LOCUS       NM_152419               5227 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens heparan-alpha-glucosaminide N-acetyltransferase
            (HGSNAT), transcript variant 1, mRNA.
ACCESSION   NM_152419 XM_372038 XM_940758
VERSION     NM_152419.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5227)
  AUTHORS   Zhao,H., Wang,L., Zhang,M., Wang,H., Zhang,S., Wu,J. and Tang,Y.
  TITLE     Identification and characterization of novel genetic variants in
            the first Chinese family of mucopolysaccharidosis IIIC (Sanfilippo
            C syndrome)
  JOURNAL   J Cell Mol Med 28 (8), e18307 (2024)
   PUBMED   38613342
  REMARK    GeneRIF: Identification and characterization of novel genetic
            variants in the first Chinese family of mucopolysaccharidosis IIIC
            (Sanfilippo C syndrome).
REFERENCE   2  (bases 1 to 5227)
  AUTHORS   da Palma,M.M., Marra,M., Igelman,A.D., Ku,C.A., Burr,A.,
            Andersen,K., Everett,L.A., Porto,F.B.O., Sallum,J.M.F., Yang,P. and
            Pennesi,M.E.
  TITLE     Expanding the phenotypic and genotypic spectrum of patients with
            HGSNAT-related retinopathy
  JOURNAL   Ophthalmic Genet 45 (2), 167-174 (2024)
   PUBMED   37592806
  REMARK    GeneRIF: Expanding the phenotypic and genotypic spectrum of
            patients with HGSNAT-related retinopathy.
REFERENCE   3  (bases 1 to 5227)
  AUTHORS   Liang,Y., Gao,X., Lu,D., Zhang,H. and Zhang.
  TITLE     Mucopolysaccharidosis type IIIC in chinese mainland: clinical and
            molecular characteristics of ten patients and report of six novel
            variants in the HGSNAT gene
  JOURNAL   Metab Brain Dis 38 (6), 2013-2023 (2023)
   PUBMED   37014526
  REMARK    GeneRIF: Mucopolysaccharidosis type IIIC in chinese mainland:
            clinical and molecular characteristics of ten patients and report
            of six novel variants in the HGSNAT gene.
REFERENCE   4  (bases 1 to 5227)
  AUTHORS   Schiff,E.R., Daich Varela,M., Robson,A.G., Pierpoint,K.,
            Ba-Abbad,R., Nutan,S., Zein,W.M., Ullah,E., Huryn,L.A.,
            Tuupanen,S., Mahroo,O.A., Michaelides,M., Burke,D., Harvey,K.,
            Arno,G., Hufnagel,R.B. and Webster,A.R.
  TITLE     A genetic and clinical study of individuals with nonsyndromic
            retinopathy consequent upon sequence variants in HGSNAT, the gene
            associated with Sanfilippo C mucopolysaccharidosis
  JOURNAL   Am J Med Genet C Semin Med Genet 184 (3), 631-643 (2020)
   PUBMED   32770643
  REMARK    GeneRIF: A genetic and clinical study of individuals with
            nonsyndromic retinopathy consequent upon sequence variants in
            HGSNAT, the gene associated with Sanfilippo C
            mucopolysaccharidosis.
REFERENCE   5  (bases 1 to 5227)
  AUTHORS   Fan,X., Zhang,H., Zhang,S., Bagshaw,R.D., Tropak,M.B.,
            Callahan,J.W. and Mahuran,D.J.
  TITLE     Identification of the gene encoding the enzyme deficient in
            mucopolysaccharidosis IIIC (Sanfilippo disease type C)
  JOURNAL   Am J Hum Genet 79 (4), 738-744 (2006)
   PUBMED   16960811
  REMARK    GeneRIF: gene encoding the enzyme deficient in
            mucopolysaccharidosis IIIC was identified as HGSNAT; mutational
            analyses identified a splice-junction mutation that accounted for
            three mutant alleles, and a single base-pair insertion accounted
            for the fourth
REFERENCE   6  (bases 1 to 5227)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
REFERENCE   7  (bases 1 to 5227)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 5227)
  AUTHORS   Ausseil,J., Loredo-Osti,J.C., Verner,A., Darmond-Zwaig,C.,
            Maire,I., Poorthuis,B., van Diggelen,O.P., Hudson,T.J.,
            Fujiwara,T.M., Morgan,K. and Pshezhetsky,A.V.
  TITLE     Localisation of a gene for mucopolysaccharidosis IIIC to the
            pericentromeric region of chromosome 8
  JOURNAL   J Med Genet 41 (12), 941-945 (2004)
   PUBMED   15591281
REFERENCE   9  (bases 1 to 5227)
  AUTHORS   Wagner,V.F. and Northrup,H.
  TITLE     Mucopolysaccharidosis Type III
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31536183
REFERENCE   10 (bases 1 to 5227)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB128369.1, DA395558.1,
            BC042037.1, BE327420.1, AC113191.13 and BC056149.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_152419.2.
            
            Summary: This gene encodes a lysosomal acetyltransferase, which is
            one of several enzymes involved in the lysosomal degradation of
            heparin sulfate. Mutations in this gene are associated with
            Sanfilippo syndrome C, one type of the lysosomal storage disease
            mucopolysaccaridosis III, which results from impaired degradation
            of heparan sulfate. [provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.139911.1,
                                           SRR1803612.72409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379644.9/ ENSP00000368965.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DB128369.1         16-48
            34-126              DA395558.1         1-93
            127-596             BC042037.1         87-556
            597-617             DA395558.1         566-586
            618-684             BE327420.1         481-547
            685-776             AC113191.13        125770-125861
            777-853             AC113191.13        127477-127553
            854-884             AC113191.13        128880-128910
            885-1045            AC113191.13        133241-133401
            1046-1161           AC113191.13        137312-137427
            1162-1283           AC113191.13        146641-146762
            1284-1410           AC113191.13        147471-147597
            1411-1497           AC113191.13        148924-149010
            1498-1575           AC113191.13        152115-152192
            1576-1646           AC113191.13        152839-152909
            1647-1759           AC113191.13        153007-153119
            1760-2772           AC113191.13        154555-155567
            2773-3741           BC056149.1         116-1084
            3742-4194           AC113191.13        156537-156989
            4195-5199           BC056149.1         1538-2542
            5200-5227           AC113191.13        157995-158022
FEATURES             Location/Qualifiers
     source          1..5227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21-p11.1"
     gene            1..5227
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /note="heparan-alpha-glucosaminide N-acetyltransferase"
                     /db_xref="GeneID:138050"
                     /db_xref="HGNC:HGNC:26527"
                     /db_xref="MIM:610453"
     exon            1..151
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1941
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /EC_number="2.3.1.78"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane protein 76"
                     /codon_start=1
                     /product="heparan-alpha-glucosaminide N-acetyltransferase
                     isoform 1 precursor"
                     /protein_id="NP_689632.2"
                     /db_xref="CCDS:CCDS47852.1"
                     /db_xref="GeneID:138050"
                     /db_xref="HGNC:HGNC:26527"
                     /db_xref="MIM:610453"
                     /translation="MSGAGRALAALLLAASVLSAALLAPGGSSGRDAQAAPPRDLDKK
                     RHAELKMDQALLLIHNELLWTNLTVYWKSECCYHCLFQVLVNVPQSPKAGKPSAAAAS
                     VSTQHGSILQLNDTLEEKEVCRLEYRFGEFGNYSLLVKNIHNGVSEIACDLAVNEDPV
                     DSNLPVSIAFLIGLAVIIVISFLRLLLSLDDFNNWISKAISSRETDRLINSELGSPSR
                     TDPLDGDVQPATWRLSALPPRLRSVDTFRGIALILMVFVNYGGGKYWYFKHASWNGLT
                     VADLVFPWFVFIMGSSIFLSMTSILQRGCSKFRLLGKIAWRSFLLICIGIIIVNPNYC
                     LGPLSWDKVRIPGVLQRLGVTYFVVAVLELLFAKPVPEHCASERSCLSLRDITSSWPQ
                     WLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGDD
                     HLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFT
                     AWCCILGLISVALTKVSENEGFIPVNKNLWSLSYVTTLSSFAFFILLVLYPVVDVKGL
                     WTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAY
                     ILYRKKIFWKI"
     exon            152..267
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            268..404
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            405..526
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            527..596
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            597..666
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            667..776
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            777..853
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            854..884
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1045
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1161
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1283
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1410
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1497
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1575
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1646
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1759
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..5227
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4178..4183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /note="hexamer: AATAAA"
     polyA_site      4199
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /note="major polyA site"
     regulatory      5177..5182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /note="hexamer: AATAAA"
     polyA_site      5199
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
     regulatory      5205..5210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
                     /note="hexamer: AGTAAA"
     polyA_site      5227
                     /gene="HGSNAT"
                     /gene_synonym="HGNAT; MPS3C; RP73; TMEM76"
ORIGIN      
        1 gggcaggcaa gggcggccga gcgggcggcg ggcatgagcg gggcgggcag ggcgctggcc
       61 gcgctgctgc tggccgcgtc cgtgctgagc gccgcgctgc tggcccccgg cggctcttcg
      121 gggcgcgatg cccaggccgc gccgccacga gacttagaca aaaaaagaca tgcagagctg
      181 aagatggatc aggctttgct actcatccat aatgaacttc tctggaccaa cttgaccgtc
      241 tactggaaat ctgaatgctg ttatcactgc ttgtttcagg ttctggtaaa cgttcctcag
      301 agtccaaaag cagggaagcc tagtgctgca gctgcctctg tcagcaccca gcacggatct
      361 atcctgcagc tgaacgacac cttggaagag aaagaagttt gtaggttgga atacagattt
      421 ggagaatttg gaaactattc tctcttggta aagaacatcc ataatggagt tagtgaaatt
      481 gcctgtgacc tggctgtgaa cgaggatcca gttgatagta accttcctgt gagcattgca
      541 ttccttattg gtcttgctgt catcattgtg atatcctttc tgaggctctt gttgagtttg
      601 gatgacttta acaattggat ttctaaagcc ataagttctc gagaaactga tcgcctcatc
      661 aattctgagc tgggatctcc cagcaggaca gaccctctcg atggtgatgt tcagccagca
      721 acgtggcgtc tatctgccct gccgccccgc ctccgcagcg tggacacctt cagggggatt
      781 gctcttatac tcatggtctt tgtcaattat ggaggaggaa aatattggta cttcaaacat
      841 gcaagttgga atgggctgac agtggctgac ctcgtgttcc cgtggtttgt atttattatg
      901 ggatcttcca tttttctatc gatgacttct atactgcaac gggggtgttc aaaattcaga
      961 ttgctgggga agattgcatg gaggagtttc ctgttaatct gcataggaat tatcattgtg
     1021 aatcccaatt attgccttgg tccattgtct tgggacaagg tgcgcattcc tggtgtgctg
     1081 cagcgattgg gagtgacata ctttgtggtt gctgtgttgg agctcctctt tgctaaacct
     1141 gtgcctgaac attgtgcctc ggagaggagc tgcctttctc ttcgagacat cacgtccagc
     1201 tggccccagt ggctgctcat cctggtgctg gaaggcctgt ggctgggctt gacattcctc
     1261 ctgccagtcc ctgggtgccc tactggttat cttggtcctg ggggcattgg agattttggc
     1321 aagtatccaa attgcactgg aggagctgca ggctacatcg accgcctgct gctgggagac
     1381 gatcaccttt accagcaccc atcttctgct gtactttacc acaccgaggt ggcctatgac
     1441 cccgagggca tcctgggcac catcaactcc atcgtgatgg cctttttagg agttcaggca
     1501 ggaaaaatac tattgtatta caaggctcgg accaaagaca tcctgattcg attcactgct
     1561 tggtgttgta ttcttgggct catttctgtt gctctgacga aggtttctga aaatgaaggc
     1621 tttattccag taaacaaaaa tctctggtcc ctttcgtatg tcactacgct cagttctttt
     1681 gccttcttca tcctgctggt cctgtaccca gttgtggatg tgaaggggct gtggacagga
     1741 accccattct tttatccagg aatgaattcc attctggtat atgtcggcca cgaggtgttt
     1801 gagaactact tcccctttca gtggaagctg aaggacaacc agtcccacaa ggagcacctg
     1861 actcagaaca tcgtcgccac tgccctctgg gtgctcattg cctacatcct ctatagaaag
     1921 aagatttttt ggaaaatctg atggctccca ctgagatgtg ctgctggaag actctagtag
     1981 gcctgcaggg aggactgaag cagcctttgt taaagggaag cattcattag gaaattgact
     2041 ggctgcgtgt ttacagactc tgggggaaga cactgatgtc ctcaaactgg ttaactgtga
     2101 cacggctcgc cagaactctg cctgtctatt tgtgacttac agatttgaaa tgtaattgtc
     2161 ttttttcctc catcttctgt ggaaatggat gtctttggaa cttcattccg aggagataag
     2221 ctttaacttt ccaaaaggga attgccatgg gtgtttttct tctgtggtga gtgaaacaat
     2281 ctgaggtctg gttcttgctg accttgttgc cctgcaaact tcctttccac gtgtacgcgc
     2341 acaccaacac gaaatgccat cactcctact gcggctgcta tgaagcttac tggttgtgat
     2401 gtgttataat ttagtctgtt tttttgattg aatgcagttt aatgtttcca gaaagccaaa
     2461 gtaattttct tttcagatat gcaaggcttt ggtgggtcca aaaaatgtct atcacaagcc
     2521 attttttcct tttcctctct cgaaaagtta aaatatctat gtgttattcc caaaccctct
     2581 tacctatgta tctgcctgtc tgtccatcat cttccttcct ccctatctct gtgtatctgg
     2641 atggcagccg ctgcccaggg gagtggctgt ggggagggca ggtactgtct ttgcctgtgg
     2701 gtccagctga gccatccctg ctgggtgatg ctgggcaaga cccttggccc gtctgggcct
     2761 tggcttcctc acttgtgaaa tgagcgggaa gatgactctc agttccttcc acctcttaga
     2821 catggtgagg taacagacat caaaagcttt tctgaaatct tcagaagaaa tagttccatt
     2881 acagaaaact cttcaaaata aatagtagtg aaaactttta aaaactctca ttggagtaag
     2941 tcttttcaag atgatcctcc acaatggagg cagcgttcct acttgtcatc acacagctga
     3001 agacattgtt tcttaggtgt gaaatcgggg acaaaggaca aacagagaca cacggcattg
     3061 ttcatgggag gcatcgtcac cctcctgggt gttctgtggg aatttcctgt gtgaggaaaa
     3121 cgtggccaca gggttgtgct gtacccaccc ttccccggcg agatggccct cggcctgtgc
     3181 cgctgcttcc accctcgcca ctccatggca gcttttggtc tgtttccggc tctgccctct
     3241 gccctgaact ctcatccggc ttgtacctgc ctgctggacc cctccacctg gaggccagcc
     3301 catgtctcag gcccagccct agcctcttct cctcaaattc taagtgtttt ctctttaggt
     3361 ttccctggct ttgtgaatgg atcatgtgtc tctaggtata aacctgacat catctttcca
     3421 cccggcttac ctccaccaga tctccccagt tctgtctcca tcttctacct gcagctgctc
     3481 tgttctcatg gtcactgctg catcactgag tctggaccct tgttatcatt ttcaaactgg
     3541 cctccttccc tcgttcccca cttcttaaag tcacctgtcc attgccacca gattaagctt
     3601 tctccagcca gatcacctct ctctgagaaa cctccattga catggaaaca ccattgtctg
     3661 gcacacatac tcacatactc accttcccgt cttgatcccc acacatcttt ccagcctccc
     3721 ctcccactcc actccctgct ctctcctcca cctccccatc ctcttgtctc ccctcccctc
     3781 tgaatccagc ccagcggggc ttctcctgcc tccatcacat cacagaagta cctcctgctt
     3841 ctggttttaa ttagagcctt ccccgattac attttcctct gaattttttc ctatctacat
     3901 ttgatctgtc atgtttaaac cccctacttc taagggaact tctctaatct cttatcctca
     3961 tccccaaata gtgttttctt cctctgggtt cttataatgt tggtatcaat ctcacagcat
     4021 ttagtgcttc ctgcctggtg tgacagttac ctgtgtgcat gtgcaatttc taatttccca
     4081 cgctagactg tgagcttcct aaggcaagaa tcatgccttg ttggtttctg tattcctcat
     4141 ggtgccaaac acagtgcctt ctacattgca ggcgctgaat aaacattttt aaagcaaaat
     4201 gatgtggatt tttaaaataa atatttaagt gctggtaaga tgagcatgta tccggggtgc
     4261 ccatgaaatg ttcttggggc cgtgtgggga cagtcgtcat tcctcctcct gccacccttt
     4321 tctttcagtg agtcactgtg gatggtccca gctgtgtcat cccaaagttc agcagggaaa
     4381 gctgagctgg gcctctccag gtgagttttc tagaagcatt tctcaaactg tgggttacat
     4441 caacttgggt gtcttgagct gtaaggaagg aactccggag tcagctgggc tacaggggag
     4501 cttctctaag tcctgcggga ggccagaccc agcctgagct tgctgttagc tagcggaggc
     4561 agctgctggt ggcccaggtg ctcgacacca ggcatcccct ctcctcccac gaagggtgtg
     4621 ccataatccc cttcaacagg aaatgcttcc cagaagcctc tcagcagcct cccctcctgt
     4681 cctatcagct agaagcgcct cgcttgtccc aagaccagca gggacaggga actgtccgag
     4741 cccgtggctg tgtggaggaa ggcgaccccc agcacaagat tggtttcctt tgggaaggga
     4801 agagggagtg tgttggggta aggggtagag cagaggaatg gtcagggggc aacaaccgct
     4861 gacagctgca acaggtgcat ggcatctcac agggaggcag ggaggtgcga gctcctaagt
     4921 aatggagcaa aaaaattcta ttctgtagaa tggggagaga aaatgtgaca ttttaatttt
     4981 tttttgcatt tatattccta attcctactt aaagtgaata tactgccgct gtagatcata
     5041 aaatgtatct tttccatggc caacaagggg catcttttat aaatgcataa taacccagtt
     5101 tgtatcaaag ggtatcgact taagtgaaat ttcaacatgc tgttactttt tccttttaat
     5161 gtaattctgt tttccaaata aatgggggag acaaatggac tttgagtaaa tttcttagca
     5221 tatcaaa
//
