LOCUS       NM_013332               1364 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens hypoxia inducible lipid droplet associated (HILPDA),
            transcript variant 1, mRNA.
ACCESSION   NM_013332
VERSION     NM_013332.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1364)
  AUTHORS   Ren,R., Wang,H., Xu,Y., Wu,J., Ma,D. and Guan,W.
  TITLE     FOXS1 acts as an oncogene and induces EMT through FAK/PI3K/AKT
            pathway by upregulating HILPDA in prostate cancer
  JOURNAL   FASEB J 38 (10), e23698 (2024)
   PUBMED   38780613
  REMARK    GeneRIF: FOXS1 acts as an oncogene and induces EMT through
            FAK/PI3K/AKT pathway by upregulating HILPDA in prostate cancer.
REFERENCE   2  (bases 1 to 1364)
  AUTHORS   Sainero-Alcolado,L., Garde-Lapido,E., Snaebjornsson,M.T.,
            Schoch,S., Stevens,I., Ruiz-Perez,M.V., Dyrager,C., Pelechano,V.,
            Axelson,H., Schulze,A. and Arsenian-Henriksson,M.
  TITLE     Targeting MYC induces lipid droplet accumulation by upregulation of
            HILPDA in clear cell renal cell carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 121 (7), e2310479121 (2024)
   PUBMED   38335255
  REMARK    GeneRIF: Targeting MYC induces lipid droplet accumulation by
            upregulation of HILPDA in clear cell renal cell carcinoma.
REFERENCE   3  (bases 1 to 1364)
  AUTHORS   Zhang,Y., Pang,C., Zhang,C., Wang,Y., Wang,P., Chen,Y., Wang,J.,
            Hu,Y., Liu,C., Liang,H., Xie,G. and Ou,J.
  TITLE     HILPDA-mediated lipidomic remodelling promotes radiotherapy
            resistance in nasopharyngeal carcinoma by accelerating mitophagy
  JOURNAL   Cell Mol Life Sci 80 (9), 242 (2023)
   PUBMED   37552373
  REMARK    GeneRIF: HILPDA-mediated lipidomic remodelling promotes
            radiotherapy resistance in nasopharyngeal carcinoma by accelerating
            mitophagy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1364)
  AUTHORS   Povero,D., Chen,Y., Johnson,S.M., McMahon,C.E., Pan,M., Bao,H.,
            Petterson,X.T., Blake,E., Lauer,K.P., O'Brien,D.R., Yu,Y.,
            Graham,R.P., Taner,T., Han,X., Razidlo,G.L. and Liu,J.
  TITLE     HILPDA promotes NASH-driven HCC development by restraining
            intracellular fatty acid flux in hypoxia
  JOURNAL   J Hepatol 79 (2), 378-393 (2023)
   PUBMED   37061197
  REMARK    GeneRIF: HILPDA promotes NASH-driven HCC development by restraining
            intracellular fatty acid flux in hypoxia.
REFERENCE   5  (bases 1 to 1364)
  AUTHORS   Liu,L., Liu,T., Jia,R., Zhang,L., Lv,Z., He,Z., Qu,Y., Sun,S. and
            Tai,F.
  TITLE     Downregulation of fatty acid oxidation led by Hilpda increases G2/M
            arrest/delay-induced kidney fibrosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (5), 166701 (2023)
   PUBMED   36990128
  REMARK    GeneRIF: Downregulation of fatty acid oxidation led by Hilpda
            increases G2/M arrest/delay-induced kidney fibrosis.
REFERENCE   6  (bases 1 to 1364)
  AUTHORS   Nishimura,S., Tsuda,H., Ito,K., Takano,M., Terai,Y., Jobo,T.,
            Kigawa,J., Sugiyama,T., Yaegashi,N. and Aoki,D.
  TITLE     Differential expression of hypoxia-inducible protein 2 among
            different histological types of epithelial ovarian cancer and in
            clear cell adenocarcinomas
  JOURNAL   Int J Gynecol Cancer 20 (2), 220-226 (2010)
   PUBMED   20134266
  REMARK    GeneRIF: may be used as a marker for early detection of ovarian
            clear cell adenocarcinoma
REFERENCE   7  (bases 1 to 1364)
  AUTHORS   Konda,R., Sugimura,J., Sohma,F., Katagiri,T., Nakamura,Y. and
            Fujioka,T.
  TITLE     Over expression of hypoxia-inducible protein 2, hypoxia-inducible
            factor-1alpha and nuclear factor kappaB is putatively involved in
            acquired renal cyst formation and subsequent tumor transformation
            in patients with end stage renal failure
  JOURNAL   J Urol 180 (2), 481-485 (2008)
   PUBMED   18550099
REFERENCE   8  (bases 1 to 1364)
  AUTHORS   Togashi,A., Katagiri,T., Ashida,S., Fujioka,T., Maruyama,O.,
            Wakumoto,Y., Sakamoto,Y., Fujime,M., Kawachi,Y., Shuin,T. and
            Nakamura,Y.
  TITLE     Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for
            renal cell carcinoma and potential target for molecular therapy
  JOURNAL   Cancer Res 65 (11), 4817-4826 (2005)
   PUBMED   15930302
REFERENCE   9  (bases 1 to 1364)
  AUTHORS   Kenny,P.A., Enver,T. and Ashworth,A.
  TITLE     Receptor and secreted targets of Wnt-1/beta-catenin signalling in
            mouse mammary epithelial cells
  JOURNAL   BMC Cancer 5, 3 (2005)
   PUBMED   15642117
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1364)
  AUTHORS   Denko,N., Schindler,C., Koong,A., Laderoute,K., Green,C. and
            Giaccia,A.
  TITLE     Epigenetic regulation of gene expression in cervical cancer cells
            by the tumor microenvironment
  JOURNAL   Clin Cancer Res 6 (2), 480-487 (2000)
   PUBMED   10690527
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD686848.1, BC001863.1, AF144755.1 and BC008573.1.
            
            On Nov 22, 2018 this sequence version replaced NM_013332.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.100004.1,
                                           SRR1660805.143322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257696.5/ ENSP00000257696.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                CD686848.1         81-107
            28-865              BC001863.1         1-838
            866-1362            AF144755.1         858-1354
            1363-1364           BC008573.1         1369-1370
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q32.1"
     gene            1..1364
                     /gene="HILPDA"
                     /gene_synonym="C7orf68; HIG-2; HIG2"
                     /note="hypoxia inducible lipid droplet associated"
                     /db_xref="GeneID:29923"
                     /db_xref="HGNC:HGNC:28859"
                     /db_xref="MIM:617905"
     exon            1..146
                     /gene="HILPDA"
                     /gene_synonym="C7orf68; HIG-2; HIG2"
                     /inference="alignment:Splign:2.1.0"
     exon            147..1364
                     /gene="HILPDA"
                     /gene_synonym="C7orf68; HIG-2; HIG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..406
                     /gene="HILPDA"
                     /gene_synonym="C7orf68; HIG-2; HIG2"
                     /note="hypoxia inducible gene 2; hypoxia-inducible protein
                     2; hypoxia-inducible gene 2 protein"
                     /codon_start=1
                     /product="hypoxia-inducible lipid droplet-associated
                     protein"
                     /protein_id="NP_037464.1"
                     /db_xref="CCDS:CCDS5802.1"
                     /db_xref="GeneID:29923"
                     /db_xref="HGNC:HGNC:28859"
                     /db_xref="MIM:617905"
                     /translation="MKHVLNLYLLGVVLTLLSIFVRVMESLEGLLESPSPGTSWTTRS
                     QLANTEPTKGLPDHPSRSM"
     regulatory      1341..1346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HILPDA"
                     /gene_synonym="C7orf68; HIG-2; HIG2"
                     /note="hexamer: AATAAA"
     polyA_site      1364
                     /gene="HILPDA"
                     /gene_synonym="C7orf68; HIG-2; HIG2"
                     /note="major polyA site"
ORIGIN      
        1 gcgctctgcg gctgacggcg cttttgtctc cggtgagttt tgtggcggga agcttctgcg
       61 ctggtgctta gtaaccgact ttcctccgga ctcctgcacg acctgctcct acagccggcg
      121 atccactccc ggctgttccc ccggagggtc cagaggcctt tcagaaggag aaggcagctc
      181 tgtttctctg cagaggagta gggtcctttc agccatgaag catgtgttga acctctacct
      241 gttaggtgtg gtactgaccc tactctccat cttcgttaga gtgatggagt ccctagaggg
      301 cttactagag agcccatcgc ctgggacctc ctggaccacc agaagccaac tagccaacac
      361 agagcccacc aagggccttc cagaccatcc atccagaagc atgtgataag acctccttcc
      421 atactggcca tattttggaa cactgaccta gacatgtcca gatgggagtc ccattcctag
      481 cagacaagct gagcaccgtt gtaaccagag aactattact aggccttgaa gaacctgtct
      541 aactggatgc tcattgcctg ggcaaggcct gtttaggccg gttgcggtgg ctcatgcctg
      601 taatcctagc actttgggag gctgaggtgg gtggatcacc tgaggtcagg agttcgagac
      661 cagcctcgcc aacatggcga aaccccatct ctactaaaaa tacaaaagtt agctgggtgt
      721 ggtggcagag gcctgtaatc ccagctcctt gggaggctga ggcgggagaa ttgcttgaac
      781 ccggggacgg aggttgcagt gagccgagat cgcactgctg tacccagcct gggccacagt
      841 gcaagactcc atctcaaaaa aaaaagaaaa gaaaaagcct gtttaatgca caggtgtgag
      901 tggattgctt atggctatga gataggttga tctcgccctt accccggggt ctggtgtatg
      961 ctgtgctttc ctcagcagta tggctctgac atctcttaga tgtcccaact tcagctgttg
     1021 ggagatggtg atattttcaa ccctacttcc taaacatctg tctggggttc ctttagtctt
     1081 gaatgtctta tgctcaatta tttggtgttg agcctctctt ccacaagagc tcctccatgt
     1141 ttggatagca gttgaagagg ttgtgtgggt gggctgttgg gagtgaggat ggagtgttca
     1201 gtgcccattt ctcattttac attttaaagt cgttcctcca acatagtgtg tattggtctg
     1261 aagggggtgg tgggatgcca aagcctgctc aagttatgga cattgtggcc accatgtggc
     1321 ttaaatgatt ttttctaact aataaagtgg aatatatatt tcta
//
