LOCUS       NM_138571               3325 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens histidine triad nucleotide binding protein 3 (HINT3),
            mRNA.
ACCESSION   NM_138571
VERSION     NM_138571.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3325)
  AUTHORS   Li,J., Liu,Y., Lian,B., Li,H., Chai,D., Gao,Y. and Wang,Y.
  TITLE     HINT3 suppresses AKT/mTOR signaling pathway activity during breast
            cancer tumorigenesis through PTEN transcriptional activation
  JOURNAL   Int J Mol Med 52 (1) (2023)
   PUBMED   37203409
  REMARK    GeneRIF: HINT3 suppresses AKT/mTOR signaling pathway activity
            during breast cancer tumorigenesis through PTEN transcriptional
            activation.
REFERENCE   2  (bases 1 to 3325)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3325)
  AUTHORS   Chou,T.F., Cheng,J., Tikh,I.B. and Wagner,C.R.
  TITLE     Evidence that human histidine triad nucleotide binding protein 3
            (Hint3) is a distinct branch of the histidine triad (HIT)
            superfamily
  JOURNAL   J Mol Biol 373 (4), 978-989 (2007)
   PUBMED   17870088
  REMARK    GeneRIF: Results show that significant differences in
            phosphoramidase activity, oligomeric state, and cellular
            localization suggest that Hint3s should be placed in a distinct
            branch of the histidine triad superfamily.
REFERENCE   4  (bases 1 to 3325)
  AUTHORS   Brenner,C.
  TITLE     Hint, Fhit, and GalT: function, structure, evolution, and mechanism
            of three branches of the histidine triad superfamily of nucleotide
            hydrolases and transferases
  JOURNAL   Biochemistry 41 (29), 9003-9014 (2002)
   PUBMED   12119013
REFERENCE   5  (bases 1 to 3325)
  AUTHORS   Bieganowski,P., Garrison,P.N., Hodawadekar,S.C., Faye,G.,
            Barnes,L.D. and Brenner,C.
  TITLE     Adenosine monophosphoramidase activity of Hint and Hnt1 supports
            function of Kin28, Ccl1, and Tfb3
  JOURNAL   J Biol Chem 277 (13), 10852-10860 (2002)
   PUBMED   11805111
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA393891.1, AY035387.1, BC015732.1, DA997963.1, CX755653.1,
            AL035689.26 and BX647228.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138571.4.
            
            Summary: Histidine triad proteins, such as HINT3, are nucleotide
            hydrolases and transferases that act on the alpha-phosphate of
            ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by
            OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647228.1, SRR1660807.176584.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229633.7/ ENSP00000229633.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DA393891.1         56-75
            21-314              AY035387.1         1-294
            315-1135            BC015732.1         304-1124
            1136-1659           DA997963.1         47-570
            1660-2311           CX755653.1         81-732
            2312-2902           AL035689.26        91592-92182         c
            2903-3325           BX647228.1         2950-3372
FEATURES             Location/Qualifiers
     source          1..3325
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.32"
     gene            1..3325
                     /gene="HINT3"
                     /gene_synonym="HINT4"
                     /note="histidine triad nucleotide binding protein 3"
                     /db_xref="GeneID:135114"
                     /db_xref="HGNC:HGNC:18468"
                     /db_xref="MIM:609998"
     exon            1..409
                     /gene="HINT3"
                     /gene_synonym="HINT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..757
                     /gene="HINT3"
                     /gene_synonym="HINT4"
                     /EC_number="3.-.-.-"
                     /note="HIT-like protein; HINT-3"
                     /codon_start=1
                     /product="adenosine 5'-monophosphoramidase HINT3"
                     /protein_id="NP_612638.3"
                     /db_xref="CCDS:CCDS5133.1"
                     /db_xref="GeneID:135114"
                     /db_xref="HGNC:HGNC:18468"
                     /db_xref="MIM:609998"
                     /translation="MAEEQVNRSAGLAPDCEASATAETTVSSVGTCEAAGKSPEPKDY
                     DSTCVFCRIAGRQDPGTELLHCENEDLICFKDIKPAATHHYLVVPKKHIGNCRTLRKD
                     QVELVENMVTVGKTILERNNFTDFTNVRMGFHMPPFCSISHLHLHVLAPVDQLGFLSK
                     LVYRVNSYWFITADHLIEKLRT"
     exon            410..527
                     /gene="HINT3"
                     /gene_synonym="HINT4"
                     /inference="alignment:Splign:2.1.0"
     exon            528..597
                     /gene="HINT3"
                     /gene_synonym="HINT4"
                     /inference="alignment:Splign:2.1.0"
     exon            598..724
                     /gene="HINT3"
                     /gene_synonym="HINT4"
                     /inference="alignment:Splign:2.1.0"
     exon            725..3325
                     /gene="HINT3"
                     /gene_synonym="HINT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3300..3305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HINT3"
                     /gene_synonym="HINT4"
                     /note="hexamer: AATAAA"
     polyA_site      3325
                     /gene="HINT3"
                     /gene_synonym="HINT4"
                     /note="major polyA site"
ORIGIN      
        1 ctctagtggc agccggtttt gaggccggcc tccggctttg aagttcctca ccgcgtctcc
       61 ttccctctcc ccaaagcctg gatcaccgcc cagcgtcagg cgaggggcga cgtctcgagg
      121 taaaacggag gaggtgcggg acgcggagac tgcgcgggcc cggtagccct ggagaggccg
      181 aggctctagg ccgcgagggg cgggtgcaat ggcggaggaa caggtgaacc gcagcgccgg
      241 cctggccccc gactgtgagg cctcggcgac tgcagaaact acggtttcct cagtggggac
      301 ctgtgaagcc gctggcaagt caccagagcc caaggactac gacagcacct gcgtgttctg
      361 ccggatcgcg gggcggcagg acccgggcac cgaactcctg cactgcgaga atgaggacct
      421 aatttgcttc aaagatatca aaccagcagc aactcatcat tatcttgtgg tgccaaagaa
      481 gcatattgga aactgcagaa ctctaaggaa agatcaagta gaactggttg agaacatggt
      541 aactgttgga aaaaccattc ttgaaagaaa taatttcact gacttcacga atgtgaggat
      601 gggttttcat atgccaccat tctgttccat ttcccacttg caccttcatg ttctggcacc
      661 agtggatcag cttggcttct tatccaagtt ggtttataga gtcaattcct attggtttat
      721 cacagctgat cacttgattg aaaaactaag aacatgaaaa tgtcaagagt ggaagatttt
      781 tctaatcttg gttcagcatg aagtggtatt taggtccctt ttaagtctaa ttgcaatttt
      841 aagatttgtt gggttttatg agaggctgtt acttagtggc cttaaatctt ttctgaatgt
      901 ctgtttccta agatctgtga tacagttatg tgaatatttt gttactgact tgtttcaatg
      961 gttacttgta taaggatttt atatatatga tactatagat aaaatcctat ttaagacaaa
     1021 ttctgttaat caacaagggc tctgtatttt tttaagttaa aatattttca tttctcagta
     1081 agtagtcagt tataatagtg atttatttat gaagaataaa ctactataga aagtactttg
     1141 tgggaacctt tattactgtg aaggagaaaa atagctattt cttgacagtt ctatagttat
     1201 acacataaat tttcaaaata aagaatacca tactacacaa tgatctctga ttttgctgag
     1261 ggaaggaatt atatatgtgc cactttttcc tcaaatttca gatgccagtt ttcacttttt
     1321 gaagcattgc atctttttaa taaatctatc ctgaaagcta tataatatat ataatttata
     1381 tcaatgaatt tacaataact atcaaattgg ctatcagaat tcactgtaat ggaattttgc
     1441 ctctaataac ataaaggggg aagaaacata aagtggttct cttaataaaa ctagcagaaa
     1501 atgttgcttt atggcatgtt tttgtatcaa agagaaatca gaggttaaac tttgctttta
     1561 tcatgaaaag ggcctgattt gaaggtagag ataggcttag atgagaaaaa ttgataacgc
     1621 aatgttaata ctattgatat ttcataggta tattttgtta gaaattggtt ttttggtgct
     1681 aatctatagg cacaatagtg aatatgaatg aagagtaggt gctgcaagtt aatcctacat
     1741 tgtgccagtg tatattagta ccatgtaaat gaatatgaat aaatgaacat gaggattaac
     1801 gaactgttga aaataggctg agatactagt tttctttctt ttttagaggg ggcatgatat
     1861 taaagatagt tttaagtaac aaattactta ttacaaagtt acaacatgtg gaatcaatag
     1921 ttttatttgt tcattaattt attcattcag caaacatttg ttgaacattt aatgtgtacc
     1981 agatattgcc aggatcagga aataaagaac taaaaatgga cattcagact gcaattgcta
     2041 gtacaggggt caaacaaaat cagtgattag aatttagtgc gttaagttcc ctgatgcctt
     2101 cacagccaga agaggctgtg aagggataaa cacttctgag agtgggtggt agtagaactg
     2161 agtattcaag actgaatgtt aggcaggtag acagtgactg gttaggctga gaaacttaca
     2221 agtattttcg ttgagttctg cttccactat tatttacttt acaatggata tgaagttcag
     2281 atttcatctt atttactgaa ggtggagaaa ggatgtggaa gtaggggtta tgggctctca
     2341 aaagtagatt tagagagatt tttttatcac tgttttatga tatagttcac tgagcactta
     2401 catagattaa cagttacaag tttccataaa tcagttagaa tatgactagc ttcagggaag
     2461 gaattttcaa caactgcaat ctttgattgt tttactgtgg gaacttgcag tgatataatt
     2521 gacaacatta tttaacaata ataggtaaag taggccgggt gtggtggctc acgcctgtaa
     2581 tcctagcact ttgggaggcc gaggtgggtg gatcacaagg tcaggagttc gagaccagcc
     2641 tggccaatat ggtgaaaccc cgtctcttct aaaaaaatac aaaaattagc cgggtatggt
     2701 ggcgcatgcc tgtagtccca gctactgggg aggctgaggc aagagaattg cttgaactcg
     2761 ggaggcggag gtcgcagtga gccgagatcg tgccactgca ctccagcctg ggtgacagag
     2821 tgagactttg tctcaaagaa aaaaaaacaa taataggtaa agtatttaag gaattctcag
     2881 atgccttatg gacctcttca aaaatgtggt tagccaattg attcaacttt tataggttta
     2941 tatgctctca tgtaaaccta tttgtttccg agatcagacg agatcgggcg cgttcagggt
     3001 ggtatggccg tagacaacct atttgttaaa aacccttgga aacacatctt ttagtagagg
     3061 ttcttattta cttataaaga ttaataatca aattactaca attaatatcc atttagcctt
     3121 ttcagtagtc taaatatttg gtaactccct agccatctat aacactagtt caaaacaagg
     3181 ctaattcata acctgtctta aaaatgtttg aagtggtatc aagagcattg tttatgcatg
     3241 ttgtgatact atttgtggaa ctgtttaatg agctatttca aactgctaga agaaaatgaa
     3301 ataaaaatgg aaaaatactg tcaaa
//
