LOCUS       NM_000601               5834 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens hepatocyte growth factor (HGF), transcript variant 1,
            mRNA.
ACCESSION   NM_000601
VERSION     NM_000601.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5834)
  AUTHORS   Alpaslan,M., Fastre,E., Mestre,S., van Haeringen,A., Repetto,G.M.,
            Keymolen,K., Boon,L.M., Belva,F., Giacalone,G., Revencu,N.,
            Sznajer,Y., Riches,K., Keeley,V., Mansour,S., Gordon,K.,
            Martin-Almedina,S., Dobbins,S., Ostergaard,P., Quere,I.,
            Brouillard,P. and Vikkula,M.
  TITLE     Pathogenic variants in HGF give rise to childhood-to-late onset
            primary lymphoedema by loss of function
  JOURNAL   Hum Mol Genet 33 (14), 1250-1261 (2024)
   PUBMED   38676400
  REMARK    GeneRIF: Pathogenic variants in HGF give rise to childhood-to-late
            onset primary lymphoedema by loss of function.
REFERENCE   2  (bases 1 to 5834)
  AUTHORS   Boschert,V., Boenke,J., Bohm,A.K., Teusch,J., Steinacker,V.,
            Straub,A. and Hartmann,S.
  TITLE     Differential Immune Checkpoint Protein Expression in HNSCC: The
            Role of HGF/MET Signaling
  JOURNAL   Int J Mol Sci 25 (13), 7334 (2024)
   PUBMED   39000441
  REMARK    GeneRIF: Differential Immune Checkpoint Protein Expression in
            HNSCC: The Role of HGF/MET Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5834)
  AUTHORS   Koksharova,G., Kokh,N., Gridina,M., Khapaev,R., Nimaev,V. and
            Fishman,V.
  TITLE     A HGF Mutation in the Familial Case of Primary Lymphedema: A Report
  JOURNAL   Int J Mol Sci 25 (10), 5464 (2024)
   PUBMED   38791500
  REMARK    GeneRIF: A HGF Mutation in the Familial Case of Primary Lymphedema:
            A Report.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5834)
  AUTHORS   Carrillo-Garcia,J., Lacerenza,S., Hindi,N., Moura,D.S.,
            Marquina,G., Parra Corral,D., Olalla,J., Maria Cano Cano,J.,
            Hoyos,S., Renshaw,M., Mondaza-Hernandez,J.L., Di Lernia,D.,
            Casado,A., Manzano,A., Gutierrez,A. and Martin-Broto,J.
  TITLE     Circulating TNF-RII, IP-10 and HGF are associated with severity of
            COVID-19 in oncologic patients
  JOURNAL   Cytokine 177, 156542 (2024)
   PUBMED   38364458
  REMARK    GeneRIF: Circulating TNF-RII, IP-10 and HGF are associated with
            severity of COVID-19 in oncologic patients.
REFERENCE   5  (bases 1 to 5834)
  AUTHORS   Nakamura,T., Sakai,K., Nakamura,T. and Matsumoto,K.
  TITLE     Hepatocyte growth factor twenty years on: Much more than a growth
            factor
  JOURNAL   J Gastroenterol Hepatol 26 Suppl 1, 188-202 (2011)
   PUBMED   21199531
  REMARK    Review article
REFERENCE   6  (bases 1 to 5834)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
REFERENCE   7  (bases 1 to 5834)
  AUTHORS   Hartmann,G., Naldini,L., Weidner,K.M., Sachs,M., Vigna,E.,
            Comoglio,P.M. and Birchmeier,W.
  TITLE     A functional domain in the heavy chain of scatter factor/hepatocyte
            growth factor binds the c-Met receptor and induces cell
            dissociation but not mitogenesis
  JOURNAL   Proc Natl Acad Sci U S A 89 (23), 11574-11578 (1992)
   PUBMED   1280830
REFERENCE   8  (bases 1 to 5834)
  AUTHORS   Naka,D., Ishii,T., Yoshiyama,Y., Miyazawa,K., Hara,H., Hishida,T.
            and Kidamura,N.
  TITLE     Activation of hepatocyte growth factor by proteolytic conversion of
            a single chain form to a heterodimer
  JOURNAL   J Biol Chem 267 (28), 20114-20119 (1992)
   PUBMED   1328193
REFERENCE   9  (bases 1 to 5834)
  AUTHORS   Lokker,N.A., Mark,M.R., Luis,E.A., Bennett,G.L., Robbins,K.A.,
            Baker,J.B. and Godowski,P.J.
  TITLE     Structure-function analysis of hepatocyte growth factor:
            identification of variants that lack mitogenic activity yet retain
            high affinity receptor binding
  JOURNAL   EMBO J 11 (7), 2503-2510 (1992)
   PUBMED   1321034
REFERENCE   10 (bases 1 to 5834)
  AUTHORS   Miyazawa,K., Tsubouchi,H., Naka,D., Takahashi,K., Okigaki,M.,
            Arakaki,N., Nakayama,H., Hirono,S., Sakiyama,O., Takahashi,K. et
            al.
  TITLE     Molecular cloning and sequence analysis of cDNA for human
            hepatocyte growth factor
  JOURNAL   Biochem Biophys Res Commun 163 (2), 967-973 (1989)
   PUBMED   2528952
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX495370.1, BU533235.1,
            M29145.1, M73240.1, AC004960.1 and AV701693.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000601.5.
            
            Summary: This gene encodes a protein that binds to the hepatocyte
            growth factor receptor to regulate cell growth, cell motility and
            morphogenesis in numerous cell and tissue types. Alternative
            splicing results in multiple transcript variants, at least one of
            which encodes a preproprotein that is proteolytically processed to
            generate alpha and beta chains, which form the mature heterodimer.
            This protein is secreted by mesenchymal cells and acts as a
            multi-functional cytokine on cells of mainly epithelial origin.
            This protein also plays a role in angiogenesis, tumorogenesis, and
            tissue regeneration. Although the encoded protein is a member of
            the peptidase S1 family of serine proteases, it lacks peptidase
            activity. Mutations in this gene are associated with nonsyndromic
            hearing loss. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X16323.1, SRR14038192.3249490.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000222390.11/ ENSP00000222390.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               BX495370.1         153-460
            309-330             BU533235.1         399-420
            331-2551            M29145.1           356-2576
            2552-2714           M73240.1           2526-2688
            2715-5818           AC004960.1         46526-49629         c
            5819-5834           AV701693.1         303-318
FEATURES             Location/Qualifiers
     source          1..5834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.11"
     gene            1..5834
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /note="hepatocyte growth factor"
                     /db_xref="GeneID:3082"
                     /db_xref="HGNC:HGNC:4893"
                     /db_xref="MIM:142409"
     exon            1..164
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2263
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; fibroblast-derived tumor cytotoxic factor; lung
                     fibroblast-derived mitogen; hepatopoietin-A; hepatocyte
                     growth factor (hepapoietin A; scatter factor)"
                     /codon_start=1
                     /product="hepatocyte growth factor isoform 1
                     preproprotein"
                     /protein_id="NP_000592.3"
                     /db_xref="CCDS:CCDS5597.1"
                     /db_xref="GeneID:3082"
                     /db_xref="HGNC:HGNC:4893"
                     /db_xref="MIM:142409"
                     /translation="MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKK
                     SAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFN
                     SMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEH
                     SFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGES
                     YRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDP
                     HTRWEYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYP
                     HEHDMTPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCY
                     RGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNENYCRNPDDDAHGP
                     WCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTRTNIGWM
                     VSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLN
                     VSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLIN
                     YDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQH
                     KMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILTYKVPQS"
     exon            165..330
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            331..443
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            444..558
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            559..701
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            702..822
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            823..941
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1116
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1244
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1347
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1481
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1520
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1617
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1692
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1833
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1940
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2086
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..5834
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5815..5820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /note="hexamer: AATAAA"
     polyA_site      5834
                     /gene="HGF"
                     /gene_synonym="DFNB39; F-TCF; HGFB; HPTA; SF"
                     /note="major polyA site"
ORIGIN      
        1 aggcactgac tccgaacagg attctttcac ccaggcatct cctccagagg gatccgccag
       61 cccgtccagc agcaccatgt gggtgaccaa actcctgcca gccctgctgc tgcagcatgt
      121 cctcctgcat ctcctcctgc tccccatcgc catcccctat gcagagggac aaaggaaaag
      181 aagaaataca attcatgaat tcaaaaaatc agcaaagact accctaatca aaatagatcc
      241 agcactgaag ataaaaacca aaaaagtgaa tactgcagac caatgtgcta atagatgtac
      301 taggaataaa ggacttccat tcacttgcaa ggcttttgtt tttgataaag caagaaaaca
      361 atgcctctgg ttccccttca atagcatgtc aagtggagtg aaaaaagaat ttggccatga
      421 atttgacctc tatgaaaaca aagactacat tagaaactgc atcattggta aaggacgcag
      481 ctacaaggga acagtatcta tcactaagag tggcatcaaa tgtcagccct ggagttccat
      541 gataccacac gaacacagct ttttgccttc gagctatcgg ggtaaagacc tacaggaaaa
      601 ctactgtcga aatcctcgag gggaagaagg gggaccctgg tgtttcacaa gcaatccaga
      661 ggtacgctac gaagtctgtg acattcctca gtgttcagaa gttgaatgca tgacctgcaa
      721 tggggagagt tatcgaggtc tcatggatca tacagaatca ggcaagattt gtcagcgctg
      781 ggatcatcag acaccacacc ggcacaaatt cttgcctgaa agatatcccg acaagggctt
      841 tgatgataat tattgccgca atcccgatgg ccagccgagg ccatggtgct atactcttga
      901 ccctcacacc cgctgggagt actgtgcaat taaaacatgc gctgacaata ctatgaatga
      961 cactgatgtt cctttggaaa caactgaatg catccaaggt caaggagaag gctacagggg
     1021 cactgtcaat accatttgga atggaattcc atgtcagcgt tgggattctc agtatcctca
     1081 cgagcatgac atgactcctg aaaatttcaa gtgcaaggac ctacgagaaa attactgccg
     1141 aaatccagat gggtctgaat caccctggtg ttttaccact gatccaaaca tccgagttgg
     1201 ctactgctcc caaattccaa actgtgatat gtcacatgga caagattgtt atcgtgggaa
     1261 tggcaaaaat tatatgggca acttatccca aacaagatct ggactaacat gttcaatgtg
     1321 ggacaagaac atggaagact tacatcgtca tatcttctgg gaaccagatg caagtaagct
     1381 gaatgagaat tactgccgaa atccagatga tgatgctcat ggaccctggt gctacacggg
     1441 aaatccactc attccttggg attattgccc tatttctcgt tgtgaaggtg ataccacacc
     1501 tacaatagtc aatttagacc atcccgtaat atcttgtgcc aaaacgaaac aattgcgagt
     1561 tgtaaatggg attccaacac gaacaaacat aggatggatg gttagtttga gatacagaaa
     1621 taaacatatc tgcggaggat cattgataaa ggagagttgg gttcttactg cacgacagtg
     1681 tttcccttct cgagacttga aagattatga agcttggctt ggaattcatg atgtccacgg
     1741 aagaggagat gagaaatgca aacaggttct caatgtttcc cagctggtat atggccctga
     1801 aggatcagat ctggttttaa tgaagcttgc caggcctgct gtcctggatg attttgttag
     1861 tacgattgat ttacctaatt atggatgcac aattcctgaa aagaccagtt gcagtgttta
     1921 tggctggggc tacactggat tgatcaacta tgatggccta ttacgagtgg cacatctcta
     1981 tataatggga aatgagaaat gcagccagca tcatcgaggg aaggtgactc tgaatgagtc
     2041 tgaaatatgt gctggggctg aaaagattgg atcaggacca tgtgaggggg attatggtgg
     2101 cccacttgtt tgtgagcaac ataaaatgag aatggttctt ggtgtcattg ttcctggtcg
     2161 tggatgtgcc attccaaatc gtcctggtat ttttgtccga gtagcatatt atgcaaaatg
     2221 gatacacaaa attattttaa catataaggt accacagtca tagctgaagt aagtgtgtct
     2281 gaagcaccca ccaatacaac tgtcttttac atgaagattt cagagaatgt ggaatttaaa
     2341 atgtcactta caacaatcct aagacaacta ctggagagtc atgtttgttg aaattctcat
     2401 taatgtttat gggtgttttc tgttgttttg tttgtcagtg ttattttgtc aatgttgaag
     2461 tgaattaagg tacatgcaag tgtaataaca tatctcctga agatacttga atggattaaa
     2521 aaaacacaca ggtatatttg ctggatgata aagatttcat gggaaaaaaa atcaattaat
     2581 ctgtctaagc tgctttctga tgttggtttc ttaataatga gtaaaccaca aattaaatgt
     2641 tattttaacc tcaccaaaac aatttatacc ttgtgtccct aaattgtagc cctatattaa
     2701 attatattac atttcatatg ctatatgtta tagttcattc atttctcttc accatgtatc
     2761 ctgcaatact ggtacacgaa cacacttttt acaaaaccac atacccatgt acacatgcct
     2821 aggtacacat gtgcatgcac tacagtttaa attatggtgt acctaatgta acccctaaat
     2881 attttagaag tatgtaccta tagttttacc tcaaaaaaac cagaaatctc taaagaccag
     2941 tagaaatatt aaaaaatgat gcaagatcaa aatgattagc taattctcca tacataatct
     3001 gcagatgatc ttctttggtt ggcatttcag gtgtggccat cacccagagt taaataacac
     3061 ctaatctagg tgtttacatg tattcattat cctagttatt tcatgtagtt tctaattctt
     3121 aaaggaaaga gggtaatagt tctatttgtg taatttgttt cctccaaact taaggccact
     3181 tatttacaca agatatttgt agatctattt tcctaaagca tttcttaagt gctcagatca
     3241 gtatctaatt gaagaagttt aaaagtgttt tggtcattaa aaatgtactt aaataggtta
     3301 aatctaagcc ttgctgctgt gattggcttc tagctcactg cctttaaatt ttaaaaaatt
     3361 taagaggaaa atttccaagt ctccaaagtt ttataaatac ccttcatcaa gtcatgcatt
     3421 aaagtatata ttggagaaaa aaataaaaat acttttctca acctggaaga ttttagccta
     3481 ataaagcttt tttgaagtaa aagacaactt gtaaaaggaa agaaactagt ttgtctcaac
     3541 tctgtattca tttatttttt ttttgaagta gagtggaatc tgttgaatca gatattttat
     3601 caagatatgt ttattttttc ttatttcatt ttacaaagtt cactcctaat gccatatgta
     3661 acagacattt aaattttgtg ttctgtataa cagccaaatt atcatattta tcattgtatt
     3721 tgtcatgctt agctaaagat catgtatttg ttgagaaata gaataacaaa aagtaatagg
     3781 ataggctttg aatttttgca gaaatcttcc tgtacaaaac acctttaaaa ataatttttt
     3841 gaatggtgtg aatccagtag tcccatttct ctgacttagt tttcttgagt gatttttatc
     3901 aaggccaagt ccccaaacaa ttccctacca gctctttaga gtactgttca atctggacta
     3961 aaatggtttt aagtttatgg agagcttagt ccacagaata tagggcggcg agtccagaaa
     4021 tgcttataca attttttttt cataataaga tatgtgctgg catcaagaaa cttaaagtgg
     4081 aagcaaaaag acatccaact agttgctggt ctctatcatc ttatctgatg gtatttctat
     4141 tttccttata taatacacca ttttagtaag aactcctaga aatttcaaga gcatattgcc
     4201 aaaatataaa gtatatttca tagtttcttc tggctgaacc agtgaaattt tattattgca
     4261 tattaatgat atttgtaaaa cttttataaa aattgtcata attttaaata ctcacatttt
     4321 aaaaatactt ctttaatgac tcttcctcta aatttcctgg aaatacagat aaagattagc
     4381 tagatacaag atacagctaa gtatttagac attttgaggc tagtattttt cattttatta
     4441 aaggctaaaa acaataccac caataaatca tcaaacaaac cgtacaaagt aattctctct
     4501 ttgggaggct cctttcgtga tagagggaca tgggtggaat tgacaatgaa acttagatga
     4561 acaaggtcca tgttatttta ggtggtagaa cagggtagag tcatgtcatt atttgctggt
     4621 ggaagacact atttaccagg tgttctttgc tgaataaatc attaaacatt tttaaaaatc
     4681 caacaatcca ctttattttg tgtcattgac aaaaggatct tttaaatcag aaggtttcaa
     4741 tgcaattttt ggtttggctg tttgaataat ggttatgtac tgttataatt gtagacattt
     4801 tctcacgtct accaggaatt gaagtgtaaa actaaaatat ttttcataat gcctctgccg
     4861 tgcagaagga atgataatcc ttttgtatac ttctttaatt ttattgtaaa atgtgtaatg
     4921 acttttacct atatgctgtg ggcaggtcct cagtaaaatc tattgagtca atttctagta
     4981 ttaacaggct tttgcttgct atctaagtgt ttcaaattat gggaagtgtg agacactgga
     5041 aggcaagaaa attaacaata atggcatgtg atagcaaaat tgtatttcac ttattcctgt
     5101 gaatatttct tgttggtacc aatggtactg tacaaagtga atgttatagc cacaacattc
     5161 tcttgaaaag aacactgtca agaagtggga aattgctgtc aggcatttca ttgttgtttt
     5221 taaacttttt taaaagaaat actggttttg caatatagag atcatgtggt aaagaatttt
     5281 aataagatct tatactaaaa agccttaaat caatttattg agattcaaaa aatactatta
     5341 taattaatta catcccatac atataggcaa actcatttaa aaaataaaac taattttggt
     5401 aaaagtacat ggcctttgtt tttaaaatac ataattttaa aataaatcac ttgtcatgat
     5461 aaagtccaaa aagaagttat cattcaacat tcaactaagg ttggagctaa gaatttacta
     5521 atacaaaaaa agttaaaatt ttttggacca tatatatctt gacagtgtaa cttttaagta
     5581 ggttcatttc catttgcaca gaaagtttct gtctttagga aactgaaaat gaaatactgt
     5641 ggatgctatg actgtttgtc ttgtatgtaa ataggaaatt aataagctgc ctattgagtg
     5701 gtatagctgt atgcttaccc aaaaaaggga acactgtggt tatgacttgt attataaact
     5761 ttctgtagtt aataaagttg ttatttttat aaccatgatt atattattat tattaataaa
     5821 atattttatc aaaa
//
