LOCUS       NM_018645               1368 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens hes family bHLH transcription factor 6 (HES6),
            transcript variant 1, mRNA.
ACCESSION   NM_018645
VERSION     NM_018645.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1368)
  AUTHORS   Chen,Z., Wang,Y., Tang,W., Xu,S., Yu,H. and Chen,Z.
  TITLE     HES6 Mediates Oxidative Phosphorylation Pathway to Promote Immune
            Infiltration of CD8 + T Cells in Lung Adenocarcinoma
  JOURNAL   J Immunother 47 (8), 313-322 (2024)
   PUBMED   39005046
  REMARK    GeneRIF: HES6 Mediates Oxidative Phosphorylation Pathway to Promote
            Immune Infiltration of CD8 + T Cells in Lung Adenocarcinoma.
REFERENCE   2  (bases 1 to 1368)
  AUTHORS   Wang,Z., Wang,P., Zhang,J., Gong,H., Zhang,X., Song,J., Nie,L.,
            Peng,Y., Li,Y., Peng,H., Cui,Y., Li,H., Hu,B., Mi,J., Liang,L.,
            Liu,H., Zhang,J., Ye,M., Yazdanbakhsh,K., Mohandas,N., An,X.,
            Han,X. and Liu,J.
  TITLE     The novel GATA1-interacting protein HES6 is an essential
            transcriptional cofactor for human erythropoiesis
  JOURNAL   Nucleic Acids Res 51 (10), 4774-4790 (2023)
   PUBMED   36929421
  REMARK    GeneRIF: The novel GATA1-interacting protein HES6 is an essential
            transcriptional cofactor for human erythropoiesis.
REFERENCE   3  (bases 1 to 1368)
  AUTHORS   Bai,Z., Luo,Y. and Tian,L.
  TITLE     ERCC5, HES6 and RORA are potential diagnostic markers of coronary
            artery disease
  JOURNAL   FEBS Open Bio 12 (10), 1814-1827 (2022)
   PUBMED   35934844
  REMARK    GeneRIF: ERCC5, HES6 and RORA are potential diagnostic markers of
            coronary artery disease.
REFERENCE   4  (bases 1 to 1368)
  AUTHORS   Pandiani,C., Strub,T., Nottet,N., Cheli,Y., Gambi,G., Bille,K.,
            Husser,C., Dalmasso,M., Beranger,G., Lassalle,S., Magnone,V.,
            Pedeutour,F., Irondelle,M., Maschi,C., Nahon-Esteve,S., Martel,A.,
            Caujolle,J.P., Hofman,P., LeBrigand,K., Davidson,I., Baillif,S.,
            Barbry,P., Ballotti,R. and Bertolotto,C.
  TITLE     Single-cell RNA sequencing reveals intratumoral heterogeneity in
            primary uveal melanomas and identifies HES6 as a driver of the
            metastatic disease
  JOURNAL   Cell Death Differ 28 (6), 1990-2000 (2021)
   PUBMED   33462406
  REMARK    GeneRIF: Single-cell RNA sequencing reveals intratumoral
            heterogeneity in primary uveal melanomas and identifies HES6 as a
            driver of the metastatic disease.
REFERENCE   5  (bases 1 to 1368)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1368)
  AUTHORS   Gratton,M.O., Torban,E., Jasmin,S.B., Theriault,F.M., German,M.S.
            and Stifani,S.
  TITLE     Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription
            repression activity by multiple mechanisms
  JOURNAL   Mol Cell Biol 23 (19), 6922-6935 (2003)
   PUBMED   12972610
  REMARK    GeneRIF: Hes6 promotes cortical neurogenesis and inhibits Hes1
            transcription repression activity.
REFERENCE   7  (bases 1 to 1368)
  AUTHORS   Swearingen,M.L., Sun,D., Bourner,M. and Weinstein,E.J.
  TITLE     Detection of differentially expressed HES-6 gene in metastatic
            colon carcinoma by combination of suppression subtractive
            hybridization and cDNA library array
  JOURNAL   Cancer Lett 198 (2), 229-239 (2003)
   PUBMED   12957362
  REMARK    GeneRIF: Differentially expressed in metastatic colon carcinoma
REFERENCE   8  (bases 1 to 1368)
  AUTHORS   Gao,X., Chandra,T., Gratton,M.O., Quelo,I., Prud'homme,J.,
            Stifani,S. and St-Arnaud,R.
  TITLE     HES6 acts as a transcriptional repressor in myoblasts and can
            induce the myogenic differentiation program
  JOURNAL   J Cell Biol 154 (6), 1161-1171 (2001)
   PUBMED   11551980
REFERENCE   9  (bases 1 to 1368)
  AUTHORS   Vasiliauskas,D. and Stern,C.D.
  TITLE     Expression of mouse HES-6, a new member of the Hairy/Enhancer of
            split family of bHLH transcription factors
  JOURNAL   Mech Dev 98 (1-2), 133-137 (2000)
   PUBMED   11044617
REFERENCE   10 (bases 1 to 1368)
  AUTHORS   Bae,S., Bessho,Y., Hojo,M. and Kageyama,R.
  TITLE     The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal
            differentiation
  JOURNAL   Development 127 (13), 2933-2943 (2000)
   PUBMED   10851137
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE796220.1, BC007939.2 and
            AC016757.10.
            
            On Nov 23, 2018 this sequence version replaced NM_018645.5.
            
            Summary: This gene encodes a member of a subfamily of basic
            helix-loop-helix transcription repressors that have homology to the
            Drosophila enhancer of split genes. Members of this gene family
            regulate cell differentiation in numerous cell types. The protein
            encoded by this gene functions as a cofactor, interacting with
            other transcription factors through a tetrapeptide domain in its
            C-terminus. Alternatively spliced transcript variants encoding
            different isoforms have been described.[provided by RefSeq, Dec
            2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007939.2, BG768708.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272937.10/ ENSP00000272937.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BE796220.1         87-95
            10-1104             BC007939.2         1-1095
            1105-1240           AC016757.10        152614-152749       c
            1241-1368           BC007939.2         1232-1359
FEATURES             Location/Qualifiers
     source          1..1368
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..1368
                     /gene="HES6"
                     /gene_synonym="bHLHb41; bHLHc23; C-HAIRY1; HES-6"
                     /note="hes family bHLH transcription factor 6"
                     /db_xref="GeneID:55502"
                     /db_xref="HGNC:HGNC:18254"
                     /db_xref="MIM:610331"
     exon            1..214
                     /gene="HES6"
                     /gene_synonym="bHLHb41; bHLHc23; C-HAIRY1; HES-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..808
                     /gene="HES6"
                     /gene_synonym="bHLHb41; bHLHc23; C-HAIRY1; HES-6"
                     /note="isoform a is encoded by transcript variant 1;
                     transcription cofactor HES-6; class B basic
                     helix-loop-helix protein 41; hairy and enhancer of split
                     6"
                     /codon_start=1
                     /product="transcription cofactor HES-6 isoform a"
                     /protein_id="NP_061115.2"
                     /db_xref="CCDS:CCDS2527.1"
                     /db_xref="GeneID:55502"
                     /db_xref="HGNC:HGNC:18254"
                     /db_xref="MIM:610331"
                     /translation="MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINES
                     LQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQ
                     CMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSG
                     WPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIAR
                     SVWRPW"
     exon            215..301
                     /gene="HES6"
                     /gene_synonym="bHLHb41; bHLHc23; C-HAIRY1; HES-6"
                     /inference="alignment:Splign:2.1.0"
     exon            302..383
                     /gene="HES6"
                     /gene_synonym="bHLHb41; bHLHc23; C-HAIRY1; HES-6"
                     /inference="alignment:Splign:2.1.0"
     exon            384..1368
                     /gene="HES6"
                     /gene_synonym="bHLHb41; bHLHc23; C-HAIRY1; HES-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1337..1342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HES6"
                     /gene_synonym="bHLHb41; bHLHc23; C-HAIRY1; HES-6"
                     /note="hexamer: AATAAA"
     polyA_site      1368
                     /gene="HES6"
                     /gene_synonym="bHLHb41; bHLHc23; C-HAIRY1; HES-6"
                     /note="major polyA site"
ORIGIN      
        1 aagccgcgag gagcgcggac ggctgggctg ctgctgggcg gccgcggggc agcggagggc
       61 gccggcactc cggtccccgc cgctccccgt ccccgctgct cctagcccct gccgcgtccc
      121 cggcggagcg ggcatggcgc cacccgcggc gcctggccgg gaccgtgtgg gccgtgagga
      181 tgaggacggc tgggagacgc gaggggaccg caaggcccgg aagcccctgg tggagaagaa
      241 gcggcgcgcg cggatcaacg agagcctgca ggagctgcgg ctgctgctgg cgggcgccga
      301 ggtgcaggcc aagctggaga acgccgaagt gctggagctg acggtgcggc gggtccaggg
      361 tgtgctgcgg ggccgggcgc gcgagcgcga gcagctgcag gcggaagcga gcgagcgctt
      421 cgctgccggc tacatccagt gcatgcacga ggtgcacacg ttcgtgtcca cgtgccaggc
      481 catcgacgct accgtcgctg ccgagctcct gaaccatctg ctcgagtcca tgccgctgcg
      541 tgagggcagc agcttccagg atctgctggg ggacgccctg gcggggccac ctagagcccc
      601 tggacggagt ggctggcctg cggggggcgc tccgggatcc ccaataccca gccccccggg
      661 tcctggggac gacctgtgct ccgacctgga ggaggcccct gaggctgaac tgagtcaggc
      721 tcctgctgag gggcccgact tggtgcccgc agccctgggc agcctgacca cagcccaaat
      781 tgcccggagt gtctggaggc cttggtgacc aatgccagcc agagtcctgc gggggtgggc
      841 ccggccctcc ctggatctcc tccctcctcc caggggttca gatgtggtgg ggtagggccc
      901 tggaagtctc ccaggtcttc cctccctcct ctgatggatg gcttgcaggg cagcccctgg
      961 taaccagccc agtcaggccc cagccccgtt tcttaagaaa cttttaggga ccctgcagct
     1021 ctggagtggg tggagggagg gagctacggg caggaggaag aattttgtag agctgccagc
     1081 gctctcccag gttcacccac ccaggcttca ccagccctgt gcgggctctg ggggcagagg
     1141 tggcagaaat ggtgctgggc actagtgttc caggcagccc tgggctaaac aaaagcttga
     1201 acttgccact tcagcgggga gatgagaggc aggtgcactg agctgcactg cccagagctg
     1261 tgatgctctg tacatcttgt ttgtagcaca cttgagtttg tgtattccat tgacatcaaa
     1321 tgtgacaatt ttactaaata aagaattttg gagttagtta cccttgaa
//
