LOCUS       NM_016438                650 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens HIG1 hypoxia inducible domain family member 1B
            (HIGD1B), transcript variant 1, mRNA.
ACCESSION   NM_016438
VERSION     NM_016438.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 650)
  AUTHORS   Wang,S., Zhang,S., Li,X., Li,X., Zhao,S., Guo,J., Wang,S., Wang,R.,
            Zhang,M. and Qiu,W.
  TITLE     HIGD1B, as a novel prognostic biomarker, is involved in regulating
            the tumor microenvironment and immune cell infiltration; its
            overexpression leads to poor prognosis in gastric cancer patients
  JOURNAL   Front Immunol 15, 1415148 (2024)
   PUBMED   39108265
  REMARK    GeneRIF: HIGD1B, as a novel prognostic biomarker, is involved in
            regulating the tumor microenvironment and immune cell infiltration;
            its overexpression leads to poor prognosis in gastric cancer
            patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 650)
  AUTHORS   Chen,X., Sun,B. and Li,S.
  TITLE     Downregulation of HIGD1B induces mitochondria-mediated apoptosis in
            gastric cancer cells by inactivating Akt and ERK pathways
  JOURNAL   Drug Dev Res 85 (4), e22221 (2024)
   PUBMED   38863387
  REMARK    GeneRIF: Downregulation of HIGD1B induces mitochondria-mediated
            apoptosis in gastric cancer cells by inactivating Akt and ERK
            pathways.
REFERENCE   3  (bases 1 to 650)
  AUTHORS   Pang,Y., Zhu,Z., Wen,Z., Lu,J., Lin,H., Tang,M., Xu,Z. and Lu,J.
  TITLE     HIGD-1B inhibits hypoxia-induced mitochondrial fragmentation by
            regulating OPA1 cleavage in cardiomyocytes
  JOURNAL   Mol Med Rep 24 (2) (2021)
   PUBMED   34080026
  REMARK    GeneRIF: HIGD1B inhibits hypoxiainduced mitochondrial fragmentation
            by regulating OPA1 cleavage in cardiomyocytes.
REFERENCE   4  (bases 1 to 650)
  AUTHORS   Lindert,S., Maslennikov,I., Chiu,E.J., Pierce,L.C., McCammon,J.A.
            and Choe,S.
  TITLE     Drug screening strategy for human membrane proteins: from NMR
            protein backbone structure to in silica- and NMR-screened hits
  JOURNAL   Biochem Biophys Res Commun 445 (4), 724-733 (2014)
   PUBMED   24525125
REFERENCE   5  (bases 1 to 650)
  AUTHORS   Jiang,Z., Gui,S. and Zhang,Y.
  TITLE     Analysis of differential gene expression in plurihormonal pituitary
            adenomas using bead-based fiber-optic arrays
  JOURNAL   J Neurooncol 108 (3), 341-348 (2012)
   PUBMED   22588334
REFERENCE   6  (bases 1 to 650)
  AUTHORS   Jiang,Z., Gui,S. and Zhang,Y.
  TITLE     Analysis of differential gene expression by bead-based fiber-optic
            array in nonfunctioning pituitary adenomas
  JOURNAL   Horm Metab Res 43 (5), 325-330 (2011)
   PUBMED   21351040
REFERENCE   7  (bases 1 to 650)
  AUTHORS   Jiang,Z.Q., Gui,S.B. and Zhang,Y.Z.
  TITLE     Differential gene expression by fiber-optic beadarray and pathway
            in adrenocorticotrophin-secreting pituitary adenomas
  JOURNAL   Chin Med J (Engl) 123 (23), 3455-3461 (2010)
   PUBMED   22166531
REFERENCE   8  (bases 1 to 650)
  AUTHORS   Jiang,Z., Gui,S. and Zhang,Y.
  TITLE     Analysis of differential gene expression by bead-based fiber-optic
            array in growth-hormone-secreting pituitary adenomas
  JOURNAL   Exp Ther Med 1 (5), 905-910 (2010)
   PUBMED   22993617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015936.14, BM503772.1,
            BG573492.1, BC020667.1 and BE041447.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016438.3.
            
            Summary: This gene encodes a member of the hypoxia inducible gene 1
            (HIG1) domain family. The encoded protein is localized to the cell
            membrane and has been linked to tumorigenesis and the progression
            of pituitary adenomas. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.69857.1,
                                           SRR5189667.329235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253410.3/ ENSP00000253410.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC015936.14        22204-22222
            20-27               BM503772.1         4-11
            28-28               BG573492.1         1-1
            29-621              BC020667.1         1-593
            622-650             BE041447.1         12-40               c
FEATURES             Location/Qualifiers
     source          1..650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..650
                     /gene="HIGD1B"
                     /gene_synonym="CLST11240; CLST11240-15"
                     /note="HIG1 hypoxia inducible domain family member 1B"
                     /db_xref="GeneID:51751"
                     /db_xref="HGNC:HGNC:24318"
                     /db_xref="MIM:620420"
     exon            1..370
                     /gene="HIGD1B"
                     /gene_synonym="CLST11240; CLST11240-15"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..570
                     /gene="HIGD1B"
                     /gene_synonym="CLST11240; CLST11240-15"
                     /codon_start=1
                     /product="HIG1 domain family member 1B"
                     /protein_id="NP_057522.1"
                     /db_xref="CCDS:CCDS11488.1"
                     /db_xref="GeneID:51751"
                     /db_xref="HGNC:HGNC:24318"
                     /db_xref="MIM:620420"
                     /translation="MSANRRWWVPPDDEDCVSEKLLRKTRESPLVPIGLGGCLVVAAY
                     RIYRLRSRGSTKMSIHLIHTRVAAQACAVGAIMLGAVYTMYSDYVKRMAQDAGEK"
     exon            371..505
                     /gene="HIGD1B"
                     /gene_synonym="CLST11240; CLST11240-15"
                     /inference="alignment:Splign:2.1.0"
     exon            506..650
                     /gene="HIGD1B"
                     /gene_synonym="CLST11240; CLST11240-15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      629..634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIGD1B"
                     /gene_synonym="CLST11240; CLST11240-15"
                     /note="hexamer: AATAAA"
     polyA_site      650
                     /gene="HIGD1B"
                     /gene_synonym="CLST11240; CLST11240-15"
                     /note="major polyA site"
ORIGIN      
        1 agtgaagaca gaatgagctg gggaagaggc agatggtagg aaatggagac ggagaaatgg
       61 cactaatggc ccagccacct gagatgggat acctgggagg gacatctttt caagtagagg
      121 ctgtgttggg gcatggtgag agagggtctt agcaggtaac cttcctttcc tctccagact
      181 gaggaatcag agttctgatt gtggagtgcc tctctctagg acggggctgc agcataggag
      241 tctcagctgc ttacatccag gtccaggatt atgtctgcta acagacgctg gtgggtacca
      301 cctgacgacg aagactgtgt gtctgagaag ctcctgagga agactcggga atctccactg
      361 gtgcctatag gcttaggagg ctgcttggtg gtagcagcat acaggattta ccggctgagg
      421 tctcgtggtt ccaccaagat gtccatacac ctgattcaca cccgagtggc agcgcaggcc
      481 tgtgcagtgg gtgcaatcat gctaggtgct gtgtacacaa tgtacagcga ttacgtcaag
      541 aggatggcac aggatgctgg agagaagtag gactcctata ggagccgggg ctgtccaact
      601 cccctaactc aatccctggt acattcctaa taaagcagtt ttgaggaaaa
//
