LOCUS       NM_024746               2572 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens HHIP like 2 (HHIPL2), mRNA.
ACCESSION   NM_024746
VERSION     NM_024746.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2572)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   2  (bases 1 to 2572)
  AUTHORS   Doyard,M., Fatih,N., Monnier,A., Island,M.L., Aubry,M., Leroyer,P.,
            Bouvet,R., Chales,G., Mosser,J., Loreal,O. and Guggenbuhl,P.
  TITLE     Iron excess limits HHIPL-2 gene expression and decreases
            osteoblastic activity in human MG-63 cells
  JOURNAL   Osteoporos Int 23 (10), 2435-2445 (2012)
   PUBMED   22237814
  REMARK    GeneRIF: HHIPL-2 was identified as a candidate gene involved in
            iron-related modulation of osteoblast markers.
REFERENCE   3  (bases 1 to 2572)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592148.7, BC016552.1, DA868891.1 and AY358602.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024746.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007638.1, AY358602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144120, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343410.7/ ENSP00000342118.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL592148.7         52454-52455         c
            3-158               BC016552.1         1-156
            159-201             DA868891.1         104-146
            202-2506            BC016552.1         200-2504
            2507-2572           AY358602.1         2487-2552
FEATURES             Location/Qualifiers
     source          1..2572
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2572
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /note="HHIP like 2"
                     /db_xref="GeneID:79802"
                     /db_xref="HGNC:HGNC:25842"
                     /db_xref="MIM:620214"
     exon            1..381
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..2235
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /note="HHIP-like protein 2; hedgehog interacting
                     protein-like 2"
                     /codon_start=1
                     /product="HHIP-like protein 2 precursor"
                     /protein_id="NP_079022.2"
                     /db_xref="CCDS:CCDS1530.2"
                     /db_xref="GeneID:79802"
                     /db_xref="HGNC:HGNC:25842"
                     /db_xref="MIM:620214"
                     /translation="MLRTSTPNLCGGLHCRAPWLSSGILCLCLIFLLGQVGLLQGHPQ
                     CLDYGPPFQPPLHLEFCSDYESFGCCDQHKDRRIAARYWDIMEYFDLKRHELCGDYIK
                     DILCQECSPYAAHLYDAENTQTPLRNLPGLCSDYCSAFHSNCHSAISLLTNDRGLQES
                     HGRDGTRFCHLLDLPDKDYCFPNVLRNDYLNRHLGMVAQDPQGCLQLCLSEVANGLRN
                     PVSMVHAGDGTHRFFVAEQVGVVWVYLPDGSRLEQPFLDLKNIVLTTPWIGDERGFLG
                     LAFHPKFRHNRKFYIYYSCLDKKKVEKIRISEMKVSRADPNKADLKSERVILEIEEPA
                     SNHNGGQLLFGLDGYMYIFTGDGGQAGDPFGLFGNAQNKSSLLGKVLRIDVNRAGSHG
                     KRYRVPSDNPFVSEPGAHPAIYAYGIRNMWRCAVDRGDPITRQGRGRIFCGDVGQNRF
                     EEVDLILKGGNYGWRAKEGFACYDKKLCHNASLDDVLPIYAYGHAVGKSVTGGYVYRG
                     CESPNLNGLYIFGDFMSGRLMALQEDRKNKKWKKQDLCLGSTTSCAFPGLISTHSKFI
                     ISFAEDEAGELYFLATSYPSAYAPRGSIYKFVDPSRRAPPGKCKYKPVPVRTKSKRIP
                     FRPLAKTVLDLLKEQSEKAARKSSSATLASGPAQGLSEKGSSKKLASPTSSKNTLRGP
                     GTKKKARVGPHVRQGKRRKSLKSHSGRMRPSAEQKRAGRSLP"
     exon            382..1034
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1178
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1510
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1637
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1783
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1865
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1948
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2572
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2551..2556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /note="hexamer: AATAAA"
     polyA_site      2572
                     /gene="HHIPL2"
                     /gene_synonym="KIAA1822L"
                     /note="major polyA site"
ORIGIN      
        1 gggcagagca gggaagccaa cctgagcaaa cacagcagcc cgagtgttcc caaggccaaa
       61 atgctgagaa cgtccactcc taatctgtgt ggtggtctgc attgccgggc cccctggctc
      121 tcttctggca ttctctgcct ctgcctcata ttcttgttgg gccaggtggg cttgctgcag
      181 ggacaccccc agtgcctgga ttacgggccc cctttccagc cccctctgca ccttgagttt
      241 tgctctgact atgagtcctt cggctgctgt gatcagcaca aggaccgccg catcgctgcc
      301 cggtactggg acatcatgga atattttgat ctgaagagac atgagctgtg tggagattac
      361 attaaagaca tcctttgcca ggagtgctcg ccctacgcag cccacctcta cgacgccgaa
      421 aacacccaga cgcctctccg gaatctcccg ggcctctgct ctgattactg ctctgccttc
      481 cattctaact gtcactcagc catttccctg ctgaccaatg accgcggcct ccaggagtct
      541 catggaaggg acggtacccg cttctgccac ctcctggacc ttcctgacaa ggactattgc
      601 ttccctaatg tcctgaggaa cgactatctc aaccgccacc tgggcatggt ggcccaagat
      661 cctcagggct gcctgcagct ctgcctgagc gaggtggcca acgggctgag gaaccccgtc
      721 tccatggtcc atgctgggga cggcacccat cgcttctttg ttgccgagca ggtaggagtg
      781 gtgtgggtct acctccctga tgggagtcgc ctggagcaac ccttcctgga cctcaagaac
      841 atcgtgttga ccaccccatg gatcggggat gagagaggct tcttggggtt ggcttttcac
      901 cccaaattcc gccacaatcg caagttctat atttattatt cgtgcctgga caagaagaag
      961 gtagaaaaga tccgaattag tgagatgaag gtttctcggg ctgatcctaa caaagctgac
     1021 ctgaaatcag agagggtcat cttggagatt gaagaaccag cctcaaacca taatggcgga
     1081 caacttcttt ttggcctgga tggctatatg tacatattca ctggggacgg gggacaggct
     1141 ggagatccct ttggcctgtt tggaaatgct cagaacaaaa gttccctgct gggaaaagtt
     1201 ttaaggatcg atgtgaacag ggcaggctca catggcaagc ggtaccgagt cccctcggac
     1261 aatccatttg tttctgagcc aggggcccac cccgccatct atgcctatgg gatcaggaac
     1321 atgtggcgtt gtgctgtgga ccgaggggac cccatcacgc gccagggccg aggccggata
     1381 ttctgtgggg acgtgggcca gaacaggttt gaagaggttg acctcatttt gaaaggtgga
     1441 aactatggct ggagagcaaa ggaagggttt gcatgttatg acaaaaaact ttgtcacaat
     1501 gcctctttgg atgatgttct gccaatctat gcttatggcc atgcagtggg gaagtcagtc
     1561 actggaggtt atgtctatcg tggttgtgaa tccccaaatc tcaatggcct gtatatcttt
     1621 ggagacttca tgagtggtcg acttatggct ttgcaggaag atagaaaaaa caagaaatgg
     1681 aagaagcagg atctttgcct gggcagcacc acgtcctgtg ccttcccagg gctgatcagc
     1741 acccatagca agttcatcat ctcctttgct gaagatgaag caggggagct gtatttcctg
     1801 gcgacctctt acccaagtgc ctatgcacca cgtggatcta tttacaagtt tgttgacccc
     1861 tcaaggcgag cacccccagg caagtgcaaa tacaagccag tgcccgtgag aaccaagagt
     1921 aagcggatcc cgttcagacc actcgccaag acagtcttgg acttgctaaa ggaacaatca
     1981 gagaaagctg ctagaaaatc ttccagtgca accttagctt ctggcccagc ccagggtttg
     2041 tctgagaaag gctcctccaa gaagctggct tctcctacaa gcagcaagaa tacattgcga
     2101 gggcctggta caaagaagaa agccagagtg gggccccacg tccgccaggg caagaggagg
     2161 aagagcctga aaagccacag tggcaggatg aggccatcag cagagcagaa gcgagctggc
     2221 agaagtctcc cttgacctat tggtcaaggt ggccgacagg gtgacgtgag agaggagagc
     2281 cacctcatca aatgaaagtc actgctgaat aaagacctta gaagtctggg aagccagggt
     2341 agaggtgggg cagggcggtt ttcctctccc tgggaaatct tgctgtctac tgaataaata
     2401 aatgcacctt ctctgtatgc agtgcttctg tgggagacca tatcccagat tgctggtgca
     2461 cctgggttat ggtaagcact agtccatgag cctgcttgga atcacactgg atgtctccgt
     2521 tttgtcttgt aaatgcctac aacctgaggt aataaatcaa catttgctca aa
//
