LOCUS       NM_001303441            1436 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens HEXIM P-TEFb complex subunit 2 (HEXIM2), transcript
            variant 7, mRNA.
ACCESSION   NM_001303441
VERSION     NM_001303441.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1436)
  AUTHORS   Walker,F.M., Sobral,L.M., Danis,E., Sanford,B., Donthula,S.,
            Balakrishnan,I., Wang,D., Pierce,A., Karam,S.D., Kargar,S.,
            Serkova,N.J., Foreman,N.K., Venkataraman,S., Dowell,R., Vibhakar,R.
            and Dahl,N.A.
  TITLE     Rapid P-TEFb-dependent transcriptional reorganization underpins the
            glioma adaptive response to radiotherapy
  JOURNAL   Nat Commun 15 (1), 4616 (2024)
   PUBMED   38816355
  REMARK    GeneRIF: Rapid P-TEFb-dependent transcriptional reorganization
            underpins the glioma adaptive response to radiotherapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1436)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1436)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1436)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1436)
  AUTHORS   Liu,P., Xiang,Y., Fujinaga,K., Bartholomeeusen,K., Nilson,K.A.,
            Price,D.H. and Peterlin,B.M.
  TITLE     Release of positive transcription elongation factor b (P-TEFb) from
            7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene
            bisacetamide-inducible protein (HEXIM1) transcription
  JOURNAL   J Biol Chem 289 (14), 9918-9925 (2014)
   PUBMED   24515107
REFERENCE   6  (bases 1 to 1436)
  AUTHORS   Li,Q., Price,J.P., Byers,S.A., Cheng,D., Peng,J. and Price,D.H.
  TITLE     Analysis of the large inactive P-TEFb complex indicates that it
            contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two
            P-TEFb molecules containing Cdk9 phosphorylated at threonine 186
  JOURNAL   J Biol Chem 280 (31), 28819-28826 (2005)
   PUBMED   15965233
  REMARK    GeneRIF: Positive transcription elongation factor b regulates
            eukaryotic gene expression at the level of elongation and is
            controlled by the reversible association with HEXIM2.
REFERENCE   7  (bases 1 to 1436)
  AUTHORS   Fraldi,A., Varrone,F., Napolitano,G., Michels,A.A., Majello,B.,
            Bensaude,O. and Lania,L.
  TITLE     Inhibition of Tat activity by the HEXIM1 protein
  JOURNAL   Retrovirology 2, 42 (2005)
   PUBMED   15992410
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1436)
  AUTHORS   Byers,S.A., Price,J.P., Cooper,J.J., Li,Q. and Price,D.H.
  TITLE     HEXIM2, a HEXIM1-related protein, regulates positive transcription
            elongation factor b through association with 7SK
  JOURNAL   J Biol Chem 280 (16), 16360-16367 (2005)
   PUBMED   15713662
  REMARK    GeneRIF: utilization of HEXIM1 or HEXIM2 to bind and inhibit P-TEFb
            can be differentially regulated in vivo.
REFERENCE   9  (bases 1 to 1436)
  AUTHORS   Yik,J.H., Chen,R., Pezda,A.C. and Zhou,Q.
  TITLE     Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the
            balance of active and inactive positive transcription elongation
            factor b complexes for control of transcription
  JOURNAL   J Biol Chem 280 (16), 16368-16376 (2005)
   PUBMED   15713661
  REMARK    GeneRIF: HEXIM2 can functionally and quantitatively compensate for
            the loss of HEXIM1
REFERENCE   10 (bases 1 to 1436)
  AUTHORS   Michels,A.A., Nguyen,V.T., Fraldi,A., Labas,V., Edwards,M.,
            Bonnet,F., Lania,L. and Bensaude,O.
  TITLE     MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a
            transcription-dependent manner
  JOURNAL   Mol Cell Biol 23 (14), 4859-4869 (2003)
   PUBMED   12832472
  REMARK    Erratum:[Mol Cell Biol. 2003 Dec;23(24):9405]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI829844.1, AA223138.1 and
            AK056946.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001303441.1.
            
            Summary: This gene encodes a member of the HEXIM family of
            proteins. This protein is a component of the 7SK small nuclear
            ribonucleoprotein. This protein has been found to negatively
            regulate the kinase activity of the cyclin-dependent kinase P-TEFb,
            which phosphorylates multiple target proteins to promote
            transcriptional elongation. This gene is located approximately 7 kb
            downstream from related family member HEXIM1 on chromosome 17.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (7) differs in the 5' UTR compared
            to variant 1. Variants 1-9 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3268247.1,
                                           SRR14038193.376715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000589230.6/ ENSP00000466200.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BI829844.1         30-109
            81-88               AA223138.1         31-38
            89-555              BI829844.1         116-582
            556-1436            AK056946.1         446-1326
FEATURES             Location/Qualifiers
     source          1..1436
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..1436
                     /gene="HEXIM2"
                     /gene_synonym="L3"
                     /note="HEXIM P-TEFb complex subunit 2"
                     /db_xref="GeneID:124790"
                     /db_xref="HGNC:HGNC:28591"
                     /db_xref="MIM:615695"
     exon            1..157
                     /gene="HEXIM2"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
     exon            158..305
                     /gene="HEXIM2"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
     exon            306..415
                     /gene="HEXIM2"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..1210
                     /gene="HEXIM2"
                     /gene_synonym="L3"
                     /note="isoform 1 is encoded by transcript variant 7;
                     hexamethylene-bis-acetamide-inducible transcript 2;
                     hexamethylene bis-acetamide inducible 2; MAQ1 paralog;
                     protein HEXIM2; hexamethylene bis-acetamide-inducible
                     protein 2; hexamethylene bisacetamide inducible 2"
                     /codon_start=1
                     /product="protein HEXIM2 isoform 1"
                     /protein_id="NP_001290370.1"
                     /db_xref="CCDS:CCDS11496.1"
                     /db_xref="GeneID:124790"
                     /db_xref="HGNC:HGNC:28591"
                     /db_xref="MIM:615695"
                     /translation="MMATPNQTACNAESPVALEEAKTSGAPGSPQTPPERHDSGGSLP
                     LTPRMESHSEDEDLAGAVGGLGWNSRSPRTQSPGGCSAEAVLARKKHRRRPSKRKRHW
                     RPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDV
                     PHGISHPGSSGESEAGDSDGRGRAHGEFQRKDFSETYERFHTESLQGRSKQELVRDYL
                     ELEKRLSQAEEETRRLQQLQACTGQQSCRQVEELAAEVQRLRTENQRLRQENQMWNRE
                     GCRCDEEPGT"
     exon            416..1436
                     /gene="HEXIM2"
                     /gene_synonym="L3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1412..1417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEXIM2"
                     /gene_synonym="L3"
                     /note="hexamer: ATTAAA"
     polyA_site      1436
                     /gene="HEXIM2"
                     /gene_synonym="L3"
                     /note="major polyA site"
ORIGIN      
        1 ctctcttccc ccccatctta gtggcctgag cggcttgacc agagctgctg caactgcagc
       61 aagaggtagg gctcaggcgt tgggaattgc accgacaggc agtcgcacag aaaggcacac
      121 agatgtagtg gtgtgcatag cccttgacag cgaataggag gacagtacag gacatgagtc
      181 ctggtgaggg acccgaggag caggacagag aagacggccc ctgaatccca tttggcccct
      241 tgctggctgg aggtgtgaaa accagcggtg gaggcagcct tcggggcctg catttgagaa
      301 taagggtgtc actagttcca ggcgtctgct gaaagatttg gaacagaaga tgatggccac
      361 tccgaaccag accgcctgta atgcagagtc accagtggcc ctggaggagg ccaagacctc
      421 tggtgccccg gggagccccc aaacaccccc tgagcgtcat gactctggtg gttccctgcc
      481 cctgacaccg cggatggaga gccactcaga ggatgaagat cttgctgggg ctgtcggtgg
      541 cctgggctgg aacagtagga gtccccggac ccagagccca gggggctgct cagcggaggc
      601 tgtgctggcc cggaagaaac accgtcggcg gccatcgaag cgcaaaaggc actggcgacc
      661 ctacctggag ctgagctggg ctgagaaaca acagcgggat gagaggcaga gccagagggc
      721 ctcccgggtc cgcgaagaga tgttcgccaa aggccagccc gtggccccct acaacaccac
      781 ccagttcctg atgaatgaca gggacccgga ggagcccaac ttggatgtgc cccatgggat
      841 ctcccaccca ggttccagtg gggagagtga ggccggggac agtgatgggc ggggccgagc
      901 gcacggtgag ttccagcgga aggacttctc tgagacttac gaacgcttcc acaccgagag
      961 cctgcagggc cgcagcaagc aggagctggt gcgagactac ctggagctgg agaagcggct
     1021 gtcgcaggcg gaggaggaga ctaggaggct gcagcagctg caggcgtgca ccggccagca
     1081 gtcctgccgc caggtggagg agctggctgc cgaggtccag aggctccgga ccgaaaacca
     1141 gcggcttcgt caggagaacc agatgtggaa ccgagagggc tgccgctgtg atgaggagcc
     1201 gggtacctag gggtgcctcc cagcctggtg gacccaagga gaaggtccca tttcgtgcac
     1261 actcaggcca gctgggtctc aaggaggcag gtggcagatg aaaaccaccg tcaacaccct
     1321 gtgcgccctg agaacagcta aatcggttca gactcccacc tcaccgtttc catagttggc
     1381 tcttttgtgt catcttaccc tttacagaga aattaaatgg ccttggtggg accaaa
//
