LOCUS       NM_006497               6707 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens HIC ZBTB transcriptional repressor 1 (HIC1),
            transcript variant 1, mRNA.
ACCESSION   NM_006497
VERSION     NM_006497.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6707)
  AUTHORS   Andrabi,S.B.A., Batkulwar,K., Bhosale,S.D., Moulder,R., Khan,M.H.,
            Buchacher,T., Khan,M.M., Arnkil,I., Rasool,O., Marson,A.,
            Kalim,U.U. and Lahesmaa,R.
  TITLE     HIC1 interacts with FOXP3 multi protein complex: Novel pleiotropic
            mechanisms to regulate human regulatory T cell differentiation and
            function
  JOURNAL   Immunol Lett 263, 123-132 (2023)
   PUBMED   37838026
  REMARK    GeneRIF: HIC1 interacts with FOXP3 multi protein complex: Novel
            pleiotropic mechanisms to regulate human regulatory T cell
            differentiation and function.
REFERENCE   2  (bases 1 to 6707)
  AUTHORS   Zhao,T., Yang,T., Zhang,J., Hao,H., Wang,D., Afirifa,J., Cai,M.,
            Cui,X., Bai,J., Fu,S. and Yu,J.
  TITLE     The promoter methylation drives down-regulation mode of HIC1 in
            gastric cancer, its molecular characteristics and downstream
            functional pathways
  JOURNAL   Gene 824, 146380 (2022)
   PUBMED   35276239
  REMARK    GeneRIF: The promoter methylation drives down-regulation mode of
            HIC1 in gastric cancer, its molecular characteristics and
            downstream functional pathways.
REFERENCE   3  (bases 1 to 6707)
  AUTHORS   Sun,C.Y., Chen,G.D., He,B.C., Fu,W.E., Lee,C.H., Leu,Y.W. and
            Hsiao,S.H.
  TITLE     Dysregulated HIC1 and RassF1A expression in vitro alters the cell
            cytoskeleton and exosomal Piwi-interacting RNA
  JOURNAL   Biochem Biophys Res Commun 594, 109-116 (2022)
   PUBMED   35081499
  REMARK    GeneRIF: Dysregulated HIC1 and RassF1A expression in vitro alters
            the cell cytoskeleton and exosomal Piwi-interacting RNA.
REFERENCE   4  (bases 1 to 6707)
  AUTHORS   Yao,J., Yang,J., Yang,Z., Wang,X.P., Yang,T., Ji,B. and Zhang,Z.Y.
  TITLE     FBXW11 contributes to stem-cell-like features and liver metastasis
            through regulating HIC1-mediated SIRT1 transcription in colorectal
            cancer
  JOURNAL   Cell Death Dis 12 (10), 930 (2021)
   PUBMED   34642302
  REMARK    GeneRIF: FBXW11 contributes to stem-cell-like features and liver
            metastasis through regulating HIC1-mediated SIRT1 transcription in
            colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6707)
  AUTHORS   Snit,M., Misiolek,M., Scierski,W., Koniewska,A.,
            Stryjewska-Makuch,G., Okla,S. and Grzeszczak,W.
  TITLE     DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal Cancer Risk
  JOURNAL   Int J Environ Res Public Health 18 (14), 7486 (2021)
   PUBMED   34299935
  REMARK    GeneRIF: DIAPH2, PTPRD and HIC1 Gene Polymorphisms and Laryngeal
            Cancer Risk.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6707)
  AUTHORS   Guerardel,C., Deltour,S., Pinte,S., Monte,D., Begue,A., Godwin,A.K.
            and Leprince,D.
  TITLE     Identification in the human candidate tumor suppressor gene HIC-1
            of a new major alternative TATA-less promoter positively regulated
            by p53
  JOURNAL   J Biol Chem 276 (5), 3078-3089 (2001)
   PUBMED   11073960
  REMARK    GeneRIF: A new major alternative promoter of HIC1 (HIC-1) is
            conserved in the murine locus and positively regulated by TP53.
REFERENCE   7  (bases 1 to 6707)
  AUTHORS   Deltour,S., Guerardel,C. and Leprince,D.
  TITLE     Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a
            general mechanism for BTB/POZ transcriptional repressors: the case
            of HIC-1 and gammaFBP-B
  JOURNAL   Proc Natl Acad Sci U S A 96 (26), 14831-14836 (1999)
   PUBMED   10611298
  REMARK    GeneRIF: HIC-1 (HIC1) is a transcriptional repressor. However, in
            contrast to other BTB/POZ transcriptional repressors ( such as BCL6
            or PLZF) it fails to recruit SMRT/NCoR-mSin3A/HDAC complexes via
            its BTB/POZ domain.
REFERENCE   8  (bases 1 to 6707)
  AUTHORS   Deltour,S., Guerardel,C., Stehelin,D. and Leprince,D.
  TITLE     The carboxy-terminal end of the candidate tumor suppressor gene
            HIC-1 is phylogenetically conserved
  JOURNAL   Biochim Biophys Acta 1443 (1-2), 230-232 (1998)
   PUBMED   9838134
REFERENCE   9  (bases 1 to 6707)
  AUTHORS   Fujii,H., Biel,M.A., Zhou,W., Weitzman,S.A., Baylin,S.B. and
            Gabrielson,E.
  TITLE     Methylation of the HIC-1 candidate tumor suppressor gene in human
            breast cancer
  JOURNAL   Oncogene 16 (16), 2159-2164 (1998)
   PUBMED   9572497
REFERENCE   10 (bases 1 to 6707)
  AUTHORS   Wales,M.M., Biel,M.A., el Deiry,W., Nelkin,B.D., Issa,J.P.,
            Cavenee,W.K., Kuerbitz,S.J. and Baylin,S.B.
  TITLE     p53 activates expression of HIC-1, a new candidate tumour
            suppressor gene on 17p13.3
  JOURNAL   Nat Med 1 (6), 570-577 (1995)
   PUBMED   7585125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ583694.1, BC030208.1,
            AC090617.16 and BQ004706.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006497.3.
            
            Summary: This gene functions as a growth regulatory and tumor
            repressor gene. Hypermethylation or deletion of the region of this
            gene have been associated with tumors and the contiguous-gene
            syndrome, Miller-Dieker syndrome. Alternative splicing of this gene
            results in multiple transcript variants. [provided by RefSeq, Sep
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.559534.1,
                                           SRR1163658.113896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619757.5/ ENSP00000477858.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AJ583694.1         210-224
            16-438              BC030208.1         1-423
            439-2762            AC090617.16        167818-170141       c
            2763-3153           BQ004706.1         18-408              c
            3154-6707           AC090617.16        163873-167426       c
FEATURES             Location/Qualifiers
     source          1..6707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..6707
                     /gene="HIC1"
                     /gene_synonym="hic-1; ZBTB29; ZNF901"
                     /note="HIC ZBTB transcriptional repressor 1"
                     /db_xref="GeneID:3090"
                     /db_xref="HGNC:HGNC:4909"
                     /db_xref="MIM:603825"
     exon            1..136
                     /gene="HIC1"
                     /gene_synonym="hic-1; ZBTB29; ZNF901"
                     /inference="alignment:Splign:2.1.0"
     exon            137..6707
                     /gene="HIC1"
                     /gene_synonym="hic-1; ZBTB29; ZNF901"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2301
                     /gene="HIC1"
                     /gene_synonym="hic-1; ZBTB29; ZNF901"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger and BTB domain-containing protein 29;
                     hypermethylated in cancer 1"
                     /codon_start=1
                     /product="hypermethylated in cancer 1 protein isoform 1"
                     /protein_id="NP_006488.2"
                     /db_xref="CCDS:CCDS42230.1"
                     /db_xref="GeneID:3090"
                     /db_xref="HGNC:HGNC:4909"
                     /db_xref="MIM:603825"
                     /translation="MLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKN
                     VLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPG
                     AEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLR
                     AATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCS
                     PLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQ
                     KLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPS
                     ERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSP
                     PGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGR
                     AEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEK
                     THWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIH
                     SGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKL
                     DFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAEL
                     GLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT"
     regulatory      3134..3139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIC1"
                     /gene_synonym="hic-1; ZBTB29; ZNF901"
                     /note="hexamer: AATAAA"
     polyA_site      3153
                     /gene="HIC1"
                     /gene_synonym="hic-1; ZBTB29; ZNF901"
                     /note="major polyA site"
     regulatory      3320..3325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIC1"
                     /gene_synonym="hic-1; ZBTB29; ZNF901"
                     /note="hexamer: ACTAAA"
     polyA_site      3345
                     /gene="HIC1"
                     /gene_synonym="hic-1; ZBTB29; ZNF901"
     regulatory      6687..6692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HIC1"
                     /gene_synonym="hic-1; ZBTB29; ZNF901"
                     /note="hexamer: AATAAA"
     polyA_site      6707
                     /gene="HIC1"
                     /gene_synonym="hic-1; ZBTB29; ZNF901"
ORIGIN      
        1 gagacgcgac caggacgcgg ggaggacgga ccagcaggac agaccgaccg ggggcccggc
       61 gggcggaggg cagcgcagcc acgtcccccc tggatccgcc gtcagccggg cccggggctt
      121 tcgacatgcc ccccaggaga gtgtgctggg cagacgatgc tggacacgat ggaggcgccc
      181 ggccactcca ggcagctgct gctgcagctc aacaaccagc gcaccaaggg cttcttgtgc
      241 gacgtgatca tcgtggtgca gaacgccctc ttccgcgcgc acaagaacgt gctggcggcc
      301 agcagcgcct acctcaagtc cctggtggtg catgacaacc tgctcaacct ggaccatgac
      361 atggtgagcc cggccgtgtt ccgcctggtg ctggacttca tctacaccgg ccgcctggct
      421 gacggcgcag aggcggctgc ggccgcggcc gtggccccgg gggctgagcc gagcctgggc
      481 gccgtgctgg ccgccgccag ctacctgcag atccccgacc tcgtggcgct gtgcaagaaa
      541 cgcctcaagc gccacggcaa gtactgccac ctgcggggcg gcggcggcgg cggcggcggc
      601 tacgcgccct atggtcggcc gggccggggc ctgcgggccg ccacgccggt catccaggcc
      661 tgctacccgt ccccagtcgg gcctccgccg ccgcctgccg cggagccgcc ctcgggccca
      721 gaggccgcgg tcaacacgca ctgcgccgag ctgtacgcgt cgggacccgg cccggccgcc
      781 gcactctgtg cctcggagcg ccgctgctcc cctctttgtg gcctggacct gtccaagaag
      841 agcccgccgg gctccgcggc gccagagcgg ccgctggctg agcgcgagct gcccccgcgc
      901 ccggacagcc ctcccagcgc cggccccgcc gcctacaagg agccgcctct cgccctgccg
      961 tcgctgccgc cgctgccctt ccagaagctg gaggaggccg caccgccttc cgacccattt
     1021 cgcggcggca gcggcagccc gggacccgag ccccccggcc gccccgacgg gcctagtctc
     1081 ctctatcgct ggatgaagca cgagccgggc ctgggtagct atggcgacga gctgggccgg
     1141 gagcgcggct cccccagcga gcgctgcgaa gagcgtggtg gggacgcggc cgtctcgccc
     1201 ggggggcccc cgctcggcct ggcgccgccg ccgcgctacc ctggcagcct ggacgggccc
     1261 ggcgcgggcg gcgacggcga cgactacaag agcagcagcg aggagaccgg tagcagcgag
     1321 gaccccagcc cgcctggcgg ccacctcgag ggctacccat gcccgcacct ggcctatggc
     1381 gagcccgaga gcttcggtga caacctgtac gtgtgcattc cgtgcggcaa gggcttcccc
     1441 agctctgagc agctgaacgc gcacgtggag gctcacgtgg aggaggagga agcgctgtac
     1501 ggcagggccg aggcggccga agtggccgct ggggccgccg gcctagggcc cccttttgga
     1561 ggcggcgggg acaaggtcgc cggggctccg ggtggcctgg gagagctgct gcggccctac
     1621 cgctgcgcgt cgtgcgacaa gagctacaag gacccggcca cgctgcggca gcacgagaag
     1681 acgcactggc tgacccggcc ctacccatgc accatctgcg ggaagaagtt cacgcagcgt
     1741 gggaccatga cgcgccacat gcgcagccac ctgggcctca agcccttcgc gtgcgacgcg
     1801 tgcggcatgc ggttcacgcg ccagtaccgc ctcacggagc acatgcgcat ccactcgggc
     1861 gagaagccct acgagtgcca ggtgtgcggc ggcaagttcg cacagcaacg caacctcatc
     1921 agccacatga agatgcacgc cgtggggggc gcggccggcg cggccggggc gctggcgggc
     1981 ttgggggggc tccccggcgt ccccggcccc gacggcaagg gcaagctcga cttccccgag
     2041 ggcgtctttg ctgtggctcg cctcacggcc gagcagctga gcctgaagca gcaggacaag
     2101 gcggccgcgg ccgagctgct ggcgcagacc acgcacttcc tgcacgaccc caaggtggcg
     2161 ctggagagcc tctacccgct ggccaagttc acggccgagc tgggcctcag ccccgacaag
     2221 gcggccgagg tgctgagcca gggcgctcac ctggcggccg ggcccgacgg ccggaccatc
     2281 gaccgtttct ctcccaccta gagcgcccct cgccagcccg ctctgtcgct gctgcgcggc
     2341 cctggcccgc accccaggga gcggcggggg cggcgcgcag ggcccactgt gcccgggaca
     2401 accgcagcgt cgccacagtg gcggctccac ctctcggcgg cctcacctgg cctcactgct
     2461 tcgtgcctta gctcgggggt cgggggagaa ccccgggacg ggggtgggat ggggtaaggg
     2521 aaatttatat ttttgatatc agctttgacc aaaggagacc ccaggcccct cccgcctctt
     2581 cctgtggttc gtcggccccc tcccccggct ccgcgctgct cttagagggg gaggggtgtc
     2641 actgtcgggg cactcctagc cctacctccg gcccttgcga ccacacccat tctcactgtg
     2701 aatctccccg ctggggtcgg agcgtcgggc agagttgggg agtggggagg ggactgagcc
     2761 ggccggaggg ccccccgcac ccccgctccc acccaccccg ggactgataa tgtgaagttc
     2821 ctcattttgc acaagtggca ctagccccag ggccaaccct tccttcctca gtcaccaagg
     2881 gcggggagtt ctggagtcgg aaggcgaaga gcctaccacc aggtctccca ctcccgcggt
     2941 gccctccctt cccttccctg cggccccgga ccatatttat tgcatgcgcc ccggcggccc
     3001 cccatcccga gcccaggctg ggctgggctg gaacgcggtc tctttagctc cctcctcttc
     3061 gtttgtatat ttcctacctt gtacacaggc tcttccagag ccgcttccat tttctatact
     3121 cgaaccaaac agcaataaag cagtaaccaa ggaccccgac cccgctgctc tcttctgccc
     3181 ctgcacaagg acctggatgg gctgcgcccg ctgggtggag gagccagaaa gggccaccct
     3241 cacacaggtg cagaggcttg gacctgcctc cctccccagt cccagaaaca gatcagcaag
     3301 aggtcaggta tgtttcataa ctaaaaattt attaaggaaa caaaaccagt gctgcaaacg
     3361 ggacagaaag gagagctggg tctccctccc gaccacccag tcatcggcct tccagctggg
     3421 gagagaatct taaaggagag gccggggacc ctgtactcca aagagcccag tcttctgaga
     3481 ctctagggga ctcctacccc caaactactg gccttggctc ccctacacgg taccccatcg
     3541 cttctggcat agtcctgggc ctcagggagg gcagagctgc gcacccatcc tccaggcagg
     3601 ctgtgcagtc aggccatggg ctctggggta tcccccactg gtcccattaa gatttgcccc
     3661 tggctccacc gaaaaccccg tcttccccta agttgtcctt gtctctggcc ctgggtttca
     3721 ggaactcatt cttggtaagg aagcctcccc actgaggtac cagctaaagg ggcaaggaaa
     3781 gggcccctgt gtcagtgtca gtttttccgg ggagtgaggg caaagctaga aaccaggtta
     3841 ggcgacggtg ccccagcact ggaatgcctc aggctgggct gtccacgcct ggaagtttct
     3901 cccagcacag gagccgaggg tggaaggccc tgggtgggag acctgtacta ggttcctgcc
     3961 atgggtagta gagagggaaa gttcagagtg agaaccccta tgacgaggaa ccgcggtgaa
     4021 gaaatgaagg ggatcaggga ggtgaaaagg atcaactaga aggggaagaa gggtgagggg
     4081 ctattctgga gggagggtag gcgggcaagg aggggtgaag ggggagctga ggggagtcag
     4141 gacatttcct gaagaggaag ctagacggaa agaaaggcca gtgaggagag agggagcagg
     4201 tggaggccac ccgagagcac gggcctgaga ccagatgccc ctttcctcta gactcatgac
     4261 tgtccacggg gacgcaactg gcgaagtgtg agggacccag gttgataagg gcaggaagag
     4321 gagcagcagg aagggtgtgt ggtaagtctg gggtggatgg tagaagaggt gggggcccag
     4381 ggctgctgtt agggacatgc tgtctagaag ccgacttggg ttcatgggcg agtccaggcc
     4441 tcagggagac tggggacaca caccctgggc acttcttcct gacttaacca aagcctcttg
     4501 aacacattca cgacagaggt tctgaagatg aaagggaact gtgatttcac tgcatctgac
     4561 ggaaactcag aacccctgcc ctgtctccac tggagaaagt ggctgcgtcc ccaggcgaga
     4621 aggccctccc tcagccttgg aatgagacgg gggagggaga aaggctgaga gcatgggcgg
     4681 cctatctggc ttgcccagct gctgttgctg tagccagcca cctccctgct aaatcctggc
     4741 agcccaggag ggtcccagca gcttccgccc gatccttggg aggggctctg tgaggagcag
     4801 gtcccccaca gcatggccgt ggcgtgggtt ggaagaggat ggtttattgt ctgggtggat
     4861 tggtggctca ggcacgtggg catcttccgt gctacactgg gcgcctggtg gcctttcagg
     4921 aacggttcca cggggggggg gccccagtgt ggctccctca gcccacctgg gcccacgtga
     4981 ggaaggctgg gatgtcccgt acaggaacat tccttgtgag cgccttcaca cgcaggttcc
     5041 ggtcatccgt caacagcacc acctcccgca gtagccggat tggctcctct gtgggcatga
     5101 gagagcagaa ggctgtcact gaggacagga ggcagagggc tggctgctct tctcaccctg
     5161 gagaatgtgg tcctggggag ggggtgccac gctagccgtg tcttggctct tctaccagtc
     5221 ctttcctccg tccgggctct cagccccggg gaccctcccc tgctggccta gagagggctg
     5281 cactgggctt ctgccttgac tccggcctcc catacaggac tctcttctgc ctagttccca
     5341 aaagctgccc aaacccgtca gcctcccagg accctaaact gagggaatag aagcagcccc
     5401 ttgacctcta ctccttttta ccacatggct ggcccccaga tcacaacacc gctctcccca
     5461 caccccactt tttttttttt aacaagtcct ctccctctaa aagccagcag gttgaagctt
     5521 tacgcatcca gaggcagaaa actaaagatg gaacagaaaa tgtatccagg gttttccaga
     5581 tgtggggaga ggggttaagg gagccctgag gagaggagag ggtaagggtc ttggcagaat
     5641 tgtgccaagg gcacaccaag gctttggcca accggtcgcc cctgctaagt aacagtaatc
     5701 catgtataca ggcgaaagtc tctaagagga cagaagagta aaaaggaaga gtagagttaa
     5761 gatgatgatc ccagttctcc gtcttgtacc ccagggaaga cctgtgtatc cttccaggtt
     5821 tctttaggca catttacaag tacatacact tggacatata accttttttt cctacagcat
     5881 catgatcata ttagccacac tttcagagta tatacttaaa aggtcttgct atagtggcac
     5941 agatatcttt cattcttttt agatgacttt tttttttttt aagcacagtc tctccactac
     6001 ctctctttcc ctaactccct aatctttaac acattggaga gaatttaagc cagggacaag
     6061 cactcacaca agtgacatcc ctaccctgac aggcctgctt gggtggcagg tctactcgtc
     6121 agtcccaggc tgggcatttc ctgacagagg tccaggtccg gcagacagca aggcacagga
     6181 agtgtcctgc tgtgctcact gactgcgtgg gctggcgggg gtggggggct gcaaatatcc
     6241 atgtcggacc tgagcagtct caggcttgcc agctccaggc agggaggctg agaactggct
     6301 ttcagcctgg ggaggagttt ggaggattcg ggagggagag gtttgtgggg ttggtggtgg
     6361 cgagagaaga ggacaggagg aaggagagtg tgaagggagg caaggggctg tgggcagagg
     6421 ggaaaggaag gtggcctcgg gtgaggggat actcagagac tactcagctg cctgggccag
     6481 gcccctctgc agataagtgt ggctggggtg gtggtatgca gggctgtgtg gggctcccag
     6541 ctgactggct gcgtctgtag cagccccact attcctgccc tgggcctcaa accaggagcg
     6601 tcccaggcct taggtcagct aaccaaggcc cgacattgct ggcaggggtc tgcaggggtt
     6661 tctgtggata ctttgacatt tttcacaata aacatcctct gttttga
//
