LOCUS       NM_016458               2534 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens HGH1 homolog (HGH1), mRNA.
ACCESSION   NM_016458 XM_937693
VERSION     NM_016458.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2534)
  AUTHORS   Zhang,X., An,K., Ge,X., Sun,Y., Wei,J., Ren,W., Wang,H., Wang,Y.,
            Du,Y., He,L., Li,O., Zhou,S., Shi,Y., Ren,T., Yang,Y.G., Kan,Q. and
            Tian,X.
  TITLE     NSUN2/YBX1 promotes the progression of breast cancer by enhancing
            HGH1 mRNA stability through m5C methylation
  JOURNAL   Breast Cancer Res 26 (1), 94 (2024)
   PUBMED   38844963
  REMARK    GeneRIF: NSUN2/YBX1 promotes the progression of breast cancer by
            enhancing HGH1 mRNA stability through m[5]C methylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2534)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2534)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2534)
  AUTHORS   Taipale,M., Tucker,G., Peng,J., Krykbaeva,I., Lin,Z.Y., Larsen,B.,
            Choi,H., Berger,B., Gingras,A.C. and Lindquist,S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   5  (bases 1 to 2534)
  AUTHORS   Van Damme,P., Lasa,M., Polevoda,B., Gazquez,C., Elosegui-Artola,A.,
            Kim,D.S., De Juan-Pardo,E., Demeyer,K., Hole,K., Larrea,E.,
            Timmerman,E., Prieto,J., Arnesen,T., Sherman,F., Gevaert,K. and
            Aldabe,R.
  TITLE     N-terminal acetylome analyses and functional insights of the
            N-terminal acetyltransferase NatB
  JOURNAL   Proc Natl Acad Sci U S A 109 (31), 12449-12454 (2012)
   PUBMED   22814378
REFERENCE   6  (bases 1 to 2534)
  AUTHORS   Olsen,J.V., Vermeulen,M., Santamaria,A., Kumar,C., Miller,M.L.,
            Jensen,L.J., Gnad,F., Cox,J., Jensen,T.S., Nigg,E.A., Brunak,S. and
            Mann,M.
  TITLE     Quantitative phosphoproteomics reveals widespread full
            phosphorylation site occupancy during mitosis
  JOURNAL   Sci Signal 3 (104), ra3 (2010)
   PUBMED   20068231
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2534)
  AUTHORS   Gauci,S., Helbig,A.O., Slijper,M., Krijgsveld,J., Heck,A.J. and
            Mohammed,S.
  TITLE     Lys-N and trypsin cover complementary parts of the phosphoproteome
            in a refined SCX-based approach
  JOURNAL   Anal Chem 81 (11), 4493-4501 (2009)
   PUBMED   19413330
REFERENCE   8  (bases 1 to 2534)
  AUTHORS   Dephoure,N., Zhou,C., Villen,J., Beausoleil,S.A., Bakalarski,C.E.,
            Elledge,S.J. and Gygi,S.P.
  TITLE     A quantitative atlas of mitotic phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 105 (31), 10762-10767 (2008)
   PUBMED   18669648
REFERENCE   9  (bases 1 to 2534)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
REFERENCE   10 (bases 1 to 2534)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC003035.1, BC015471.1, AW002157.1 and AC104592.6.
            
            On Nov 23, 2018 this sequence version replaced NM_016458.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003035.1, SRR1163658.380940.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000347708.5/ ENSP00000321320.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2400              BC003035.1         6-2405
            2401-2525           BC015471.1         1937-2061
            2526-2526           AW002157.1         19-19               c
            2527-2534           AC104592.6         64441-64448
FEATURES             Location/Qualifiers
     source          1..2534
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2534
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /note="HGH1 homolog"
                     /db_xref="GeneID:51236"
                     /db_xref="HGNC:HGNC:24161"
                     /db_xref="MIM:620684"
     exon            1..655
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1235
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /note="brain protein 16; protein FAM203A; family with
                     sequence similarity 203, member B; protein FAM203B; brain
                     protein 16-like; family with sequence similarity 203,
                     member A"
                     /codon_start=1
                     /product="protein HGH1 homolog"
                     /protein_id="NP_057542.2"
                     /db_xref="CCDS:CCDS6417.1"
                     /db_xref="GeneID:51236"
                     /db_xref="HGNC:HGNC:24161"
                     /db_xref="MIM:620684"
                     /translation="MGEAGAGAGASGGPEASPEAEVVKLLPFLAPGARADLQAAAVRH
                     VLALTGCGPGRALLAGQAALLQALMELAPASAPARDAARALVNLAADPGLHETLLAAD
                     PGLPARLMGRALDPQWPWAEEAAAALANLSREPAPCAALMAALAAAEPADSGLERLVR
                     ALCTPGYNARAPLHYLAPLLSNLSQRPAARAFLLDPDRCVVQRLLPLTQYPDSSVRRG
                     GVVGTLRNCCFEHRHHEWLLGPEVDILPFLLLPLAGPEDFSEEEMERLPVDLQYLPPD
                     KQREPDADIRKMLVEAIMLLTATAPGRQQVRDQGAYLILRELHSWEPEPDVRTACEKL
                     IQVLIGDEPERGMENLLEVQVPEDVEQQLQQLDCREQEQLERELAPEPWVERATPT"
     exon            656..756
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /inference="alignment:Splign:2.1.0"
     exon            757..855
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /inference="alignment:Splign:2.1.0"
     exon            856..947
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1070
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..2534
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2382..2387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /note="hexamer: ATTAAA"
     polyA_site      2404
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /note="major polyA site"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
                     /note="hexamer: AATAAA"
     polyA_site      2534
                     /gene="HGH1"
                     /gene_synonym="BRP16; BRP16L; C8orf30A; C8orf30B; FAM203A;
                     FAM203B"
ORIGIN      
        1 acacagcgga cccctaagcg gaccgctggc accggtcggg tggcagcaga gtgtcgctcg
       61 acatggggga ggccggggct ggcgctggcg cctcgggagg gccggaggca agcccggagg
      121 cagaggtggt gaagctgctg cccttcctgg cgccgggcgc gcgggcggac ctgcaggcgg
      181 cggcggtgcg gcacgtgctg gcgctgactg gctgcggacc cggccgcgcg ctgttggcgg
      241 ggcaggcggc gctgctgcag gcgctgatgg agctggcgcc ggcctctgcc ccggcccggg
      301 acgccgcccg cgcgctcgtg aacttggccg ccgaccccgg cctgcacgag acattgctgg
      361 cggccgaccc cgggctgcca gcgcgcctga tgggccgcgc gttggacccg cagtggccct
      421 gggccgagga ggcggccgcc gcgctagcca acctcagtcg cgagccggcg ccgtgtgcag
      481 cgctcatggc ggcgctggcg gccgcggagc cggcagactc gggcctggag cggctggtgc
      541 gcgcgctgtg cacgcccggc tacaacgccc gcgcgcccct gcactaccta gcgccgctgc
      601 tctccaacct cagccaacgc cctgcggcgc gggccttcct actggacccc gacaggtgcg
      661 tggtccagcg gctgctgccc cttacccagt accccgactc ctctgtacgc aggggcgggg
      721 tggtggggac gctgcggaat tgctgcttcg agcaccgaca tcacgagtgg ttgcttggac
      781 ctgaggtgga cattctcccc tttttgctcc tgcccttggc tgggcctgag gatttctccg
      841 aggaagagat ggaacggctg cctgtcgact tgcagtacct gccaccagac aagcagcgag
      901 aacctgatgc agacatccgc aagatgcttg ttgaagccat catgctgctg acagccacag
      961 caccaggtcg gcagcaggtg cgggaccagg gagcctacct gatccttcga gagctgcaca
     1021 gctgggagcc ggagcccgac gtgcggacgg cttgtgagaa gctcatccag gtgcttattg
     1081 gggacgagcc tgaacgtggc atggaaaacc tgctggaggt gcaggtgcct gaggatgtgg
     1141 agcagcagct gcagcagctg gattgcaggg agcaggagca gttggagcgg gagctggccc
     1201 cagagccatg ggtggagagg gccacaccca cctgaggccc ctgcagccgg acaccagctc
     1261 cagggtcccc tttgccaggc tttctcagac caggccttcc tgcagctgtc tgcaggcccc
     1321 ctgggtcccc ttgttcagag actgtgctct tctgagaagc agagctacgc ttaggctcca
     1381 gtaaggattg gaggcacttt ccagccctgt gcagtgttgc taccagcaag aatgaaggtt
     1441 gtgcagagca gtactgtgag gtaggcaccg tgactcggct gcctgtgcag aaggtggagg
     1501 tggcaggcgg atggccaggg agccatgaga agactcttcc tgggcacggc gtggggactg
     1561 gacagaaaac cactgcaagc cccaaggagc cagctgaagc ctcccaatcc ccagggcact
     1621 gcagagtctg ggcagaggtg ggcgcatagg tacaagtgct gctttgtcag cctcactccc
     1681 tgcagctctc agctccctgt tccctgagac ctggcctcaa agggctgacc cagccatacg
     1741 tagatcctgg ggtctttcta ggactgtgcc tccctgcttg acctatgctc caggaccctg
     1801 ccctcaaccc ttgtcagctc cctaagtctt cctgtttccc agtctcagat tgagtgggtg
     1861 ctctcattgg cctctctagc taggccgtct ccctggtcag cttccttgag cctgggccac
     1921 tcctccctgg ccttcttacc tctgccaaga gcctccagat gtgcctgcag cctagtccct
     1981 gcccaagctt ctcccccagc caccctctgc ccctgtggta gagcccacta taggcccagg
     2041 cgccttacgt gcttctcccc tggacctatg tgcatccctc acctgccagt tatgtggctg
     2101 ccaagcccca caggctgtca tggtggctct tgccacactt cccttcctga gctgacctga
     2161 cctcactgcc acctcttgca ttgggatcct gagggctggc ccctgctcac tgatgggccc
     2221 tcccaggccc gtcaagccct ggtgaaggag cttagcttgt cttcttggca attcacaatg
     2281 cctcactcca caccctaaaa ctggagcgtc ccctatggtc tcctgctgtg gcttgggtgc
     2341 cgggcgtctc ccgcctccag gatctcctct cacctgcccc cattaaagct ctgccactca
     2401 tgcaggcatg tgtggaccat gttttcccct ggccagagcc cccacctgcc actggaggcc
     2461 agttgccctc ttagcactca gacatcagca ctgtcttcac agaataaatg ctttatctgg
     2521 ccttgcccca ccca
//
