LOCUS       NM_001010926            1324 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens hes family bHLH transcription factor 5 (HES5), mRNA.
ACCESSION   NM_001010926 XM_371215
VERSION     NM_001010926.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1324)
  AUTHORS   Morris,H.E., Neves,K.B., Nilsen,M., Montezano,A.C., MacLean,M.R.
            and Touyz,R.M.
  TITLE     Notch3/Hes5 Induces Vascular Dysfunction in Hypoxia-Induced
            Pulmonary Hypertension Through ER Stress and Redox-Sensitive
            Pathways
  JOURNAL   Hypertension 80 (8), 1683-1696 (2023)
   PUBMED   37254738
  REMARK    GeneRIF: Notch3/Hes5 Induces Vascular Dysfunction in
            Hypoxia-Induced Pulmonary Hypertension Through ER Stress and
            Redox-Sensitive Pathways.
REFERENCE   2  (bases 1 to 1324)
  AUTHORS   Chen,L.J., Hu,B., Han,Z.Q., Liu,W., Zhu,J.H., Chen,X.X., Li,Z.P.
            and Zhou,H.
  TITLE     Repression of FBXW7 by HES5 contributes to inactivation of the
            TGF-beta signaling pathway and alleviation of endometriosis
  JOURNAL   FASEB J 35 (2), e20938 (2021)
   PUBMED   33496006
  REMARK    GeneRIF: Repression of FBXW7 by HES5 contributes to inactivation of
            the TGF-beta signaling pathway and alleviation of endometriosis.
REFERENCE   3  (bases 1 to 1324)
  AUTHORS   Luiken,S., Fraas,A., Bieg,M., Sugiyanto,R., Goeppert,B., Singer,S.,
            Ploeger,C., Warsow,G., Marquardt,J.U., Sticht,C., De La Torre,C.,
            Pusch,S., Mehrabi,A., Gretz,N., Schlesner,M., Eils,R.,
            Schirmacher,P., Longerich,T. and Roessler,S.
  TITLE     NOTCH target gene HES5 mediates oncogenic and tumor suppressive
            functions in hepatocarcinogenesis
  JOURNAL   Oncogene 39 (15), 3128-3144 (2020)
   PUBMED   32055024
  REMARK    GeneRIF: NOTCH target gene HES5 mediates oncogenic and tumor
            suppressive functions in hepatocarcinogenesis.
REFERENCE   4  (bases 1 to 1324)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 1324)
  AUTHORS   Gu,S., Zhang,R., Gu,J., Li,X., Lv,L., Jiang,J., Xu,Z., Wang,S.,
            Shi,C., Wang,D.P. and Wu,C.
  TITLE     HES5 promotes cellular proliferation of non-small cell lung cancer
            through STAT3 signaling
  JOURNAL   Oncol Rep 37 (1), 474-482 (2017)
   PUBMED   27878283
  REMARK    GeneRIF: HES5 might contribute to the proliferation of non-small
            cell lung cancer by STAT3 signaling.
REFERENCE   6  (bases 1 to 1324)
  AUTHORS   Liu,J., Ye,F., Chen,H., Lu,W., Zhou,C. and Xie,X.
  TITLE     Expression of differentiation associated protein Hes1 and Hes5 in
            cervical squamous carcinoma and its precursors
  JOURNAL   Int J Gynecol Cancer 17 (6), 1293-1299 (2007)
   PUBMED   17388915
  REMARK    GeneRIF: expression significantly higher in squamous cervical
            carcinoma than in CIN as well as higher in CIN than normal cervical
            epithelia
REFERENCE   7  (bases 1 to 1324)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Integrative genomic analyses on HES/HEY family: Notch-independent
            HES1, HES3 transcription in undifferentiated ES cells, and
            Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal
            tissues, adult tissues, or cancer
  JOURNAL   Int J Oncol 31 (2), 461-466 (2007)
   PUBMED   17611704
REFERENCE   8  (bases 1 to 1324)
  AUTHORS   Karlsson,C., Jonsson,M., Asp,J., Brantsing,C., Kageyama,R. and
            Lindahl,A.
  TITLE     Notch and HES5 are regulated during human cartilage differentiation
  JOURNAL   Cell Tissue Res 327 (3), 539-551 (2007)
   PUBMED   17093926
  REMARK    GeneRIF: Human HES5 gene is coupled to the Notch receptor family
            and expression of Notch markers (including HES5) decreases during
            cartilage differentiation.
REFERENCE   9  (bases 1 to 1324)
  AUTHORS   Karlsson,C., Brantsing,C., Svensson,T., Brisby,H., Asp,J.,
            Tallheden,T. and Lindahl,A.
  TITLE     Differentiation of human mesenchymal stem cells and articular
            chondrocytes: analysis of chondrogenic potential and expression
            pattern of differentiation-related transcription factors
  JOURNAL   J Orthop Res 25 (2), 152-163 (2007)
   PUBMED   17072841
  REMARK    GeneRIF: The HLH gene HES5 on the other hand was only detected in
            chondrocytes.
REFERENCE   10 (bases 1 to 1324)
  AUTHORS   Kamakura,S., Oishi,K., Yoshimatsu,T., Nakafuku,M., Masuyama,N. and
            Gotoh,Y.
  TITLE     Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT
            signalling
  JOURNAL   Nat Cell Biol 6 (6), 547-554 (2004)
   PUBMED   15156153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139246.21, DQ272660.1 and
            BX104111.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001010926.3.
            
            Summary: This gene encodes a member of a family of basic
            helix-loop-helix transcriptional repressors. The protein product of
            this gene, which is activated downstream of the Notch pathway,
            regulates cell differentiation in multiple tissues. Disruptions in
            the normal expression of this gene have been associated with
            developmental diseases and cancer. [provided by RefSeq, Dec 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ272660.1, HY107217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378453.4/ ENSP00000367714.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL139246.21        83436-83453         c
            19-943              DQ272660.1         1-925
            944-944             BX104111.1         122-122
            945-1324            DQ272660.1         927-1306
FEATURES             Location/Qualifiers
     source          1..1324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..1324
                     /gene="HES5"
                     /gene_synonym="bHLHb38"
                     /note="hes family bHLH transcription factor 5"
                     /db_xref="GeneID:388585"
                     /db_xref="HGNC:HGNC:19764"
                     /db_xref="MIM:607348"
     exon            1..153
                     /gene="HES5"
                     /gene_synonym="bHLHb38"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..600
                     /gene="HES5"
                     /gene_synonym="bHLHb38"
                     /note="hairy and enhancer of split 5; class B basic
                     helix-loop-helix protein 38"
                     /codon_start=1
                     /product="transcription factor HES-5"
                     /protein_id="NP_001010926.1"
                     /db_xref="CCDS:CCDS41233.1"
                     /db_xref="GeneID:388585"
                     /db_xref="HGNC:HGNC:19764"
                     /db_xref="MIM:607348"
                     /translation="MAPSTVAVELLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLE
                     QEFARHQPNSKLEKADILEMAVSYLKHSKAFVAAAGPKSLHQDYSEGYSWCLQEAVQF
                     LTLHAASDTQMKLLYHFQRPPAAPAAPAKEPKAPGAAPPPALSAKATAAAAAAHQPAC
                     GLWRPW"
     exon            154..319
                     /gene="HES5"
                     /gene_synonym="bHLHb38"
                     /inference="alignment:Splign:2.1.0"
     exon            320..1324
                     /gene="HES5"
                     /gene_synonym="bHLHb38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1298..1303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HES5"
                     /gene_synonym="bHLHb38"
                     /note="hexamer: AATAAA"
     polyA_site      1324
                     /gene="HES5"
                     /gene_synonym="bHLHb38"
                     /note="major polyA site"
ORIGIN      
        1 gtccgcgcca gcccgggacg cgcttggcct tgcccgcgcc cgctcgcctc gtctcgcccg
       61 gcctccccgc gtcgcctcgt cgcctgttcc gcgccaggca tggcccccag cactgtggcc
      121 gtggagctgc tcagccccaa agagaaaaac cgactgcgga agccggtggt ggagaagatg
      181 cgccgcgacc gcatcaacag cagcatcgag cagctgaagc tgctgctgga gcaggagttc
      241 gcgcggcacc agcccaactc caagctggag aaggccgaca tcctggagat ggctgtcagc
      301 tacctgaagc acagcaaagc cttcgtcgcc gccgccggcc ccaagagcct gcaccaggac
      361 tacagcgaag gctactcgtg gtgcctgcag gaggccgtgc agttcctgac gctccacgcc
      421 gccagcgaca cgcagatgaa gctgctgtac cacttccagc ggcccccggc cgcgcccgcc
      481 gcgcccgcca aggagcccaa ggcgccgggc gccgcgcccc cgcccgcgct ctccgccaag
      541 gccaccgccg ccgccgccgc cgcgcaccag cccgcctgcg gcctctggcg gccctggtga
      601 cccggcggga cctgcgggcg cgcggcccga cgaccagagg gcgagcctgc tcctctcgcc
      661 tgtagggaag cgccttcccg ccgtcgtccg ccccgggctt ggacgcgccc ttctccggaa
      721 ggctctggcc ccaagctggc cggcccgcag gagccccatt ctcagagaat gtgtgtgcag
      781 agtccctgcc gttttaggac aatcagggcc catcttctgc caagtgtctg accccatggg
      841 gttgttctgt gtttgcattt aagcaagtga cttctgggaa gtccccggcc gcccggggtt
      901 ctatgatatt tgtagtgccg gggctcgcac actgctgccc ccagcctgta gaggactttc
      961 ttcagggccc gtagctgctg ggcgtacccc tggcaggcgg gctgtgccgc gggcacattt
     1021 gccttttgtg aaggccgaac tcgagctgta tcctcatagg aaacagtgat caccccggac
     1081 gggcgtccag gaccctgagg gccatggcca aaaggctcct gagtgtgcct ggtggtctgg
     1141 ctggggctca cggtgggctg tctggggagg gtgggtgcct ccactatgat ccttaaagga
     1201 ttcctctgtg tgggtggatg cgtgtgggca cgactttgta ctcagaaatt gaactctcag
     1261 tcacgtggaa gccacgggac tgctccgaag ccgccataat aaaatctgat tgttcagccc
     1321 ccaa
//
