LOCUS       NM_015094               6831 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens HIC ZBTB transcriptional repressor 2 (HIC2), mRNA.
ACCESSION   NM_015094
VERSION     NM_015094.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6831)
  AUTHORS   Huang,P., Peslak,S.A., Shehu,V., Keller,C.A., Giardine,B., Shi,J.,
            Hardison,R.C., Blobel,G.A. and Khandros,E.
  TITLE     let-7 miRNAs repress HIC2 to regulate BCL11A transcription and
            hemoglobin switching
  JOURNAL   Blood 143 (19), 1980-1991 (2024)
   PUBMED   38364109
  REMARK    GeneRIF: let-7 miRNAs repress HIC2 to regulate BCL11A transcription
            and hemoglobin switching.
REFERENCE   2  (bases 1 to 6831)
  AUTHORS   Luo,F., Liao,Y., Cao,E., Yang,Y., Tang,K., Zhou,D., Zhou,D. and
            Cai,H.
  TITLE     Hypermethylation of HIC2 is a potential prognostic biomarker and
            tumor suppressor of glioma based on bioinformatics analysis and
            experiments
  JOURNAL   CNS Neurosci Ther 29 (4), 1154-1167 (2023)
   PUBMED   36650953
  REMARK    GeneRIF: Hypermethylation of HIC2 is a potential prognostic
            biomarker and tumor suppressor of glioma based on bioinformatics
            analysis and experiments.
REFERENCE   3  (bases 1 to 6831)
  AUTHORS   Huang,P., Peslak,S.A., Ren,R., Khandros,E., Qin,K., Keller,C.A.,
            Giardine,B., Bell,H.W., Lan,X., Sharma,M., Horton,J.R.,
            Abdulmalik,O., Chou,S.T., Shi,J., Crossley,M., Hardison,R.C.,
            Cheng,X. and Blobel,G.A.
  TITLE     HIC2 controls developmental hemoglobin switching by repressing
            BCL11A transcription
  JOURNAL   Nat Genet 54 (9), 1417-1426 (2022)
   PUBMED   35941187
  REMARK    GeneRIF: HIC2 controls developmental hemoglobin switching by
            repressing BCL11A transcription.
            Erratum:[Nat Genet. 2023 Sep;55(9):1608. doi:
            10.1038/s41588-023-01488-7.. PMID: 37524792]
REFERENCE   4  (bases 1 to 6831)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6831)
  AUTHORS   Song,J.Y., Lee,S.H., Kim,M.K., Jeon,B.N., Cho,S.Y., Lee,S.H.,
            Kim,K.S. and Hur,M.W.
  TITLE     HIC2, a new transcription activator of SIRT1
  JOURNAL   FEBS Lett 593 (14), 1763-1776 (2019)
   PUBMED   31127867
  REMARK    GeneRIF: HIC2 is a pivotal transcriptional activator of SIRT1
REFERENCE   6  (bases 1 to 6831)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 6831)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   8  (bases 1 to 6831)
  AUTHORS   Deltour,S., Pinte,S., Guerardel,C., Wasylyk,B. and Leprince,D.
  TITLE     The human candidate tumor suppressor gene HIC1 recruits CtBP
            through a degenerate GLDLSKK motif
  JOURNAL   Mol Cell Biol 22 (13), 4890-4901 (2002)
   PUBMED   12052894
REFERENCE   9  (bases 1 to 6831)
  AUTHORS   Deltour,S., Pinte,S., Guerardel,C. and Leprince,D.
  TITLE     Characterization of HRG22, a human homologue of the putative tumor
            suppressor gene HIC1
  JOURNAL   Biochem Biophys Res Commun 287 (2), 427-434 (2001)
   PUBMED   11554746
  REMARK    GeneRIF: HIC1 and HRG22 define a subgroup of BTB/POZ domains unable
            to recruit repressing complexes containing a histone deacetylase
            activity.
REFERENCE   10 (bases 1 to 6831)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000552.1, AP000556.2, CN373403.1, AP000557.2, BC094787.1 and
            BM675330.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015094.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB028943.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407464.7/ ENSP00000385319.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AP000552.1         157079-157086
            9-33                AP000556.2         67423-67447
            34-38               AP000556.2         67448-67452
            39-236              CN373403.1         1-198
            237-245             AP000557.2         13024-13032
            246-1120            BC094787.1         146-1020
            1121-6279           AP000557.2         15972-21130
            6280-6831           BM675330.1         15-566              c
FEATURES             Location/Qualifiers
     source          1..6831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..6831
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /note="HIC ZBTB transcriptional repressor 2"
                     /db_xref="GeneID:23119"
                     /db_xref="HGNC:HGNC:18595"
                     /db_xref="MIM:607712"
     exon            1..190
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /inference="alignment:Splign:2.1.0"
     exon            191..289
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..2111
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /note="hic-2; hic-3; HIC1-related gene on chromosome 22
                     protein; zinc finger and BTB domain-containing protein 30"
                     /codon_start=1
                     /product="hypermethylated in cancer 2 protein"
                     /protein_id="NP_055909.2"
                     /db_xref="CCDS:CCDS13789.1"
                     /db_xref="GeneID:23119"
                     /db_xref="HGNC:HGNC:18595"
                     /db_xref="MIM:607712"
                     /translation="MVSGPLALRWCAWAGRGDMGPDMELPSHSKQLLLQLNQQRTKGF
                     LCDVIIMVENSIFRAHKNVLAASSIYFKSLVLHDNLINLDTDMVSSTVFQQILDFIYT
                     GKLLPSDQPAEPNFSTLLTAASYLQLPELAALCRRKLKRAGKPFGSGRAGSTGMGRPP
                     RSQRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAV
                     CPAGGEAGLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDS
                     QHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHST
                     RKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPP
                     YPCKEEEENGKDASEDSAQSGSEGGSGHASAHYMYRQEGYETVSYGDNLYVCIPCAKG
                     FPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEEAEDLSAPSAAYTAEPRPFKCS
                     VCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDEC
                     GMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHTSPS"
     exon            290..6831
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6812..6817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /note="hexamer: ATTAAA"
     polyA_site      6831
                     /gene="HIC2"
                     /gene_synonym="HRG22; ZBTB30; ZNF907"
                     /note="major polyA site"
ORIGIN      
        1 acaagcttcc aagatggcgc tgggcgggcg gctgtgagcg gcgctcgggg cgcgctaggc
       61 ggggagccga gccgggctgg cggcaggcgg acggggcggg cgcgtgcggc gcgagccggg
      121 cgctgaggac aagggccgct ggtagggccg gccggccggc gggcggagcg ccgccgccga
      181 cgcacacgag gtgaccaggc attgatgcac ccccaggaag gccacgcgct caggagcccc
      241 ccccgccgct ggctgctgct cacatggtgt ctgggccctt ggcactccgg tggtgcgcgt
      301 gggcagggcg cggggacatg gggcccgaca tggagctgcc cagccactcg aagcagctcc
      361 tgctgcagct gaaccagcag aggaccaagg gcttcctgtg tgacgtcatc atcatggtgg
      421 agaactccat cttccgggcc cacaagaacg tcctagccgc cagcagcatc tatttcaagt
      481 ccctggtcct gcacgacaac ctcatcaacc tggacacaga catggtcagc tccacagtgt
      541 tccagcagat cttggacttc atctacacag gcaagctgct gcccagcgac cagccagccg
      601 agcccaactt cagcaccctc ctcactgccg ccagctacct ccagctgccc gagttggcag
      661 ccctctgccg ccgcaaactc aagcgagccg gcaagccctt tggctctggg agggcggggt
      721 ccactggcat ggggcggccc ccccgcagcc agcggctgtc cacggcctct gtcatccaag
      781 ctcggtatca ggggctcgtg gatgggcgca agggggccca cgccccccag gagctccccc
      841 aagccaaagg ctcagacgat gaactctttc ttggtggctc taaccaggat agcgtgcaag
      901 gtctgggccg ggctgtctgc ccagctggcg gggaggcggg tctggggggc tgcagcagca
      961 gcaccaacgg gagcagcggg ggctgcgagc aggagctggg cttggacctg tccaagaaaa
     1021 gcccaccctt gccccctgcc accccaggtc cccacctcac tcccgatgac gcagcccagc
     1081 tgagcgacag ccaacatggc tcgccccctg cggcctctgc tcctcccgtt gccaacagtg
     1141 cctcttattc tgagctgggg ggcacccctg atgagcccat ggatctggag ggggccgagg
     1201 acaaccacct gagcctgctg gaggcgcctg gtgggcagcc tcggaagagc ctccggcact
     1261 ccactcggaa gaaggagtgg ggcaagaagg agcctgtggc tggctccccc tttgagcgga
     1321 gagaagcagg gcccaagggt ccctgcccgg gagaggaggg tgagggggtc ggggacaggg
     1381 ttcccaatgg catcctggct agtggggctg gccctagcgg gccctatggg gagcccccct
     1441 acccctgcaa ggaggaggag gagaacggca aggatgcaag tgaagacagt gcgcagagcg
     1501 ggagcgaggg gggcagcggc catgccagcg cccactacat gtaccggcag gagggctacg
     1561 agacggtgtc ctacggggac aacttgtatg tgtgcattcc ctgcgccaag ggcttcccca
     1621 gctctgagca gctcaatgcg cacgtggaga ctcacacgga ggaagagctg ttcatcaagg
     1681 aagagggggc ctacgagaca ggcagtgggg gtgccgagga ggaggccgag gacctgtcag
     1741 cacccagtgc ggcctacacg gctgagcccc ggcccttcaa gtgttcggtc tgcgagaaga
     1801 cctacaagga cccagccacg ctgcggcagc acgagaagac gcactggctg acacggccct
     1861 tcccctgcaa catctgtggc aaaatgttca cgcagcgcgg caccatgacg cgtcacatgc
     1921 ggagccacct gggcctgaag cccttcgcct gcgatgagtg tggcatgcgc ttcacccgtc
     1981 agtaccgcct cacggagcac atgcgtgtgc actcgggcga gaaaccttac gagtgccagc
     2041 tgtgcggggg caagttcacc cagcagcgca acctcatcag ccacctgcgc atgcacacct
     2101 ccccctccta gaagccaaag acccgcgggc gccctctgcc accttgctcc ccgggaaccc
     2161 atggaaggag aagcgaggtg atgcagcagc aggggcaaga ccctgggtcc agtggaggct
     2221 ccgggtggcc cctctggccc ccactgccca cacccagagc tttaatggac agtccgtacc
     2281 aagcagagcc gagaggaggg aagccagggg tcccagcccg tctacctccc catcccaccc
     2341 aggcccccag ctccccgcgg gggccaccgc agggcctgtg ggctgggtca cgtgggtctc
     2401 gctgggacct ggtccctttg ttgcaggcgg cttggagaaa gggcagtggg acgctggcca
     2461 cggccagggt ggtgtcggga gcaggcctca ccccgctggc cgtgtctgtg tgtgtgcacg
     2521 tgtgcttgtg tctgtgcggg cgcgtgcagc cctggttctg cagggaacag gtgctggggg
     2581 tgcagatccc tccctccttg agccagggtg gcactgttca ctggcgctgg gacagtcagg
     2641 gtgaccccac cgcctacctc tctacatcta aagagccctc tgggcctgtg ttgctgttat
     2701 tcctactgat ctgttcctct gtttttcttt ttgatttttg ttttttaaac caaaacagac
     2761 aatagcttat tttctttccg ccccctccgg ggctgagcct gggtctgaag actgaatgta
     2821 acaggggccg ctggcactcc tgcgcgtccc ccggctctgg cgctgcaggg gtgtcggcgc
     2881 gccacctctc caggccccag aagcccttct tgcccaaagg cttccctggt ccctgagccc
     2941 tgcctcggct gcctcagggg agagtgcttt tcctgtagtt tccaaggaat attctttgtt
     3001 tagaggtact tgttttttat taagagaaaa accagtgtaa cgtttatgtg actgtttgaa
     3061 ctggaaggtc tggggttccg gggggtgggg ggaggctaga ctcaatgccg gggccgtcgg
     3121 tactcttgtt ttcatttgtg tgtgcgtgcg tgtgtgtgtg tgtatgtgcg tatgtgtgtg
     3181 tctatgtgtg gtgtgtgccg tatgcatggg cagatgtttc gctttccctc cttcctcgct
     3241 gaacaaggtg gagacttctg accttttgct acctcttgaa ttcatgacaa cgatatgttg
     3301 gtgactggca gtggaagccc ttgacactct tgttttcctt cgcttagcac ctaggaagtc
     3361 gtgtgcagga gccagcaggg cgccaagtgg cccagtgcct gcagctcacc tgtgggtttt
     3421 ccctttgagc ctttggccac atccacctcg aggggaccct ggcaccccgg gcacacaaac
     3481 ctctgtggta taggtgaggg gtgtgaggcc ccagcctgga gccaggcact gggtgctgac
     3541 aggggaacca tgaggagggt ggcaggtctt tgcagctccc ggccagggtg aggcggaagt
     3601 gagccctcat cctgccactc ctatcctcca ttcctgcaag agttttaagc ttgagagagc
     3661 tgaccacagg gccccccggg gaacagggat ggcacttccc tgagcagtcc tggcccccgg
     3721 ccactgtctc ggggcccacc tctcgcccct catcttggta attagccagc ctcagatact
     3781 tctgtgggcc ctgaagtggg ctctcaaggt cagaccaagg ttgctgatct cagtcccact
     3841 gtcttcagcc agctgaagct gtggggctgg gctggcagcc tttattgtca tcttgcttca
     3901 ccattttttt ttctctctct tttcattcta ttttaagttt agaccaaaaa aatacagagt
     3961 catcccctac ccccacccct ctagagaccc tccagctaaa aacagagcct gagttcaggg
     4021 acccaagtgg tgagcggcgt cttttggggg tgagggagct tgggtagatg aggctcctgg
     4081 ctgagccctc cctgtggtga tcccagccta agatggcccc tcttccctcc tggtgggaga
     4141 cagaggactg gaccctgggt ctcaggttcc agcaagtcag gctagggacc tggggggagg
     4201 agacccatgg acttcaccca tactcagtga gggggctcct gccgtcctga cgccaccccg
     4261 ccccatcagc acttaagcca catgacacaa agtctgtacc gcacgggaaa tgttcacgcg
     4321 cctggccgtg tgcatggcct cccgggctgt gggcagccgc atctgtgagg tgactcgtga
     4381 aagtaggtga ttcctttgca gaacttcagg gactgggagc agaggcccct cactcaacga
     4441 cgtttgtgcg acatagtatt gtatccacct tagtattgta tcgagccttt tctgtgtttt
     4501 aatgagaaag cagaacacta gtttcctatt taagacttta agggtttgtg gggcggggcg
     4561 ggattaacac aacatttggc tttgttttct ttttcctttg atttccacat caggtgtgtg
     4621 cgagtgtgtg tgtgtggaga tgttaagagc ctcacaagga aactgggtta ttggaggcca
     4681 aggcggctta cagttctctg cgttcgtcac ttaattcctg aatgtttcag agaaacagga
     4741 atcagaaaat agcagatatc atgtaggaaa gagaggataa acaaagaaaa aagaaaaaaa
     4801 aataagctca tacccaaatt cacaaagcct attttttaaa ccaaagcaca ttttgaatga
     4861 gtatggaacc tccatgggct cagaaaaaag atgctaatat atttatctca ttgtttacat
     4921 aagcttttac agtttcagac ctcagcagct gtaaggccag tccagggaac cctcccctgc
     4981 tgctggaaac ccttctgagt tggccctgga gtggctcacg ggcagagaag ggtagccctg
     5041 gggctggggg agggattgga agcctccctg gagtcacctg agccctcgtc cccattccca
     5101 gggcccctcc aagcccagct ggcaccaaag agcttgggcc cgtgctgacc agcccccaag
     5161 gccctctggc cggaccatgc tggtcctgac cagctagcct acgcggggat ggccgtcagt
     5221 tctggccaca ggacccgagt ctgggcttgg gtccccctgc tgctctgccc gtgacccttg
     5281 gggatgggtt gatgcgaggg tcccactcaa gccaaaaagc cgggaccttt gcgcagctct
     5341 gtcgactctg gtgggtcccc actcctgggg ccccctaacc ccaccccagg cagcggaagg
     5401 ggctgactgg gtctggtcct taccaacata gacggtgcaa acactcttaa cagtgttgtt
     5461 tttgtatcaa tatgtttgtg cagtgatgaa tgtatttatt tctcagactt ggggcgagtg
     5521 agcgggtggc aggccgggct ccgccactgc atgctcccgc cggaccgagc cccagcaagg
     5581 gctcctccag gattgcaaaa aaaaaaggaa gagaaaagat gaacctttaa gcaaataaga
     5641 atctcagaga ctcgcagcat agccatacac ctcagcctgt gaaatgaacg atccggaccc
     5701 tcaccaactt tccccacctc aggcagccct gtgtgtttac cgttcatcac cactcggggg
     5761 caccgggccg cccacccact cccaaaatcc gtcagtattc actggacctc aggccctgtg
     5821 caggagtgcg atccgggctg ggccgctggg caggctgacc ccctgccctc ctgcggccat
     5881 cctgagttgg ggtgaggcct gggcagccgg agggcagggc tcagggagca ggaggctgca
     5941 tccgtccacc cccaggcgtg ggggacaaaa gccaaaggtg ccaggcctta gagcagacaa
     6001 gggctctcag ccctggcatg ccccctaaag ggaccaaggt cctcctattt cccagaaccc
     6061 cgttggggca gatgttactg aacctgtgaa tcagacgcca ggagtgaggg ctggggaggg
     6121 acctaactgg agcctcagtc tgacattcca cgccggggtg ggggtgggca tgagcggtgg
     6181 gaactgaggc tgcccaggac ccccttccta ggatgccccg gcttcagtca ccccacttta
     6241 actttctacc aggaccccct ccccctacct caccttgcta tttattgctg taatttattg
     6301 acctcaaaaa tgctgcataa cagacctcac tggggcaggg aggatcccca gggctcccac
     6361 cctccacttg gcgggccccg tggggccagg tgctgagggg agcctctcta ccccacccat
     6421 cactagcttc cctctgccct ctcccacccc gggggggacc caggttgggc actggctcat
     6481 ttctcgcaaa tacctcgaag gggagggggg agggatgggg ttatagctgt tttgtttaat
     6541 tggaactgga agagggatca tgttttgttt tatgcccttc ccagaagggg ggagggacac
     6601 cgggatcgca ctcctgtact ggccaccgcc gctgtcactt gtcacattga gttcatgtcc
     6661 cttgagagtt tgtataaatt caggtcagag ctgcagctac acagctgccc agtgtcatag
     6721 aaaagcaatt caccaacgac tgatctctcc attcagaagt gtgcagtctt aaatgtacag
     6781 cgataagaaa ctgttatttt atgatctttt cattaaaagc ttgattgaaa a
//
