LOCUS       NM_001127258            7371 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens HHIP like 1 (HHIPL1), transcript variant 1, mRNA.
ACCESSION   NM_001127258
VERSION     NM_001127258.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7371)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 7371)
  AUTHORS   Aravani,D., Morris,G.E., Jones,P.D., Tattersall,H.K.,
            Karamanavi,E., Kaiser,M.A., Kostogrys,R.B., Ghaderi Najafabadi,M.,
            Andrews,S.L., Nath,M., Ye,S., Stringer,E.J., Samani,N.J. and
            Webb,T.R.
  TITLE     HHIPL1, a Gene at the 14q32 Coronary Artery Disease Locus,
            Positively Regulates Hedgehog Signaling and Promotes
            Atherosclerosis
  JOURNAL   Circulation 140 (6), 500-513 (2019)
   PUBMED   31163988
  REMARK    GeneRIF: HHIPL1 expression was measured in coronary artery
            disease-relevant smooth muscle cells.
REFERENCE   3  (bases 1 to 7371)
  AUTHORS   Rodriguez-Perez,J.M., Posadas-Sanchez,R., Blachman-Braun,R.,
            Vargas-Alarcon,G., Posadas-Romero,C., Rodriguez-Cortes,A.A.,
            Lopez-Bautista,F., Tovilla-Zarate,C.A., Rojas-Toledo,E.X.,
            Borgonio-Cuadra,V.M. and Perez-Hernandez,N.
  TITLE     HHIPL-1 (rs2895811) gene polymorphism is associated with
            cardiovascular risk factors and cardiometabolic parameters in
            Mexicans patients with myocardial infarction
  JOURNAL   Gene 663, 34-40 (2018)
   PUBMED   29655894
  REMARK    GeneRIF: Results suggest an association of the HHIPL-1 (rs2895811)
            polymorphism with cardiometabolic parameters and cardiovascular
            risk factors in Mexican patients with myocardial infarction.
REFERENCE   4  (bases 1 to 7371)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7371)
  AUTHORS   Schunkert,H., Konig,I.R., Kathiresan,S., Reilly,M.P., Assimes,T.L.,
            Holm,H., Preuss,M., Stewart,A.F., Barbalic,M., Gieger,C.,
            Absher,D., Aherrahrou,Z., Allayee,H., Altshuler,D., Anand,S.S.,
            Andersen,K., Anderson,J.L., Ardissino,D., Ball,S.G.,
            Balmforth,A.J., Barnes,T.A., Becker,D.M., Becker,L.C., Berger,K.,
            Bis,J.C., Boekholdt,S.M., Boerwinkle,E., Braund,P.S., Brown,M.J.,
            Burnett,M.S., Buysschaert,I., Carlquist,J.F., Chen,L., Cichon,S.,
            Codd,V., Davies,R.W., Dedoussis,G., Dehghan,A., Demissie,S.,
            Devaney,J.M., Diemert,P., Do,R., Doering,A., Eifert,S.,
            Mokhtari,N.E., Ellis,S.G., Elosua,R., Engert,J.C., Epstein,S.E., de
            Faire,U., Fischer,M., Folsom,A.R., Freyer,J., Gigante,B.,
            Girelli,D., Gretarsdottir,S., Gudnason,V., Gulcher,J.R.,
            Halperin,E., Hammond,N., Hazen,S.L., Hofman,A., Horne,B.D.,
            Illig,T., Iribarren,C., Jones,G.T., Jukema,J.W., Kaiser,M.A.,
            Kaplan,L.M., Kastelein,J.J., Khaw,K.T., Knowles,J.W., Kolovou,G.,
            Kong,A., Laaksonen,R., Lambrechts,D., Leander,K., Lettre,G., Li,M.,
            Lieb,W., Loley,C., Lotery,A.J., Mannucci,P.M., Maouche,S.,
            Martinelli,N., McKeown,P.P., Meisinger,C., Meitinger,T.,
            Melander,O., Merlini,P.A., Mooser,V., Morgan,T., Muhleisen,T.W.,
            Muhlestein,J.B., Munzel,T., Musunuru,K., Nahrstaedt,J.,
            Nelson,C.P., Nothen,M.M., Olivieri,O., Patel,R.S., Patterson,C.C.,
            Peters,A., Peyvandi,F., Qu,L., Quyyumi,A.A., Rader,D.J.,
            Rallidis,L.S., Rice,C., Rosendaal,F.R., Rubin,D., Salomaa,V.,
            Sampietro,M.L., Sandhu,M.S., Schadt,E., Schafer,A., Schillert,A.,
            Schreiber,S., Schrezenmeir,J., Schwartz,S.M., Siscovick,D.S.,
            Sivananthan,M., Sivapalaratnam,S., Smith,A., Smith,T.B.,
            Snoep,J.D., Soranzo,N., Spertus,J.A., Stark,K., Stirrups,K.,
            Stoll,M., Tang,W.H., Tennstedt,S., Thorgeirsson,G.,
            Thorleifsson,G., Tomaszewski,M., Uitterlinden,A.G., van Rij,A.M.,
            Voight,B.F., Wareham,N.J., Wells,G.A., Wichmann,H.E., Wild,P.S.,
            Willenborg,C., Witteman,J.C., Wright,B.J., Ye,S., Zeller,T.,
            Ziegler,A., Cambien,F., Goodall,A.H., Cupples,L.A., Quertermous,T.,
            Marz,W., Hengstenberg,C., Blankenberg,S., Ouwehand,W.H., Hall,A.S.,
            Deloukas,P., Thompson,J.R., Stefansson,K., Roberts,R.,
            Thorsteinsdottir,U., O'Donnell,C.J., McPherson,R., Erdmann,J. and
            Samani,N.J.
  CONSRTM   Cardiogenics; CARDIoGRAM Consortium
  TITLE     Large-scale association analysis identifies 13 new susceptibility
            loci for coronary artery disease
  JOURNAL   Nat Genet 43 (4), 333-338 (2011)
   PUBMED   21378990
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7371)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL160313.4 and AB593096.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 16, 2020 this sequence version replaced NM_001127258.2.
            
            Summary: This gene encodes a protein that belongs to the
            glucose/sorbosone dehydrogenase family. The encoded protein also
            contains a domain that binds folate and reduced folic acid
            derivatives. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB593096.1, AB593097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330710.10/ ENSP00000330601.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AL160313.4         66348-66561         c
            215-2153            AB593096.1         1-1939
            2154-7371           AL160313.4         31121-36338         c
FEATURES             Location/Qualifiers
     source          1..7371
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..7371
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /note="HHIP like 1"
                     /db_xref="GeneID:84439"
                     /db_xref="HGNC:HGNC:19710"
     exon            1..334
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2428
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; HHIP-like protein 1; ARAR9245"
                     /codon_start=1
                     /product="HHIP-like protein 1 isoform a precursor"
                     /protein_id="NP_001120730.1"
                     /db_xref="CCDS:CCDS45162.1"
                     /db_xref="GeneID:84439"
                     /db_xref="HGNC:HGNC:19710"
                     /translation="MARARAGALLALWVLGAAAHPQCLDFRPPFRPTQPLRLCAQYSD
                     FGCCDEGRDAELTRRFWALASRVDAAEWAACAGYARDLLCQECSPYAAHLYDAEDPFT
                     PLRTVPGLCQDYCLDMWHKCRGLFRHLSTDQELWALEGNLARFCRYLSLDDTDYCFPY
                     LLVNKNLNSNLGHVVADAKGCLQLCLEEVANGLRNPVAMVHARDGTHRFFVAEQVGLV
                     WAYLPDRSRLGKPFLNISRVVLTSPWEGDERGFLGIAFHPSFQHNRRLYVYYSVGIRS
                     SEWIRISEFRVSEDDENAVDHSSERIILEVKEPASNHNGGQLLFGDDGYLYIFTGDGG
                     MAGDPFGTFGNAQNKSALLGKVLRIDVDRKERGLPYGIPPDNPFVGDPAAQPEVYALG
                     VRNMWRCSFDRGDPSSGTGRGRLFCGDVGQNKFEEVDVVERGGNYGWRAREGFECYDR
                     SLCANTSLNDLLPIFAYPHTVGKSVTGGYVYRGCEYPNLNGLYIFGDFMSGRLMSLQE
                     NPGTGQWQYSEICMGHGQTCEFPGLINNYYPYIISFGEDEAGELYFMSTGEPSATAPR
                     GVVYKIIDASRRAPPGKCQIQPAQVKIRSRLIPFVPKEKFIPKTRSTPRPTARAPTRA
                     PRRGRPTAAPPAPTPRPARPTQQPGSRRGGGRRRGRLNSASRAFRDGEVRLVRPAGLS
                     SGSGRVEVFVGGRWGTVCDDSWNISGAAVVCRQLGFAYAVRAVKRAEFGQGGSLPILL
                     DDVRCAGWERNLLECQHNGVGTHNCEHDEDAGVVCSHQNPDL"
     exon            335..981
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1125
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1454
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1581
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1727
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1809
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1892
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..7371
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3453..3458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /note="hexamer: AATAAT"
     polyA_site      3476
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /note="major polyA site"
     regulatory      5181..5186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /note="hexamer: CATAAA"
     polyA_site      5199
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
     regulatory      5627..5632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /note="hexamer: CATAAA"
     polyA_site      5651
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
     regulatory      5664..5669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /note="hexamer: AAGAAA"
     polyA_site      5684
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
     regulatory      7352..7357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
                     /note="hexamer: AGTAAA"
     polyA_site      7371
                     /gene="HHIPL1"
                     /gene_synonym="KIAA1822; UNQ9245"
ORIGIN      
        1 cccttccctg ccgccgcgag cgccccggga ggggaccggg gctgccgtcc ctccgcctct
       61 tcccccgcgg ggcgtagcga tggcccgggc cagggccggg gcgctgctgg cgctttgggt
      121 gctcggggcc gccgcgcatc cgcagtgcct ggacttcagg ccgcccttcc ggccgacgca
      181 gccgctgcgc ctctgcgcgc agtactcgga cttcggctgc tgcgatgagg ggcgcgacgc
      241 cgagctgacc cgccgcttct gggccctggc gagccgcgtg gacgccgccg agtgggccgc
      301 gtgcgccggc tacgcgaggg acctgctgtg ccaggaatgc tcgccgtatg cagcccacct
      361 ctatgacgcc gaggacccat tcacgcccct gcgcacggtg cccgggctct gccaggatta
      421 ctgcctggac atgtggcata agtgccgggg gctgttccgt cacctgtcaa ctgaccagga
      481 gctctgggcg ctggagggca accttgccag gttctgccgc tacctgtccc tggatgacac
      541 ggactactgc ttcccttacc tgctggtcaa caagaacctc aactcaaacc tgggccacgt
      601 ggtagccgat gccaagggct gcctgcagct gtgcctggag gaggtggcca acgggctgcg
      661 caaccccgtg gccatggtcc atgccaggga tggcacccac cgcttcttcg tggccgagca
      721 ggtggggctg gtgtgggcct acctgcccga ccgctcgagg ctggggaagc ctttcctgaa
      781 catcagccgg gtggtgctca cctcgccctg ggagggtgac gagcgtggct tcctgggcat
      841 tgccttccac cccagcttcc agcacaaccg caggctctac gtctactact cagtgggtat
      901 ccgcagcagt gagtggatcc gcatcagcga gttcagagtc tccgaggatg acgagaacgc
      961 cgtggaccac agctctgaga ggataatcct ggaggtcaaa gaaccagcct caaaccacaa
     1021 cgggggccag ctgcttttcg gggatgacgg gtacctctac atcttcactg gagatggcgg
     1081 gatggccgga gacccctttg ggacatttgg aaatgcccaa aacaagtcgg cgctgctggg
     1141 caaggtgctg cgcatcgacg tggaccgtaa ggagcgcggc ctgccctacg gcatcccgcc
     1201 cgacaacccg ttcgtgggcg accccgcggc gcagcccgag gtctacgccc tgggcgtgcg
     1261 caacatgtgg cgctgctcct tcgaccgtgg cgacccctcc tcgggcactg gccgcgggcg
     1321 cctcttctgc ggcgacgtgg gccagaacaa gttcgaggag gtggacgtgg tggagcgcgg
     1381 cggcaactat ggctggcgcg cgcgcgaagg gttcgagtgc tacgaccgca gcctgtgcgc
     1441 caacacctct ctcaatgact tgctgccgat tttcgcctac ccgcacacgg ttggcaagtc
     1501 ggtcacaggg ggctacgtgt accggggctg cgagtacccc aacctgaacg gcctctacat
     1561 ttttggggat ttcatgagcg ggcgtctgat gtccctccaa gagaacccag ggacaggcca
     1621 gtggcagtac agtgagatct gcatgggcca cggccagacc tgtgagttcc caggcctcat
     1681 caacaactac tacccgtaca tcatctcctt cggggaggac gaggccgggg agctgtactt
     1741 catgtcgaca ggggagccga gtgccacagc tccacgcgga gttgtctaca aaataattga
     1801 cgcatccagg cgggcaccac ctggcaaatg tcagatccag cctgctcagg tgaagatcag
     1861 aagccgtctc atcccctttg tgcccaaaga aaagttcatc ccgaagacac ggagcacccc
     1921 gcggcctaca gcgcgggcgc ccacgcgggc gccccgccga gggcgcccca cggccgctcc
     1981 ccccgcgcca accccgcggc cagcgcggcc cacccagcag ccagggagcc ggaggggcgg
     2041 cgggcggcgg cgggggcggc tgaactcggc gagccgggcg ttccgggatg gcgaggtgcg
     2101 cctggtgcgg cccgcgggcc tgagctctgg cagcgggcgc gtggaggtgt tcgtgggcgg
     2161 acgctggggc accgtgtgcg acgactcctg gaacatcagc ggcgccgccg tcgtgtgtcg
     2221 ccagctgggg tttgcctacg ccgtgcgcgc cgtcaagaga gccgagttcg gccagggcgg
     2281 ctcgctgccc attctgctgg acgatgtgcg ctgcgcgggc tgggagcgga acctgctgga
     2341 gtgccagcac aacggcgtgg gcacccacaa ctgcgagcac gacgaggatg cgggcgtcgt
     2401 gtgcagccac cagaaccccg acctgtaggc aacacgccgc tgccccaggc catcccgccg
     2461 gcgggggagc ctggcagggg ccgctccgcc ctgtgtgcgc ccagcgggtg cacacgtgtt
     2521 ctagagtgaa gggggtgcgg gtgtgtgctg tcctggggac atgtgtgagg cgctgcagtg
     2581 catgtgtgtc ctctgcagac ccaaggcagg agtgtgtgtt gggggcggtg tgggctctgg
     2641 aagtgcatgg tccatcatgg gcgggaggag ttcctttctt acctccaagc gtttcagaca
     2701 ccagcaggaa cagcagccgg gctgtgggac cctgaggagg gagggcagcc aggcttcgag
     2761 gacggacatg gcccctggct gtgctaacag aggcacagct tgcagactga gggcggtggg
     2821 gagaaccagg cttgtcctgc ccacagctgg aatggaaggt gcaagaacag ccggagggtg
     2881 gcctgaggaa tgtggcccgg acagcatggc ctggtgcccg catccccccc accccctggc
     2941 agtcagaggc gctggagaga accggaaggc atccagtggg gaagggaaag ccttctggaa
     3001 ggtgggagca gggtgagctg caggcctggg gccccactgg aggggcaggc tgcgtggagg
     3061 agccagcacc tgctcaggga ggatggctgt gaggactgga tgacctccaa ggccgtatgc
     3121 tggagaagcc actcagcagc atactcagtc cttgtgggtg ctcctgggat gggaccagcc
     3181 tcctccaacc ctgaggcctg attctctctt gctcttgggg cagaagccac ccacactagc
     3241 tgggcagagc tttcaccctg gccctccagt gagtcggtgg gcctccacta ctttcaaagc
     3301 tgtgtttggg ccctggggcc acctctgtcc tttccatccc catccctgct cagtgtaaac
     3361 ccaggagacc tgattcctcc agccctacct cggggctgac caggctgggg gtccagtgaa
     3421 actactgaca ctttttcacc cagggctatg ccaataatgt ggctgtttac acaccacttt
     3481 cctgcctcct ctctgacctg cacctgtgtg ggagccgggg tgggaaccag gagaaagggg
     3541 tgaggcctcc cgcttcccac ctgcatcaca ggtggaagct ccttcactcc agggatgctc
     3601 ggccctggct ctgtgccagg ccgcagaggg gcacttagta tgactgcgct cagcctcgga
     3661 tgggagcacg ggtggggggt gggtaagcag atgagtcacc aggcagtgaa gacaggatgt
     3721 ggcccatgtc gggggttgga agaggtctgg gtggggcacc caaacccaac ctatgggggg
     3781 gctttgggag ggggtgatgc tgtgccaagt tctgggagct ggcaccaggg gtggctgggc
     3841 aggccttggg gcaggcatga gtctggcagg gtctcctagc tgctagtata gggtctccta
     3901 gccactagta taggatcctg ggctgcagca gaaagcttta ggtcactgtc ttggactcct
     3961 catactctgt gctttacaga atgggaaact gaggcacaca gaggttagat atcttagggc
     4021 accaagccag ggaagggaga agtcaagttt gaatacagca gcttagttta gagtccccgc
     4081 accctaacca ctgccctccc cagctacact atgcctgcag agagcggtgt gctggggctc
     4141 ctgcctggtg tgggagtgcc agcctggctg ggaagcagct gatggagatc cctgggggct
     4201 cctcttgcct ggcaggtgcc cccgctgctg gcctcatgct cctctcgggc ctccagtggc
     4261 ccaggggagg ttgagtgggc atcttcctgg gatgcagggg agttctgagc tctgacgccg
     4321 ggcgtgttag gagatagcag gccgttaatg accatcccag ccgaattcct cactgtgcag
     4381 atgaggaagt gagctcaggg aggctgagtg tcccaggcct gttgccagat gaggccacgc
     4441 tgagactgga gccagggaag gtgcagcaag ccttgaggcc ctcaagaatg cagccgagcc
     4501 agggccctgc ttgcctggcc ccagaagctg ttttgctcag agctggatta ggagggttgg
     4561 caaagggagc tctgggtgcg gcctcaggcc ctccagtact tctctgggca gttcgggctt
     4621 tggccttcag tcttccaggc caggcgctct tcctccccag cctccaactc atcacctctc
     4681 aggccccaaa ccaggcctgg gctaggctgc agcctgcctc ctggggactc actccacagt
     4741 ccccaggtca gtggtcccca acctttttgg catcatggac tggtttcatg taagacaatt
     4801 tttccatgga tgggggttgg ggggatggtt ttgggatgaa atgtcccacc tcagatcatc
     4861 aggcattaga ttctcataag gagttcacag cctagatccc tcgcatgcac agttcatagt
     4921 aggtttcatg ttcctatgcg gatctaatgc cactgctgat ctggcaggag gcagagctca
     4981 ggtgggaatg cttgctcccc acactaccct gccccactgc cactcacctc ctgctgtgtg
     5041 gcccggttcc taacaggcca cccatcagta ctggtccgtg gcccagggtt tggagacctc
     5101 tgccctaggt agtaataaga gtggacagct gttatatgta aatacttgtt ccccgatgct
     5161 ggaaagaaat agcactaaaa cataaattta attctttcag caaggcaatt ttactttctg
     5221 cagaaagggt gctcatcgca gatggaacaa tagtgagagg acacctgaac aaaggaggga
     5281 agcaattgtt agcccttatg cagtttgtcc ctgctactgt gtcctatgtc cattggcaga
     5341 agccagaccg cacaatctaa actaaaaccc gattggctgt ttaaaatttt tctaaatagg
     5401 taaaagtaat ggaaggataa aggaaaagag gaagttgctt acgaaaggac ttagaaaagt
     5461 aataatattc ccaaataagg aaggggtata ggctgtgagc tgggacatgc ctgtgagcac
     5521 gtccagcaca gatatcttgg ttaaagtata aggacataga acgtactatg tgcctgtgag
     5581 cacgtctaac agttacatag aatagggctt gacaaagagt tattagcata aagcaaggag
     5641 gtttgaagga agttcgtctt taaaagaaac cattatttct aacacttacg atttattctt
     5701 taacaagaag ggaaactttc aagaggaact tttactttct acaacagctg acctctgctg
     5761 agcgcttact acatgccaag cactgctctg aaagtttaac ataccattca ctcatgtaat
     5821 cctcatatta atgcacattt actcacgtgg aagccgagtt ccagggcatt tgtcacttac
     5881 caaatgtcac atagccaaaa tttgaatttg agcccaggta gtccagctct gggaccctgc
     5941 tgtgggcctt cctgctgggc cacctcaagg gcattgaaag ccagccccac cccactggga
     6001 cacaagttca gagaagggca gagctggctg cctgtccagt gcttctttca ctccaccacc
     6061 tacagctggc cgctgaggga gcattcacat gtgactctgt ccccagggac tccgatcttg
     6121 ccttaaagtc ctccagggcc tctgaggatg ggggcacagc cttcaccctc accccctcta
     6181 atccaacctc tagtcaatag ccaggatcag attctcagag aggggctgcc ctgcccagtg
     6241 ccacacagct tagtgctgga gcctcagggt caatgctgca ggggtggccc agtgtccagg
     6301 actgtgttca agacatcagt cagaggtcac aacatcccag gccctagact gagcctaggg
     6361 gtcaccatgt tgatacctta gaaatgtttg ggaggttcaa ggaagctgga aactgggttc
     6421 cagtcctggc tctgtgcctc tctgagtctc attgcaaaat agaggtcacc agaaggatta
     6481 ctggatgaaa aatgaggtag cattgcagac gtgcatggca cgtacactct aggttgcttc
     6541 ctagacagaa agctcagttc gaggctggtg gcatccatgc tggcagcagc caactgtctg
     6601 cgacagagtg aggaggggca tgccacgtga aggaccagca tcagaatgac atgggaagaa
     6661 actctcacaa tagcagaaga aagagctcct tcagcctaac atgtagaact caagtcttct
     6721 tgtcgcgctt ctgtcccctc gcccctcctc ccccactgag aactagcttt tactgagcag
     6781 ttattacatg ccagctacct cgggtgtgtc agctcattta atcttgacaa cagctccacg
     6841 agacaccctc aatatcactg tccctgtttt ccagatgagg ggacagattc ctagggtgtt
     6901 atgtaagtgg tccccggggc tttagaggca ggtttgcacc aaggcccatt ctcccagagc
     6961 cggatccttc tccttccctg ggatacagca cctccaccct gccaggccac ccatgtaaag
     7021 gcagccaatt cagagccacc tcttatgcct gcatctcccc aacaattcct gctgggaaac
     7081 cactcctcgt atggtgtcat ctacaccagt gggtttcaag cttgagaaga atcaagttct
     7141 acagggctgc ttaaaacaca ggttgctggg tcctgtctct cagagttttt gactcagtct
     7201 tggttgagaa ttttcagttc tagaagctcc tgggtaatgc taatcctcct gttctagggg
     7261 ccatagtcat tgtccatact ggtgctatcc aatagaaaca taatgtgagc caaataggta
     7321 atttaaaatc tgcttgtagc catgttaaaa aagtaaaaca ggtaaaatta a
//
