt taaaaaatac aaaaaaatac cacatttgct ttttccctgt
    13141 gaactgtatt gacagcgtgt tcttaggaca gtcttttggt ggaaatgtta ctgtaaaata
    13201 gttttcatct cacccctcct aatcatactc ccactttcct gtttgtgtgg tggtgttgct
    13261 gttttttcct ttacatgaat taaccaaatg aattttgtgt cattgttttt ggggcttata
    13321 tttttaaaac atagaaattg ccttttgttc atttgaaaag taagtatgtt gtatctgaaa
    13381 aagggctctg cctctgctct ccctcgcttc cttgtaacca atctccaaac gaatctctcc
    13441 tggcaccgcc cccttcctta tatagggtca ctgtccccgg ggccacctct gcctccaccc
    13501 tgctgtcacc actgccctgg gccaaggcac ccaggactcc cagaaagcgc gagagccagc
    13561 aagaaggccc cactcagcct tgagactggt ggtcacacct ccctgtcaga gtcgcctgct
    13621 gggctgaagg ggcaatggat tgtcattgtt gaaattgttt ggctcaggtt ataaggagga
    13681 acttgggaag tagaaagtga cttgaccatg tgcatccttg gtagcttcct gtaactaaca
    13741 aatggaacag agagcacacc cccgccccgc cccaccccaa gcagatgttc ccgtcagcgc
    13801 tgccctgagt cagtcggtcc cccgtttctg ctctcctccc ttttgtgttc ctgctcactt
    13861 caagcttctt ccatggactt tccagggcac agtcatctct agcccccaaa tcatctcttc
    13921 atcctctgtg tgtgcatttt tttaaccaaa tgaaatagac aagaaagtca tactttgggg
    13981 cagcagaatt tctaatttag tagaatcact gtatagagat agatgttgat atatatgttt
    14041 gtgtatatat atcaaaccaa attggatagg agaagtatag ctttacagat gaggagaagg
    14101 agctctttag aggtcggagt caagactggt gtcttggacg tgcatgggct gtgtcccagg
    14161 ccactccgca cacatggggc tgaggcgtgg cgccgggccc ttgtcatcca cctcaccacg
    14221 gcagagccag caggccctgt agggtgctgc tgctgtctca ctgggtccca gcttcaagcg
    14281 catcagtggg tgacgggggc aacaaatcag agtgactgga agtttccatc ccgttttgct
    14341 ttgaccacgt gtactgagct gcagcctctg atactctgtc acgtttccaa aaatggtatc
    14401 cattaggata gaaagagaat ggatctgcag aaatgtttac ctttcaactg ctcatgaatt
    14461 caggacactg gatagaaaga ctcactcccc aaaatgagaa cagggaagag gagacccggc
    14521 gacactaagt caccaggtcc aaggaacgtg gctccctccc cagggtcatc tcacctagat
    14581 ctttctctcc caggtcatct cagctcaatc tcaataaccc tatgaaagcc ctggtctgtt
    14641 gtgttccttc accgtacggt ttctgtaata aaaagtgtta atccatgtta atctgtgtga
    14701 aaattattgc gtgcaacagt attttctcgt gtacctcttt ttcctatgtg aattgtccct
    14761 cttttttatt tataaatgtc tacttttgtt tttttaaaga caaaccaatg tgttgtagac
    14821 ctatatgtaa cctattcctt agtctcatat tataggtatg ttataagaat ggatatttta
    14881 cttggcttta gaatgtttta caagaaaact aattcttaac tgatcaagtc cttgctacta
    14941 aaatgcttgt gtttttcatc atgacgtcgt gtgcttctaa attaatcatt ttcgttgtag
    15001 aaaaatggag tgaatttata ttagtcttgg aaactaataa tagcattgta aatttatgag
    15061 atgattttaa cagaaaaaat atagaagaat atagttattt taattgtaat attactaact
    15121 gtagggtgag aaaaaggggg gggggtccca ttgtggtgaa ctatgttata gcttgttact
    15181 catagtttct ttttgatcat tttttcggtc tccgaggtga aatgacttat taattaaaat
    15241 ttgtaaactc acatatgcat attgtatatg tgtagaaatg taatcacact ttgtcttgga
    15301 attacattaa actgtttgaa atcactgta
//
