LOCUS       NM_001024598             710 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens hes family bHLH transcription factor 3 (HES3), mRNA.
ACCESSION   NM_001024598 XM_372757
VERSION     NM_001024598.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 710)
  AUTHORS   Fang,C., Jiang,B., Shi,X. and Fan,C.
  TITLE     Hes3 Enhances the Malignant Phenotype of Lung Cancer through
            Upregulating Cyclin D1, Cyclin D3 and MMP7 Expression
  JOURNAL   Int J Med Sci 16 (3), 470-476 (2019)
   PUBMED   30911281
  REMARK    GeneRIF: Hes3 regulated cell proliferation and lung cancer
            invasion.Hes3 regulated Cyclin D1, Cyclin D3 and MMP7 expression in
            lung cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 710)
  AUTHORS   Kendall,G.C., Watson,S., Xu,L., LaVigne,C.A., Murchison,W.,
            Rakheja,D., Skapek,S.X., Tirode,F., Delattre,O. and Amatruda,J.F.
  TITLE     PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator
            of rhabdomyosarcoma tumorigenesis
  JOURNAL   Elife 7, e33800 (2018)
   PUBMED   29869612
  REMARK    GeneRIF: HES3 overexpression is associated with impaired myogenic
            differentiation and rhabdomyosarcoma tumorigenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 710)
  AUTHORS   Nikolakopoulou,P., Poser,S.W., Masjkur,J., Fernandez Rubin de
            Celis,M., Toutouna,L., Andoniadou,C.L., McKay,R.D., Chrousos,G.,
            Ehrhart-Bornstein,M., Bornstein,S.R. and Androutsellis-Theotokis,A.
  TITLE     STAT3-Ser/Hes3 Signaling: A New Molecular Component of the
            Neuroendocrine System?
  JOURNAL   Horm Metab Res 48 (2), 77-82 (2016)
   PUBMED   26783739
  REMARK    GeneRIF: The STAT3-Ser/Hes3 Signaling Axis was first identified as
            a major regulator of neural stem cells and, subsequently, cancer
            stem cells
            Review article
REFERENCE   4  (bases 1 to 710)
  AUTHORS   Masjkur,J., Arps-Forker,C., Poser,S.W., Nikolakopoulou,P.,
            Toutouna,L., Chenna,R., Chavakis,T., Chatzigeorgiou,A., Chen,L.S.,
            Dubrovska,A., Choudhary,P., Uphues,I., Mark,M., Bornstein,S.R. and
            Androutsellis-Theotokis,A.
  TITLE     Hes3 is expressed in the adult pancreatic islet and regulates gene
            expression, cell growth, and insulin release
  JOURNAL   J Biol Chem 289 (51), 35503-35516 (2014)
   PUBMED   25371201
  REMARK    GeneRIF: Data show that transcription factor Hes3 is expressed in
            adult pancreatic islets and dissociated cultures of pancreatic
            islet cells.
REFERENCE   5  (bases 1 to 710)
  AUTHORS   Economopoulou,M., Masjkur,J., Raiskup,F., Ebermann,D., Saha,S.,
            Karl,M.O., Funk,R., Jaszai,J., Chavakis,T., Ehrhart-Bornstein,M.,
            Pillunat,L.E., Kunz-Schughart,L., Kurth,I., Dubrovska,A. and
            Androutsellis-Theotokis,A.
  TITLE     Expression of the transcription factor Hes3 in the mouse and human
            ocular surface, and in pterygium
  JOURNAL   Int J Radiat Biol 90 (8), 700-709 (2014)
   PUBMED   24512568
  REMARK    GeneRIF: expression of the transcription factor Hes3 in the mouse
            and human ocular surface, and in pterygium
REFERENCE   6  (bases 1 to 710)
  AUTHORS   Park,D.M., Jung,J., Masjkur,J., Makrogkikas,S., Ebermann,D.,
            Saha,S., Rogliano,R., Paolillo,N., Pacioni,S., McKay,R.D., Poser,S.
            and Androutsellis-Theotokis,A.
  TITLE     Hes3 regulates cell number in cultures from glioblastoma multiforme
            with stem cell characteristics
  JOURNAL   Sci Rep 3, 1095 (2013)
   PUBMED   23393614
  REMARK    GeneRIF: Hes3 is expressed in cultures from glioblastoma multiforme
            which express neural stem cell markers
REFERENCE   7  (bases 1 to 710)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 710)
  AUTHORS   Fukami,M., Wada,Y., Okada,M., Kato,F., Katsumata,N., Baba,T.,
            Morohashi,K., Laporte,J., Kitagawa,M. and Ogata,T.
  TITLE     Mastermind-like domain-containing 1 (MAMLD1 or CXorf6)
            transactivates the Hes3 promoter, augments testosterone production,
            and contains the SF1 target sequence
  JOURNAL   J Biol Chem 283 (9), 5525-5532 (2008)
   PUBMED   18162467
  REMARK    GeneRIF: CXorf6 transactivates the Hes3 promoter, augments
            testosterone production
REFERENCE   9  (bases 1 to 710)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Integrative genomic analyses on HES/HEY family: Notch-independent
            HES1, HES3 transcription in undifferentiated ES cells, and
            Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal
            tissues, adult tissues, or cancer
  JOURNAL   Int J Oncol 31 (2), 461-466 (2007)
   PUBMED   17611704
REFERENCE   10 (bases 1 to 710)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human HES2, HES3, and HES5
            genes in silico
  JOURNAL   Int J Oncol 25 (2), 529-534 (2004)
   PUBMED   15254753
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031847.17 and CN370501.1.
            
            On May 23, 2019 this sequence version replaced NM_001024598.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX755241.1, CN370501.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2149178 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000377898.4/
                                                ENSP00000367130.3
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL031847.17        65667-65684         c
            19-363              CN370501.1         22-366
            364-710             AL031847.17        64285-64631         c
FEATURES             Location/Qualifiers
     source          1..710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..710
                     /gene="HES3"
                     /gene_synonym="bHLHb43"
                     /note="hes family bHLH transcription factor 3"
                     /db_xref="GeneID:390992"
                     /db_xref="HGNC:HGNC:26226"
                     /db_xref="MIM:609971"
     exon            1..63
                     /gene="HES3"
                     /gene_synonym="bHLHb43"
                     /inference="alignment:Splign:2.1.0"
     exon            64..159
                     /gene="HES3"
                     /gene_synonym="bHLHb43"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..639
                     /gene="HES3"
                     /gene_synonym="bHLHb43"
                     /note="class B basic helix-loop-helix protein 43; hairy
                     and enhancer of split 3"
                     /codon_start=1
                     /product="transcription factor HES-3"
                     /protein_id="NP_001019769.1"
                     /db_xref="CCDS:CCDS41238.1"
                     /db_xref="GeneID:390992"
                     /db_xref="HGNC:HGNC:26226"
                     /db_xref="MIM:609971"
                     /translation="MEKKRRARINVSLEQLKSLLEKHYSHQIRKRKLEKADILELSVK
                     YMRSLQNSLQGLWPVPRGAEQPSGFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAAGS
                     TMDSAGLGQEAPALFRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPPQPA
                     SSRCAESPGLGLRVWRPWGSPGDDLN"
     exon            160..241
                     /gene="HES3"
                     /gene_synonym="bHLHb43"
                     /inference="alignment:Splign:2.1.0"
     exon            242..710
                     /gene="HES3"
                     /gene_synonym="bHLHb43"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggactgca acatgggcac ggagcctgct gcccggggca gcctccccgg caacttccga
       61 aagatttcca agccgctgat ggagaaaaag cgccgggcac gcatcaatgt gtcactggag
      121 cagctcaagt cgctgctgga gaaacactac tcgcaccaga tccggaagcg caaattggag
      181 aaggccgaca tcctggagtt gagcgtgaag tacatgagaa gccttcagaa ctccttgcaa
      241 gggctctggc ctgtgcccag gggagccgag caaccgtcgg gcttccgcag ctgcctgccc
      301 ggcgtgagcc agctccttcg gcgcggagat gaggtcggca gcggcctgcg ctgccccctg
      361 gtgcccgaga gcgccgccgg cagcaccatg gacagcgccg ggttgggcca ggaggcgccc
      421 gcgctgttcc gcccttgcac ccctgccgtc tgggctcctg ctccggccgc cggcggcccg
      481 cggtccccac cacccctgct cctcctcccc gaaagtctcc ctggctcgtc cgccagcgtc
      541 cccccgccgc agccagcgtc gagtcgctgc gccgagagtc ccgggctggg cctgcgcgtg
      601 tggcggccct ggggaagccc cggggatgac ctgaactgaa ggcgctccct atttggtctc
      661 gcgacacagg gactattttc agcacgccca cagtgactgc caggaccccc
//
