LOCUS       NM_152795               5856 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens hypoxia inducible factor 3 subunit alpha (HIF3A),
            transcript variant 3, mRNA.
ACCESSION   NM_152795
VERSION     NM_152795.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5856)
  AUTHORS   Zarychta,J., Kowalczyk,A., Slowik,K., Przywara,D., Petniak,A.,
            Kondracka,A., Wojtowicz-Marzec,M., Slyk-Gulewska,P.,
            Kwasniewska,A., Kocki,J. and Gil-Kulik,P.
  TITLE     Pilot Study on the Effect of Patient Condition and Clinical
            Parameters on Hypoxia-Induced Factor Expression: HIF1A, EPAS1 and
            HIF3A in Human Colostrum Cells
  JOURNAL   Int J Mol Sci 25 (20), 11042 (2024)
   PUBMED   39456823
  REMARK    GeneRIF: Pilot Study on the Effect of Patient Condition and
            Clinical Parameters on Hypoxia-Induced Factor Expression: HIF1A,
            EPAS1 and HIF3A in Human Colostrum Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5856)
  AUTHORS   Kaur,L., Sundrani,D., Dave,K., Randhir,K., Mehendale,S.,
            Bayyana,S., Kalyanaraman,K., Chandak,G.R. and Joshi,S.
  TITLE     Hypoxia Inducible Factors (HIF1alpha and HIF3alpha) are
            differentially methylated in preeclampsia placentae and are
            associated with birth outcomes
  JOURNAL   Mol Cell Biochem 478 (10), 2309-2318 (2023)
   PUBMED   36708442
  REMARK    GeneRIF: Hypoxia Inducible Factors (HIF1alpha and HIF3alpha) are
            differentially methylated in preeclampsia placentae and are
            associated with birth outcomes.
REFERENCE   3  (bases 1 to 5856)
  AUTHORS   Dai,Y., Xuan,G. and Yin,M.
  TITLE     DUXAP8 Promotes LPS-Induced Cell Injury in Pulpitis by Regulating
            miR-18b-5p/HIF3A
  JOURNAL   Int Dent J 73 (5), 636-644 (2023)
   PUBMED   36522211
  REMARK    GeneRIF: DUXAP8 Promotes LPS-Induced Cell Injury in Pulpitis by
            Regulating miR-18b-5p/HIF3A.
REFERENCE   4  (bases 1 to 5856)
  AUTHORS   Gao,Q., Ren,Z., Jiao,S., Guo,J., Miao,X., Wang,J. and Liu,J.
  TITLE     HIF-3alpha-Induced miR-630 Expression Promotes Cancer Hallmarks in
            Cervical Cancer Cells by Forming a Positive Feedback Loop
  JOURNAL   J Immunol Res 2022, 5262963 (2022)
   PUBMED   36277475
  REMARK    GeneRIF: HIF-3alpha-Induced miR-630 Expression Promotes Cancer
            Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback
            Loop.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5856)
  AUTHORS   Pasanen,A., Heikkila,M., Rautavuoma,K., Hirsila,M., Kivirikko,K.I.
            and Myllyharju,J.
  TITLE     Hypoxia-inducible factor (HIF)-3alpha is subject to extensive
            alternative splicing in human tissues and cancer cells and is
            regulated by HIF-1 but not HIF-2
  JOURNAL   Int J Biochem Cell Biol 42 (7), 1189-1200 (2010)
   PUBMED   20416395
  REMARK    GeneRIF: Hypoxia upregulated transcription from all three
            alternative HIF-3alpha promoters. siRNA experiments showed that
            this induction is mediated specifically by HIF-1 and not by HIF-2.
REFERENCE   6  (bases 1 to 5856)
  AUTHORS   Li,Q.F., Wang,X.R., Yang,Y.W. and Lin,H.
  TITLE     Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha
            expression in lung epithelial cells: characterization and
            comparison with HIF-1alpha
  JOURNAL   Cell Res 16 (6), 548-558 (2006)
   PUBMED   16775626
  REMARK    GeneRIF: findings suggest that HIF-3alpha, as a member of the HIF
            system, is complementary rather than redundant to HIF-1alpha
            induction in protection against hypoxic damage in alveolar
            epithelial cells.
REFERENCE   7  (bases 1 to 5856)
  AUTHORS   Jang,M.S., Park,J.E., Lee,J.A., Park,S.G., Myung,P.K., Lee,D.H.,
            Park,B.C. and Cho,S.
  TITLE     Binding and regulation of hypoxia-inducible factor-1 by the
            inhibitory PAS proteins
  JOURNAL   Biochem Biophys Res Commun 337 (1), 209-215 (2005)
   PUBMED   16182248
  REMARK    GeneRIF: IPAS1 and IPAS2 inhibit angiogenesis by binding to and
            inhibiting HIF-1alpha and HIF-1beta.
REFERENCE   8  (bases 1 to 5856)
  AUTHORS   Maynard,M.A., Evans,A.J., Hosomi,T., Hara,S., Jewett,M.A. and
            Ohh,M.
  TITLE     Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is
            down-regulated in renal cell carcinoma
  JOURNAL   FASEB J 19 (11), 1396-1406 (2005)
   PUBMED   16126907
  REMARK    GeneRIF: The splice isoform HIF-3alpha4 inhibits transcription of
            VEGF and GLUT1 by binding to and inhibiting HIF-1alpha and
            HIF-1beta.
REFERENCE   9  (bases 1 to 5856)
  AUTHORS   Maynard,M.A., Qi,H., Chung,J., Lee,E.H., Kondo,Y., Hara,S.,
            Conaway,R.C., Conaway,J.W. and Ohh,M.
  TITLE     Multiple splice variants of the human HIF-3 alpha locus are targets
            of the von Hippel-Lindau E3 ubiquitin ligase complex
  JOURNAL   J Biol Chem 278 (13), 11032-11040 (2003)
   PUBMED   12538644
  REMARK    GeneRIF: multiple splice variants of locus are targets of the von
            Hippel-Lindau E3 ubiquitin ligase complex
REFERENCE   10 (bases 1 to 5856)
  AUTHORS   Hara,S., Hamada,J., Kobayashi,C., Kondo,Y. and Imura,N.
  TITLE     Expression and characterization of hypoxia-inducible factor
            (HIF)-3alpha in human kidney: suppression of HIF-mediated gene
            expression by HIF-3alpha
  JOURNAL   Biochem Biophys Res Commun 287 (4), 808-813 (2001)
   PUBMED   11573933
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007193.1, DR001068.1,
            BC080551.1 and BM971722.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_152795.3.
            
            Summary: The protein encoded by this gene is the alpha-3 subunit of
            one of several alpha/beta-subunit heterodimeric transcription
            factors that regulate many adaptive responses to low oxygen tension
            (hypoxia). The alpha-3 subunit lacks the transactivation domain
            found in factors containing either the alpha-1 or alpha-2 subunits.
            It is thought that factors containing the alpha-3 subunit are
            negative regulators of hypoxia-inducible gene expression. Multiple
            alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (c).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.242587.1, BC080551.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377670.9/ ENSP00000366898.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC007193.1         42256-42259
            5-33                DR001068.1         9-37
            34-886              BC080551.1         1-853
            887-887             AC007193.1         57456-57456
            888-1062            BC080551.1         855-1029
            1063-1112           AC007193.1         65659-65708
            1113-2333           BC080551.1         1080-2300
            2334-5244           AC007193.1         85125-88035
            5245-5856           BM971722.1         16-627              c
FEATURES             Location/Qualifiers
     source          1..5856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..5856
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /note="hypoxia inducible factor 3 subunit alpha"
                     /db_xref="GeneID:64344"
                     /db_xref="HGNC:HGNC:15825"
                     /db_xref="MIM:609976"
     exon            1..61
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2045
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /note="isoform c is encoded by transcript variant 3;
                     inhibitory PAS domain protein; member of PAS protein 7;
                     PAS domain-containing protein 7;
                     basic-helix-loop-helix-PAS protein MOP7; class E basic
                     helix-loop-helix protein 17; hypoxia inducible factor 3
                     alpha subunit"
                     /codon_start=1
                     /product="hypoxia-inducible factor 3-alpha isoform c"
                     /protein_id="NP_690008.2"
                     /db_xref="CCDS:CCDS12681.2"
                     /db_xref="GeneID:64344"
                     /db_xref="HGNC:HGNC:15825"
                     /db_xref="MIM:609976"
                     /translation="MALGLQRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFA
                     RGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTA
                     EGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPT
                     ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQC
                     LVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYE
                     YIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESI
                     VCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFL
                     HPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPD
                     ELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISMDDDFQLNASEQL
                     PRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRLSCSSPSRGDPSASSPMA
                     GARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLLFPLSLSFLLTGGPAPGSLQ
                     DPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGSAQAD"
     exon            62..252
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            253..398
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            399..483
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            484..596
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            597..805
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            806..912
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1060
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1179
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1370
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1475
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1747
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1865
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1947
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..5856
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5827..5832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /note="hexamer: CATAAA"
     polyA_site      5856
                     /gene="HIF3A"
                     /gene_synonym="bHLHe17; HIF-3A; HIF3-alpha-1; IPAS; MOP7;
                     PASD7"
                     /note="major polyA site"
ORIGIN      
        1 gcctccgagg gctccggagc ggcgactggc gagccatggc gctggggctg cagcgcgcaa
       61 ggtcgaccac ggagctgcgc aaggaaaagt cccgggatgc ggcccgcagc cggcgcagcc
      121 aggagaccga ggtgctgtac cagctggctc acacgctgcc cttcgcccgc ggcgtcagcg
      181 cccacctgga caaggcctct atcatgcgcc tcaccatcag ctacctgcgc atgcaccgcc
      241 tctgcgccgc aggggagtgg aaccaggtgg gagcaggggg agaaccactg gatgcctgct
      301 acctgaaggc cctggagggc ttcgtcatgg tgctcaccgc cgagggagac atggcttacc
      361 tgtcggagaa tgtcagcaaa cacctgggcc tcagtcagct ggagctcatt ggacacagca
      421 tctttgattt catccacccc tgtgaccaag aggagcttca ggacgccctg accccccagc
      481 agaccctgtc caggaggaag gtggaggccc ccacggagcg gtgcttctcc ttgcgcatga
      541 agagtacact caccagccgc gggcgcaccc tcaacctcaa ggcggccacc tggaaggtgc
      601 tgaactgctc tggacatatg agggcctaca agccacctgc gcagacttct ccagctggga
      661 gccctgactc agagcccccg ctgcagtgcc tggtgctcat ctgcgaagcc atcccccacc
      721 caggcagcct ggagccccca ctgggccgag gggccttcct cagccgccac agcctggaca
      781 tgaagttcac ctactgtgac gacaggattg cagaagtggc tggctatagt cccgatgacc
      841 tgatcggctg ttccgcctac gagtacatcc acgcgctgga ctccgatgcg gtcagcaaga
      901 gcatccacac cttgctgagc aagggccagg cagtaacagg gcagtatcgc ttcctggccc
      961 ggagtggtgg ctacctgtgg acccagaccc aggccacagt ggtgtcaggg ggacggggcc
     1021 cccagtcgga gagtatcgtc tgtgtccatt ttttaatcag ccaggtggaa gagaccggag
     1081 tggtgctgtc cctggagcaa acggagcaac actctcgcag acccattcag cggggcgccc
     1141 cctctcagaa ggacacccct aaccctgggg acagccttga cacccctggc ccccggatcc
     1201 ttgccttcct gcacccgcct tccctgagcg aggctgccct ggccgctgac ccccgccgtt
     1261 tctgcagccc tgacctccgt cgcctcctgg gacccatcct ggatggggct tcagtagcag
     1321 ccactcccag caccccgctg gccacacggc acccccaaag tcctctttcg gctgatctcc
     1381 cagatgaact acctgtgggc accgagaatg tgcacagact cttcacctcc gggaaagaca
     1441 ctgaggcagt ggagacagat ttagatatag ctcaggatgc tgatgctctg gatttggaga
     1501 tgctggcccc ctacatctcc atggatgatg acttccagct caacgccagc gagcagctac
     1561 ccagggccta ccacagacct ctgggggctg tcccccggcc ccgtgctcgg agcttccatg
     1621 gcctgtcacc tccagccctt gagccctccc tgctaccccg ctgggggagt gacccccggc
     1681 tgagctgctc cagcccttcc agaggggacc cctcagcatc ctctcccatg gctggggctc
     1741 ggaagaggac cctggcccag agctcagagg acgaggacga gggagtggag ctgctgggag
     1801 tgagacctcc caaaaggtcc cccagcccag aacacgaaaa ctttctgctc tttcctctca
     1861 gcctgagttt ccttctgaca ggaggaccag ccccagggag cctgcaggac cccagcaccc
     1921 cactcctgaa cctgaatgag cccctgggcc tgggcccctc actgctctct ccgtactcag
     1981 acgaggacac tacccagccc gggggcccct tccagccaag ggcaggctca gcccaggctg
     2041 actgagccgg ctcctctccc catctgcctt ctcctccccc agaaaggacc tcaaccacac
     2101 tccacgccgg cagccaacgc acaggatggg ggcgccagga gaggggcccc tctctcctct
     2161 atgtaccccc tgcccacctc gggcctacct cagccctcac ccctctgcct gctcccaatc
     2221 tgggggctct ctggggtggt ctcagctcag tgacctctgg gaggtggtcc ctggccccct
     2281 cctccttctc tcaggatttc tcttggggtt ctcaatactt ggttacctca ttatcccttt
     2341 ctctgcctct cttggcttta ttttggggaa tcaggggtga ggagggttgg gggggtcata
     2401 tctgtgtttc caggttctgg ggagaacaat gatccacggg tcaacgtgat cacatttcct
     2461 tctatccttc ttgtattatt atttttattt ttgtcaattt catgatatgg tttttaatca
     2521 tgatgaattg cctggggtct gtaagaatgt gggactctga tcttccccct cttcaggtgt
     2581 cagtgcggag aggctctggg ccagacctca cccccagtga cttccgattg aggccaaaga
     2641 ccccaagctg cccgccagct ctgactgccc cttgcgctct gggcttcctg ccgcccccag
     2701 ctttgcctgg acactgactt cattcatggt cctcctactt caggggcagc ctcccagttc
     2761 ctctgcttcc aaactatgca acctccaacc tgctccagtt ccagactgta taacctctga
     2821 cctgcactgg ttctagacca cacaacctcc aatgtggtct gctttagatc accttcttct
     2881 tcttccttct tcctcttcct cttcctcctg ctcctcttcc tcttcttctt cttttttttt
     2941 tttgacagag tcttgctctg tcacccaggc tggagtgcag tggcgcgatt tcagcttact
     3001 gcagcctccg cgccctgggt tcaagtgatt ctcctgcctc aacttcccaa atagccggga
     3061 ctacgggcat gtgccacatt gcccggctaa tttttgtatt tttagtagag atggggtttc
     3121 accacgttgt ccagtctggt ctcgaactcc tgacctcaag tgctccacct gcctcagcct
     3181 tccaaagtgc tgggattaca ggcgtgagcc actgcacccg gctagaactc actttctcca
     3241 aatccctctg cttcgaattt caccgtcttc agctctttct agttctgggc ctcaccagcc
     3301 tctcattctg cctgttttca aaccttacga tccccaaaaa ttgtctggtt ctgggcctct
     3361 aactccctct ggctctatag tctatgacta ccagattctt ttggttctag aattcactaa
     3421 cttcctctgg ttctagacct cttcctataa attaatccct cttgttttag atctcacacc
     3481 ctccaacgcc ctccggttcc agatcttata ttcagtgatt tcctctggtt ctggacccca
     3541 caactccaag cttcctattg gttccagttc tcctgatcgg taatacattt ggttccaaat
     3601 ccagacctct taatctctct cttttttttt tttttttttt gagacagagt cccactctgt
     3661 cacccaggct ggagtacagt ggctcaatct cggctcactg cagcctccac ctcctgggtt
     3721 caagcaattc ttgggcctca gcctcccaaa tagctgggat tacaggcatg tgccaccacg
     3781 cccagctaag ttttatattt ttagtagaga cagtgtttca ccatgttggc caggctggtc
     3841 ttgaactccc gacctcaact gatccacccg cctcagcctc ccaaagtgct gaaattacag
     3901 gagtgagcct ggccagactt cttaatttct aaatcacttt tgttttagac cttatgaggc
     3961 tcagcttatt cttctgcagt tctctataac caagactcat tttctctcat caaaaacaag
     4021 tacagagagt ttgatgtgtt tatctctttt ttcttcctct tctttttttt ttttttcttt
     4081 tttgagatgg agtctctctc tgttgcccag gctggagtat aatggtgcca tctaggctca
     4141 ctgcaacctc cgcctcctga ttcaagtgat tctcctgcct cagcctccta aattggtggg
     4201 attacaggag cccaccacca catccggcta cctttgtgta ttttttagta gagacggggt
     4261 tttgccaagt tggaggggct ggtcttgaac tcttgacctc agatgatcca cccgcctcag
     4321 cctcccaaag tgctgggatt acaggcataa gccaccgtgc ccgaccctgt ccttatctta
     4381 taataaccag ttcttctaga accagacgat gctctagttc tcctagattc tgaacctcat
     4441 gacctgtacc actcactagt tccagactac acaacttcta gaaggtgcca cctccagggt
     4501 cctgattcaa gatctggtga tctgctgttt ctctggttct agaactgact tacaagtgcc
     4561 ttctgattct agacctcatt ccgtaagttc ccttggctct agacttcatc atttccagct
     4621 cctcctcact caagatctga ctccaaatta ccctgggtct agaattcagc cttcaaatat
     4681 cttctgattt tagactttgc cttatacatt tctctggttt tagatcttac caccctcaac
     4741 tccttctgat tctagatctt atggttccca aatctctctg gttctagaac tcagatttta
     4801 ggcttttgtt tttccttttt tttgttaaaa aaaaaaaaat agagacgggg tttcaccatg
     4861 ttgcccaggc tggtcgcgaa ctactgagct caagcaattc tccctccttg gcctcaccaa
     4921 agtgctggga ctacaggcat gagccactga gcccagccag gctttttcta attctatgct
     4981 ttattctata aattcctctg cttctaagcc tcacagcttc caactgcctt tgatttcaga
     5041 tccaaattcc tctgattcta taattcagcc tccaaatgct tctgattctg gaatctagac
     5101 ttttccctaa agattcctct ggttctgaat cttataacct caactcccta attccagacc
     5161 ccagcctcct aaatctattc tgggcttccc accccactga acttacccaa ttccttcttt
     5221 cagtcttaag ttttcccatt ctaaacccct accctctagg ctgtgctgct cctggacttc
     5281 atgcctctcc attctcattg cctacaatct ctgtgcccca gaaccccctc cacttcccac
     5341 cccagccctc cagacatgca cttaccttga ctttacccca catgtttggg gcacctgggg
     5401 ctccctcacc ccttgggtgg tttgcaatct gaagacttct ccagccacac aggcacatgc
     5461 acaggcacgg tgctgtctgc atattgccag gtggggagag aagccaggac ccctcagctg
     5521 tctgccacca tctatgtgcc tcccttaccc cccagctttc tttctacaga tggtgctact
     5581 cttggtctcc cacaggaaaa ggcctccccc cttcttagcc ccatttaccc cgtttgtgga
     5641 aggcactgct cgctctgttt tgtcagagag tggcctatcc agattggtgc tatggggggg
     5701 tctgacccct ccctcctccc tctggaggtg atgtgggccc tcaatggagg gaattgtgct
     5761 gggctaggga aaggggaggg actagactgg ccacactggc tctgaaactc accaatctct
     5821 atacaccata aagacctcac cttggtaggc accaga
//
