LOCUS       NM_005524               1575 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens hes family bHLH transcription factor 1 (HES1), mRNA.
ACCESSION   NM_005524
VERSION     NM_005524.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1575)
  AUTHORS   Lodewijk,G.A., de Geus,M., Guimaraes,R.L.F.P. and Jacobs,F.M.J.
  TITLE     Emergence of the ZNF675 Gene During Primate Evolution-Influenced
            Human Neurodevelopment Through Changing HES1 Autoregulation
  JOURNAL   J Comp Neurol 532 (7), e25648 (2024)
   PUBMED   38958676
  REMARK    GeneRIF: Emergence of the ZNF675 Gene During Primate
            Evolution-Influenced Human Neurodevelopment Through Changing HES1
            Autoregulation.
REFERENCE   2  (bases 1 to 1575)
  AUTHORS   Sfeir,N., Kajdan,M., Jalaguier,S., Bonnet,S., Teyssier,C.,
            Pyrdziak,S., Yuan,R., Bousquet,E., Maraver,A., Bernex,F., Pirot,N.,
            Boissiere-Michot,F., Castet-Nicolas,A., Lapierre,M. and
            Cavailles,V.
  TITLE     RIP140 regulates transcription factor HES1 oscillatory expression
            and mitogenic activity in colon cancer cells
  JOURNAL   Mol Oncol 18 (6), 1510-1530 (2024)
   PUBMED   38459621
  REMARK    GeneRIF: RIP140 regulates transcription factor HES1 oscillatory
            expression and mitogenic activity in colon cancer cells.
REFERENCE   3  (bases 1 to 1575)
  AUTHORS   Xu,Y., Mao,S., Fan,H., Wan,J., Wang,L., Zhang,M., Zhu,S., Yuan,J.,
            Lu,Y., Wang,Z., Yu,B., Jiang,Z. and Huang,Y.
  TITLE     LINC MIR503HG Controls SC-beta Cell Differentiation and Insulin
            Production by Targeting CDH1 and HES1
  JOURNAL   Adv Sci (Weinh) 11 (13), e2305631 (2024)
   PUBMED   38243869
  REMARK    GeneRIF: LINC MIR503HG Controls SC-beta Cell Differentiation and
            Insulin Production by Targeting CDH1 and HES1.
REFERENCE   4  (bases 1 to 1575)
  AUTHORS   Zhang,C., Ye,W., Zhao,M., Long,L., Xia,D. and Fan,Z.
  TITLE     MLL1 inhibits the neurogenic potential of SCAPs by interacting with
            WDR5 and repressing HES1
  JOURNAL   Int J Oral Sci 15 (1), 48 (2023)
   PUBMED   37852994
  REMARK    GeneRIF: MLL1 inhibits the neurogenic potential of SCAPs by
            interacting with WDR5 and repressing HES1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1575)
  AUTHORS   Wang,L., Gu,W., Zou,B., Kalady,M., Xin,W. and Zhou,L.
  TITLE     Loss of HES1 expression is associated with extracellular matrix
            remodeling and tumor immune suppression in KRAS mutant colon
            adenocarcinomas
  JOURNAL   Sci Rep 13 (1), 15999 (2023)
   PUBMED   37749297
  REMARK    GeneRIF: Loss of HES1 expression is associated with extracellular
            matrix remodeling and tumor immune suppression in KRAS mutant colon
            adenocarcinomas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1575)
  AUTHORS   Votruba,M., Payne,A., Moore,A.T. and Bhattacharya,S.S.
  TITLE     Dominant optic atrophy: exclusion and fine genetic mapping of the
            candidate gene, HRY
  JOURNAL   Mamm Genome 9 (10), 784-787 (1998)
   PUBMED   9745030
REFERENCE   7  (bases 1 to 1575)
  AUTHORS   Strom,A., Castella,P., Rockwood,J., Wagner,J. and Caudy,M.
  TITLE     Mediation of NGF signaling by post-translational inhibition of
            HES-1, a basic helix-loop-helix repressor of neuronal
            differentiation
  JOURNAL   Genes Dev 11 (23), 3168-3181 (1997)
   PUBMED   9389649
REFERENCE   8  (bases 1 to 1575)
  AUTHORS   Grbavec,D. and Stifani,S.
  TITLE     Molecular interaction between TLE1 and the carboxyl-terminal domain
            of HES-1 containing the WRPW motif
  JOURNAL   Biochem Biophys Res Commun 223 (3), 701-705 (1996)
   PUBMED   8687460
REFERENCE   9  (bases 1 to 1575)
  AUTHORS   Feder,J.N., Li,L., Jan,L.Y. and Jan,Y.N.
  TITLE     Genomic cloning and chromosomal localization of HRY, the human
            homolog to the Drosophila segmentation gene, hairy
  JOURNAL   Genomics 20 (1), 56-61 (1994)
   PUBMED   8020957
REFERENCE   10 (bases 1 to 1575)
  AUTHORS   Takebayashi,K., Sasai,Y., Sakai,Y., Watanabe,T., Nakanishi,S. and
            Kageyama,R.
  TITLE     Structure, chromosomal locus, and promoter analysis of the gene
            encoding the mouse helix-loop-helix factor HES-1. Negative
            autoregulation through the multiple N box elements
  JOURNAL   J Biol Chem 269 (7), 5150-5156 (1994)
   PUBMED   7906273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK000415.1, AI370424.1 and
            AC080129.26.
            
            On Nov 22, 2018 this sequence version replaced NM_005524.3.
            
            Summary: This protein belongs to the basic helix-loop-helix family
            of transcription factors. It is a transcriptional repressor of
            genes that require a bHLH protein for their transcription. The
            protein has a particular type of basic domain that contains a helix
            interrupting protein that binds to the N-box rather than the
            canonical E-box. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA569975.1, AK000415.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000232424.4/ ENSP00000232424.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1450              AK000415.1         4-1453
            1451-1455           AI370424.1         15-19               c
            1456-1575           AC080129.26        35767-35886         c
FEATURES             Location/Qualifiers
     source          1..1575
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..1575
                     /gene="HES1"
                     /gene_synonym="bHLHb39; HES-1; HHL; HRY"
                     /note="hes family bHLH transcription factor 1"
                     /db_xref="GeneID:3280"
                     /db_xref="HGNC:HGNC:5192"
                     /db_xref="MIM:139605"
     exon            1..341
                     /gene="HES1"
                     /gene_synonym="bHLHb39; HES-1; HHL; HRY"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1076
                     /gene="HES1"
                     /gene_synonym="bHLHb39; HES-1; HHL; HRY"
                     /note="hairy-like protein; class B basic helix-loop-helix
                     protein 39; hairy homolog"
                     /codon_start=1
                     /product="transcription factor HES-1"
                     /protein_id="NP_005515.1"
                     /db_xref="CCDS:CCDS3305.1"
                     /db_xref="GeneID:3280"
                     /db_xref="HGNC:HGNC:5192"
                     /db_xref="MIM:139605"
                     /translation="MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEK
                     RRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALST
                     DPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPH
                     PALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGG
                     FQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTADSMWR
                     PWRN"
     exon            342..437
                     /gene="HES1"
                     /gene_synonym="bHLHb39; HES-1; HHL; HRY"
                     /inference="alignment:Splign:2.1.0"
     exon            438..525
                     /gene="HES1"
                     /gene_synonym="bHLHb39; HES-1; HHL; HRY"
                     /inference="alignment:Splign:2.1.0"
     exon            526..1575
                     /gene="HES1"
                     /gene_synonym="bHLHb39; HES-1; HHL; HRY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1429..1434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HES1"
                     /gene_synonym="bHLHb39; HES-1; HHL; HRY"
                     /note="hexamer: AATAAA"
     polyA_site      1450
                     /gene="HES1"
                     /gene_synonym="bHLHb39; HES-1; HHL; HRY"
                     /note="major polyA site"
     regulatory      1550..1555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HES1"
                     /gene_synonym="bHLHb39; HES-1; HHL; HRY"
                     /note="hexamer: ATTAAA"
     polyA_site      1575
                     /gene="HES1"
                     /gene_synonym="bHLHb39; HES-1; HHL; HRY"
ORIGIN      
        1 acacaggatc cggagctggt gctgataaca gcggaatccc ccgtctacct ctctccttgg
       61 tcctggaaca gcgctactga tcaccaagta gccacaaaat ataataaacc ctcagcactt
      121 gctcagtagt tttgtgaaag tctcaagtaa aagagacaca aacaaaaaat tctttttcgt
      181 gaagaactcc aaaaataaaa ttctctagag ataaaaaaaa aaaaaaaagg aaaatgccag
      241 ctgatataat ggagaaaaat tcctcgtccc cggtggctgc taccccagcc agtgtcaaca
      301 cgacaccgga taaaccaaag acagcatctg agcacagaaa gtcatcaaag cctattatgg
      361 agaaaagacg aagagcaaga ataaatgaaa gtctgagcca gctgaaaaca ctgattttgg
      421 atgctctgaa gaaagatagc tcgcggcatt ccaagctgga gaaggcggac attctggaaa
      481 tgacagtgaa gcacctccgg aacctgcagc gggcgcagat gacggctgcg ctgagcacag
      541 acccaagtgt gctggggaag taccgagccg gcttcagcga gtgcatgaac gaggtgaccc
      601 gcttcctgtc cacgtgcgag ggcgttaata ccgaggtgcg cactcggctg ctcggccacc
      661 tggccaactg catgacccag atcaatgcca tgacctaccc cgggcagccg caccccgcct
      721 tgcaggcgcc gccaccgccc ccaccgggac ccggcggccc ccagcacgcg ccgttcgcgc
      781 cgccgccgcc actcgtgccc atccccgggg gcgcggcgcc ccctcccggc ggcgccccct
      841 gcaagctggg cagccaggct ggagaggcgg ctaaggtgtt tggaggcttc caggtggtac
      901 cggctcccga tggccagttt gctttcctca ttcccaacgg ggccttcgcg cacagcggcc
      961 ctgtcatccc cgtctacacc agcaacagcg gcacctccgt gggccccaac gcagtgtcac
     1021 cttccagcgg cccctcgctt acggcggact ccatgtggag gccgtggcgg aactgagggg
     1081 gctcaggcca cccctcctcc taaactcccc aacccacctc tcttccctcc ggactctaaa
     1141 caggaacttg aatactggga gagaagagga cttttttgat taagtggtta ctttgtgttt
     1201 ttttaatttc taagaagtta ctttttgtag agagagctgt attaagtgac tgaccatgca
     1261 ctatatttgt atatatttta tatgttcata ttggattgcg cctttgtatt ataaaagctc
     1321 agatgacatt tcgtttttta cacgagattt cttttttatg tgatgccaaa gatgtttgaa
     1381 aatgctctta aaatatcttc ctttggggaa gtttatttga gaaaatataa taaaagaaaa
     1441 aagtaaaggc ttttatgtct tcgaactgat tcttccagaa tatgtaaaaa ggcttttggt
     1501 ggaatttgaa ttacatgtaa ttggtaattc aggaattgac tcttttgtta ttaaaagaac
     1561 atttgtaaaa atcca
//
