LOCUS       NM_001010931            1200 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens hepatocyte growth factor (HGF), transcript variant 2,
            mRNA.
ACCESSION   NM_001010931
VERSION     NM_001010931.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1200)
  AUTHORS   Alpaslan,M., Fastre,E., Mestre,S., van Haeringen,A., Repetto,G.M.,
            Keymolen,K., Boon,L.M., Belva,F., Giacalone,G., Revencu,N.,
            Sznajer,Y., Riches,K., Keeley,V., Mansour,S., Gordon,K.,
            Martin-Almedina,S., Dobbins,S., Ostergaard,P., Quere,I.,
            Brouillard,P. and Vikkula,M.
  TITLE     Pathogenic variants in HGF give rise to childhood-to-late onset
            primary lymphoedema by loss of function
  JOURNAL   Hum Mol Genet 33 (14), 1250-1261 (2024)
   PUBMED   38676400
  REMARK    GeneRIF: Pathogenic variants in HGF give rise to childhood-to-late
            onset primary lymphoedema by loss of function.
REFERENCE   2  (bases 1 to 1200)
  AUTHORS   Boschert,V., Boenke,J., Bohm,A.K., Teusch,J., Steinacker,V.,
            Straub,A. and Hartmann,S.
  TITLE     Differential Immune Checkpoint Protein Expression in HNSCC: The
            Role of HGF/MET Signaling
  JOURNAL   Int J Mol Sci 25 (13), 7334 (2024)
   PUBMED   39000441
  REMARK    GeneRIF: Differential Immune Checkpoint Protein Expression in
            HNSCC: The Role of HGF/MET Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1200)
  AUTHORS   Koksharova,G., Kokh,N., Gridina,M., Khapaev,R., Nimaev,V. and
            Fishman,V.
  TITLE     A HGF Mutation in the Familial Case of Primary Lymphedema: A Report
  JOURNAL   Int J Mol Sci 25 (10), 5464 (2024)
   PUBMED   38791500
  REMARK    GeneRIF: A HGF Mutation in the Familial Case of Primary Lymphedema:
            A Report.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1200)
  AUTHORS   Carrillo-Garcia,J., Lacerenza,S., Hindi,N., Moura,D.S.,
            Marquina,G., Parra Corral,D., Olalla,J., Maria Cano Cano,J.,
            Hoyos,S., Renshaw,M., Mondaza-Hernandez,J.L., Di Lernia,D.,
            Casado,A., Manzano,A., Gutierrez,A. and Martin-Broto,J.
  TITLE     Circulating TNF-RII, IP-10 and HGF are associated with severity of
            COVID-19 in oncologic patients
  JOURNAL   Cytokine 177, 156542 (2024)
   PUBMED   38364458
  REMARK    GeneRIF: Circulating TNF-RII, IP-10 and HGF are associated with
            severity of COVID-19 in oncologic patients.
REFERENCE   5  (bases 1 to 1200)
  AUTHORS   Nakamura,T., Sakai,K., Nakamura,T. and Matsumoto,K.
  TITLE     Hepatocyte growth factor twenty years on: Much more than a growth
            factor
  JOURNAL   J Gastroenterol Hepatol 26 Suppl 1, 188-202 (2011)
   PUBMED   21199531
  REMARK    Review article
REFERENCE   6  (bases 1 to 1200)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
REFERENCE   7  (bases 1 to 1200)
  AUTHORS   Hartmann,G., Naldini,L., Weidner,K.M., Sachs,M., Vigna,E.,
            Comoglio,P.M. and Birchmeier,W.
  TITLE     A functional domain in the heavy chain of scatter factor/hepatocyte
            growth factor binds the c-Met receptor and induces cell
            dissociation but not mitogenesis
  JOURNAL   Proc Natl Acad Sci U S A 89 (23), 11574-11578 (1992)
   PUBMED   1280830
REFERENCE   8  (bases 1 to 1200)
  AUTHORS   Naka,D., Ishii,T., Yoshiyama,Y., Miyazawa,K., Hara,H., Hishida,T.
            and Kidamura,N.
  TITLE     Activation of hepatocyte growth factor by proteolytic conversion of
            a single chain form to a heterodimer
  JOURNAL   J Biol Chem 267 (28), 20114-20119 (1992)
   PUBMED   1328193
REFERENCE   9  (bases 1 to 1200)
  AUTHORS   Lokker,N.A., Mark,M.R., Luis,E.A., Bennett,G.L., Robbins,K.A.,
            Baker,J.B. and Godowski,P.J.
  TITLE     Structure-function analysis of hepatocyte growth factor:
            identification of variants that lack mitogenic activity yet retain
            high affinity receptor binding
  JOURNAL   EMBO J 11 (7), 2503-2510 (1992)
   PUBMED   1321034
REFERENCE   10 (bases 1 to 1200)
  AUTHORS   Miyazawa,K., Tsubouchi,H., Naka,D., Takahashi,K., Okigaki,M.,
            Arakaki,N., Nakayama,H., Hirono,S., Sakiyama,O., Takahashi,K. et
            al.
  TITLE     Molecular cloning and sequence analysis of cDNA for human
            hepatocyte growth factor
  JOURNAL   Biochem Biophys Res Commun 163 (2), 967-973 (1989)
   PUBMED   2528952
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX495370.1, BU533235.1,
            L02931.1 and BM971901.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001010931.2.
            
            Summary: This gene encodes a protein that binds to the hepatocyte
            growth factor receptor to regulate cell growth, cell motility and
            morphogenesis in numerous cell and tissue types. Alternative
            splicing results in multiple transcript variants, at least one of
            which encodes a preproprotein that is proteolytically processed to
            generate alpha and beta chains, which form the mature heterodimer.
            This protein is secreted by mesenchymal cells and acts as a
            multi-functional cytokine on cells of mainly epithelial origin.
            This protein also plays a role in angiogenesis, tumorogenesis, and
            tissue regeneration. Although the encoded protein is a member of
            the peptidase S1 family of serine proteases, it lacks peptidase
            activity. Mutations in this gene are associated with nonsyndromic
            hearing loss. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (2) lacks multiple 3' exons but
            includes an alternate 3' exon, compared to variant 1. The resulting
            protein (isoform 2) has a shorter and distinct C-terminus, compared
            to isoform 1. Isoform 2, also named NK2, has been shown to act as a
            competitive antagonist to active hepatocyte growth factor for the
            c-Met receptor.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L02931.1, X57574.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               BX495370.1         153-460
            309-330             BU533235.1         399-420
            331-1160            L02931.1           315-1144
            1161-1200           BM971901.1         19-58               c
FEATURES             Location/Qualifiers
     source          1..1200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.11"
     gene            1..1200
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /note="hepatocyte growth factor"
                     /db_xref="GeneID:3082"
                     /db_xref="HGNC:HGNC:4893"
                     /db_xref="MIM:142409"
     exon            1..164
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..949
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; fibroblast-derived tumor cytotoxic factor; lung
                     fibroblast-derived mitogen; hepatopoietin-A; hepatocyte
                     growth factor (hepapoietin A; scatter factor)"
                     /codon_start=1
                     /product="hepatocyte growth factor isoform 2 precursor"
                     /protein_id="NP_001010931.1"
                     /db_xref="CCDS:CCDS47627.1"
                     /db_xref="GeneID:3082"
                     /db_xref="HGNC:HGNC:4893"
                     /db_xref="MIM:142409"
                     /translation="MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKK
                     SAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFN
                     SMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEH
                     SFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGES
                     YRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDP
                     HTRWEYCAIKTCET"
     exon            165..330
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            331..443
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            444..558
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            559..701
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            702..822
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            823..941
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1200
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /note="hexamer: AATAAA"
     polyA_site      1200
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /note="major polyA site"
ORIGIN      
        1 aggcactgac tccgaacagg attctttcac ccaggcatct cctccagagg gatccgccag
       61 cccgtccagc agcaccatgt gggtgaccaa actcctgcca gccctgctgc tgcagcatgt
      121 cctcctgcat ctcctcctgc tccccatcgc catcccctat gcagagggac aaaggaaaag
      181 aagaaataca attcatgaat tcaaaaaatc agcaaagact accctaatca aaatagatcc
      241 agcactgaag ataaaaacca aaaaagtgaa tactgcagac caatgtgcta atagatgtac
      301 taggaataaa ggacttccat tcacttgcaa ggcttttgtt tttgataaag caagaaaaca
      361 atgcctctgg ttccccttca atagcatgtc aagtggagtg aaaaaagaat ttggccatga
      421 atttgacctc tatgaaaaca aagactacat tagaaactgc atcattggta aaggacgcag
      481 ctacaaggga acagtatcta tcactaagag tggcatcaaa tgtcagccct ggagttccat
      541 gataccacac gaacacagct ttttgccttc gagctatcgg ggtaaagacc tacaggaaaa
      601 ctactgtcga aatcctcgag gggaagaagg gggaccctgg tgtttcacaa gcaatccaga
      661 ggtacgctac gaagtctgtg acattcctca gtgttcagaa gttgaatgca tgacctgcaa
      721 tggggagagt tatcgaggtc tcatggatca tacagaatca ggcaagattt gtcagcgctg
      781 ggatcatcag acaccacacc ggcacaaatt cttgcctgaa agatatcccg acaagggctt
      841 tgatgataat tattgccgca atcccgatgg ccagccgagg ccatggtgct atactcttga
      901 ccctcacacc cgctgggagt actgtgcaat taaaacatgc gagacataac atgggctctc
      961 aactgatggt gaacttcttc tggtgagtga cagaggctgc agtgaagaat aatgagtcta
     1021 atagaagttt atcacagatg tctctaatct ttatagctga tccctacctc tctcgctgtc
     1081 tttgtaccca gcctgcattc tgtttcgatc tgtcttttag cagtccatac aatcattttt
     1141 ctacatgctg gcccttacct agcttttctg aatttacaat aaaaactatt ttttaacgtg
//
