LOCUS       NM_019089               4262 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens hes family bHLH transcription factor 2 (HES2), mRNA.
ACCESSION   NM_019089 XM_375684
VERSION     NM_019089.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4262)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 4262)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 4262)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Integrative genomic analyses on HES/HEY family: Notch-independent
            HES1, HES3 transcription in undifferentiated ES cells, and
            Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal
            tissues, adult tissues, or cancer
  JOURNAL   Int J Oncol 31 (2), 461-466 (2007)
   PUBMED   17611704
REFERENCE   4  (bases 1 to 4262)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human HES2, HES3, and HES5
            genes in silico
  JOURNAL   Int J Oncol 25 (2), 529-534 (2004)
   PUBMED   15254753
REFERENCE   5  (bases 1 to 4262)
  AUTHORS   Nishimura,M., Isaka,F., Ishibashi,M., Tomita,K., Tsuda,H.,
            Nakanishi,S. and Kageyama,R.
  TITLE     Structure, chromosomal locus, and promoter of mouse Hes2 gene, a
            homologue of Drosophila hairy and Enhancer of split
  JOURNAL   Genomics 49 (1), 69-75 (1998)
   PUBMED   9570950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK091122.1, AK023754.1 and BU729177.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019089.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK091122.1, BC142687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377834.8/ ENSP00000367065.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2446              AK091122.1         1-2446
            2447-3926           AK023754.1         1632-3111
            3927-4222           AK091122.1         3927-4222
            4223-4262           BU729177.1         12-51               c
FEATURES             Location/Qualifiers
     source          1..4262
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.31"
     gene            1..4262
                     /gene="HES2"
                     /gene_synonym="bHLHb40"
                     /note="hes family bHLH transcription factor 2"
                     /db_xref="GeneID:54626"
                     /db_xref="HGNC:HGNC:16005"
                     /db_xref="MIM:609970"
     exon            1..144
                     /gene="HES2"
                     /gene_synonym="bHLHb40"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..621
                     /gene="HES2"
                     /gene_synonym="bHLHb40"
                     /note="class B basic helix-loop-helix protein 40; hairy
                     and enhancer of split 2"
                     /codon_start=1
                     /product="transcription factor HES-2"
                     /protein_id="NP_061962.2"
                     /db_xref="CCDS:CCDS30574.1"
                     /db_xref="GeneID:54626"
                     /db_xref="HGNC:HGNC:16005"
                     /db_xref="MIM:609970"
                     /translation="MGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLL
                     GRENSNCSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDSYREGYSACVARLARVLP
                     ACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSAPAPAPASAPEPASAPVPSP
                     PSPPCGPGLWRPW"
     exon            145..240
                     /gene="HES2"
                     /gene_synonym="bHLHb40"
                     /inference="alignment:Splign:2.1.0"
     exon            241..340
                     /gene="HES2"
                     /gene_synonym="bHLHb40"
                     /inference="alignment:Splign:2.1.0"
     exon            341..4262
                     /gene="HES2"
                     /gene_synonym="bHLHb40"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1585
                     /gene="HES2"
                     /gene_synonym="bHLHb40"
     regulatory      4241..4246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HES2"
                     /gene_synonym="bHLHb40"
                     /note="hexamer: AATAAA"
     polyA_site      4262
                     /gene="HES2"
                     /gene_synonym="bHLHb40"
                     /note="major polyA site"
ORIGIN      
        1 actcgtctgg caccagcccg ggccgcgccc gggacctcat ttcggacctc ggtttccctt
       61 tgcgtggggc tcgcagctgc caccgcttcc ccgcggagca tggggctgcc tcgccgggca
      121 ggggacgcgg cggagctgcg caagagcctg aagccgctgc tggagaagcg ccggcgcgcg
      181 cgcatcaacc agagcctgag ccagcttaag gggctcatcc tgccgctgct gggccgggag
      241 aactccaact gctcgaagct agagaaggca gacgtcctgg aaatgaccgt gcgcttcctg
      301 caggagctgc ctgcgtcctc atggcccacg gcagcgcccc tgccttgcga cagctaccgc
      361 gagggctaca gcgcctgtgt ggcgcgcctg gcccgcgtgc tgcccgcctg ccgtgtcctg
      421 gagcccgccg tgagcgcgcg cctgctggag cacctgtggc ggagagcggc cagcgccacc
      481 ctggacggcg ggcgcgctgg ggattccagt ggcccgtctg cccccgcccc agcgcccgcg
      541 tctgccccag agcccgcatc cgctccggtg ccctcgccgc cctcgcctcc ctgcggccct
      601 ggcctctggc ggccgtggta gcccctcggc cgatccacag accctgccga ctgcttggga
      661 ccttggggca ctggacaggt tgaagctctt ggtggcggct gctgttccca tcattagggg
      721 ccagcccagt acccacaccc aggccggaag ccggctgttt gtgactggcg tggcagactg
      781 aaagccctgg ggctggggct cggctcaggg aataaaagga gcgtccctgc ttcaccccca
      841 acttggctgg agaagaaagg acaagaggca gcagggtgaa gaagaagccc cccatcccag
      901 ctggtggaga tagttctgga actggacccc gcagctgcgt gggcagccga cacacccacc
      961 ccagcactgg caccagacca gagccagagc caggacctgg gcaaagtgca gccgtgcacc
     1021 ctgcctggtc actgctctcc cagccctgcc tgggcctacc tcctgcccag ctctgcttgg
     1081 gaccctctgg gcatgcagca gcagtagcct aagggctctg gtcacttcca gggctctaca
     1141 gggcagcaga gcagagcaaa agggtgcata tgctgggagc tgtcacctcc actcctaggc
     1201 ttttctgcct agagcagaat tataggggca gtatacatcc aggggtctgt gcggtggggc
     1261 tgggggattc cttaagtgac tttgggaagg atttgttttc ccgagcatca atttcacacc
     1321 tgggcattgc accccaggct atgcagtctt tcagtgtgag gaaggggcag aacaagaatg
     1381 aggcggcccc gtggcctcaa ggaagcttgt ggctttggag gatctgactc cagcagagtc
     1441 tgtgccaatg tggggtgagc agggcccctg ccatggagca gcaggaattt gagggatgga
     1501 gcaggttaaa gaatgggaaa catcttcact tgtttttttt tcttgcaaac tactccctgc
     1561 tactcattga gactggttac tggaagcaac ttgttaagat ttttctttct gggcgggcgc
     1621 ggtggctcac gcctgtaatc ccagcacttt gggaggccaa ggcgggtgga tcacctgagg
     1681 tcaggagttc gagaccagct tagccaatat ggtgaaaccc cgtctctact aaaaatacaa
     1741 aaattagccg ggtgtggtgg catgtgccag ctactcggga ggctgaggca agagaatcac
     1801 ttgaacctcg gaggctgaag ttgcagtgag ccaagattga gccattgctc tccagcctgg
     1861 gtgacacagc aagactctgt ctcaaaaaaa attttttatt tctttctttt ccatggaggc
     1921 ctagagtccc tgtgaaggct aggaaggggc tgctgatccc aggagtgccc acgaggagtg
     1981 gggggcactg ttggcccata atcaggcaaa cacccatcat ttcatggggg attcatgaaa
     2041 tcatagtcag gcaaacaccc gtcatttcat ggctaagcat ttgcagaagg tggaggattc
     2101 tcccccgagt ccccaaatca gcagcctgtg ctagggacca gagcaccggg ggcaagaaga
     2161 cagaaccaat gtgggagtgg ggatggtcac taaatctgac tgtgccacac aagcccatga
     2221 tgaccttggc actggtttgg gtggcaggat atgaaggaag ctgtaggcat tattgaaaaa
     2281 atcattgttc agccaacagg gtgaggctcc cagcaaggcc gtgccatctt cccacctccc
     2341 tgtgcccaga gggttagact gtaagctccc ggagggcgag gctggggctg agcgtgcctc
     2401 cacgtcccca aggcacaggg tgcacagtgg gtgctcactg aatatagtgg actagtgagc
     2461 agaggatgag aggactaccc tgtaatgagc cttggacagt ctggcatttg ccttaactcc
     2521 cactcccatg ccctgggatc actgttggat atttactcca tgaggacaaa tactggggag
     2581 gtgtggagag gagggagggc aggttcctct tactttcacc cattgctgag aatgagcgcc
     2641 tgttggcact gcctttgtga gcctccggga gcaggtaacc tgcggcccaa gcccgcctag
     2701 gactccacat caggcaggca caggactggc cccttgtcct cataaaaact ctcagtacag
     2761 cttaaactct gtaagatcta accagccagg aggaccctcg cttcctctcc gccatgcttg
     2821 ccacctcttg cttctgagag tccatctcag ttcgcagttc tgtgacttgc attgacctgg
     2881 ctccaatcaa gctacaactc aagcagtcac ggggagaagg attgtagatg ggccagtgac
     2941 tcacagggtc aggcactcgg gggagcctga gtcaggaggt cagtgggccc tggaagggag
     3001 ggggcaagcc tgggtgggta aggttctggg ccccaggcaa gaaggcagag tttctccgca
     3061 ggggtgtgtg caagagctag ctgcgcagaa ggtctccgct ggctctccaa gccgggcttg
     3121 tgaaatagga acgccaacat cctcctccac aggcagtggc aggcacctcc tcctcaggtg
     3181 ccccccaagc cctatctgat gggcaaaggt gaacgcaggg cggtgggctt ttcctgtgca
     3241 gagggagact gattcaaagg gtcatttatg acctttcaca agtcccacat cctgcccaat
     3301 ggccaggtct tgggatgctg ttgcaagatg gttctgtgac tccatgtgac tgtctgatga
     3361 ttgccccagc tggggaaaag gctcccatgt ctctttctca taaaaccagt gggcaaggcc
     3421 gggcgcagtg gctcacgtct gtaatgccag cacttcggga gaccaaggtg ggcggatcac
     3481 ctgaggtcag gagttcaaga ccagcctgac caacatggtg aaaccccgtc tctacaaaaa
     3541 tatggaaatt agctgggcat gacggcgggt gcctgtaacc ccagctactt gggaggctga
     3601 ggagggataa tcagttgaac ccaggaggtg gaggttgcag tgagccgaga tcgcgccact
     3661 gcactccagc ctgggtgaca gagcaagact ccatctcaaa aacaaacaaa caaaaaacta
     3721 gcgggtgaaa tgattcagtg acctaaggac agccagagca ctaagctgct gggaacccat
     3781 ctgtgctgaa atgtagattt cccaggaaac tcaggcttgg gacaggcgcc tacctgctcc
     3841 tcgggcacca ggtgattagg agaggtcgaa tctcatttcc acgtgagtga ggataaagac
     3901 tgggctgcca aggaggactc ctcataaaca ttgacaaatt gctctgcccc gcctgtgatc
     3961 ccagacgact cctgcagtct gggatcctga gtgtcctgtg ggttcatctc ggatgggcgc
     4021 tgcataaaca gcctgcaggg aacgtctggg agaaccagct tcacaacaga tataataagg
     4081 aagaagtttg aaatattgca agaattgcga aagtgtgaca cacagataca aagtgggcac
     4141 atgctcgtgg gaaaatgttg ccaatagact tgcttgactc tggagttacc ccgaaccttc
     4201 aatttgttta aaaaaaaaaa aaggcaatat cttgacgtgc aataaagtga actgcaataa
     4261 aa
//
