LOCUS       NM_003959               4509 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens huntingtin interacting protein 1 related (HIP1R),
            transcript variant 1, mRNA.
ACCESSION   NM_003959 XM_290592
VERSION     NM_003959.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4509)
  AUTHORS   Zhu,S., Xu,H., Chen,R., Shen,Q., Yang,D., Peng,H., Tong,J. and
            Fu,Q.
  TITLE     DNA methylation and miR-92a-3p-mediated repression of HIP1R
            promotes pancreatic cancer progression by activating the PI3K/AKT
            pathway
  JOURNAL   J Cell Mol Med 27 (6), 788-802 (2023)
   PUBMED   36811277
  REMARK    GeneRIF: DNA methylation and miR-92a-3p-mediated repression of
            HIP1R promotes pancreatic cancer progression by activating the
            PI3K/AKT pathway.
REFERENCE   2  (bases 1 to 4509)
  AUTHORS   Yang,N., Liang,Y., Yang,P. and Jiang,L.
  TITLE     Flurbiprofen inhibits cell proliferation in thyroid cancer through
            interrupting HIP1R-induced endocytosis of PTEN
  JOURNAL   Eur J Med Res 27 (1), 29 (2022)
   PUBMED   35209947
  REMARK    GeneRIF: Flurbiprofen inhibits cell proliferation in thyroid cancer
            through interrupting HIP1R-induced endocytosis of PTEN.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4509)
  AUTHORS   Zhu,J., Wang,X., Guan,H., Xiao,Q., Wu,Z., Shi,J., Zhang,F., Gao,P.,
            Song,Y. and Wang,Z.
  TITLE     HIP1R acts as a tumor suppressor in gastric cancer by promoting
            cancer cell apoptosis and inhibiting migration and invasion through
            modulating Akt
  JOURNAL   J Clin Lab Anal 34 (9), e23425 (2020)
   PUBMED   32548851
  REMARK    GeneRIF: HIP1R acts as a tumor suppressor in gastric cancer by
            promoting cancer cell apoptosis and inhibiting migration and
            invasion through modulating Akt.
REFERENCE   4  (bases 1 to 4509)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4509)
  AUTHORS   Biancospino,M., Buel,G.R., Nino,C.A., Maspero,E., Scotto di
            Perrotolo,R., Raimondi,A., Redlingshofer,L., Weber,J.,
            Brodsky,F.M., Walters,K.J. and Polo,S.
  TITLE     Clathrin light chain A drives selective myosin VI recruitment to
            clathrin-coated pits under membrane tension
  JOURNAL   Nat Commun 10 (1), 4974 (2019)
   PUBMED   31672988
  REMARK    GeneRIF: There is coordinated action of myosin VI and CLCa at the
            apical surface where these proteins are essential for fission of
            clathrin-coated pits. Myosin VI and Huntingtin-interacting protein
            1-related protein (Hip1R) are mutually exclusive interactors with
            CLCa, and suggest a model for the sequential function of myosin VI
            and Hip1R in actin-mediated clathrin-coated vesicle budding.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4509)
  AUTHORS   Okano,A., Usuda,N., Furihata,K., Nakayama,K., Bao Tian,Q.,
            Okamoto,T. and Suzuki,T.
  TITLE     Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is
            localized in the postsynaptic regions
  JOURNAL   Brain Res 967 (1-2), 210-225 (2003)
   PUBMED   12650982
REFERENCE   7  (bases 1 to 4509)
  AUTHORS   Legendre-Guillemin,V., Metzler,M., Charbonneau,M., Gan,L.,
            Chopra,V., Philie,J., Hayden,M.R. and McPherson,P.S.
  TITLE     HIP1 and HIP12 display differential binding to F-actin, AP2, and
            clathrin. Identification of a novel interaction with clathrin light
            chain
  JOURNAL   J Biol Chem 277 (22), 19897-19904 (2002)
   PUBMED   11889126
  REMARK    GeneRIF: HIP1 and HIP12 display differential binding to F-actin,
            AP2, and clathrin. Identification of a novel interaction with
            clathrin light chain. (HIP12)
REFERENCE   8  (bases 1 to 4509)
  AUTHORS   Chopra,V.S., Metzler,M., Rasper,D.M., Engqvist-Goldstein,A.E.,
            Singaraja,R., Gan,L., Fichter,K.M., McCutcheon,K., Drubin,D.,
            Nicholson,D.W. and Hayden,M.R.
  TITLE     HIP12 is a non-proapoptotic member of a gene family including HIP1,
            an interacting protein with huntingtin
  JOURNAL   Mamm Genome 11 (11), 1006-1015 (2000)
   PUBMED   11063258
REFERENCE   9  (bases 1 to 4509)
  AUTHORS   Seki,N., Muramatsu,M., Sugano,S., Suzuki,Y., Nakagawara,A.,
            Ohhira,M., Hayashi,A., Hori,T. and Saito,T.
  TITLE     Cloning, expression analysis, and chromosomal localization of
            HIP1R, an isolog of huntingtin interacting protein (HIP1)
  JOURNAL   J Hum Genet 43 (4), 268-271 (1998)
   PUBMED   9852681
REFERENCE   10 (bases 1 to 4509)
  AUTHORS   Puigvert,A.
  TITLE     Caliceal urodynamics
  JOURNAL   Urol Int 30 (4), 282-296 (1975)
   PUBMED   1189126
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN999807.1, AB014555.1, DA779723.1 and AC027290.31.
            
            On Nov 23, 2018 this sequence version replaced NM_003959.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.221395.1, AB014555.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253083.9/ ENSP00000253083.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                DN999807.1         38-84
            48-303              AB014555.1         1-256
            304-502             DA779723.1         376-574
            503-3042            AB014555.1         456-2995
            3043-3043           AC027290.31        68440-68440         c
            3044-3971           AB014555.1         2997-3924
            3972-3999           AC027290.31        67178-67205         c
            4000-4508           AB014555.1         3949-4457
            4509-4509           AC027290.31        66668-66668         c
FEATURES             Location/Qualifiers
     source          1..4509
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..4509
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /note="huntingtin interacting protein 1 related"
                     /db_xref="GeneID:9026"
                     /db_xref="HGNC:HGNC:18415"
                     /db_xref="MIM:605613"
     exon            1..187
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3301
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /note="isoform 1 is encoded by transcript variant 1;
                     huntingtin interacting protein 12; huntingtin-interacting
                     protein 1-related protein; HIP-12; HIP1-related protein"
                     /codon_start=1
                     /product="huntingtin-interacting protein 1-related protein
                     isoform 1"
                     /protein_id="NP_003950.1"
                     /db_xref="CCDS:CCDS31922.1"
                     /db_xref="GeneID:9026"
                     /db_xref="HGNC:HGNC:18415"
                     /db_xref="MIM:605613"
                     /translation="MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEA
                     PVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVL
                     HDCQRYRSNIREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEV
                     LEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQ
                     VIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRL
                     IQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVA
                     DLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALE
                     GELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKL
                     KEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLE
                     EKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQR
                     EADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVL
                     RGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSL
                     ADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQ
                     DQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAV
                     RRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAA
                     TQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAAST
                     AQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLS
                     LIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAP
                     RSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY"
     exon            188..251
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            252..394
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            395..451
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            452..532
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            533..609
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            610..671
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            672..812
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            813..870
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            871..946
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1087
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1149
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1222
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1406
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1495
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1612
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1714
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1909
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2057
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2144
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2252
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2389
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2500
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2559
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2590
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2653
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2754
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2860
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2984
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3046
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3253
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..4509
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4480..4485
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /note="hexamer: AATAAA"
     polyA_site      4509
                     /gene="HIP1R"
                     /gene_synonym="HIP12; HIP3; ILWEQ"
                     /note="major polyA site"
ORIGIN      
        1 gcggtggcct cgcggtgcct aggctggggc tgccggaccg tgaggctgtg agtcgcgcgg
       61 acggagccgg acaaaagcgg gcggcggcgg caggatgaac agcatcaaga acgtgccggc
      121 gcgggtgctg agccgcaggc cgggccacag cctggaggcc gagcgcgagc agttcgacaa
      181 gacccaggcc atcagcatca gcaaagccat caacacccag gaggcccccg tgaaggagaa
      241 gcacgcccgg cgcatcattc tgggcacaca ccacgagaag ggggctttca ccttctggtc
      301 ctacgccatt gggctgccgc tgcccagcag ctccattctc agctggaagt tctgccacgt
      361 cctccacaag gtccttcgag acgggcaccc caatgtgctg catgactgcc agcggtaccg
      421 cagcaacatc cgggagattg gagacctgtg gggacatttg catgaccgct acggacagct
      481 ggtgaatgtc tacaccaagc tgctgctgac caagatctcc ttccacctca agcatcccca
      541 gtttcccgcg ggcctggagg tgacagatga ggtactggag aaggcagctg ggaccgatgt
      601 caacaacatc ttccagctca ctgtggagat gtttgattac atggattgtg agctgaagct
      661 ttctgaatca gttttccgac agctcaacac ggccatcgcc gtatcccaga tgtcctcagg
      721 ccagtgccgc ctggcccccc tcatccaggt catccaggac tgcagccacc tctaccacta
      781 cacggtcaag ctcctgttca agctacactc ttgtctccct gcggacaccc tgcaaggcca
      841 cagggaccgg ttccacgagc agtttcacag cctcaggaac ttcttccgca gagcctccga
      901 catgctgtac ttcaagcggc tcatccagat cccccggctg cccgagggac cccctaactt
      961 cctgcgggcc tcagccctgg ctgagcacat caagccggtg gtggtgatcc ccgaggaggc
     1021 cccggaagat gaggagccgg agaatctcat tgagatcagc acagggcccc ccgcggggga
     1081 gccagtggtg gtggctgacc tcttcgatca gacgtttgga ccccccaatg ggtctgtgaa
     1141 ggacgacagg gacctccaga ttgagagctt gaagagagag gtggaaatgc tccgctctga
     1201 actggagaag atcaagctgg aggcccagcg gtacatcgcg cagctgaaga gccaggtgaa
     1261 tgcactggag ggtgagctgg aggagcagcg gaagcagaag cagaaggccc tggtggataa
     1321 tgagcagctc cgccacgagc tggcccagct gagggctgcc cagctggagg gcgagcggag
     1381 ccagggcctg cgtgaggagg ctgagaggaa ggccagtgcc acggaggcgc gctacaacaa
     1441 gctgaaggaa aagcacagtg agctcgtcca tgtgcacgcg gagctgctca gaaagaacgc
     1501 ggacacagcc aagcagctga cggtgacgca gcaaagccag gaggaggtgg cgcgggtgaa
     1561 ggagcagctg gccttccagg tggagcaggt gaagcgggag tcggagttga agctagagga
     1621 gaagagcgac cagctggaga agctcaagag ggagctggag gccaaggccg gagagctggc
     1681 ccgcgcgcag gaggccctga gccacacaga gcagagcaag tcggagctga gctcacggct
     1741 ggacacgctg agtgcggaga aggatgctct gagtggagct gtgcggcagc gggaggcaga
     1801 cctgctggcg gcgcagagcc tggtgcgcga gacagaggcg gcgctgagcc gggagcagca
     1861 gcgcagctcc caggagcagg gcgagttgca gggccggctg gcagagaggg agtctcagga
     1921 gcaggggctg cggcagaggc tgctggacga gcagttcgca gtgttgcggg gcgctgctgc
     1981 cgaggccgcg ggcatcctgc aggatgccgt gagcaagctg gacgaccccc tgcacctgcg
     2041 ctgtaccagc tccccagact acctggtgag cagggcccag gaggccttgg atgccgtgag
     2101 caccctggag gagggccacg cccagtacct gacctccttg gcagacgcct ccgccctggt
     2161 ggcagctctg acccgcttct cccacctggc tgcggatacc atcatcaatg gcggtgccac
     2221 ctcgcacctg gctcccaccg accctgccga ccgcctcata gacacctgca gggagtgcgg
     2281 ggcccgggct ctggagctca tggggcagct gcaggaccag caggctctgc ggcacatgca
     2341 ggccagcctg gtgcggacac ccctgcaggg catccttcag ctgggccagg aactgaaacc
     2401 caagagccta gatgtgcggc aggaggagct gggggccgtg gtcgacaagg agatggcggc
     2461 cacatccgca gccattgaag atgctgtgcg gaggattgag gacatgatga accaggcacg
     2521 ccacgccagc tcgggggtga agctggaggt gaacgagagg atcctcaact cctgcacaga
     2581 cctgatgaag gctatccggc tcctggtgac gacatccact agcctgcaga aggagatcgt
     2641 ggagagcggc aggggggcag ccacgcagca ggaattttac gccaagaact cgcgctggac
     2701 cgaaggcctc atctcggcct ccaaggctgt gggctgggga gccacacagc tggtggaggc
     2761 agctgacaag gtggtgcttc acacgggcaa gtatgaggag ctcatcgtct gctcccacga
     2821 gatcgcagcc agcacggccc agctggtggc ggcctccaag gtgaaggcca acaagcacag
     2881 cccccacctg agccgcctgc aggaatgttc tcgcacagtc aatgagaggg ctgccaatgt
     2941 ggtggcctcc accaagtcag gccaggagca gattgaggac agagacacca tggatttctc
     3001 cggcctgtcc ctcatcaagc tgaagaagca ggagatggag acccaggtgc gtgtcctgga
     3061 gctggagaag acgctggagg ctgaacgcat gcggctgggg gagttgcgga agcaacacta
     3121 cgtgctggct ggggcatcag gcagccctgg agaggaggtg gccatccggc ccagcactgc
     3181 cccccgaagt gtaaccacca agaaaccacc cctggcccag aagcccagcg tggcccccag
     3241 acaggaccac cagcttgaca aaaaggatgg catctaccca gctcaactcg tgaactacta
     3301 ggccccccag gggtccagca gggtggctgg tgacaggcct gggcctctgc aactgccctg
     3361 acaggaccga gaggccttgc ccctccacct ggtgcccaag cctcccgccc caccgtctgg
     3421 atcaatgtcc tcaaggcccc tggcccttac tgagcctgca gggtcctggg ccatgtgggt
     3481 ggtgcttctg gatgtgagtc tcttatttat ctgcagaagg aactttgggg tgcagccagg
     3541 acccggtagg cctgagcctc aactcttcag aaaatagtgt ttttaatatt cctcttcaga
     3601 aaatagtgtt tttaatattc cgagctagag ctcttcttcc tacgtttgta gtcagcacac
     3661 tgggaaaccg ggccagcgtg gggctccctg ccttctggac tcctgaaggt cgtggatgga
     3721 tggaaggcac acagcccgtg ccggctgatg ggacgagggt caggcatcct gtctgtggcc
     3781 ttctggggca ccgattctac caggccctcc agctgcgtgg tctccgcaga ccaggctctg
     3841 tgtgggctag aggaatgtcg cccattactc ctcaggcctg gccctcgggc ctccgtgatg
     3901 ggagcccccc aggaggggtc agatgctgga aggggccgct ttctggggag tgaggtgaga
     3961 catagcggcc cgggcgctgc cttcactcct ggagtgagtt tccatttcca gctggaatct
     4021 gcagccaccc ccatttcctg ttttccattc ccccgttctg gccgcgcccc actgcccacc
     4081 tgaaggggtg gtttccagcc ctccggagag tgggcttggc cctaggccct ccagctcagc
     4141 cagaaaaagc ccagaaaccc aggtgctgga ccagggccct cagggagggg accctgcggc
     4201 tagagtgggc taggccctgg ctttgcccgt cagatttgaa cgaatgtgtg tcccttgagc
     4261 ccaaggagag cggcaggagg ggtgggacca ggctgggagg acagagccag cagctgccat
     4321 gccctcctgc tccccccacc ccagccctag ccctttagcc tttcaccctg tgctctggaa
     4381 aggctaccaa atactggcca aggtcaggag gagcaaaaat gagccagcac cagcgccttg
     4441 gctttgtgtt agcatttcct cctgaagtgt tctgttggca ataaaatgca ctttgactgt
     4501 ttgttgtca
//
