LOCUS       NM_022475               9937 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens hedgehog interacting protein (HHIP), mRNA.
ACCESSION   NM_022475
VERSION     NM_022475.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9937)
  AUTHORS   Zhang,J., Zhao,D., Zhang,L., Feng,X., Li,B., Dong,H., Qi,Y.,
            Jia,Z., Liu,F., Zhao,S. and Zhang,J.
  TITLE     Impact of HHIP gene polymorphisms on phenotypes, serum IL-17 and
            IL-18 in COPD patients of the Chinese Han population
  JOURNAL   Respir Res 25 (1), 386 (2024)
   PUBMED   39468530
  REMARK    GeneRIF: Impact of HHIP gene polymorphisms on phenotypes, serum
            IL-17 and IL-18 in COPD patients of the Chinese Han population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9937)
  AUTHORS   Guo,F., Zhang,L., Yu,Y., Gong,L., Tao,S., Werder,R.B., Mishra,S.,
            Zhou,Y., Anamika,W.J., Lao,T., Inuzuka,H., Zhang,Y., Pham,B.,
            Liu,T., Tufenkjian,T.S., Richmond,B.W., Wei,W., Mou,H.,
            Wilson,A.A., Hu,M., Chen,W. and Zhou,X.
  TITLE     Identification of a distal enhancer regulating hedgehog interacting
            protein gene in human lung epithelial cells
  JOURNAL   EBioMedicine 101, 105026 (2024)
   PUBMED   38417378
  REMARK    GeneRIF: Identification of a distal enhancer regulating hedgehog
            interacting protein gene in human lung epithelial cells.
REFERENCE   3  (bases 1 to 9937)
  AUTHORS   Jin,A.L., Ding,L., Yang,W.J., Liu,T., Chen,W., Li,T., Zhang,C.Y.,
            Pan,B.S., Qiu,S.J., Zhou,J., Fan,J., Guo,W., Yang,X.R. and
            Wang,B.L.
  TITLE     Exosomal microRNAs in the DLK1-DIO3 imprinted region derived from
            cancer-associated fibroblasts promote progression of hepatocellular
            carcinoma by targeting hedgehog interacting protein
  JOURNAL   BMC Gastroenterol 22 (1), 505 (2022)
   PUBMED   36482325
  REMARK    GeneRIF: Exosomal microRNAs in the DLK1-DIO3 imprinted region
            derived from cancer-associated fibroblasts promote progression of
            hepatocellular carcinoma by targeting hedgehog interacting protein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9937)
  AUTHORS   Chakraborty,B., Basu,M., Mukhopadhyay,D., Alam,N., Ghosh,S.,
            Dutta,S. and Panda,C.K.
  TITLE     Differential promoter usages of PTCH1 and down regulation of HHIP
            are associated with HNSCC progression
  JOURNAL   Pathol Res Pract 232, 153827 (2022)
   PUBMED   35276608
  REMARK    GeneRIF: Differential promoter usages of PTCH1 and down regulation
            of HHIP are associated with HNSCC progression.
REFERENCE   5  (bases 1 to 9937)
  AUTHORS   Yang,Y., Cheng,Y., Mou,Y., Tang,X. and Mu,X.
  TITLE     Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses
            Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability
            via Interaction with CELF2
  JOURNAL   Crit Rev Eukaryot Gene Expr 33 (1), 67-77 (2022)
   PUBMED   36374812
  REMARK    GeneRIF: Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses
            Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability
            via Interaction with CELF2.
REFERENCE   6  (bases 1 to 9937)
  AUTHORS   Olsen,C.L., Hsu,P.P., Glienke,J., Rubanyi,G.M. and Brooks,A.R.
  TITLE     Hedgehog-interacting protein is highly expressed in endothelial
            cells but down-regulated during angiogenesis and in several human
            tumors
  JOURNAL   BMC Cancer 4, 43 (2004)
   PUBMED   15294024
  REMARK    GeneRIF: These results suggest that reduced expression of HIP, a
            naturally occurring Hh pathway antagonist, in tumor neo-vasculature
            may contribute to increased Hh signaling within the tumor and
            possibly promote angiogenesis.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 9937)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 9937)
  AUTHORS   Ingham,P.W. and McMahon,A.P.
  TITLE     Hedgehog signaling in animal development: paradigms and principles
  JOURNAL   Genes Dev 15 (23), 3059-3087 (2001)
   PUBMED   11731473
  REMARK    Review article
REFERENCE   9  (bases 1 to 9937)
  AUTHORS   Bak,M., Hansen,C., Friis Henriksen,K. and Tommerup,N.
  TITLE     The human hedgehog-interacting protein gene: structure and
            chromosome mapping to 4q31.21-->q31.3
  JOURNAL   Cytogenet Cell Genet 92 (3-4), 300-303 (2001)
   PUBMED   11435703
REFERENCE   10 (bases 1 to 9937)
  AUTHORS   Chuang,P.T. and McMahon,A.P.
  TITLE     Vertebrate Hedgehog signalling modulated by induction of a
            Hedgehog-binding protein
  JOURNAL   Nature 397 (6720), 617-621 (1999)
   PUBMED   10050855
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY009951.1, BC025311.1 and
            AC098588.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022475.2.
            
            Summary: This gene encodes a member of the hedgehog-interacting
            protein (HHIP) family. The hedgehog (HH) proteins are
            evolutionarily conserved protein, which are important morphogens
            for a wide range of developmental processes, including
            anteroposterior patterns of limbs and regulation of left-right
            asymmetry in embryonic development. Multiple cell-surface receptors
            are responsible for transducing and/or regulating HH signals. The
            HHIP encoded by this gene is a highly conserved,
            vertebrate-specific inhibitor of HH signaling. It interacts with
            all three HH family members, SHH, IHH and DHH. Two single
            nucleotide polymorphisms (SNPs) near this gene are significantly
            associated with risk of chronic obstructive pulmonary disease
            (COPD). A single nucleotide polymorphism in this gene is also
            strongly associated with human height.[provided by RefSeq, Feb
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY009317.1, SRR1660805.192992.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296575.8/ ENSP00000296575.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-922               AY009951.1         136-1057
            923-2691            BC025311.1         909-2677
            2692-3395           AY009951.1         2828-3531
            3396-9937           AC098588.3         117073-123614
FEATURES             Location/Qualifiers
     source          1..9937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..9937
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /note="hedgehog interacting protein"
                     /db_xref="GeneID:64399"
                     /db_xref="HGNC:HGNC:14866"
                     /db_xref="MIM:606178"
     exon            1..799
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             521..2623
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /codon_start=1
                     /product="hedgehog-interacting protein precursor"
                     /protein_id="NP_071920.1"
                     /db_xref="CCDS:CCDS3762.1"
                     /db_xref="GeneID:64399"
                     /db_xref="HGNC:HGNC:14866"
                     /db_xref="MIM:606178"
                     /translation="MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNP
                     PKRLKRRDRRMMSQLELLSGGEMLCGGFYPRLSCCLRSDSPGLGRLENKIFSVTNNTE
                     CGKLLEEIKCALCSPHSQSLFHSPEREVLERDLVLPLLCKDYCKEFFYTCRGHIPGFL
                     QTTADEFCFYYARKDGGLCFPDFPRKQVRGPASNYLDQMEEYDKVEEISRKHKHNCFC
                     IQEVVSGLRQPVGALHSGDGSQRLFILEKEGYVKILTPEGEIFKEPYLDIHKLVQSGI
                     KGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQV
                     DLRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSV
                     LRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTI
                     LCSDSNGKNRSSARILQIIKGKDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYGS
                     YVFGDRNGNFLTLQQSPVTKQWQEKPLCLGTSGSCRGYFSGHILGFGEDELGEVYILS
                     SSKSMTQTHNGKLYKIVDPKRPLMPEECRATVQPAQTLTSECSRLCRNGYCTPTGKCC
                     CSPGWEGDFCRTAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDRNIRRVTRAGIL
                     DQIIDMTSYLLDLTSYIV"
     exon            800..992
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1149
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1351
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1503
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1677
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1821
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1943
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2067
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2198
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2280
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2429
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..9937
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9914..9919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /note="hexamer: ATTAAA"
     polyA_site      9937
                     /gene="HHIP"
                     /gene_synonym="HIP"
                     /note="major polyA site"
ORIGIN      
        1 atgagaggct gtgtgagaag ctgcagccgc cggcagagga gacctcagca tcatctagag
       61 cccagcgctg gccctgcctc cgcctgcccc gccgccgccg tcgccgtttc tgttcctgct
      121 actgtcccac ctaaacaact cccgttacac ggacaagtga acatctgtgg ctgtcctctc
      181 cttttcttcc tcctcttcca actccttctc ctcctcccac ttcccagccg cagcagaaag
      241 cccccaaccc aactgacact ggcacaactg caaacggtgt catccgcaca actttatctc
      301 gctcctcggg ctcccctaag gcattggacc catcgccgcg tcttttattt tttgcaaagt
      361 tgcatcgctg tacatatttt tgtccccgcc acctccctct gtctctggag tgccctacag
      421 ccccgcaaac tcctcctgga gctgcgccct agtgcccctg ctgggcagtg gcgttccccc
      481 ccatcctccc gcgcccagcc cctgctgctc tgggcagacg atgctgaaga tgctctcctt
      541 taagctgctg ctgctggccg tggctctggg cttctttgaa ggagatgcta agtttgggga
      601 aagaaacgaa gggagcggag caaggaggag aaggtgcctg aatgggaacc ccccgaagcg
      661 cctgaaaagg agagacagga ggatgatgtc ccagctggag ctgctgagtg ggggagagat
      721 gctgtgcggt ggcttctacc ctcggctgtc ctgctgcctg cggagtgaca gcccggggct
      781 agggcgcctg gagaataaga tattttctgt taccaacaac acagaatgtg ggaagttact
      841 ggaggaaatc aaatgtgcac tttgctctcc acattctcaa agcctgttcc actcacctga
      901 gagagaagtc ttggaaagag acctagtact tcctctgctc tgcaaagact attgcaaaga
      961 attcttttac acttgccgag gccatattcc aggtttcctt caaacaactg cggatgagtt
     1021 ttgcttttac tatgcaagaa aagatggtgg gttgtgcttt ccagattttc caagaaaaca
     1081 agtcagagga ccagcatcta actacttgga ccagatggaa gaatatgaca aagtggaaga
     1141 gatcagcaga aagcacaaac acaactgctt ctgtattcag gaggttgtga gtgggctgcg
     1201 gcagcccgtt ggtgccctgc atagtgggga tggctcgcaa cgtctcttca ttctggaaaa
     1261 agaaggttat gtgaagatac ttacccctga aggagaaatt ttcaaggagc cttatttgga
     1321 cattcacaaa cttgttcaaa gtggaataaa gggaggagat gaaagaggac tgctaagcct
     1381 cgcattccat cccaattaca agaaaaatgg aaagttgtat gtgtcctata ccaccaacca
     1441 agaacggtgg gctatcgggc ctcatgacca cattcttagg gttgtggaat acacagtatc
     1501 cagaaaaaat ccacaccaag ttgatttgag aacagccaga gtctttcttg aagttgcaga
     1561 actccacaga aagcatctgg gaggacaact gctctttggc cctgacggct ttttgtacat
     1621 cattcttggt gatgggatga ttacactgga tgatatggaa gaaatggatg ggttaagtga
     1681 tttcacaggc tcagtgctac ggctggatgt ggacacagac atgtgcaacg tgccttattc
     1741 cataccaagg agcaacccac acttcaacag caccaaccag ccccccgaag tgtttgctca
     1801 tgggctccac gatccaggca gatgtgctgt ggatagacat cccactgata taaacatcaa
     1861 tttaacgata ctgtgttcag actccaatgg aaaaaacaga tcatcagcca gaattctaca
     1921 gataataaag gggaaagatt atgaaagtga gccatcactt ttagaattca agccattcag
     1981 taatggtcct ttggttggtg gatttgtata ccggggctgc cagtcagaaa gattgtatgg
     2041 aagctacgtg tttggagatc gtaatgggaa tttcctaact ctccagcaaa gtcctgtgac
     2101 aaagcagtgg caagaaaaac cactctgtct cggcactagt gggtcctgta gaggctactt
     2161 ttccggtcac atcttgggat ttggagaaga tgaactaggt gaagtttaca ttttatcaag
     2221 cagtaaaagt atgacccaga ctcacaatgg aaaactctac aaaattgtag atcccaaaag
     2281 acctttaatg cctgaggaat gcagagccac ggtacaacct gcacagacac tgacttcaga
     2341 gtgctccagg ctctgtcgaa acggctactg cacccccacg ggaaagtgct gctgcagtcc
     2401 aggctgggag ggggacttct gcagaactgc aaaatgtgag ccagcatgtc gtcatggagg
     2461 tgtctgtgtt agaccgaaca agtgcctctg taaaaaagga tatcttggtc ctcaatgtga
     2521 acaagtggac agaaacatcc gcagagtgac cagggcaggt attcttgatc agatcattga
     2581 catgacatct tacttgctgg atctaacaag ttacattgta tagtttctgg gactgtttga
     2641 atattctatt ccaatgggca tttatttttt atcctgtcat taaaaaaaaa agactgttat
     2701 cctgctacac actcctgtga tttcattctc ttttattaat ttaaaaataa tttccagaaa
     2761 tgtgcagatc ctctgtgtgt atgtcagcat gtttgttcac atatgcacat acacatactc
     2821 ataaccccta tatgcgttgt tgcataacag atgatttttt aaaatatata cttccttatg
     2881 caaagtaatt tacacagaaa ttccattgta aattgataat ggatttttta tgttactaga
     2941 agagattatt tgacttccca ggaattttct gtctgtaatc actaaagtca actttaatag
     3001 agttttgaaa cagtactgtg caatccgatg gatctaatta aaaaaaaggc aatattttta
     3061 tattaaagta ctatactagg agagaatgtt tcagaactcc ctgatgaatt tctaagtgag
     3121 caacttgata taaaattgta atcttcattt ttgtcagtgt atccagttac agaatgctac
     3181 acacttacct ttttattggc tgagaaatct ggttatttca tcttaatctc aagattgttt
     3241 tcaagtgttt tataattaaa tcataatagc atattttaaa atcaatcttc ctaaaaggtc
     3301 tgcttttatt gtatatttta tttaacaata ggcactgggt ttgtgttaca tatttatata
     3361 ttttatttta tttttataat atagacatca cctagatgaa acacctttac cctgtcctgt
     3421 aaaacactaa agttacattt ttcaccaact taattggaaa gaaggggagt gagaaagcaa
     3481 acagtcttta atgtgctgtg gatctaatct agcaaggtat ccttgtgcca acatgtaatc
     3541 attaacgacg gatgaaaaag caagaaaaca gccaatcctt ataaaattcc agcattaaac
     3601 atttgtaaag tgcttttcac catagcaaga ctgtcagagt ctatgttatt agaatgttgc
     3661 agatttccac tgaatcgaac ctcactggag aagagctcac ttgtttttaa aaatcttggc
     3721 tatgtaagct gtcacctgta caaattttta acataataat tcttgccaaa tatgacttta
     3781 aatgtacgtg ttccttcaga actcaatgaa aatactcttt ggctaatgta tcaataaatt
     3841 ttctgtaaat gttctgttca gggttttaca gagatgacat gttctgactt aaaactgcaa
     3901 aaagtctagt agatattttt cttcatggtt ttcaaagcca gctctccacg tttggatttt
     3961 aacaaaatat aaggcctctt tgcactagtg aaaaaacacg tctactcatg acaagtgcac
     4021 acccactatg gctgtccttc ttctgtaaac atccattcct ctagaatcta aattgtagag
     4081 cagtatagat tatgcagcgc cagctgactt tctaaacctt ctccttacct ttaggaatac
     4141 aagcctcaat ttaaaaaata tattgtagct agtatttctc tattgtttta aggtgagaga
     4201 tttgcaatta aagcccagta agcatttata tagaagccac aatgtagaaa gattggttaa
     4261 gtacactgct cttgtcttcc atatatgatt acttaagttt caagtgacct catgccaaat
     4321 ggaaatgggt tgagaaatct tggttcagtg cttagtgaac aatagcctgc attaaaaagt
     4381 gcatgcataa ttttgcacaa tttagattca attgacagtc tattcaaaga agtctcagga
     4441 ttaaatgagc atggagacca aattgccctc ttaccccaga aaaggggtgg tcccttctag
     4501 tcacactaac acttcattgg cccaacagtg tgacaaatct tgcaatgaac catgcagtag
     4561 cctgcatctg taggttaata gcaatctttt gtctccattg ctttctcttc atagcccttt
     4621 tactgaattc catcacagaa agttttacaa ttaaaaaaaa atgtcctgac aaccattttt
     4681 gtaaatggac cttaccatct aattgtccct tattcaacgt gggtgacatt aacaaaatgt
     4741 gaacttcttg tgagggagcc agctgtctaa atctgtcaaa tcgtgcagtt ttattacaca
     4801 ttctccaatt cttcctagtt tccctgaaaa caataaggat actgctatat attcagtaaa
     4861 atctaaaaaa atcaagcatt acttcttaca tctttaaact ttccatctcc tccccaaaat
     4921 aaaaggtgtt ctattgccat tagttctact gttttaaaat atctatatta agttgaccag
     4981 gcccagattt tttatacagc tttttcccaa gtgaaagatt ttcaagtgac ttagaaaaac
     5041 atatgtgccc caggtgtcat tgccttttct tttgtgagtc attagaatga aaggccaagt
     5101 tcttctcaag agaagatagc aagatccacg gatattaagc caagcaaaga aagtaaaatc
     5161 attggagtca tttctttctg ttcttaggag aaaagtagat agcactggct aattgatggc
     5221 aacatatttt aaattaagtg gtcaattcaa aaattctctt tgaccttttc tttcaagtag
     5281 atttttttaa atgcatgact ggagaattat cttcaatgat tcatgatgag aggcaggtag
     5341 gaattggtta agaagtatga gcaggaaaaa attattgttt aatcacatga aaggcaacat
     5401 ctgttcagtt cataaagcac acagtctcga atggaagaaa aaaaggtcct tcgtaagaat
     5461 actgatgcat aagataaaga cgaaataatg aaaaagaaaa atgtatatta ttattccctt
     5521 gtccattctc aagtttaagc tgcggttgtc agttgaatgt gaaatgatgt tatagttgtt
     5581 ttaaatggtt ggaaataacc tttctactac tgtttctgcc acactgttgt cctggttcat
     5641 agaaccttgt tttcttgaca gttatttaag gtaataaaag gaacacaatt tggcagatct
     5701 ttaagtgaaa gagagaaaaa atttaagaaa ttgagtgatg gctaaaagta agtgcttcca
     5761 tccataactt ttcttcttgg atttttttca atgtaattat tgtaaaatat atttttttat
     5821 tttatcatga agaatactcg gaaggtttct cagattaatg agtatctcat aaagagtaga
     5881 gaaaccaaca catacaatat atacacacaa cctaaataga aaactatttt ctttgtcatt
     5941 tgcatgcccc agagaagtta cttcttccct atttatttct ttgaaaataa ttacaaaata
     6001 gtatactaac aattttaatc catttgctgt tttttttttt tttttggttt cttttttttt
     6061 ttttttgaga cggagccttg ctatgttgcc caggctgcag agcagcacaa tctcagctca
     6121 ctacaacctc cgcctcccgg gttcaagcaa ttctcctgcc tcagcctccc aagtagctgg
     6181 gattacaggt gcccgccacc acacccggct aatttttttg tgtttttagt agagacaggg
     6241 tttcaccatg ttggccaggc tgatttcaaa ctccagactt caagtgatcc agccccccag
     6301 gcctcccaaa gtgctaggat tacaggcgtg agccaccatg cccagcttcc atttgctttt
     6361 gatattgttt ttatctctga gttacaaact atacaagctt accaggtata aggttagatg
     6421 ctacatctag gagcattcaa gatatacatt aatttaaact tttattagtc taactttctg
     6481 ttaagtctct tagctttgaa acataaaaga gaaatcaagc ccaaattttt agaggaaggc
     6541 taaggtatac tattggcagt tgtagtttta attgtaattg actgattaac caagtaattt
     6601 ataaaatgtt acctatactg tcagtgttca cctcctctcc ctccctcctt ctctctctct
     6661 ctccccctct cgctctctcg gctaatatat atgtgtatgt gtatatatat atgtatgtat
     6721 atatatacac acacacacac acatacatac atacatacat atattctttt tccttttaac
     6781 cacttccctc tcctacattt tctattggtt ttgcctaaat agacatgttc tcaatacacc
     6841 catgttgaag gtatcctggg ctagattgct gttgattttg ctggttatga tcttttcttt
     6901 gtttttctga aaaatagcct ctcttgattc cacattttct caaattctat ataacaaata
     6961 atagtggata gtaaacaaat gacatactag gctgatctat tacaatcatt gaaagaaata
     7021 aggaagagca gaaatcacta acagtccaga ggctccaatt cagctgctct agcatagata
     7081 caggaaagac atggagaata acactggggt tagctaacag cagggaaagt tagtagctat
     7141 ttcctagcca aggaacaacc ttctctatgg aataatttta agaaaattat tccaaatctg
     7201 tgaggaaaaa ataagaagca gttcctcaat ggagacttta taaatcttaa tttcctcacc
     7261 cctgggatga gatttgaagt tgcagaggac tcagaccaaa gtcccatggc agaaaatgta
     7321 catattttta aactactccc aggaagtaaa ctagtactgt gaatgctggc aataccatca
     7381 gaaagtttat ctttaaaata cctaaaaata aatatatatt tgctatctta tcctcttttt
     7441 gtcacacaaa cataaattgg tcatatatat atttatatat atggttatat atatttggtt
     7501 atatatatat ctttatatat atatcttata tatatatctt tttatatata tcttatatat
     7561 atatcttttt atatatatct tatatatata tctttatata tatcttatat atatatctta
     7621 tacatataag atatatgtat atatatatac attatatata tataatatat atatattata
     7681 tatatataat atatatctta tatatatata tatcttaata catatatata accatggaac
     7741 ctgccaaaca ctaatcctag ccaacttcaa tccttctttc tcttaactat cttctctgaa
     7801 taagttctgg acttcacctt aaaataagtt tttaggagag taatatatat tcatgggatt
     7861 gtgagggagc attgtagagc tgttttcttc tcagtcatag tggtggtttt cctagctgct
     7921 atggaaaggt ttgttcactt atgagattag gacttttctt aaattcctca ttaaatatga
     7981 acctaaggca tacccatcat ttaccttgat tcccatataa tttgtataag tcatatataa
     8041 gtccattgac aaaataaaaa aataaataat tggattcctt gtatcaacag aaagccttgt
     8101 gcttaaaacc tgttattctt ctttgagcca gactaaacag taacatttac aaaatggtat
     8161 cagctcaaca ttaaatctaa ggttacttct cacatacatc ataaagtcag ccatcatctt
     8221 tcatttagga tttcttgggg ttttcttttt gcatatatag attatgtatt acttaaatcc
     8281 aaaatacatg tgtgtatata tatacatata tatgtaactt aatataaatg tttgatgagt
     8341 tatctcaatt gactataatc ttctaagtca aaaagaaaac atttaagtac ataatataaa
     8401 aagaactgaa cattaacagt aatgggaaat tcataatggc taaatatgaa ataagctttg
     8461 tctttgcagt tacaaactaa ttcttgtaca ttttcctttt cactaaaaaa ataactaatt
     8521 gatagtttcc attcacatga acaagttata atcaggtttg ggatagtatg cccaaaacct
     8581 atgtttcttt actttatatt cttaaaatct gagacatgat ttttctggaa caaattaaga
     8641 tttcatgtac aatagagtcc ctttcctaat actgttatga agaaaccaag ttgactacct
     8701 tatgagagat cagatatttc ccttatctca ttatattcac agcatatgtt tggacatgcg
     8761 tttcaccaag aaccatgtag taataagata aatggtaact gaggtactat ggaattttta
     8821 gaacttgatt ccccaggaca tgctacagta aactaaacta tttattcaaa agtaacccaa
     8881 ctaattaaag tgaaaaaaaa ttgttgaatc acaatgaaca aacataaaac aatacttaaa
     8941 tgagaattct gtgtcttttt tggttttatc tgtgatttat tttgtccagt attaaggaat
     9001 ggttatcttt atcattcttc taacatgttt tggtttctct aatggttcat tttcctttag
     9061 cttgtgaaaa ttagggcagt ttgtccagag ccttactcgc aggagacacc agacccaacc
     9121 catgcttaga tttctgttaa taaaagggag aagggtattt gaataggtag taaaggcagg
     9181 tacaagttta agggagcagg gctatcatat gtactaggtg agatttctat aaatgtctga
     9241 aaagttacat gcatagtcat tggctcaggt aatttctctg aatttgaact tatttgattt
     9301 atttaaccaa gttattataa tatgcagttc tctttaatca atcttctatt attcaatcat
     9361 ctatccattt attaattcaa caaatattta ttaaagtgcc taccatgatt atgtgctgta
     9421 gaaaagacaa ggacatttac taggggggga ttgtgggccc aatcggcatc ataagcatgt
     9481 ctgaagcaaa agacaataat cacatccaac ggcaccagtt cagctcaact ttagaattca
     9541 gcagtaacag tacagatggc ctaaagtaca tctgtgtgta tctgtacgtg tgcacacacc
     9601 catgtatata tatttatcta tctgtacaaa cactacatat gtatacacac tatctatgta
     9661 aaatataata tatgtataat gcatataaat tctaacaagt gtatttgtgt tatctttaaa
     9721 atagaacaat tgtatcttga agtggtaaat gcagagaatt ggttttattg ttgatctgtg
     9781 gatttaatga tttctaggtg aaaaggacgt ttaagtgtac aatttctttt cttaatttaa
     9841 tatatttatg taaatgcatg cctgaaattt ggttagattg gctgtgtttt gtgtctttta
     9901 acatgatcaa atgattaaac tttatcttat gacttga
//
