LOCUS       NM_005340                852 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens histidine triad nucleotide binding protein 1 (HINT1),
            transcript variant 1, mRNA.
ACCESSION   NM_005340
VERSION     NM_005340.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 852)
  AUTHORS   Suchanecka,A., Boron,A., Chmielowiec,K., Stronska-Pluta,A.,
            Masiak,J., Lachowicz,M., Chmielowiec,J., Trybek,G. and Grzywacz,A.
  TITLE     HINT1 Gene Polymorphisms, Smoking Behaviour, and Personality
            Traits: A Haplotype Case-Control Study
  JOURNAL   Int J Mol Sci 25 (14), 7657 (2024)
   PUBMED   39062900
  REMARK    GeneRIF: HINT1 Gene Polymorphisms, Smoking Behaviour, and
            Personality Traits: A Haplotype Case-Control Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 852)
  AUTHORS   Suchanecka,A., Boron,A., Chmielowiec,K., Stronska-Pluta,A.,
            Masiak,J., Lachowicz,M., Chmielowiec,J., Janiszewska-Olszowska,J.
            and Grzywacz,A.
  TITLE     The HINT1 Gene rs2526303 Polymorphism and Its Association with
            Personality Traits in Cigarette Smokers
  JOURNAL   Int J Mol Sci 25 (2), 1218 (2024)
   PUBMED   38279213
  REMARK    GeneRIF: The HINT1 Gene rs2526303 Polymorphism and Its Association
            with Personality Traits in Cigarette Smokers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 852)
  AUTHORS   Suchanecka,A., Boron,A., Chmielowiec,K., Stronska-Pluta,A.,
            Masiak,J., Lachowicz,M., Chmielowiec,J. and Grzywacz,A.
  TITLE     Association of the rs3864283 Polymorphism Located in the HINT1 Gene
            with Cigarette Use and Personality Traits
  JOURNAL   Int J Mol Sci 24 (12), 10244 (2023)
   PUBMED   37373392
  REMARK    GeneRIF: Association of the rs3864283 Polymorphism Located in the
            HINT1 Gene with Cigarette Use and Personality Traits.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 852)
  AUTHORS   Malcorps,M., Amor-Barris,S., Burnyte,B., Vilimiene,R.,
            Armirola-Ricaurte,C., Grigalioniene,K., Ekshteyn,A., Morkuniene,A.,
            Vaitkevicius,A., De Vriendt,E., Baets,J., Scherer,S.S.,
            Ambrozaityte,L., Utkus,A., Jordanova,A. and Peeters,K.
  TITLE     HINT1 neuropathy in Lithuania: clinical, genetic, and functional
            profiling
  JOURNAL   Orphanet J Rare Dis 17 (1), 374 (2022)
   PUBMED   36242072
  REMARK    GeneRIF: HINT1 neuropathy in Lithuania: clinical, genetic, and
            functional profiling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 852)
  AUTHORS   Zhang,C., Bao,T., Ke,Y., Liu,X., Wang,X., Liao,W., He,Y. and
            Wang,L.
  TITLE     Integrated analysis of ceRNA network reveals potential prognostic
            Hint1-related lncRNAs involved in hepatocellular carcinoma
            progression
  JOURNAL   World J Surg Oncol 20 (1), 67 (2022)
   PUBMED   35241097
  REMARK    GeneRIF: Integrated analysis of ceRNA network reveals potential
            prognostic Hint1-related lncRNAs involved in hepatocellular
            carcinoma progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 852)
  AUTHORS   Klein,M.G., Yao,Y., Slosberg,E.D., Lima,C.D., Doki,Y. and
            Weinstein,I.B.
  TITLE     Characterization of PKCI and comparative studies with FHIT, related
            members of the HIT protein family
  JOURNAL   Exp Cell Res 244 (1), 26-32 (1998)
   PUBMED   9770345
REFERENCE   7  (bases 1 to 852)
  AUTHORS   Lima,C.D., Klein,M.G. and Hendrickson,W.A.
  TITLE     Structure-based analysis of catalysis and substrate definition in
            the HIT protein family
  JOURNAL   Science 278 (5336), 286-290 (1997)
   PUBMED   9323207
REFERENCE   8  (bases 1 to 852)
  AUTHORS   Brzoska,P.M., Chen,H., Levin,N.A., Kuo,W.L., Collins,C., Fu,K.K.,
            Gray,J.W. and Christman,M.F.
  TITLE     Cloning, mapping, and in vivo localization of a human member of the
            PKCI-1 protein family (PRKCNH1)
  JOURNAL   Genomics 36 (1), 151-156 (1996)
   PUBMED   8812426
REFERENCE   9  (bases 1 to 852)
  AUTHORS   Lima,C.D., Klein,M.G., Weinstein,I.B. and Hendrickson,W.A.
  TITLE     Three-dimensional structure of human protein kinase C interacting
            protein 1, a member of the HIT family of proteins
  JOURNAL   Proc Natl Acad Sci U S A 93 (11), 5357-5362 (1996)
   PUBMED   8643579
REFERENCE   10 (bases 1 to 852)
  AUTHORS   Brzoska,P.M., Chen,H., Zhu,Y., Levin,N.A., Disatnik,M.H.,
            Mochly-Rosen,D., Murnane,J.P. and Christman,M.F.
  TITLE     The product of the ataxia-telangiectasia group D complementing
            gene, ATDC, interacts with a protein kinase C substrate and
            inhibitor
  JOURNAL   Proc Natl Acad Sci U S A 92 (17), 7824-7828 (1995)
   PUBMED   7644499
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007090.1, AA076103.1 and
            AC004650.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005340.6.
            
            Summary: This gene encodes a protein that hydrolyzes purine
            nucleotide phosphoramidates substrates, including AMP-morpholidate,
            AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester,
            and AMP-NH2. The encoded protein interacts with these substrates
            via a histidine triad motif. This gene is considered a tumor
            suppressor gene. In addition, mutations in this gene can cause
            autosomal recessive neuromyotonia and axonal neuropathy. There are
            several related pseudogenes on chromosome 7. Several transcript
            variants have been observed. [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.404584.1,
                                           SRR1163658.189956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000304043.10/
                                                  ENSP00000304229.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-588               BC007090.1         45-632
            589-596             AA076103.1         212-219
            597-852             AC004650.1         44058-44313         c
FEATURES             Location/Qualifiers
     source          1..852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.3"
     gene            1..852
                     /gene="HINT1"
                     /gene_synonym="HINT; NMAN; PKCI-1; PRKCNH1"
                     /note="histidine triad nucleotide binding protein 1"
                     /db_xref="GeneID:3094"
                     /db_xref="HGNC:HGNC:4912"
                     /db_xref="MIM:601314"
     exon            1..162
                     /gene="HINT1"
                     /gene_synonym="HINT; NMAN; PKCI-1; PRKCNH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..432
                     /gene="HINT1"
                     /gene_synonym="HINT; NMAN; PKCI-1; PRKCNH1"
                     /note="epididymis secretory sperm binding protein; protein
                     kinase C inhibitor 1; adenosine 5'-monophosphoramidase;
                     protein kinase C-interacting protein 1; desumoylating
                     isopeptidase HINT1"
                     /codon_start=1
                     /product="adenosine 5'-monophosphoramidase HINT1"
                     /protein_id="NP_005331.1"
                     /db_xref="CCDS:CCDS4147.1"
                     /db_xref="GeneID:3094"
                     /db_xref="HGNC:HGNC:4912"
                     /db_xref="MIM:601314"
                     /translation="MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDI
                     SPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGS
                     DGGQSVYHVHLHVLGGRQMHWPPG"
     exon            163..267
                     /gene="HINT1"
                     /gene_synonym="HINT; NMAN; PKCI-1; PRKCNH1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..852
                     /gene="HINT1"
                     /gene_synonym="HINT; NMAN; PKCI-1; PRKCNH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      564..569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HINT1"
                     /gene_synonym="HINT; NMAN; PKCI-1; PRKCNH1"
                     /note="hexamer: AATAAA"
     polyA_site      587
                     /gene="HINT1"
                     /gene_synonym="HINT; NMAN; PKCI-1; PRKCNH1"
                     /note="major polyA site"
ORIGIN      
        1 ctcccttctt ccgagcctct cctctggccg ccgcgcggga gagaggccga gatggcagat
       61 gagattgcca aggctcaggt cgctcggcct ggtggcgaca cgatctttgg gaagatcatc
      121 cgcaaggaaa taccagccaa aatcattttt gaggatgacc ggtgccttgc tttccatgac
      181 atttcccctc aagcaccaac acattttctg gtgataccca agaaacatat atcccagatt
      241 tctgtggcag aagatgatga tgaaagtctt cttggacact taatgattgt tggcaagaaa
      301 tgtgctgctg atctgggcct gaataagggt tatcgaatgg tggtgaatga aggttcagat
      361 ggtggacagt ctgtctatca cgttcatctc catgttcttg gaggtcggca aatgcattgg
      421 cctcctggtt aagcacgttt tggggataat tttctcttct ttaggcaatg attaagttag
      481 gcaatttcca gtatgttaag taacacactt atttttgcct gtgtatggag agattcaaga
      541 aataatttta aaaccgcata cataataaaa gacattgttg catggcttat agtctctctg
      601 agtgttgcgt ttgatttgtt attttaaaaa catatttgtt ggaatatgtg aaggtgggtt
      661 tataattttg gatgtttctt gctttttctt cccaaggagg actcaacata tgaacatcgc
      721 attgttttaa tggtgttact agtctttgaa gacaaataat gagagtttat aaatttagct
      781 ttaacttcga aatatctttc caggctaaaa taggtccaac ttagattttt aagctaattc
      841 tcacattttc ta
//
