LOCUS       NM_001145095            4188 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens HHLA1 neighbor of OC90 (HHLA1), mRNA.
ACCESSION   NM_001145095 XR_040231 XR_040232 XR_040233
VERSION     NM_001145095.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4188)
  AUTHORS   Eriksson,N., Macpherson,J.M., Tung,J.Y., Hon,L.S., Naughton,B.,
            Saxonov,S., Avey,L., Wojcicki,A., Pe'er,I. and Mountain,J.
  TITLE     Web-based, participant-driven studies yield novel genetic
            associations for common traits
  JOURNAL   PLoS Genet 6 (6), e1000993 (2010)
   PUBMED   20585627
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4188)
  AUTHORS   Kowalski,P.E., Freeman,J.D. and Mager,D.L.
  TITLE     Intergenic splicing between a HERV-H endogenous retrovirus and two
            adjacent human genes
  JOURNAL   Genomics 57 (3), 371-379 (1999)
   PUBMED   10329003
REFERENCE   3  (bases 1 to 4188)
  AUTHORS   Feuchter-Murthy,A.E., Freeman,J.D. and Mager,D.L.
  TITLE     Splicing of a human endogenous retrovirus to a novel phospholipase
            A2 related gene
  JOURNAL   Nucleic Acids Res 21 (1), 135-143 (1993)
   PUBMED   8382789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131042.6 and AC100868.2.
            
            On Mar 17, 2021 this sequence version replaced NM_001145095.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968968, SAMEA2145743
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000414222.2/ ENSP00000388322.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC131042.6         126108-126163
            57-156              AC131042.6         131979-132078
            157-216             AC131042.6         133098-133157
            217-276             AC131042.6         137131-137190
            277-357             AC131042.6         138303-138383
            358-441             AC100868.2         158190-158273       c
            442-525             AC100868.2         158006-158089       c
            526-609             AC100868.2         152003-152086       c
            610-666             AC100868.2         150332-150388       c
            667-753             AC100868.2         150140-150226       c
            754-1002            AC100868.2         142205-142453       c
            1003-1248           AC100868.2         140213-140458       c
            1249-1317           AC100868.2         138962-139030       c
            1318-1392           AC100868.2         138542-138616       c
            1393-1546           AC100868.2         133827-133980       c
            1547-1629           AC100868.2         128373-128455       c
            1630-4188           AC100868.2         123967-126525       c
FEATURES             Location/Qualifiers
     source          1..4188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.22"
     gene            1..4188
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /note="HHLA1 neighbor of OC90"
                     /db_xref="GeneID:10086"
                     /db_xref="HGNC:HGNC:4904"
                     /db_xref="MIM:604109"
     exon            1..56
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            57..156
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1673
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /note="HERV-H LTR-associating protein 1; HERV-H
                     LTR-associating 1"
                     /codon_start=1
                     /product="HERV-H LTR-associating protein 1 precursor"
                     /protein_id="NP_001138567.1"
                     /db_xref="GeneID:10086"
                     /db_xref="HGNC:HGNC:4904"
                     /db_xref="MIM:604109"
                     /translation="MLGFLSRGPSMKLCMGLACVLSLWNTVSGIKGEAKKEKGMTFLP
                     TTVSGLREEERKEKGVAFLATTELPARSIDLSALNLTELVNGMLSRALKDSKKFFSLL
                     SVTSYSSFAFHKFSVAVYNISNLKTVDPAKFPTRYCYCLNNRTNDLSDFTALLVDIIG
                     NSTSYLTEIFKSTSILSVNQSNESDCIFICVMTGKSGRNLSDFWEIEEKYPIINYTFT
                     SGLSGVLGAATRGTARTSKPTTKSQKTLPSTSPGHWTQSTPWASALRSSPWTETAAPS
                     ETEETLNTGRPPELPARATATWFSASHTLPALATRRVARTQWLTADRQTWASISSVPW
                     AQTISEKKPGGSLWETRSSPPTTAGTEEAMNTTSLLAPAAEIMATPGSPSQASPTLGA
                     FTHGTQTPSPTKATAPRYPQTGDLSAEWPFTAGEEPVLVPRPHQVSRCPQPLFKVGAM
                     AAAPLTLAIQRLNPCLMELCQFFQQCLCMSQRSPRTEDMRYCLEYYSWFLKNATYICQ
                     RVKRVSHSHTLKQKCLENICKSV"
     exon            157..216
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            217..276
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            277..357
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            358..441
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            442..525
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            526..609
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            610..666
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            667..753
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1002
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1248
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1317
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1392
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1546
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1629
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..4188
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4161..4166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /note="hexamer: ATTAAA"
     polyA_site      4188
                     /gene="HHLA1"
                     /gene_synonym="PLA2L"
                     /note="major polyA site"
ORIGIN      
        1 taatctttct agctgtttaa gttctttgaa gtcaatttat cctgctcaga agataggtgg
       61 gccagagtat cacaagcatg ctgggcttcc tgtcacgtgg tccttcaatg aagctgtgca
      121 tgggcctggc atgtgtcttg tccctttgga acacagtgtc tggcatcaaa ggagaagcca
      181 agaaagagaa gggaatgacc tttttaccta caacagtgtc tggccttaga gaagaagaga
      241 ggaaggagaa gggggtggca tttcttgcta cgacggagct gcccgcaagg tcaatcgatc
      301 tgtccgcgct taacctgaca gagcttgtga atgggatgct cagtagagcg ttaaaagata
      361 gcaagaagtt cttctccttg ctgagtgtca cttcctacag ttccttcgcc ttccacaagt
      421 tttctgtagc tgtttacaac atttctaacc tgaagacagt agaccccgcc aaattcccca
      481 caaggtattg ctactgttta aacaatcgga ccaatgactt atcagatttt acagctctac
      541 tggtagatat catcggcaat tctaccagct acctcacaga gatttttaag tcaacctcca
      601 tcctctcagt gaatcaaagc aatgaatcag attgcatctt catctgtgtg atgacaggaa
      661 agtcaggaag gaatctttct gacttctggg agatagaaga aaaatatccc attatcaatt
      721 acacatttac cagcggcttg tctggtgttc tgggtgcagc taccagggga actgccagga
      781 cttcaaagcc cacaaccaaa agccagaaaa cactaccaag tacaagcccc ggacactgga
      841 cccagagcac accctgggca tctgctctga gatcctctcc ctggacagag acagctgctc
      901 cttcagaaac agaggagacc ctgaacacag gcaggcctcc tgagcttcca gccagggcca
      961 cagccacatg gttcagtgcc tcccacactc tcccagcctt ggctaccagg agggtggcca
     1021 gaactcagtg gttgacagct gacagacaga cgtgggcttc catatcgtcc gtgccctggg
     1081 ctcagaccat cagtgagaaa aaacctggag ggtctctctg ggaaactcgt tcttccccac
     1141 cgactactgc agggaccgag gaagccatga acactacaag ccttttggcg cctgctgctg
     1201 agataatggc cacacctggc agcccatccc aggccagccc taccttggga gcattcaccc
     1261 atggcacaca gactccgagt ccaaccaagg caacagcccc cagatatcca caaacaggtg
     1321 atctctctgc agagtggcca ttcactgctg gtgaagagcc agtcctggtc ccaagacccc
     1381 atcaagtttc aaggtgtcct cagccactct tcaaggtggg agctatggca gctgctcctc
     1441 tcaccctggc tattcagagg ctcaacccat gcctgatgga gctgtgccaa ttcttccagc
     1501 aatgcctctg catgagccag aggagtccca ggacagagga catgagatac tgtcttgaat
     1561 actattcctg gtttctgaag aatgcaacat atatctgtca gagggtgaaa agggtgtccc
     1621 actcgcacac cttaaagcaa aagtgccttg agaatatctg caagtctgtg tgaggccttg
     1681 aaaataacac tagggcataa caattacttc aggggatacg ccatccaccc tggctcttgt
     1741 cccaagtggg ctacatttga agaattcacc caggctccag ctagatcatc agttaattta
     1801 aagtggttat tcttggaagt agcatttttt ttccctctcc tgtgaatctg tgcaaaacat
     1861 tgaaggtaga agttttcttg ttagaggcct cacaattaat acagtaatgc cagactcctt
     1921 gcctgcttca aaatcatgga aatctagtgt tcatgctcaa gaaactccta caatgcttga
     1981 ggcaatcctg acaatttaaa aactggggat gcgtgggcac tctagcctgc acaaaccagt
     2041 tcagccatgg agactctgac acaatacctg aggtgactta aacttgagac ttttgaaaga
     2101 caacaaaagc ataaattaat attgaattca tactctagag agattcacat atactgatag
     2161 ttaactaata catgtacaac caatcagact tgccatggta tgggatctat ataatcttcc
     2221 aagccccctt aagtgggcga taatgaaaac tttatcatta ggaggaggtt tagagagttg
     2281 tttttattga catcttgtct tgattcctct tctgtgtgac ccactggatt cagaggtccc
     2341 catgagcacc ctcaggttca atgattcatg agtagaactc agaggtaggg aaaactgtta
     2401 tatgcacatt tagcatttat tacaacaaaa ggatgcagat gaaaagcagc aaatgtgaaa
     2461 ggcacctcta gagagagtcc aagagagccc aggcacaagc ttccagtggg gttgcacagt
     2521 cagcatctaa tcctcccaga aataatgttt aacaacacgt ggagtattgt cagccaggaa
     2581 agctcatcca agttttggtg tccaggggat gtttgggggt atggagtagg tatggagtgc
     2641 cttcatggcc tgcatggcta aacttagtta ttcagtctcc agtccctcta gaggtcaagc
     2701 tgatactgca cgacctaagg ccccaccata aatcacattg ttaacataaa ctatctgtca
     2761 tggcacgaag ccccaggtac aagagacact catcaggcag gatattccaa ggatttacag
     2821 gggattcccc aggagctggt caaggaccag atgttcctct gaaaggtgca ggatttgagc
     2881 tcatctgtgg agtacgtctg tggagtcaac tttcttctgc atccccacat actgatttgc
     2941 caccttcatt gtatcagatt cctttttcac tatattcagg tttgcggttg ctccagtatc
     3001 cctatctatg ctgagtctcc acgtagagca tgtgtgccct ctccagtggc tctgcacgga
     3061 ccccttattt ctcattacca gggacagttt ttctcctgat gtgcctggtg ctccttctcc
     3121 actctcttgc cttaggactc tgctgggcca tgagtatttt ttttaccctt ttgtgaccta
     3181 gggctgccct tgggtgagga aagtcacttt ctgttcatca tctaagtaga aaacagtttc
     3241 tgccattgga agacccctga gttccctggc actcctgtga accacaaggt gcctggggag
     3301 gtagaacttg gacattggag agaggagcag ccagacattt ctctttctaa tcatatgcag
     3361 aaagatttct ttttattctc cagaacactt gaaagactct ccaagttatg caaatgtcaa
     3421 gctcataaat gtatattatc atgacttttg caaagatgaa gaggatacag caaattttct
     3481 gggaggcaaa gggacttcta cctggatagg aaccaagcaa actcattaag catggattaa
     3541 tttgattcaa cccttgcgtg gatattaatt aaggaccttt gacaggagag ggtcctcaag
     3601 gttcctcaaa gagtaactta tcatcaagga aggtgaagaa tggatggatg gcttgggccc
     3661 aagactgggg ctattcactt gtggggaaac ccatgtgaac ccagttaccc catactttgg
     3721 gaataatgac tgagcatgac tataatcttt aagaagctca aatgcggaat acctctgagg
     3781 cttatgcaag gatctggcct agcatcaagg acaaaggctc agaggactcc ttggggccag
     3841 ttttctacag tcataccatc agccacaaca gcagcaaagg cagaaggaaa acagggccca
     3901 ggagtggctg acgactgcct ggagtccaac tggtctcctg gagttcataa gaggtttgac
     3961 cccttctgag ctgaatgtgt cctgatttag gggatagcta gggcaataag aaagcctcag
     4021 ggggtgctac tgatctggaa ctcctactaa ttagtgtgta tgtatgtggc caccagtggt
     4081 tagcagatga ggtgaaagag atgggacagt gactgtatct gttctgatga aggagattgt
     4141 gcagttacat gcgtaacgtc attaaacttc attcttccag gtagcaaa
//
