LOCUS       NM_006460               3625 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens HEXIM P-TEFb complex subunit 1 (HEXIM1), mRNA.
ACCESSION   NM_006460
VERSION     NM_006460.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3625)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3625)
  AUTHORS   Walker,F.M., Sobral,L.M., Danis,E., Sanford,B., Donthula,S.,
            Balakrishnan,I., Wang,D., Pierce,A., Karam,S.D., Kargar,S.,
            Serkova,N.J., Foreman,N.K., Venkataraman,S., Dowell,R., Vibhakar,R.
            and Dahl,N.A.
  TITLE     Rapid P-TEFb-dependent transcriptional reorganization underpins the
            glioma adaptive response to radiotherapy
  JOURNAL   Nat Commun 15 (1), 4616 (2024)
   PUBMED   38816355
  REMARK    GeneRIF: Rapid P-TEFb-dependent transcriptional reorganization
            underpins the glioma adaptive response to radiotherapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3625)
  AUTHORS   Lv,X., Murphy,K., Murphy,Z., Getman,M., Rahman,N., Nakamura,Y.,
            Blanc,L., Gallagher,P.G., Palis,J., Mohandas,N. and Steiner,L.A.
  TITLE     HEXIM1 is an essential transcription regulator during human
            erythropoiesis
  JOURNAL   Blood 142 (25), 2198-2215 (2023)
   PUBMED   37738561
  REMARK    GeneRIF: HEXIM1 is an essential transcription regulator during
            human erythropoiesis.
REFERENCE   4  (bases 1 to 3625)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3625)
  AUTHORS   Mozar,F., Sharma,V., Gorityala,S., Albert,J.M., Xu,Y. and
            Montano,M.M.
  TITLE     Downregulation of Dihydrotestosterone and Estradiol Levels by
            HEXIM1
  JOURNAL   Endocrinology 163 (1) (2022)
   PUBMED   34864989
  REMARK    GeneRIF: Downregulation of Dihydrotestosterone and Estradiol Levels
            by HEXIM1.
REFERENCE   6  (bases 1 to 3625)
  AUTHORS   Paushkin,S.V., Patel,M., Furia,B.S., Peltz,S.W. and Trotta,C.R.
  TITLE     Identification of a human endonuclease complex reveals a link
            between tRNA splicing and pre-mRNA 3' end formation
  JOURNAL   Cell 117 (3), 311-321 (2004)
   PUBMED   15109492
REFERENCE   7  (bases 1 to 3625)
  AUTHORS   Yik,J.H., Chen,R., Nishimura,R., Jennings,J.L., Link,A.J. and
            Zhou,Q.
  TITLE     Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II
            transcription by the coordinated actions of HEXIM1 and 7SK snRNA
  JOURNAL   Mol Cell 12 (4), 971-982 (2003)
   PUBMED   14580347
REFERENCE   8  (bases 1 to 3625)
  AUTHORS   Michels,A.A., Nguyen,V.T., Fraldi,A., Labas,V., Edwards,M.,
            Bonnet,F., Lania,L. and Bensaude,O.
  TITLE     MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a
            transcription-dependent manner
  JOURNAL   Mol Cell Biol 23 (14), 4859-4869 (2003)
   PUBMED   12832472
  REMARK    GeneRIF: MAQ1 cooperates with 7SK RNA to form a novel type of CDK
            inhibitor.
            Erratum:[Mol Cell Biol. 2003 Dec;23(24):9405]
REFERENCE   9  (bases 1 to 3625)
  AUTHORS   Ouchida,R., Kusuhara,M., Shimizu,N., Hisada,T., Makino,Y.,
            Morimoto,C., Handa,H., Ohsuzu,F. and Tanaka,H.
  TITLE     Suppression of NF-kappaB-dependent gene expression by a
            hexamethylene bisacetamide-inducible protein HEXIM1 in human
            vascular smooth muscle cells
  JOURNAL   Genes Cells 8 (2), 95-107 (2003)
   PUBMED   12581153
  REMARK    GeneRIF: Biochemically characterized a hexamethylene
            bisacetamide-inducible protein HEXIM1, which is a novel nuclear
            protein. Interacts with p50 of NF-kB and suppresses NF-kB
            transcription.
REFERENCE   10 (bases 1 to 3625)
  AUTHORS   Huang,F., Wagner,M. and Siddiqui,M.A.
  TITLE     Structure, expression, and functional characterization of the mouse
            CLP-1 gene
  JOURNAL   Gene 292 (1-2), 245-259 (2002)
   PUBMED   12119119
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC142472.2.
            
            On Aug 2, 2019 this sequence version replaced NM_006460.2.
            
            Summary: Expression of this gene is induced by
            hexamethylene-bis-acetamide in vascular smooth muscle cells. This
            gene has no introns. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB021179.1, SRR7346977.1616100.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332499.4/ ENSP00000328773.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3625              AC142472.2         595-4219            c
FEATURES             Location/Qualifiers
     source          1..3625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..3625
                     /gene="HEXIM1"
                     /gene_synonym="CLP1; EDG1; HIS1; MAQ1"
                     /note="HEXIM P-TEFb complex subunit 1"
                     /db_xref="GeneID:10614"
                     /db_xref="HGNC:HGNC:24953"
                     /db_xref="MIM:607328"
     exon            1..3625
                     /gene="HEXIM1"
                     /gene_synonym="CLP1; EDG1; HIS1; MAQ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             717..1796
                     /gene="HEXIM1"
                     /gene_synonym="CLP1; EDG1; HIS1; MAQ1"
                     /note="hexamethylene-bis-acetamide-inducible transcript 1;
                     menage a quatre 1; hexamthylene bis-acetamide inducible 1;
                     hexamethylene bisacetamide-inducible protein;
                     HMBA-inducible; cardiac lineage protein 1; menage a quatre
                     protein 1; hexamethylene bisacetamide inducible 1;
                     estrogen down-regulated gene 1 protein; hexamethylene
                     bis-acetamide-inducible protein 1; hexamethylene
                     bis-acetamide inducible 1"
                     /codon_start=1
                     /product="protein HEXIM1"
                     /protein_id="NP_006451.1"
                     /db_xref="CCDS:CCDS11495.1"
                     /db_xref="GeneID:10614"
                     /db_xref="HGNC:HGNC:24953"
                     /db_xref="MIM:607328"
                     /translation="MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEED
                     SRWQSRAFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGD
                     FPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKK
                     KRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEP
                     DLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHT
                     ESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRA
                     ENLQLLTENELHRQQERAPLSKFGD"
     regulatory      2152..2157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEXIM1"
                     /gene_synonym="CLP1; EDG1; HIS1; MAQ1"
                     /note="hexamer: AATAAA"
     polyA_site      2177
                     /gene="HEXIM1"
                     /gene_synonym="CLP1; EDG1; HIS1; MAQ1"
                     /note="major polyA site"
     regulatory      3606..3611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEXIM1"
                     /gene_synonym="CLP1; EDG1; HIS1; MAQ1"
                     /note="hexamer: ATTAAA"
     polyA_site      3625
                     /gene="HEXIM1"
                     /gene_synonym="CLP1; EDG1; HIS1; MAQ1"
ORIGIN      
        1 agcagttgga agttggcagg tggagaggca ggttgggagg gaaagtcggg ggaggacgcg
       61 gaagaggagc tgtgggaagg gggaggaggg agggaggaaa agaggaggag gcggaggaga
      121 actgagcaga gcagagcatc gagccaaagg ggagatgagt ttgtctgtcc tctgctgagg
      181 ctacggccgg gcctagggaa ctgggagctt gggtggaagc gacacccgtg gaagtgggag
      241 gaggtggcgc cgggacttta accccttgtg ggctctgcgg caggggattt aaccctttgt
      301 ggatctggcc cctcggaggc agcgtcatcg gtagttttaa ccccttcggg gctgggtttc
      361 acgcactgga cttaccctca tcaccttgct caccaactcc tttattgggg tgctccgctt
      421 ggaggtttga ggcccacctc cgcccattac gtactgttcc tgccgctgca cccccttgga
      481 cccgctagct ggccgcactg tgggcgctta accctttact gacttgagct ccccagattg
      541 cagttggagt ttgctgatag aaggactagc taaaggcgtc actgcaggaa ttacaaactg
      601 aagaggactc tgttggactg tttttttttt ctttttcttt tttttaagaa aaacccattt
      661 ttttccttaa ggacttacta gccaaaattt cttaaacttc gaggactcta ctagccatgg
      721 ccgagccatt cttgtcagaa tatcaacacc agcctcaaac tagcaactgt acaggtgctg
      781 ctgctgtcca ggaagagctg aaccctgagc gccccccagg cgcggaggag cgggtgcccg
      841 aggaggacag taggtggcaa tcgagagcgt tcccccagtt gggtggccgt ccggggccgg
      901 agggggaagg gagcctggaa tcccaaccac ctcccttgca gacccaggcc tgtccagaat
      961 ctagctgcct gagagagggc gagaagggcc agaatgggga cgactcgtcc gctggcggcg
     1021 acttcccgcc gccggcagaa gtggaaccga cgcccgaggc cgagctgctc gcccagcctt
     1081 gtcatgactc cgaggccagt aagttggggg ctcctgccgc agggggcgaa gaggagtggg
     1141 gacagcagca gagacagctg gggaagaaaa aacataggag acgcccgtcc aagaagaagc
     1201 ggcattggaa accgtactac aagctgacct gggaagagaa gaaaaagttc gacgagaaac
     1261 agagccttcg agcttcaagg atccgagccg agatgttcgc caagggccag ccggtcgcgc
     1321 cctataacac cacgcagttc ctcatggatg atcacgacca ggaggagccg gatctcaaaa
     1381 ccggcctgta ctccaagcgg gccgccgcca aatccgacga caccagcgat gacgacttca
     1441 tggaagaagg gggtgaggag gatgggggca gcgatgggat gggaggggac ggcagcgagt
     1501 ttctgcagcg ggacttctcg gagacgtacg agcggtacca cacggagagc ctgcagaaca
     1561 tgagcaagca ggagctcatc aaggagtacc tggaactgga gaagtgcctc tcgcgcatgg
     1621 aggacgagaa caaccggctg cggctggaga gcaagcggct gggtggcgac gacgcgcgtg
     1681 tgcgggagct ggagctggag ctggaccggc tgcgcgccga gaacctccag ctgctgaccg
     1741 agaacgaact gcaccggcag caggagcgag cgccgctttc caagtttgga gactagactg
     1801 aaactttttt gggggagggg gcaaagggga ctttttacag tgatggaatg taacattata
     1861 tacatgtgta tataagacag tggacctttt tatgacacat aatcagaaga gaaatccccc
     1921 tggctttggt ttcgtaaatt tagctatatg tagcttgcgt gctttctcct gttcttttaa
     1981 ttatgtgaaa ctgaagagtt gcttttcttg ttttcctttt tagaagtttt tttccttaat
     2041 gtgaaagtaa tttgaccaag ttataatgca tttttgtttt taacaaatcc cctccttaaa
     2101 cggagctata aggtggccaa atctgagaac aattaaattc attttagtta taataaattt
     2161 aatatttgta aatgtaacat agtttcagtg tgatttctag agctaattca aaatagtatt
     2221 gatatatttt atgtgactgc atttttgggg aggggtaccg aaatcgttaa atttgtcagt
     2281 ttgcaaaaat atcaatcttt aatgggagaa ttttcaattt gccaattttt tccttgaatg
     2341 ggtttaagta tgctacaata tacagttcag gcaaaattta agatgtaatt atcttcaata
     2401 cttaagtgtg cttgctttct agtgccttgg ttttctttct tgatgctgga aaaataaaca
     2461 aaccggtatt gagtgtttag gcgagtggaa agtggctaca atccaaaatt ttaaatttaa
     2521 ctctgcctcg gccattcaaa agtctaataa caaaaaatgt aaacctaatt tggcagtttg
     2581 ttaggttaga caactgacag cctcatttca ttcctacaag ttggttttca gtaatctctt
     2641 ccttcccccc agtaaggctg gaagaggctc ttggcaaact tcttagtgca agcaatggtt
     2701 agattaattt gtgaggcagc tctttaagac gttcagaggt aagaaatact ggatttataa
     2761 agcaaatggc tgtttggggg attccaagga tttacctaat tgtccaattc tacgtgctct
     2821 ctataccaaa acaaaaaaaa aaagctatcc acctttccat gtgggtcaaa ctaaaattag
     2881 aaatgtcccc tcactgcaga tcaaatgtaa agcttccagt taaggagcta aatgaggtcc
     2941 tcagctgaat gaggaaccct gtacatcccc ttgcacagcc ctattctaaa tcgcttaaac
     3001 tatgctgata gctgcttagg ttcttgagta gttctgctct taaacgtagg gaggccctga
     3061 gaactaaatt ttgccccaaa ataaaaacag aaattatgag attgcctcct gtcattttgg
     3121 ttaacccagt ccttcacctg ccctgtgtca gtgtcttctg agggcaattg cgttgctcaa
     3181 atcactagca cagaggttcc ttaatttggg gccttagaaa ccattgtggg ccttggggtc
     3241 catgaacccc atgaaattat ttgtagactt gtatgtacat ttttctgggg agaaggttca
     3301 agagattcat aagattgtca aactccttga aggttcagaa cctctgcagg gaagggggaa
     3361 gaaaaccctc ccattaggaa gcatgctttt gcagttaaat ggcgatggtg gaggtgatag
     3421 ggacttcaag agtaaaatgc accttgtatt gcataagaag catacacaaa tcaataaatc
     3481 aagggagatt ataccagtag gactgaatca gggccttcaa agctggactg agttggtcct
     3541 gttctggcac atatggtcca ctggagacaa tgtatgattg agtttttctt tggtctaaaa
     3601 attatattaa acatttattt tgaaa
//
