LOCUS       NM_198268               8201 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens homeodomain interacting protein kinase 1 (HIPK1),
            transcript variant 1, mRNA.
ACCESSION   NM_198268
VERSION     NM_198268.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8201)
  AUTHORS   Sanjeev,D., George,M., John,L., Gopalakrishnan,A.P., Priyanka,P.,
            Mendon,S., Yandigeri,T., Nisar,M., Nisar,M., Kanekar,S.,
            Balaya,R.D.A. and Raju,R.
  TITLE     Tyr352 as a Predominant Phosphosite in the Understudied Kinase and
            Molecular Target, HIPK1: Implications for Cancer Therapy
  JOURNAL   OMICS 28 (3), 111-124 (2024)
   PUBMED   38498023
  REMARK    GeneRIF: Tyr352 as a Predominant Phosphosite in the Understudied
            Kinase and Molecular Target, HIPK1: Implications for Cancer
            Therapy.
REFERENCE   2  (bases 1 to 8201)
  AUTHORS   Bei,Y., Zhu,Y., Wei,M., Yin,M., Li,L., Chen,C., Huang,Z., Liang,X.,
            Gao,J., Yao,J., van der Kraak,P.H., Vink,A., Lei,Z., Dai,Y.,
            Chen,H., Liang,Y., Sluijter,J.P. and Xiao,J.
  TITLE     HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy
            by Inhibiting the CREB-C/EBPbeta Axis
  JOURNAL   Adv Sci (Weinh) 10 (18), e2300585 (2023)
   PUBMED   37098980
  REMARK    GeneRIF: HIPK1 Inhibition Protects against Pathological Cardiac
            Hypertrophy by Inhibiting the CREB-C/EBPbeta Axis.
REFERENCE   3  (bases 1 to 8201)
  AUTHORS   Gong,J., Zhao,S., Luo,S., Yin,S., Li,X. and Feng,Y.
  TITLE     Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell
            injury via miR-335-5p/HIPK1 axis
  JOURNAL   Environ Toxicol 37 (12), 2855-2864 (2022)
   PUBMED   36052886
  REMARK    GeneRIF: Downregulation of circ-ZNF644 alleviates LPS-induced HK2
            cell injury via miR-335-5p/HIPK1 axis.
REFERENCE   4  (bases 1 to 8201)
  AUTHORS   Zhu,Q., Li,Y., Li,L., Guo,M., Zou,C., Xu,Y. and Yang,Z.
  TITLE     MicroRNA-889-3p restrains the proliferation and
            epithelial-mesenchymal transformation of lung cancer cells via
            down-regulation of Homeodomain-interacting protein kinase 1
  JOURNAL   Bioengineered 12 (2), 10945-10958 (2021)
   PUBMED   34723781
  REMARK    GeneRIF: MicroRNA-889-3p restrains the proliferation and
            epithelial-mesenchymal transformation of lung cancer cells via
            down-regulation of Homeodomain-interacting protein kinase 1.
REFERENCE   5  (bases 1 to 8201)
  AUTHORS   Kaltheuner,I.H., Anand,K., Moecking,J., Duster,R., Wang,J.,
            Gray,N.S. and Geyer,M.
  TITLE     Abemaciclib is a potent inhibitor of DYRK1A and HIP kinases
            involved in transcriptional regulation
  JOURNAL   Nat Commun 12 (1), 6607 (2021)
   PUBMED   34785661
  REMARK    GeneRIF: Abemaciclib is a potent inhibitor of DYRK1A and HIP
            kinases involved in transcriptional regulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8201)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   7  (bases 1 to 8201)
  AUTHORS   Song,J.J. and Lee,Y.J.
  TITLE     Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and
            ASK1 oligomerization
  JOURNAL   J Biol Chem 278 (47), 47245-47252 (2003)
   PUBMED   12968034
REFERENCE   8  (bases 1 to 8201)
  AUTHORS   Kondo,S., Lu,Y., Debbas,M., Lin,A.W., Sarosi,I., Itie,A.,
            Wakeham,A., Tuan,J., Saris,C., Elliott,G., Ma,W., Benchimol,S.,
            Lowe,S.W., Mak,T.W. and Thukral,S.K.
  TITLE     Characterization of cells and gene-targeted mice deficient for the
            p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)
  JOURNAL   Proc Natl Acad Sci U S A 100 (9), 5431-5436 (2003)
   PUBMED   12702766
REFERENCE   9  (bases 1 to 8201)
  AUTHORS   Ecsedy,J.A., Michaelson,J.S. and Leder,P.
  TITLE     Homeodomain-interacting protein kinase 1 modulates Daxx
            localization, phosphorylation, and transcriptional activity
  JOURNAL   Mol Cell Biol 23 (3), 950-960 (2003)
   PUBMED   12529400
REFERENCE   10 (bases 1 to 8201)
  AUTHORS   Kim,Y.H., Choi,C.Y., Lee,S.J., Conti,M.A. and Kim,Y.
  TITLE     Homeodomain-interacting protein kinases, a novel family of
            co-repressors for homeodomain transcription factors
  JOURNAL   J Biol Chem 273 (40), 25875-25879 (1998)
   PUBMED   9748262
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL137856.24, BC033012.2,
            AL731797.9, AK302726.1 and AA995033.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198268.2.
            
            Summary: The protein encoded by this gene belongs to the Ser/Thr
            family of protein kinases and HIPK subfamily. It phosphorylates
            homeodomain transcription factors and may also function as a
            co-repressor for homeodomain transcription factors. Alternative
            splicing results in four transcript variants encoding four distinct
            isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302726.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000426820.7/ ENSP00000407442.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AL137856.24        136411-136460
            51-2253             BC033012.2         1-2203
            2254-2254           AL731797.9         27847-27847
            2255-3980           AK302726.1         2389-4114
            3981-7944           AL731797.9         39118-43081
            7945-8201           AA995033.1         5-261               c
FEATURES             Location/Qualifiers
     source          1..8201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..8201
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /note="homeodomain interacting protein kinase 1"
                     /db_xref="GeneID:204851"
                     /db_xref="HGNC:HGNC:19006"
                     /db_xref="MIM:608003"
     exon            1..209
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..1287
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..3844
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeodomain interacting protein kinase 1-like protein;
                     nuclear body associated kinase 2b; nuclear body-associated
                     kinase 2"
                     /codon_start=1
                     /product="homeodomain-interacting protein kinase 1 isoform
                     1"
                     /protein_id="NP_938009.1"
                     /db_xref="CCDS:CCDS867.1"
                     /db_xref="GeneID:204851"
                     /db_xref="HGNC:HGNC:19006"
                     /db_xref="MIM:608003"
                     /translation="MASQLQVFSPPSVSSSAFCSAKKLKIEPSGWDVSGQSSNDKYYT
                     HSKTLPATQGQANSSHQVANFNIPAYDQGLLLPAPAVEHIVVTAADSSGSAATSTFQS
                     SQTLTHRSNVSLLEPYQKCGLKRKSEEVDSNGSVQIIEEHPPLMLQNRTVVGAAATTT
                     TVTTKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAI
                     KILKNHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLVFEMLEQNLY
                     DFLKQNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVK
                     VIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLY
                     PGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETG
                     IKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRIT
                     PLKTLNHQFVTMTHLLDFPHSNHVKSCFQNMEICKRRVHMYDTVSQIKSPFTTHVAPN
                     TSTNLTMSFSNQLNTVHNQASVLASSSTAAAATLSLANSDVSLLNYQSALYPSSAAPV
                     PGVAQQGVSLQPGTTQICTQTDPFQQTFIVCPPAFQTGLQATTKHSGFPVRMDNAVPI
                     VPQAPAAQPLQIQSGVLTQGSCTPLMVATLHPQVATITPQYAVPFTLSCAAGRPALVE
                     QTAAVLQAWPGGTQQILLPSTWQQLPGVALHNSVQPTAMIPEAMGSGQQLADWRNAHS
                     HGNQYSTIMQQPSLLTNHVTLATAQPLNVGVAHVVRQQQSSSLPSKKNKQSAPVSSKS
                     SLDVLPSQVYSLVGSSPLRTTSSYNSLVPVQDQHQPIIIPDTPSPPVSVITIRSDTDE
                     EEDNKYKPSSSGLKPRSNVISYVTVNDSPDSDSSLSSPYSTDTLSALRGNSGSVLEGP
                     GRVVADGTGTRTIIVPPLKTQLGDCTVATQASGLLSNKTKPVASVSGQSSGCCITPTG
                     YRAQRGGTSAAQPLNLSQNQQSSAAPTSQERSSNPAPRRQQAFVAPLSQAPYTFQHGS
                     PLHSTGHPHLAPAPAHLPSQAHLYTYAAPTSAAALGSTSSIAHLFSPQGSSRHAAAYT
                     THPSTLVHQVPVSVGPSLLTSASVAPAQYQHQFATQSYIGSSRGSTIYTGYPLSPTKI
                     SQYSYL"
     exon            1288..1411
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1531
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1618
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1803
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1966
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2192
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2314
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2449
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2592
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2775
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2982
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3224
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3355
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..8201
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8110..8115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /note="hexamer: AATAAA"
     polyA_site      8132
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /note="major polyA site"
     regulatory      8179..8184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
                     /note="hexamer: AATAAA"
     polyA_site      8201
                     /gene="HIPK1"
                     /gene_synonym="Myak; Nbak2"
ORIGIN      
        1 gacattttac agttggatcc cgtaccaccg ccaggcacct ttaaatcacc gcagagtctg
       61 cagtgcggag ggggcgggaa gtccaggccc cgcactcgat ccacgctggc tccctacgga
      121 ggcccaccta ctcgaggccc accgactcct actgcaatca gtactatgcg atcgtcctag
      181 agagtccatt cagctgcact tccgcctcag tatggcatca cagctgcaag tgttttcgcc
      241 cccatcagtg tcgtcgagtg ccttctgcag tgcgaagaaa ctgaaaatag agccctctgg
      301 ctgggatgtt tcaggacaga gtagcaacga caaatattat acccacagca aaaccctccc
      361 agccacacaa gggcaagcca actcctctca ccaggtagca aatttcaaca tccctgctta
      421 cgaccagggc ctcctcctcc cagctcctgc agtggagcat attgttgtaa cagccgctga
      481 tagctcgggc agtgctgcta catcaacctt ccaaagcagc cagaccctga ctcacagaag
      541 caacgtttct ttgcttgagc catatcaaaa atgtggattg aaacgaaaaa gtgaggaagt
      601 tgacagcaac ggtagtgtgc agatcataga agaacatccc cctctcatgc tgcaaaacag
      661 gactgtggtg ggtgctgctg ccacaaccac cactgtgacc acaaagagta gcagttccag
      721 cggagaaggg gattaccagc tggtccagca tgagatcctt tgctctatga ccaatagcta
      781 tgaagtcttg gagttcctag gccgggggac atttggacag gtggctaagt gctggaagag
      841 gagcaccaag gaaattgtgg ctattaaaat cttgaagaac cacccctcct atgccagaca
      901 aggacagatt gaagtgagca tcctttcccg cctaagcagt gaaaatgctg atgagtataa
      961 ttttgtccgt tcatacgagt gctttcagca taagaatcac acctgccttg tttttgaaat
     1021 gttggagcag aacttatatg attttctaaa gcaaaacaaa tttagcccac tgccactcaa
     1081 gtacatcaga ccaatcttgc agcaggtggc cacagccttg atgaagctca agagtcttgg
     1141 tctgatccac gctgacctta agcctgaaaa catcatgctg gttgatccag ttcgccagcc
     1201 ctaccgagtg aaggtcattg actttggttc tgctagtcac gtttccaaag ctgtgtgctc
     1261 aacctactta cagtcacgtt actacagagc tcctgaaatt attcttgggt taccattttg
     1321 tgaagctatt gatatgtggt cactgggctg tgtgatagct gagctgttcc tgggatggcc
     1381 tctttatcct ggtgcttcag aatatgatca gattcgttat atttcacaaa cacaaggctt
     1441 gccagctgaa tatcttctca gtgccggaac aaaaacaacc aggtttttca acagagatcc
     1501 taatttgggg tacccactgt ggaggcttaa gacacctgaa gaacatgaac tggagactgg
     1561 aataaaatca aaagaagctc ggaagtacat ttttaattgc ttagatgaca tggctcaggt
     1621 gaatatgtct acagacctgg agggaacaga catgttggca gagaaggcag accgaagaga
     1681 atacattgat ctgttaaaga aaatgctcac aattgatgca gataagagaa ttacccctct
     1741 aaaaactctt aaccatcagt ttgtgacaat gactcacctt ttggattttc cacatagcaa
     1801 tcatgttaag tcttgttttc agaacatgga gatctgcaag cggagggttc acatgtatga
     1861 tacagtgagt cagatcaaga gtcccttcac tacacatgtt gccccaaata caagcacaaa
     1921 tctaaccatg agcttcagca atcagctcaa tacagtgcac aatcaggcca gtgttctagc
     1981 ttccagttct actgcagcag ctgctactct ttctctggct aattcagatg tctcactact
     2041 aaactaccag tcagctttgt acccatcatc tgctgcacca gttcctggag ttgcccagca
     2101 gggtgtttcc ttgcagcctg gaaccaccca gatttgcact cagacagatc cattccaaca
     2161 gacatttata gtatgtccac ctgcgtttca aactggacta caagcaacaa caaagcattc
     2221 tggattccct gtgaggatgg ataatgctgt accgattgta ccccaggcac cagctgctca
     2281 gccactacag attcagtcag gagttctcac gcagggaagc tgtacaccac taatggtagc
     2341 aactctccac cctcaagtag ccaccatcac accgcagtat gcggtgccct ttactctgag
     2401 ctgcgcagcc ggccggccgg cgctggttga acagactgcc gctgtactgc aggcgtggcc
     2461 tggagggact cagcaaattc tcctgccttc aacttggcaa cagttgcctg gggtagctct
     2521 acacaactct gtccagccca cagcaatgat tccagaggcc atggggagtg gacagcagct
     2581 agctgactgg aggaatgccc actctcatgg caaccagtac agcactatca tgcagcagcc
     2641 atccttgctg actaaccatg tgacattggc cactgctcag cctctgaatg ttggtgttgc
     2701 ccatgttgtc agacaacaac aatccagttc cctcccttcg aagaagaata agcagtcagc
     2761 tccagtctct tccaagtcct ctctagatgt tctgccttcc caagtctatt ctctggttgg
     2821 gagcagtccc ctccgcacca catcttctta taattccttg gtccctgtcc aagatcagca
     2881 tcagcccatc atcattccag atactcccag ccctcctgtg agtgtcatca ctatccgaag
     2941 tgacactgat gaggaagagg acaacaaata caagcccagt agctctggac tgaagccaag
     3001 gtctaatgtc atcagttatg tcactgtcaa tgattctcca gactctgact cttctttgag
     3061 cagcccttat tccactgata ccctgagtgc tctccgaggc aatagtggat ccgttttgga
     3121 ggggcctggc agagttgtgg cagatggcac tggcacccgc actatcattg tgcctccact
     3181 gaaaactcag cttggtgact gcactgtagc aacccaggcc tcaggtctcc tgagcaataa
     3241 gactaagcca gtcgcttcag tgagtgggca gtcatctgga tgctgtatca cccccacagg
     3301 gtatcgagct caacgcgggg ggaccagtgc agcacaacca ctcaatctta gccagaacca
     3361 gcagtcatcg gcggctccaa cctcacagga gagaagcagc aacccagccc cccgcaggca
     3421 gcaggcgttt gtggcccctc tctcccaagc cccctacacc ttccagcatg gcagcccgct
     3481 acactcgaca gggcacccac accttgcccc ggcccctgct cacctgccaa gccaggctca
     3541 tctgtatacg tatgctgccc cgacttctgc tgctgcactg ggctcaacca gctccattgc
     3601 tcatcttttc tccccacagg gttcctcaag gcatgctgca gcctatacca ctcaccctag
     3661 cactttggtg caccaggtcc ctgtcagtgt tgggcccagc ctcctcactt ctgccagcgt
     3721 ggcccctgct cagtaccaac accagtttgc cacccaatcc tacattgggt cttcccgagg
     3781 ctcaacaatt tacactggat acccgctgag tcctaccaag atcagccagt attcctactt
     3841 atagttggtg agcatgaggg aggaggaatc atggctacct tctcctggcc ctgcgttctt
     3901 aatattgggc tatggagaga tcctccttta ccctcttgaa atttcttagc cagcaacttg
     3961 ttctgcaggg gcccactgaa gcagaaggtt tttctctggg ggaacctgtc tcagtgttga
     4021 ctgcattgtt gtagtcttcc caaagtttgc cctattttta aattcattat ttttgtgaca
     4081 gtaattttgg tacttggaag agttcagatg cccatcttct gcagttacca aggaagagag
     4141 attgttctga agttaccctc tgaaaaatat tttgtctctc tgacttgatt tctataaatg
     4201 cttttaaaaa caagtgaagc ccctctttat ttcattttgt gttattgtga ttgctggtca
     4261 ggaaaaatgc tgatagaagg agttgaaatc tgatgacaaa aaaagaaaaa ttactttttg
     4321 tttgtttata aactcagact tgcctatttt attttaaaag cggcttacac aatctccctt
     4381 ttgtttattg gacatttaaa cttacagagt ttcagttttg ttttaatgtc atattatact
     4441 taatgggcaa ttgttatttt tgcaaaactg gttacgtatt actctgtgtt actattgaga
     4501 ttctctcaat tgctcctgtg tttgttataa agtagtgttt aaaaggcagc tcaccatttg
     4561 ctggtaactt aatgtgagag aatccatatc tgcgtgaaaa caccaagtat tctttttaaa
     4621 tgaagcacca tgaattcttt tttaaattat tttttaaaag tctttctctc tctgattcag
     4681 cttaaatttt tttatcgaaa aagccattaa ggtggttatt attacatggt ggtggtggtt
     4741 ttattatatg caaaatctct gtctattatg agatactggc attgatgagc tttgcctaaa
     4801 gattagtatg aattttcagt aatacacctc tgttttgctc atctctccct tctgttttat
     4861 gtgatttgtt tggggagaaa gctaaaaaaa cctgaaacca gataagaaca tttcttgtgt
     4921 atagctttta tacttcaaag tagcttcctt tgtatgccag cagcaaattg aatgctctct
     4981 tattaagact tatataataa gtgcatgtag gaattgcaaa aaatatttta aaaatttatt
     5041 actgaattta aaaatatttt agaagttttg taatggtggt gttttaatat tttacataat
     5101 taaatatgta catattgatt agaaaaatat aacaagcaat ttttcctgct aacccaaaat
     5161 gttatttgta atcaaatgtg tagtgattac acttgaattg tgtacttagt gtgtatgtga
     5221 tcctccagtg ttatcccgga gatggattga tgtctccatt gtatttaaac caaaatgaac
     5281 tgatacttgt tggaatgtat gtgaactaat tgcaattata ttagagcata ttactgtagt
     5341 gctgaatgag caggggcatt gcctgcaagg agaggagacc cttggaattg ttttgcacag
     5401 gtgtgtctgg tgaggagttt ttcagtgtgt gtctcttcct tccctttctt cctccttccc
     5461 ttattgtagt gccttatatg ataatgtagt ggttaataga gtttacagtg agcttgcctt
     5521 aggatggacc agcaagcccc cgtggaccct aagttgttca ccgggattta tcagaacagg
     5581 attagtagct gtattgtgta atgcattgtt ctcagtttcc ctgccaacat tgaaaaataa
     5641 aaacagcagc ttttctcctt taccaccacc tctacccctt tccattttgg attctcggct
     5701 gagttctcac agaagcattt tccccatgtg gctctctcac tgtgcgttgc taccttgctt
     5761 ctgtgagaat tcaggaagca ggtgagagga gtcaagccaa tattaaatat gcattctttt
     5821 aaagtatgtg caatcacttt tagaatgaat ttttttttcc ttttcccatg tggcagtcct
     5881 tcctgcacat agttgacatt cctagtaaaa tatttgcttg ttgaaaaaaa catgttaaca
     5941 gatgtgttta taccaaagag cctgttgtat tgcttaccat gtccccatac tatgaggaga
     6001 agttttgtgg tgccgctggt gacaaggaac tcacagaaag gtttcttagc tggtgaagaa
     6061 tatagagaag gaaccaaagc ctgttgagtc attgaggctt ttgaggtttc ttttttaaca
     6121 gcttgtatag tcttggggcc cttcaagctg tgaaattgtc cttgtactct cagctcctgc
     6181 atggatctgg gtcaagtaga aggtactggg gatggggaca ttcctgccca taaaggattt
     6241 ggggaaagaa gattaatcct aaaatacagg tgtgttccat ctgaattgaa aatgatatat
     6301 ttgagatata attttaggac tggttctgtg tagatagaga tggtgtcaag gaggtgcagg
     6361 atggagatgg gagatttcat ggagcctggt cagccagctc tgtaccaggt tgaacaccga
     6421 ggagctgtca aagtatttgg agtttcttca ttgtaaggag taagggcttc caagatgggg
     6481 caggtagtcc gtacagccta ccaggaacat gttgtgtttt ctttattttt taaaatcatt
     6541 atattgagtt gtgttttcag cactatattg gtcaagatag ccaagcagtt tgtataattt
     6601 ctgtcactag tgtcatacag ttttctggtc aacatgtgtg atctttgtgt ctcctttttg
     6661 ccaagcacat tctgattttc ttgttggaac acaggtctag tttctaaagg acaaattttt
     6721 tgttccttgt cttttttctg taagggacaa gatttgttgt ttttgtaaga aatgagatgc
     6781 aggaaagaaa accaaatccc attcctgcac cccagtccaa taagcagata ccacttaaga
     6841 taggagtcta aactccacag aaaaggataa taccaagagc ttgtattgtt accttagtca
     6901 cttgcctagc agtgtgtggc tttaaaaact agagattttt cagtcttagt ctgcaaactg
     6961 gcatttccga ttttccagca taaaaatcca cctgtgtctg ctgaatgtgt atgtatgtgc
     7021 tcactgtggc tttagattct gtccctgggg ttagccctgt tggccctgac aggaagggag
     7081 gaagcctggt gaatttagtg agcagctggc ctgggtcaca gtgacctgac ctcaaaccag
     7141 cttaaggctt taagtcctct ctcagaactt ggcatttcca acttcttcct ttccgggtga
     7201 gagaagaagc ggagaagggt tcagtgtagc cactctgggc tcatagggac acttggtcac
     7261 tccagagttt ttaatagctc ccaggaggtg atattatttt cagtgctcag ctgaaatacc
     7321 aaccccagga ataagaactc catttcaaac agttctggcc attctgagcc tgcttttgtg
     7381 attgctcatc cattgtcctc cactagaggg gctaagcttg actgccctta gccaggcaag
     7441 cacagtaatg tgtgttttgt tcagcattat tatgcaaaaa ttcactagtt gagatggttt
     7501 gttttaggat aggaaatgaa attgcctctc agtgacagga gtggcccgag cctgcttcct
     7561 attttgattt tttttttttt taactgatag atggtgcagc atgtctacat ggttgtttgt
     7621 tgctaaactt tatataatgt gtggtttcaa ttcagcttga aaaataatct cactacatgt
     7681 agcagtacat tatatgtaca ttatatgtaa tgttagtatt tctgctttga atccttgata
     7741 ttgcaatgga attcctactt tattaaatgt atttgatatg ctagttattg tgtgcgattt
     7801 aaactttttt tgctttctcc ctttttttgg ttgtgcgctt tcttttacaa caagcctcta
     7861 gaaacagata gtttctgaga attactgagc tatgtttgta atgcagatgt acttagggag
     7921 tatgtaaaat aatcatttta acaaaagaaa tagatattta aaatttaata ctaactatgg
     7981 gaaaagggtc cattgtgtaa aacatagttt atctttggat tcaatgtttg tctttggttt
     8041 tacaaagtag cttgtatttt cagtattttc tacataatat ggtaaaatgt agagcaattg
     8101 caatgcatca ataaaatggg taaattttct gacttatgtg gctgtttttg acttctgtta
     8161 taggatataa aggggatcaa taaatgacat ctttgaaagt g
//
