LOCUS       NM_001109619             630 bp    mRNA    linear   PRI 26-APR-2024
DEFINITION  Homo sapiens HIG1 hypoxia inducible domain family member 1C
            (HIGD1C), mRNA.
ACCESSION   NM_001109619 XM_024449121
VERSION     NM_001109619.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 630)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 630)
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study of 14,000 cases of seven common
            diseases and 3,000 shared controls
  JOURNAL   Nature 447 (7145), 661-678 (2007)
   PUBMED   17554300
REFERENCE   3  (bases 1 to 630)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   4  (bases 1 to 630)
  AUTHORS   Nielsen,R., Bustamante,C., Clark,A.G., Glanowski,S., Sackton,T.B.,
            Hubisz,M.J., Fledel-Alon,A., Tanenbaum,D.M., Civello,D.,
            White,T.J., J Sninsky,J., Adams,M.D. and Cargill,M.
  TITLE     A scan for positively selected genes in the genomes of humans and
            chimpanzees
  JOURNAL   PLoS Biol 3 (6), e170 (2005)
   PUBMED   15869325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008121.43.
            
            On Jun 24, 2021 this sequence version replaced NM_001109619.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.207528.1,
                                           SRR1803613.123406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000695931.1/
                                                  ENSP00000512274.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AC008121.43        22016-22187         c
            173-227             AC008121.43        21472-21526         c
            228-329             AC008121.43        20639-20740         c
            330-464             AC008121.43        13629-13763         c
            465-630             AC008121.43        4124-4289           c
FEATURES             Location/Qualifiers
     source          1..630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..630
                     /gene="HIGD1C"
                     /gene_synonym="GM921"
                     /note="HIG1 hypoxia inducible domain family member 1C"
                     /db_xref="GeneID:613227"
                     /db_xref="HGNC:HGNC:28044"
                     /db_xref="MIM:620803"
     exon            1..172
                     /gene="HIGD1C"
                     /gene_synonym="GM921"
                     /inference="alignment:Splign:2.1.0"
     exon            173..227
                     /gene="HIGD1C"
                     /gene_synonym="GM921"
                     /inference="alignment:Splign:2.1.0"
     exon            228..329
                     /gene="HIGD1C"
                     /gene_synonym="GM921"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..529
                     /gene="HIGD1C"
                     /gene_synonym="GM921"
                     /note="HIG1 domain family, member 1C"
                     /codon_start=1
                     /product="HIG1 domain family member 1C"
                     /protein_id="NP_001103089.1"
                     /db_xref="CCDS:CCDS44882.1"
                     /db_xref="GeneID:613227"
                     /db_xref="HGNC:HGNC:28044"
                     /db_xref="MIM:620803"
                     /translation="MSSDNQWSADEDEGQLSRLIRKSRDSPFVPIGIAGFVTVVSCGL
                     YKLKYRRDQKMSIHLIHMRVAAQGFVVGAVTLGVLYSMYKDYIRPRFFSESKK"
     exon            330..464
                     /gene="HIGD1C"
                     /gene_synonym="GM921"
                     /inference="alignment:Splign:2.1.0"
     exon            465..630
                     /gene="HIGD1C"
                     /gene_synonym="GM921"
                     /inference="alignment:Splign:2.1.0"
     regulatory      588..593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIGD1C"
                     /gene_synonym="GM921"
                     /note="hexamer: AATAAA"
     polyA_site      630
                     /gene="HIGD1C"
                     /gene_synonym="GM921"
                     /note="major polyA site"
ORIGIN      
        1 accaccgacc cacctcaaga gccacagcct ctcgggtctc cacagcccca ctcaggtctc
       61 acacacaggc gcagggacta gccacaggtg cagcaacgtc acgtctttcc cctgggcgcg
      121 tgtgcagctc gaggctttgc aggaggcgca cctgcgatgg ccttaccgcc agcctcttgc
      181 tgaaggaaca acaggagaca gacagcaggt ggcggggtgt gccacagaga aaaaaatgtc
      241 ttcagataac cagtggtcag cagatgagga tgaaggccaa ttatcccgac taatcaggaa
      301 atctagagac tccccctttg tccctatagg tatagcaggc tttgtgactg tggtgtcctg
      361 tggtctttac aagctaaagt acagaagaga tcagaaaatg tcaattcatc ttattcacat
      421 gagagttgct gcccaaggat ttgttgttgg agctgtgact ctaggtgttc tctattctat
      481 gtataaggat tacattagac cacgattctt cagtgagtcc aaaaaatgaa gcttacatgc
      541 tggaagcaag aaagacaaga agcttctgaa aactatttat tatgaagaat aaattttcaa
      601 tatgtagcaa attttactac acaagtgtca
//
