LOCUS       NM_198971               3185 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens histone H4 transcription factor (HINFP), transcript
            variant 2, mRNA.
ACCESSION   NM_198971
VERSION     NM_198971.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3185)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3185)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   3  (bases 1 to 3185)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3185)
  AUTHORS   Mitra,P., Ghule,P.N., van der Deen,M., Medina,R., Xie,R.L.,
            Holmes,W.F., Ye,X., Nakayama,K.I., Harper,J.W., Stein,J.L.,
            Stein,G.S. and van Wijnen,A.J.
  TITLE     CDK inhibitors selectively diminish cell cycle controlled
            activation of the histone H4 gene promoter by p220NPAT and HiNF-P
  JOURNAL   J Cell Physiol 219 (2), 438-448 (2009)
   PUBMED   19170105
  REMARK    GeneRIF: Results suggest that cyclin-dependent kinase inhibitors
            selectively control stimulation of the histone H4 gene promoter by
            the p220(NPAT)/HiNF-P complex.
REFERENCE   5  (bases 1 to 3185)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 3185)
  AUTHORS   Sekimata,M. and Homma,Y.
  TITLE     Regulation of Rb gene expression by an MBD2-interacting zinc finger
            protein MIZF during myogenic differentiation
  JOURNAL   Biochem Biophys Res Commun 325 (3), 653-659 (2004)
   PUBMED   15541338
  REMARK    GeneRIF: These results suggest that transcriptional repression of
            Rb by MIZF could be one of the critical determinants in myogenic
            differentiation.
REFERENCE   7  (bases 1 to 3185)
  AUTHORS   Sekimata,M. and Homma,Y.
  TITLE     Sequence-specific transcriptional repression by an MBD2-interacting
            zinc finger protein MIZF
  JOURNAL   Nucleic Acids Res 32 (2), 590-597 (2004)
   PUBMED   14752047
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3185)
  AUTHORS   Mitra,P., Xie,R.L., Medina,R., Hovhannisyan,H., Zaidi,S.K., Wei,Y.,
            Harper,J.W., Stein,J.L., van Wijnen,A.J. and Stein,G.S.
  TITLE     Identification of HiNF-P, a key activator of cell cycle-controlled
            histone H4 genes at the onset of S phase
  JOURNAL   Mol Cell Biol 23 (22), 8110-8123 (2003)
   PUBMED   14585971
  REMARK    GeneRIF: purified and functionally characterized the critical
            transcription factor HiNF-P, which is required for E2F-independent
            activation of the histone H4 multigene family
REFERENCE   9  (bases 1 to 3185)
  AUTHORS   Sekimata,M., Takahashi,A., Murakami-Sekimata,A. and Homma,Y.
  TITLE     Involvement of a novel zinc finger protein, MIZF, in
            transcriptional repression by interacting with a methyl-CpG-binding
            protein, MBD2
  JOURNAL   J Biol Chem 276 (46), 42632-42638 (2001)
   PUBMED   11553631
REFERENCE   10 (bases 1 to 3185)
  AUTHORS   Aziz,F., van Wijnen,A.J., Vaughan,P.S., Wu,S., Shakoori,A.R.,
            Lian,J.B., Soprano,K.J., Stein,J.L. and Stein,G.S.
  TITLE     The integrated activities of IRF-2 (HiNF-M), CDP/cut (HiNF-D) and
            H4TF-2 (HiNF-P) regulate transcription of a cell cycle controlled
            human histone H4 gene: mechanistic differences between distinct H4
            genes
  JOURNAL   Mol Biol Rep 25 (1), 1-12 (1998)
   PUBMED   9540062
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003391.1 and AP002956.1.
            
            On May 17, 2019 this sequence version replaced NM_198971.2.
            
            Summary: This gene encodes a transcription factor that interacts
            with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1
            histone deacetylase (HDAC) complex, and plays a role in DNA
            methylation and transcription repression. Alternatively spliced
            transcript variants have been found for this gene.[provided by
            RefSeq, Aug 2011].
            
            Transcript Variant: This variant (2), as well as variants 1, 5, 6,
            and 7, encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.240518.1,
                                           SRR1660805.257060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000350777.7/ ENSP00000318085.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AP003391.1         36352-36411
            61-251              AP003391.1         41707-41897
            252-256             AP003391.1         45497-45501
            257-481             AP002956.1         1-225
            482-593             AP002956.1         806-917
            594-746             AP002956.1         1101-1253
            747-824             AP002956.1         1767-1844
            825-945             AP002956.1         1932-2052
            946-1084            AP002956.1         2135-2273
            1085-1209           AP002956.1         2366-2490
            1210-3185           AP002956.1         3355-5330
FEATURES             Location/Qualifiers
     source          1..3185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..3185
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /note="histone H4 transcription factor"
                     /db_xref="GeneID:25988"
                     /db_xref="HGNC:HGNC:17850"
                     /db_xref="MIM:607099"
     exon            1..60
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /inference="alignment:Splign:2.1.0"
     exon            61..251
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1624
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /note="isoform 1 is encoded by transcript variant 2; MBD2
                     (methyl-CpG-binding protein)-interacting zinc finger
                     protein; MBD2-interacting zinc finger 1; histone nuclear
                     factor P; histone H4 gene-specific protein HiNF-P;
                     MBD2-interacting zinc finger protein; methyl-CpG-binding
                     protein 2-interacting zinc finger protein"
                     /codon_start=1
                     /product="histone H4 transcription factor isoform 1"
                     /protein_id="NP_945322.1"
                     /db_xref="CCDS:CCDS8414.1"
                     /db_xref="GeneID:25988"
                     /db_xref="HGNC:HGNC:17850"
                     /db_xref="MIM:607099"
                     /translation="MPPPGKVPRKENLWLQCEWGSCSFVCSTMEKFFEHVTQHLQQHL
                     HGSGEEEEEEEEDDPLEEEFSCLWQECGFCSLDSSADLIRHVYFHCYHTKLKQWGLQA
                     LQSQADLGPCILDFQSRNVIPDIPDHFLCLWEHCENSFDNPEWFYRHVEAHSLCCEYE
                     AVGKDNPVVLCGWKGCTCTFKDRSKLREHLRSHTQEKVVACPTCGGMFANNTKFLDHI
                     RRQTSLDQQHFQCSHCSKRFATERLLRDHMRNHVNHYKCPLCDMTCPLPSSLRNHMRF
                     RHSEDRPFKCDCCDYSCKNLIDLQKHLDTHSEEPAYRCDFENCTFSARSLCSIKSHYR
                     KVHEGDSEPRYKCHVCDKCFTRGNNLTVHLRKKHQFKWPSGHPRFRYKEHEDGYMRLQ
                     LVRYESVELTQQLLRQPQEGSGLGTSLNESSLQGIILETVPGEPGRKEEEEEGKGSEG
                     TALSASQDNPSSVIHVVNQTNAQGQQEIVYYVLSEAPGEPPPAPEPPSGGIMEKLQGI
                     AEEPEIQMV"
     exon            252..481
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /inference="alignment:Splign:2.1.0"
     exon            482..593
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /inference="alignment:Splign:2.1.0"
     exon            594..746
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /inference="alignment:Splign:2.1.0"
     exon            747..824
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /inference="alignment:Splign:2.1.0"
     exon            825..945
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1084
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1209
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..3185
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2162..2167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /note="hexamer: AATAAA"
     polyA_site      2181
                     /gene="HINFP"
                     /gene_synonym="HiNF-P; MIZF; ZNF743"
                     /note="major polyA site"
ORIGIN      
        1 gcctctccgg agatggtctg aggtgggaga agagctgaag agacctggag ccgacagacg
       61 ggtgaaggcc atgccgcctc ctgggaaagt tccccgaaag gagaatctgt ggctacagtg
      121 tgagtggggg tcctgctcct ttgtgtgctc aaccatggaa aagttctttg agcatgtcac
      181 tcagcacctg cagcagcacc tgcatggctc tggggaggag gaggaagagg aagaggagga
      241 tgacccactt gaggaagaat tctcctgctt gtggcaggaa tgtggctttt gttctctgga
      301 cagttctgct gacctcatcc gccatgtcta cttccactgc taccacacca agctgaaaca
      361 gtgggggctg caggccttgc aaagccaggc tgaccttggc ccctgcatcc tggacttcca
      421 gagccggaac gtcatccctg atatccctga ccacttcctg tgtctgtggg agcactgtga
      481 gaattccttc gacaatcctg agtggtttta tcggcatgtg gaagcacaca gtctgtgctg
      541 tgaatacgaa gcagtcggca aggacaaccc ggtggtgctg tgtggctgga aaggctgtac
      601 ctgcaccttc aaggaccgca gtaaacttcg agagcacctc cgcagccata cccaggagaa
      661 agtggtagcc tgccccacct gtgggggcat gtttgccaac aataccaagt tcttagatca
      721 catccgtcgc cagacctcat tggatcagca gcacttccag tgttctcact gttccaagag
      781 atttgccaca gagcggctat tgcgggacca catgcgcaac catgtgaatc actataagtg
      841 ccctctgtgt gacatgacct gcccgctgcc ttcctccctc cgcaaccaca tgcgctttcg
      901 tcacagtgag gaccggccct ttaaatgtga ctgttgtgac tacagctgca agaatcttat
      961 tgacctccag aagcacctgg atacccacag cgaggagcca gcctacaggt gtgattttga
     1021 gaactgcacc ttcagtgccc gatccctctg ctctatcaag tcccattacc gcaaagtaca
     1081 tgaaggagac tctgagccaa ggtacaaatg tcatgtgtgt gacaaatgct tcacacgggg
     1141 caacaacctc accgtgcacc ttcgcaagaa gcaccagttc aagtggccct cagggcatcc
     1201 ccgttttcgg tacaaggaac atgaagatgg ctatatgcgg ctgcagctgg ttcgctacga
     1261 gagtgtagag ctgacacagc aactgctgcg gcaaccacaa gagggatcgg gcctgggaac
     1321 gtcgctgaac gagagcagcc tgcagggcat tattctagaa acagtgccag gggagccagg
     1381 acgtaaggaa gaggaagagg agggcaaggg tagcgaaggg acagccctct cagcctctca
     1441 ggacaacccc agttctgtca tccacgtggt gaatcagacc aatgcccaag gccagcaaga
     1501 gatcgtctac tatgtgctgt ctgaagcccc aggggagcct cccccagccc ctgagccacc
     1561 ttcagggggc atcatggaaa agcttcaagg aatagctgag gagccagaga tccagatggt
     1621 ttgaaggccg cagagccaga ccatttcttc cccaggtcct gaagtttgag ccaggcaagt
     1681 ggcagtgccc ctagtgggca gccgttgcca atggatgcct ttaggagtgg tgccgagagc
     1741 agtgtggtcc actctggcct gggtttgcat cattctgcag actctaaaga cttccctttt
     1801 ctgccagact acattttgtg gggagcctga ggactctgga ttctttgagg ggatcctgga
     1861 tgtgtgtgtt cttgttaaag aggctgttat caggcttaac cataaccctc aagatctgct
     1921 tgacagtgat taaatcctta gctcacatcc attcccatct ttcgggctcc ttaggcccaa
     1981 ggatggcatg tgactggtcc ctgcaagggt cctttctttg tcaccagcca aggcattgat
     2041 aaccaagtag ccattttcct cttaaggttt cctctacaac cccaaggact ttcatgatta
     2101 tcctcaggga caggattgga ggcattgagc gtgtttatta acaaattgtt tttggtaata
     2161 aaataaatgc ttggactctt atttatttct tcttacattt ggtggcagtt tactaggtaa
     2221 tgaggagata cagccaccca gaagaggagc tgaatagtta ggcttgttcc ccttctggtg
     2281 actcaggtgg tttgtttttt gtttgcttaa ctgtcctgtt gtcttctcct cctccccttg
     2341 gtgaaacttc gctattctca gagcgtatgc catttccatg gaggtcccag gtgtttggct
     2401 gtgagtgggc agtagtggtg ctatagaatg aacaagaatg ggctcactgg gaggataggg
     2461 cagctgacca tggcctcact ctgaatactg attagaaccc agtgcctcta gggtaggggt
     2521 tctttacctg ggagtgggaa ggaagctggg gggtggagag gattgggaag cctcccaggg
     2581 aagggaggca atcaagtggt ccaggaacca aactagaaaa ttgtgtgtct gaatgtgcat
     2641 tttcctgggg aaaggatctg ttttttgcta gattatcaaa gagattgaaa cctcccaaaa
     2701 taagaatcat catttcgtct ggttcagctg cttctcagca ccctgtgtcc atttttatgg
     2761 tctactgcta tgctggagag gtcaaggaaa tagtcttggg gacaggaagc tgcccaaaaa
     2821 ggatctctgg gccttttttt gtaagaccta attctattac tagaaaaact aaggctgaat
     2881 gcagtggttc acgcctgtaa tcccaacact ttgggaggct gaggcgggcg gatcacaagg
     2941 tcaagagatg gagaccatcc tggccaacat ggtgaaaccc cgtctctact aaaaatataa
     3001 aaatcagctg ggcatggtgg cacacatctg tagtcccagc tactcgggag gctgaggcag
     3061 gagaattgct tgaacccggg aggctgaggt tgcagtgagc cgagatcatg ccactgcact
     3121 ccagcctggc gacacagtga gactccgtct caaataaata aataaataaa gaaagaaaag
     3181 aaaaa
//
