LOCUS       NM_032593                649 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens histidine triad nucleotide binding protein 2 (HINT2),
            mRNA.
ACCESSION   NM_032593
VERSION     NM_032593.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 649)
  AUTHORS   Yao,J., Miao,Y., Zhu,L., Wan,M., Lu,Y. and Tang,W.
  TITLE     Histidine triad nucleotide-binding protein 2: From basic science to
            clinical implications
  JOURNAL   Biochem Pharmacol 212, 115527 (2023)
   PUBMED   37004779
  REMARK    GeneRIF: Histidine triad nucleotide-binding protein 2: From basic
            science to clinical implications.
            Review article
REFERENCE   2  (bases 1 to 649)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 649)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 649)
  AUTHORS   Dolot,R., Krakowiak,A., Kaczmarek,R., Wlodarczyk,A., Pichlak,M. and
            Nawrot,B.
  TITLE     Biochemical, crystallographic and biophysical characterization of
            histidine triad nucleotide-binding protein 2 with different ligands
            including a non-hydrolyzable analog of Ap4A
  JOURNAL   Biochim Biophys Acta Gen Subj 1865 (11), 129968 (2021)
   PUBMED   34329705
  REMARK    GeneRIF: Biochemical, crystallographic and biophysical
            characterization of histidine triad nucleotide-binding protein 2
            with different ligands including a non-hydrolyzable analog of Ap4A.
            Erratum:[Biochim Biophys Acta Gen Subj. 2022 Feb;1866(2):130035.
            doi: 10.1016/j.bbagen.2021.130035.. PMID: 34687819]
REFERENCE   5  (bases 1 to 649)
  AUTHORS   Strom,A., Tong,C.L. and Wagner,C.R.
  TITLE     Histidine triad nucleotide-binding proteins HINT1 and HINT2 share
            similar substrate specificities and little affinity for the
            signaling dinucleotide Ap4A
  JOURNAL   FEBS Lett 594 (10), 1497-1505 (2020)
   PUBMED   31990367
  REMARK    GeneRIF: Histidine triad nucleotide-binding proteins HINT1 and
            HINT2 share similar substrate specificities and little affinity for
            the signaling dinucleotide Ap4A.
REFERENCE   6  (bases 1 to 649)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 649)
  AUTHORS   Lenglet,S., Antigny,F., Vetterli,L., Dufour,J.F. and Rossier,M.F.
  TITLE     Hint2 is expressed in the mitochondria of H295R cells and is
            involved in steroidogenesis
  JOURNAL   Endocrinology 149 (11), 5461-5469 (2008)
   PUBMED   18653718
  REMARK    GeneRIF: Hint2 is required for an optimal steroidogenic response,
            possibly because of a particular signalling function exerted within
            the mitochondria.
REFERENCE   8  (bases 1 to 649)
  AUTHORS   Martin,J., Magnino,F., Schmidt,K., Piguet,A.C., Lee,J.S.,
            Semela,D., St-Pierre,M.V., Ziemiecki,A., Cassio,D., Brenner,C.,
            Thorgeirsson,S.S. and Dufour,J.F.
  TITLE     Hint2, a mitochondrial apoptotic sensitizer down-regulated in
            hepatocellular carcinoma
  JOURNAL   Gastroenterology 130 (7), 2179-2188 (2006)
   PUBMED   16762638
REFERENCE   9  (bases 1 to 649)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 649)
  AUTHORS   Brenner,C.
  TITLE     Hint, Fhit, and GalT: function, structure, evolution, and mechanism
            of three branches of the histidine triad superfamily of nucleotide
            hydrolases and transferases
  JOURNAL   Biochemistry 41 (29), 9003-9014 (2002)
   PUBMED   12119013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI759951.1, BM764627.1 and BC047737.2.
            
            On Nov 22, 2018 this sequence version replaced NM_032593.2.
            
            Summary: Histidine triad proteins, such as HINT2, are nucleotide
            hydrolases and transferases that act on the alpha-phosphate of
            ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by
            OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.327484.1, DN994618.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000259667.6/
                                                  ENSP00000259667.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BI759951.1         4-12
            10-641              BM764627.1         10-641
            642-649             BC047737.2         621-628
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..649
                     /gene="HINT2"
                     /gene_synonym="HIT-17"
                     /note="histidine triad nucleotide binding protein 2"
                     /db_xref="GeneID:84681"
                     /db_xref="HGNC:HGNC:18344"
                     /db_xref="MIM:609997"
     exon            1..144
                     /gene="HINT2"
                     /gene_synonym="HIT-17"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..555
                     /gene="HINT2"
                     /gene_synonym="HIT-17"
                     /note="PKCI-1-related HIT protein; histidine triad
                     nucleotide-binding protein 2, mitochondrial; protein
                     kinase C inhibitor-2; HINT-2; HINT-3; HIT-17kDa; adenosine
                     5'-monophosphoramidase HINT2"
                     /codon_start=1
                     /product="adenosine 5'-monophosphoramidase HINT2
                     precursor"
                     /protein_id="NP_115982.1"
                     /db_xref="CCDS:CCDS6594.1"
                     /db_xref="GeneID:84681"
                     /db_xref="HGNC:HGNC:18344"
                     /db_xref="MIM:609997"
                     /translation="MAAAVVLAAGLRAARRAVAATGVRGGQVRGAAGVTDGNEVAKAQ
                     QATPGGAAPTIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQ
                     AEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQW
                     PPG"
     exon            145..285
                     /gene="HINT2"
                     /gene_synonym="HIT-17"
                     /inference="alignment:Splign:2.1.0"
     exon            286..390
                     /gene="HINT2"
                     /gene_synonym="HIT-17"
                     /inference="alignment:Splign:2.1.0"
     exon            391..463
                     /gene="HINT2"
                     /gene_synonym="HIT-17"
                     /inference="alignment:Splign:2.1.0"
     exon            464..649
                     /gene="HINT2"
                     /gene_synonym="HIT-17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      629..634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HINT2"
                     /gene_synonym="HIT-17"
                     /note="hexamer: AATAAA"
     polyA_site      649
                     /gene="HINT2"
                     /gene_synonym="HIT-17"
                     /note="major polyA site"
ORIGIN      
        1 acccacggcc ggccgcggag ccgagtgctg acccgggtga gaggttcccg cggctcaggg
       61 aagatggcgg cagccgtggt gctggctgct gggttgcgcg cggcgcgcag agccgtggcg
      121 gccacggggg tgcgcggggg gcaggtccga ggagctgcag gtgtgactga tgggaatgaa
      181 gtggccaagg cccagcaggc aactcctggg ggagcagccc caaccatctt ctcccggatc
      241 ctggacaaga gcctcccagc tgacattctc tatgaggacc agcagtgtct tgtgttccgt
      301 gatgtggccc ctcaggctcc tgtgcacttc ctggtcattc ctaagaagcc cattcctcgg
      361 attagccagg ctgaagaaga agaccagcag cttctaggac acctactcct tgtggccaag
      421 cagacagcaa aggctgaggg cctgggagat ggataccgac ttgtgatcaa cgatgggaag
      481 ctgggtgcac aatctgtgta tcatctgcac attcatgtac ttgggggccg gcagctccag
      541 tggcctccag gttgaacctg ccaactgatt aaaggacacc agactctgga tgcttggatg
      601 gaaagggaaa aatggaccct gtgatgctaa taaaactgtt ctcccttaa
//
