LOCUS       NM_001350932            1134 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens HIG1 hypoxia inducible domain family member 2B
            (HIGD2B), mRNA.
ACCESSION   NM_001350932 NR_002780 XM_372578
VERSION     NM_001350932.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1134)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009712.22 and BC040890.1.
            
            On Aug 31, 2019 this sequence version replaced NM_001350932.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040890.1, BM564128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311755.6/ ENSP00000307951.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC009712.22        71684-71716         c
            34-1134             BC040890.1         1-1101
FEATURES             Location/Qualifiers
     source          1..1134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..1134
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /note="HIG1 hypoxia inducible domain family member 2B"
                     /db_xref="GeneID:123346"
                     /db_xref="HGNC:HGNC:26984"
     exon            1..365
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            366..544
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            545..1134
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             558..878
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /note="HIG1 hypoxia inducible domain family, member 2B
                     (pseudogene)"
                     /codon_start=1
                     /product="putative HIG1 domain family member 2B"
                     /protein_id="NP_001337861.1"
                     /db_xref="CCDS:CCDS86473.1"
                     /db_xref="GeneID:123346"
                     /db_xref="HGNC:HGNC:26984"
                     /translation="MATLGFVTPEAPFESSKPPIFEGLSPTVYSNPEGFKEKFLRKTR
                     ENPVVPIGFLCTAAVLTNGLYCFHQGNSQCSRLMMHTQIAAQGFTIAAILLGLAATAM
                     KSPP"
     regulatory      1109..1114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /note="hexamer: AATAAA"
     polyA_site      1134
                     /gene="HIGD2B"
                     /gene_synonym="HIGD2BP"
                     /note="major polyA site"
ORIGIN      
        1 agacgacgag gcaagcggaa gtcgtagggc tgtggaggac tgtgaggaag cgggggaagg
       61 aagtaaatcg ccgagtgacc taaggaatca gggggaggat tagggtctgc tccacagaag
      121 gcttacctct gaaagagtcg gggagggaat gcgcagccac tcgctgcctt tatcccgaga
      181 agcccctaac acccctcgcc gtggtctgta catggtctgt acctccggcc gcgctggctg
      241 gtaggccagc cacctgggat ggcagcctag ttctcccgcc accttaccct gccctgactc
      301 taatctgcat ttaattcagt ccttcttccg ggagatttcg gcggagaatt tctttctcgc
      361 cttagctact gaggtcaaac ctgaaatagg ctgtagactc caccagctgg gtaagaatgg
      421 gaagaagatc agaaaaccta aactttggtt gatggactat tttgcccagg caaaagcagg
      481 gaatctatga ggaatatgaa gacattcgtc gggagaactc tgttggcact ttccactgtt
      541 ccatctgtgg cctaggcatg gcgactctcg gctttgtgac tccggaggcc ccctttgaat
      601 catcgaagcc ccccatcttt gaggggctta gccccactgt ttacagcaat ccagagggtt
      661 tcaaggaaaa gttccttcgc aagacccgcg agaatccggt ggtacccata ggtttcctgt
      721 gcacggcggc cgtcctcacc aacggcctct actgcttcca ccagggcaac agccaatgtt
      781 cacggcttat gatgcacacc cagatcgccg cccagggctt caccattgca gccatcttgc
      841 tgggtctagc tgccaccgct atgaagtctc caccctgagc ccagggtctt gaaaactctg
      901 cagaaatcat tccaaaaccc aggagcaacc actggcccta ccatgggact tactctctcc
      961 tctcctttga gaggtccctg tgtcgttggg ggaggaagtg acccttcctg taaccataac
     1021 tgaaagattt tttcaaaaat cccagattct gttgtttgaa tgttacatat ttctatttgt
     1081 gccacatctt ccctccactc ccctgcttaa taaactctaa aaataagaaa aaag
//
