LOCUS       NM_002729               1724 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens hematopoietically expressed homeobox (HHEX), mRNA.
ACCESSION   NM_002729 NM_001529
VERSION     NM_002729.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1724)
  AUTHORS   Li,H., Liu,J., Lai,J., Su,X., Wang,X., Cao,J., Mao,S., Zhang,T. and
            Gu,Q.
  TITLE     The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties
            and tumorigenesis in HCC
  JOURNAL   J Transl Med 22 (1), 537 (2024)
   PUBMED   38844969
  REMARK    GeneRIF: The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like
            properties and tumorigenesis in HCC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1724)
  AUTHORS   Xie,W., Zhang,L., Wang,J. and Wang,Y.
  TITLE     Association of HHEX and SLC30A8 Gene Polymorphisms with Gestational
            Diabetes Mellitus Susceptibility: A Meta-analysis
  JOURNAL   Biochem Genet 61 (6), 2203-2221 (2023)
   PUBMED   37103601
  REMARK    GeneRIF: Association of HHEX and SLC30A8 Gene Polymorphisms with
            Gestational Diabetes Mellitus Susceptibility: A Meta-analysis.
            Review article
REFERENCE   3  (bases 1 to 1724)
  AUTHORS   Xu,Z., Feng,Y., Yan,Y., Jin,H., Chen,Y., Han,Y., Huang,S., Feng,F.,
            Fu,H., Yin,Y., Huang,Y., Wang,H. and Cheng,W.
  TITLE     HHEX suppresses advanced thyroid cancer by interacting with TLE3
  JOURNAL   Mol Cell Endocrinol 574, 111988 (2023)
   PUBMED   37302518
  REMARK    GeneRIF: HHEX suppresses advanced thyroid cancer by interacting
            with TLE3.
REFERENCE   4  (bases 1 to 1724)
  AUTHORS   Ito,R., Kimura,A., Hirose,Y., Hatano,Y., Mima,A., Mae,S.I.,
            Keidai,Y., Nakamura,T., Fujikura,J., Nishi,Y., Ohta,A., Toyoda,T.,
            Inagaki,N. and Osafune,K.
  TITLE     Elucidation of HHEX in pancreatic endoderm differentiation using a
            human iPSC differentiation model
  JOURNAL   Sci Rep 13 (1), 8659 (2023)
   PUBMED   37248264
  REMARK    GeneRIF: Elucidation of HHEX in pancreatic endoderm differentiation
            using a human iPSC differentiation model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1724)
  AUTHORS   Guo,Y., Zhu,Z., Huang,Z., Cui,L., Yu,W., Hong,W., Zhou,Z., Du,P.
            and Liu,C.Y.
  TITLE     CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes
            colorectal tumorigenesis
  JOURNAL   Nat Commun 13 (1), 4995 (2022)
   PUBMED   36008411
  REMARK    GeneRIF: CK2-induced cooperation of HHEX with the YAP-TEAD4 complex
            promotes colorectal tumorigenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1724)
  AUTHORS   Manfioletti,G., Gattei,V., Buratti,E., Rustighi,A., De Iuliis,A.,
            Aldinucci,D., Goodwin,G.H. and Pinto,A.
  TITLE     Differential expression of a novel proline-rich homeobox gene (Prh)
            in human hematolymphopoietic cells
  JOURNAL   Blood 85 (5), 1237-1245 (1995)
   PUBMED   7858254
REFERENCE   7  (bases 1 to 1724)
  AUTHORS   Neidle,S. and Goodwin,G.H.
  TITLE     A homology-based molecular model of the proline-rich homeodomain
            protein Prh, from haematopoietic cells
  JOURNAL   FEBS Lett 345 (2-3), 93-98 (1994)
   PUBMED   7911091
  REMARK    Review article
REFERENCE   8  (bases 1 to 1724)
  AUTHORS   Hromas,R., Radich,J. and Collins,S.
  TITLE     PCR cloning of an orphan homeobox gene (PRH) preferentially
            expressed in myeloid and liver cells
  JOURNAL   Biochem Biophys Res Commun 195 (2), 976-983 (1993)
   PUBMED   8103988
REFERENCE   9  (bases 1 to 1724)
  AUTHORS   Bedford,F.K., Ashworth,A., Enver,T. and Wiedemann,L.M.
  TITLE     HEX: a novel homeobox gene expressed during haematopoiesis and
            conserved between mouse and human
  JOURNAL   Nucleic Acids Res 21 (5), 1245-1249 (1993)
   PUBMED   8096636
REFERENCE   10 (bases 1 to 1724)
  AUTHORS   Crompton,M.R., Bartlett,T.J., MacGregor,A.D., Manfioletti,G.,
            Buratti,E., Giancotti,V. and Goodwin,G.H.
  TITLE     Identification of a novel vertebrate homeobox gene expressed in
            haematopoietic cells
  JOURNAL   Nucleic Acids Res 20 (21), 5661-5667 (1992)
   PUBMED   1360645
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC015110.1 and BM543214.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002729.4.
            
            Summary: This gene encodes a member of the homeobox family of
            transcription factors, many of which are involved in developmental
            processes. Expression in specific hematopoietic lineages suggests
            that this protein may play a role in hematopoietic differentiation.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050638.1, BC015110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282728.10/ ENSP00000282728.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1723              BC015110.1         5-1727
            1724-1724           BM543214.1         247-247
FEATURES             Location/Qualifiers
     source          1..1724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..1724
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /note="hematopoietically expressed homeobox"
                     /db_xref="GeneID:3087"
                     /db_xref="HGNC:HGNC:4901"
                     /db_xref="MIM:604420"
     exon            1..393
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..845
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /note="homeobox, hematopoietically expressed; proline-rich
                     homeodomain-containing transcription factor; homeobox
                     protein HEX; homeobox protein PRH; proline-rich
                     homeodomain protein"
                     /codon_start=1
                     /product="hematopoietically-expressed homeobox protein
                     HHEX"
                     /protein_id="NP_002720.1"
                     /db_xref="CCDS:CCDS7423.1"
                     /db_xref="GeneID:3087"
                     /db_xref="HGNC:HGNC:4901"
                     /db_xref="MIM:604420"
                     /translation="MQYPHPGPAAGAVGVPLYAPTPLLQPAHPTPFYIEDILGRGPAA
                     PTPAPTLPSPNSSFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYP
                     FPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQK
                     YLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKEELESLDSSCDQR
                     QDLPSEQNKGASLDSSQCSPSPASQEDLESEISEDSDQEVDIEGDKSYFNAG"
     exon            394..572
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /inference="alignment:Splign:2.1.0"
     exon            573..623
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /inference="alignment:Splign:2.1.0"
     exon            624..1724
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1692..1697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /note="hexamer: AATAAA"
     polyA_site      1724
                     /gene="HHEX"
                     /gene_synonym="HEX; HMPH; HOX11L-PEN; PRH; PRHX"
                     /note="major polyA site"
ORIGIN      
        1 agctctgcga ggggccggag cgcggcggag ccatgcagta cccgcacccc gggccggcgg
       61 cgggcgccgt gggggtgccg ctgtacgcgc ccacgccgct gctgcaaccc gcacacccga
      121 cgccctttta catcgaggac atcctgggcc gcgggcccgc cgcgcccacg cccgccccca
      181 cgctgccgtc ccccaactcc tccttcacca gcctcgtgtc cccctaccgg accccggtgt
      241 acgagcccac gccgatccat ccagccttct cgcaccactc cgccgccgcg ctggccgctg
      301 cctacggacc cggcggcttc gggggccctc tgtacccctt cccgcggacg gtgaacgact
      361 acacgcacgc cctgctccgc cacgaccccc tgggcaaacc tctactctgg agccccttct
      421 tgcagaggcc tctgcataaa aggaaaggcg gccaggtgag attctccaac gaccagacca
      481 tcgagctgga gaagaaattc gagacgcaga aatatctctc tccgcccgag aggaagcgtc
      541 tggccaagat gctgcagctc agcgagagac aggtcaaaac ctggtttcag aatcgacgcg
      601 ctaaatggag gagactaaaa caggagaacc ctcaaagcaa taaaaaagaa gaactggaaa
      661 gtttggacag ttcctgtgat cagaggcaag atttgcccag tgaacagaat aaaggtgctt
      721 ctttggatag ctctcaatgt tcgccctccc ctgcctccca ggaagacctt gaatcagaga
      781 tttcagagga ttctgatcag gaagtggaca ttgagggcga taaaagctat tttaatgctg
      841 gatgatgacc actggcattg gcatgttcag aaaactggat ttaggaataa tgttttgcta
      901 cagaaaatct tcatagaaga actggaaggc tatataagaa agggaatcaa ttctctggta
      961 ttctggaaac ctaaaaatat ttggtgcact gctcaattaa caaacctaca tggagacctt
     1021 aattttgact taacaaatag tttatgtact gctcttaggt tgttttgata aagtgacatt
     1081 atagtgatta aattcttccc cctttaaaaa aacagttagt ggttttcact atttataaaa
     1141 aattaatttt gaactttttg ttaaattttt aagttatagc tttaaaggtt ttaataggac
     1201 cttcttgaac gacttttctg taatctgttt atctcccact taatggaaag gcaaaggggt
     1261 accccaaatc cagaggtgcc tacatttcag gcagccttgg agtattttaa aaggaaaaca
     1321 ttctttactt ttatatgaca ttcttatact gctgtctcaa atccaaaaac atttcagagc
     1381 tcttgtctca gagatgtgtg ttctttttgt cagagatatg gttgatgaga atcttaaatg
     1441 cttgttttgc actatcactt agtacctgtt tgaccaaggt gttaagggga tagtacctcc
     1501 caattcaagc agagaaactg acctgactaa agttaatcgc agatgaacta gaagtcacag
     1561 gttaattaaa tgtaagtaga ttgtagatac tgttttatat caaacaatgt ttataatgtg
     1621 tatatagaat tgttcactgt aaaaaaaatg gccaaaatgt gttttttttt taataagtaa
     1681 cttgactata aaataaagcc gtccgtggga cgactgacct cgtt
//
