LOCUS       NM_005338               8009 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens huntingtin interacting protein 1 (HIP1), transcript
            variant 1, mRNA.
ACCESSION   NM_005338
VERSION     NM_005338.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8009)
  AUTHORS   Laragione,T., Harris,C. and Gulko,P.S.
  TITLE     KIF1C and new Huntingtin-interacting protein 1 binding proteins
            regulate rheumatoid arthritis fibroblast-like synoviocytes'
            phenotypes
  JOURNAL   Front Immunol 15, 1323410 (2024)
   PUBMED   38726004
  REMARK    GeneRIF: KIF1C and new Huntingtin-interacting protein 1 binding
            proteins regulate rheumatoid arthritis fibroblast-like
            synoviocytes' phenotypes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8009)
  AUTHORS   Bettencourt,C., Miki,Y., Piras,I.S., de Silva,R., Foti,S.C.,
            Talboom,J.S., Revesz,T., Lashley,T., Balazs,R., Vire,E.,
            Warner,T.T., Huentelman,M.J. and Holton,J.L.
  TITLE     MOBP and HIP1 in multiple system atrophy: New alpha-synuclein
            partners in glial cytoplasmic inclusions implicated in the disease
            pathogenesis
  JOURNAL   Neuropathol Appl Neurobiol 47 (5), 640-652 (2021)
   PUBMED   33368549
  REMARK    GeneRIF: MOBP and HIP1 in multiple system atrophy: New
            alpha-synuclein partners in glial cytoplasmic inclusions implicated
            in the disease pathogenesis.
REFERENCE   3  (bases 1 to 8009)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8009)
  AUTHORS   Gervais,F.G., Singaraja,R., Xanthoudakis,S., Gutekunst,C.A.,
            Leavitt,B.R., Metzler,M., Hackam,A.S., Tam,J., Vaillancourt,J.P.,
            Houtzager,V., Rasper,D.M., Roy,S., Hayden,M.R. and Nicholson,D.W.
  TITLE     Recruitment and activation of caspase-8 by the
            Huntingtin-interacting protein Hip-1 and a novel partner Hippi
  JOURNAL   Nat Cell Biol 4 (2), 95-105 (2002)
   PUBMED   11788820
  REMARK    GeneRIF: Results show that pro-apoptotic Hippi-Hip-1 heterodimers
            can recruit procaspase-8 into a complex of Hippi, Hip-1 and
            procaspase-8, and launch apoptosis through components of the
            'extrinsic' cell-death pathway.
REFERENCE   5  (bases 1 to 8009)
  AUTHORS   Rao,D.S., Chang,J.C., Kumar,P.D., Mizukami,I., Smithson,G.M.,
            Bradley,S.V., Parlow,A.F. and Ross,T.S.
  TITLE     Huntingtin interacting protein 1 Is a clathrin coat binding protein
            required for differentiation of late spermatogenic progenitors
  JOURNAL   Mol Cell Biol 21 (22), 7796-7806 (2001)
   PUBMED   11604514
REFERENCE   6  (bases 1 to 8009)
  AUTHORS   Chopra,V.S., Metzler,M., Rasper,D.M., Engqvist-Goldstein,A.E.,
            Singaraja,R., Gan,L., Fichter,K.M., McCutcheon,K., Drubin,D.,
            Nicholson,D.W. and Hayden,M.R.
  TITLE     HIP12 is a non-proapoptotic member of a gene family including HIP1,
            an interacting protein with huntingtin
  JOURNAL   Mamm Genome 11 (11), 1006-1015 (2000)
   PUBMED   11063258
REFERENCE   7  (bases 1 to 8009)
  AUTHORS   Ross,T.S., Bernard,O.A., Berger,R. and Gilliland,D.G.
  TITLE     Fusion of Huntingtin interacting protein 1 to platelet-derived
            growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic
            leukemia with t(5;7)(q33;q11.2)
  JOURNAL   Blood 91 (12), 4419-4426 (1998)
   PUBMED   9616134
REFERENCE   8  (bases 1 to 8009)
  AUTHORS   Wedemeyer,N., Peoples,R., Himmelbauer,H., Lehrach,H., Francke,U.
            and Wanker,E.E.
  TITLE     Localization of the human HIP1 gene close to the elastin (ELN)
            locus on 7q11.23
  JOURNAL   Genomics 46 (2), 313-315 (1997)
   PUBMED   9417924
REFERENCE   9  (bases 1 to 8009)
  AUTHORS   Kalchman,M.A., Koide,H.B., McCutcheon,K., Graham,R.K., Nichol,K.,
            Nishiyama,K., Kazemi-Esfarjani,P., Lynn,F.C., Wellington,C.,
            Metzler,M., Goldberg,Y.P., Kanazawa,I., Gietz,R.D. and Hayden,M.R.
  TITLE     HIP1, a human homologue of S. cerevisiae Sla2p, interacts with
            membrane-associated huntingtin in the brain
  JOURNAL   Nat Genet 16 (1), 44-53 (1997)
   PUBMED   9140394
REFERENCE   10 (bases 1 to 8009)
  AUTHORS   Wanker,E.E., Rovira,C., Scherzinger,E., Hasenbank,R., Walter,S.,
            Tait,D., Colicelli,J. and Lehrach,H.
  TITLE     HIP-I: a huntingtin interacting protein isolated by the yeast
            two-hybrid system
  JOURNAL   Hum Mol Genet 6 (3), 487-495 (1997)
   PUBMED   9147654
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC110545.2, AF365404.1,
            AK296390.1, AC211429.4 and BQ446538.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005338.6.
            
            Summary: The product of this gene is a membrane-associated protein
            that functions in clathrin-mediated endocytosis and protein
            trafficking within the cell. The encoded protein binds to the
            huntingtin protein in the brain; this interaction is lost in
            Huntington's disease. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110545.2, AF365404.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336926.11/ ENSP00000336747.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2516              BC110545.2         7-2522
            2517-2811           AF365404.1         2475-2769
            2812-3765           AK296390.1         202-1155
            3766-7328           AC211429.4         148727-152289       c
            7329-8009           BQ446538.1         17-697              c
FEATURES             Location/Qualifiers
     source          1..8009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..8009
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /note="huntingtin interacting protein 1"
                     /db_xref="GeneID:3092"
                     /db_xref="HGNC:HGNC:4913"
                     /db_xref="MIM:601767"
     exon            1..141
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..3135
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /note="isoform 1 is encoded by transcript variant 1;
                     huntingtin-interacting protein I"
                     /codon_start=1
                     /product="huntingtin-interacting protein 1 isoform 1"
                     /protein_id="NP_005329.3"
                     /db_xref="CCDS:CCDS34669.1"
                     /db_xref="GeneID:3092"
                     /db_xref="HGNC:HGNC:4913"
                     /db_xref="MIM:601767"
                     /translation="MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSI
                     NKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKL
                     LRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFP
                     GNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAG
                     QCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRS
                     SNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMD
                     MDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGLKAQLE
                     NMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKA
                     QRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLER
                     EKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANW
                     AAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLL
                     VGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACP
                     EDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLE
                     EEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETAT
                     ARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTA
                     SPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAAST
                     AQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMT
                     LTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQ
                     EVVTEKE"
     exon            142..205
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            206..348
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            349..405
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            406..486
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            487..563
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            564..625
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            626..766
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            767..824
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            825..900
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1041
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1139
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1212
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1396
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1485
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1602
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1704
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1848
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1984
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2071
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2179
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2316
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2427
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2486
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2580
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2681
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2787
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2788..2911
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..2973
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3082
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..8009
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7988..7993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /note="hexamer: AATAAA"
     polyA_site      8009
                     /gene="HIP1"
                     /gene_synonym="HIP-I; ILWEQ; SHON; SHONbeta; SHONgamma"
                     /note="major polyA site"
ORIGIN      
        1 gactcggctc ctcgcggcga catggatcgg atggccagct ccatgaagca ggtgcccaac
       61 ccactgccca aggtgctgag ccggcgcggg gtcggcgctg ggctggaggc ggcggagcgc
      121 gagagcttcg agcggactca gactgtcagc atcaataagg ccattaatac gcaggaagtg
      181 gctgtaaagg aaaaacacgc cagaacgtgc atactgggca cccaccatga gaaaggggca
      241 cagaccttct ggtctgttgt caaccgcctg cctctgtcta gcaacgcagt gctctgctgg
      301 aagttctgcc atgtgttcca caaactcctc cgagatggac acccgaacgt cctgaaggac
      361 tctctgagat acagaaatga attgagtgac atgagcagga tgtggggcca cctgagcgag
      421 gggtatggcc agctgtgcag catctacctg aaactgctaa gaaccaagat ggagtaccac
      481 accaaaaatc ccaggttccc aggcaacctg cagatgagtg accgccagct ggacgaggct
      541 ggagaaagtg acgtgaacaa ctttttccag ttaacagtgg agatgtttga ctacctggag
      601 tgtgaactca acctcttcca aacagtattc aactccctgg acatgtcccg ctctgtgtcc
      661 gtgacggcag cagggcagtg ccgcctcgcc ccgctgatcc aggtcatctt ggactgcagc
      721 cacctttatg actacactgt caagcttctc ttcaaactcc actcctgcct cccagctgac
      781 accctgcaag gccaccggga ccgcttcatg gagcagttta caaagttgaa agatctgttc
      841 taccgctcca gcaacctgca gtacttcaag cggctcattc agatccccca gctgcctgag
      901 aacccaccca acttcctgcg agcctcagcc ctgtcagaac atatcagccc tgtggtggtg
      961 atccctgcag aggcctcatc ccccgacagc gagccagtcc tagagaagga tgacctcatg
     1021 gacatggatg cctctcagca gaatttattt gacaacaagt ttgatgacat ctttggcagt
     1081 tcattcagca gtgatccctt caatttcaac agtcaaaatg gtgtgaacaa ggatgagaag
     1141 gaccacttaa ttgagcgact atacagagag atcagtggat tgaaggcaca gctagaaaac
     1201 atgaagactg agagccagcg ggttgtgctg cagctgaagg gccacgtcag cgagctggaa
     1261 gcagatctgg ccgagcagca gcacctgcgg cagcaggcgg ccgacgactg tgaattcctg
     1321 cgggcagaac tggacgagct caggaggcag cgggaggaca ccgagaaggc tcagcggagc
     1381 ctgtctgaga tagaaaggaa agctcaagcc aatgaacagc gatatagcaa gctaaaggag
     1441 aagtacagcg agctggttca gaaccacgct gacctgctgc ggaagaatgc agaggtgacc
     1501 aaacaggtgt ccatggccag acaagcccag gtagatttgg aacgagagaa aaaagagctg
     1561 gaggattcgt tggagcgcat cagtgaccag ggccagcgga agactcaaga acagctggaa
     1621 gttctagaga gcttgaagca ggaacttgcc acaagccaac gggagcttca ggttctgcaa
     1681 ggcagcctgg aaacttctgc ccagtcagaa gcaaactggg cagccgagtt cgccgagcta
     1741 gagaaggagc gggacagcct ggtgagtggc gcagctcata gggaggagga attatctgct
     1801 cttcggaaag aactgcagga cactcagctc aaactggcca gcacagagga atctatgtgc
     1861 cagcttgcca aagaccaacg aaaaatgctt ctggtggggt ccaggaaggc tgcggagcag
     1921 gtgatacaag acgccctgaa ccagcttgaa gaacctcctc tcatcagctg cgctgggtct
     1981 gcagatcacc tcctctccac ggtcacatcc atttccagct gcatcgagca actggagaaa
     2041 agctggagcc agtatctggc ctgcccagaa gacatcagtg gacttctcca ttccataacc
     2101 ctgctggccc acttgaccag cgacgccatt gctcatggtg ccaccacctg cctcagagcc
     2161 ccacctgagc ctgccgactc actgaccgag gcctgtaagc agtatggcag ggaaaccctc
     2221 gcctacctgg cctccctgga ggaagaggga agccttgaga atgccgacag cacagccatg
     2281 aggaactgcc tgagcaagat caaggccatc ggcgaggagc tcctgcccag gggactggac
     2341 atcaagcagg aggagctggg ggacctggtg gacaaggaga tggcggccac ttcagctgct
     2401 attgaaactg ccacggccag aatagaggag atgctcagca aatcccgagc aggagacaca
     2461 ggagtcaaat tggaggtgaa tgaaaggatc cttggttgct gtaccagcct catgcaagct
     2521 attcaggtgc tcatcgtggc ctctaaggac ctccagagag agattgtgga gagcggcagg
     2581 ggtacagcat cccctaaaga gttttatgcc aagaactctc gatggacaga aggacttatc
     2641 tcagcctcca aggctgtggg ctggggagcc actgtcatgg tggatgcagc tgatctggtg
     2701 gtacaaggca gagggaaatt tgaggagcta atggtgtgtt ctcatgaaat tgctgctagc
     2761 acagcccagc ttgtggctgc atccaaggtg aaagctgata aggacagccc caacctagcc
     2821 cagctgcagc aggcctctcg gggagtgaac caggccactg ccggcgttgt ggcctcaacc
     2881 atttccggca aatcacagat cgaagagaca gacaacatgg acttctcaag catgacgctg
     2941 acacagatca aacgccaaga gatggattct caggttaggg tgctagagct agaaaatgaa
     3001 ttgcagaagg agcgtcaaaa actgggagag cttcggaaaa agcactacga gcttgctggt
     3061 gttgctgagg gctgggaaga aggaacagag gcatctccac ctacactgca agaagtggta
     3121 accgaaaaag aatagagcca aaccaacacc ccatatgtca gtgtaaatcc ttgttaccta
     3181 tctcgtgtgt gttatttccc cagccacagg ccaaatcctt ggagtcccag gggcagccac
     3241 accactgcca ttacccagtg ccgaggacat gcatgacact tccaaagact ccctccatag
     3301 cgacaccctt tctgtttgga cccatggtca tctctgttct tttcccgcct ccctagttag
     3361 catccaggct ggccagtgct gcccatgagc aagcctaggt acgaagaggg gtggtggggg
     3421 gcagggccac tcaacagaga ggaccaacat ccagtcctgc tgactatttg acccccacaa
     3481 caatgggtat ccttaataga ggagctgctt gttgtttgtt gacagcttgg aaagggaaga
     3541 tcttatgcct tttcttttct gttttcttct cagtcttttc agtttcatca tttgcacaaa
     3601 cttgtgagca tcagagggct gatggattcc aaaccaggac actaccctga gatctgcaca
     3661 gtcagaagga cggcaggagt gtcctggctg tgaatgccaa agccattctc cccctctttg
     3721 ggcagtgcca tggatttcca ctgcttctta tggtggttgg ttgggttttt tggttttgtt
     3781 ttttttttta agtttcactc acatagccaa ctctcccaaa gggcacaccc ctggggctga
     3841 gtctccaggg ccccccaact gtggtagctc cagcgatggt gctgcccagg cctctcggtg
     3901 ctccatctcc gcctccacac tgaccaagtg ctggcccacc cagtccatgc tccagggtca
     3961 ggcggagctg ctgagtgaca gctttcctca aaaagcagaa ggagagtgag tgcctttccc
     4021 tcctaaagct gaatcccggc ggaaagcctc tgtccgcctt tacaagggag aagacaacag
     4081 aaagagggac aagagggttc acacagccca gttcccgtga cgaggctcaa aaacttgatc
     4141 acatgcttga atggagctgg tgagatcaac aacactactt ccctgccgga atgaactgtc
     4201 cgtgaatggt ctctgtcaag cgggccgtct cccttggccc agagacggag tgtgggagtg
     4261 attcccaact cctttctgca gacgtctgcc ttggcatcct cttgaatagg aagatcgttc
     4321 caccttctac gcaattgaca aacccggaag atcagatgca attgctccca tcagggaaga
     4381 accctatact tggtttgcta cccttagtat ttattactaa cctcccttaa gcagcaacag
     4441 cctacaaaga gatgcttgga gcaatcagaa cttcaggtgt gactctagca aggctcatct
     4501 ttctgcccgg ctacatcagc cttcaagaat cagaagaaag gccaaggtgc tggactgtta
     4561 ctgacttgga tcccaaagca aggagatcat ttggagctct tgggtcagag aaaatgagaa
     4621 aggacagagc cagcggctcc aactcctttc agccacatgc cccaggctct cgctgccctg
     4681 tggacaggat gaggacagag ggcacatgaa cagcttgcca gggatgggca gcccaacagc
     4741 acttttcctc ttctagatgg accccagcat ttaagtgacc ttctgatctt ggaaaaacag
     4801 cgtcttcctt ctttatctat agcaactcat tggtggtagc catcaagcac ttcccaggat
     4861 ctgctccaac agaatattgc taggttttgc tacatgacgg gttgtgagac ttctgtttga
     4921 tcactgtgaa ccaaccccca tctccctagc ccacccccct ccccaactcc ctctctgtgc
     4981 attttctaag tgggacattc aaaaaactct ctcccaggac ctcggatgac catactcaga
     5041 cgtgtgacct ccatactggg ctaaggaagt atcagcacta gaaattgggc agtcttaatg
     5101 ttgaatgctg ctttctgctt agtatttttt tgattcaagg ctcagaagga atggtgcgtg
     5161 gcttccctgt cccagttgtg gcaactaaac caatcggtgt gttcttgatg cgggtcaaca
     5221 tttccaaaag tggctagtcc tcacttctag atctcagcca ttctaactca tatgttccca
     5281 attaccaagg ggtggccggg cacagtggct cacgcctgta atcccagcac tttgagaggc
     5341 tgaggtggta ggatcacctg aggtcaggag ttcaagacca gcctgtccaa catggtgaaa
     5401 cccccatctc tactaaaaat accaaaaatt agccgagcgt agtgacgggt gcccgtaatc
     5461 ccagctactc aggaggctga gacaggagaa tcacctgaac cccagaggca gaggttgcag
     5521 tgagctgaga tcacgccatt gtactccagc ctgggcaaca agagcaaaac tccgtctcaa
     5581 aaaaaaaaaa aaattacaaa tggggcaaac agtctagtgt aatggatcaa attaagattc
     5641 tctgcccagc cgggcacagt ggcgcatgcc tgtaatccca gaactttggg aggccaagac
     5701 gggatgattg cttgagctca ggagtttgag accaggctgg gcatcatagc aagacctcat
     5761 ctctactaaa attcaaaaac aaaattagcc gggcatgatg gtgcatgcct gtagtctcag
     5821 ctagttgggg agctaaggtg ggagaattgc ttgagcttgg gaagtcgagg ctgcagtcag
     5881 ccctgattgt gccagtgcac tccggcctgg gtgacagagt gagaccctgt ctcaaaaaaa
     5941 aaaagattct gtgtcagagc ccagcccagg agtttgaggc tgcaatgagc catgatttcc
     6001 cactgcactc cagcctgagt gacagagcga gactccatct ctttaaaaac aaacaaaaaa
     6061 ttatctgaat gatcctgtct ctaaaaagaa gccacagaaa tgtttaaaaa cttcatcgac
     6121 ttagcctgag tcataacggt taagaaagca cttaaacaga agcagaggct aattcagtgt
     6181 cacatgagga agtagctgtc agatgtcaca taattacttt cgtaatagct cagattagaa
     6241 tggctacccc attctctaga caaaatcaaa ttgtcctatt gtgactcttc taaaaatgaa
     6301 gatgaagagc tatttaatga cacaccttgg attaaaacgg gaatcacatc ttaaagctaa
     6361 aaatgaacct gcaagccttc taaatgagtc actgagcatc actagtgaca agtctcgggt
     6421 gagcgtaaat gggtcatgac aagatgggac agcaacaaaa tcatggctta ggatcgacaa
     6481 gaagttaaaa aacagctgca tctgttactt aagtttgtaa gacagtgccc tgagacctct
     6541 agagaaaaga tgtttgttta cataagagaa agaggccaga catggtgtct cacacgttta
     6601 atcccagcac tttgggaggc aggggcgggt ggatcacctg aggtcaggag ttcaagacta
     6661 gcctggccaa catggtgaaa ccccgtctct actaaaaata caaaaattag ccgggcatgg
     6721 tggcaggcgc ctataatccc agctactggg gaggctgagg caggagaatc acttgaaccc
     6781 gggggacaga ggttgtagtg agccaagatc gcaccactgc actccagcct gggtcacaga
     6841 gtgagactcc atctcaaaaa aaaaaaagag agagagagag aaagaaatag aagagaagag
     6901 ccatcttggc agggttattt tatatctgag caaggagttt aaatgagact agtttagatt
     6961 gtctgctgat gcagccgtcc atagcagtac ccctaaaatc ccaccagaat acgggtccct
     7021 ctaacccagt ggctggaaga accactgtct agagcaactt ttcttggaac tgtcccagct
     7081 accaagtcag acaccaaggt ttatgccacc aggtaacacg ggaatcacag gtacatgtcg
     7141 ctccggtcag attagttggc tttggcccct cgaccctgtg caggagctag ttctcagctt
     7201 gcagctggaa gttccctctt agctccttag tctagagggg tctcctggct ccatttgacc
     7261 ctggtcttta ataaccggtc agcatcttgc taccttctac cacctttcca aatctctgga
     7321 aatcctgcca gggaaagcct ccagttccaa cattggcttt ccaagcaaac tggctttgcc
     7381 ctctctctgc catccttgtc ctccagagac tgcaccacct gtagcataga aaaccaccac
     7441 cacggacctg ccagccatcg gcgcagcaaa ccagccagct gtttgctgcc aaattccttc
     7501 ctctcccagg tccagaccaa atacaagatc agcaccacac cgtggtgttg tcaggagcca
     7561 aagcaacagg aaacaattca atgctgttgg gttcgattct gagagtagat ttttccagac
     7621 atgtctttca ggtgaccctc aactacctca ggtttgaagg ccctaaatga aactgattac
     7681 cactcatagg gacaaaccga gggggttcgg ttacatcttg gtgataatgc agttgtctca
     7741 aacttataac agactctttc acatttcagt ttgcagggat agggttgggt ttgtttttct
     7801 tctgttttta acctttcccc tgggtttcca ttagggtagt tccttgaaat gaatttcatt
     7861 tttcactgag tgcctacctt cccagggcag gtggccactg gcttctgttt ccctccaaca
     7921 atacttttat tatggtatta agacctttct ttgtataata cattgcatct gtgttttcaa
     7981 tttttcaaat aaatatttcc gcctggcaa
//
