LOCUS       NM_022373               2884 bp    mRNA    linear   PRI 17-MAY-2024
DEFINITION  Homo sapiens HERPUD family member 2 (HERPUD2), mRNA.
ACCESSION   NM_022373 XM_001716505 XM_001717741 XM_001717961 XM_001718593
VERSION     NM_022373.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2884)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2884)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2884)
  AUTHORS   Cox,A.J., Hugenschmidt,C.E., Raffield,L.M., Langefeld,C.D.,
            Freedman,B.I., Williamson,J.D., Hsu,F.C. and Bowden,D.W.
  TITLE     Heritability and genetic association analysis of cognition in the
            Diabetes Heart Study
  JOURNAL   Neurobiol Aging 35 (8), 1958 (2014)
   PUBMED   24684796
REFERENCE   4  (bases 1 to 2884)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 2884)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA778088.1, DA282706.1, AK315685.1 and BC020264.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022373.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020264.1, SRR1660805.89114.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311350.8/ ENSP00000310729.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               DA778088.1         53-153
            102-154             DA282706.1         105-157
            155-491             DA282706.1         159-495
            492-1853            AK315685.1         143-1504
            1854-2884           BC020264.1         1838-2868
FEATURES             Location/Qualifiers
     source          1..2884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.2"
     gene            1..2884
                     /gene="HERPUD2"
                     /note="HERPUD family member 2"
                     /db_xref="GeneID:64224"
                     /db_xref="HGNC:HGNC:21915"
                     /db_xref="MIM:620829"
     exon            1..335
                     /gene="HERPUD2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..779
                     /gene="HERPUD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             633..1853
                     /gene="HERPUD2"
                     /note="homocysteine-inducible, endoplasmic reticulum
                     stress-inducible, ubiquitin-like domain member 2"
                     /codon_start=1
                     /product="homocysteine-responsive endoplasmic
                     reticulum-resident ubiquitin-like domain member 2 protein"
                     /protein_id="NP_071768.3"
                     /db_xref="CCDS:CCDS5446.1"
                     /db_xref="GeneID:64224"
                     /db_xref="HGNC:HGNC:21915"
                     /db_xref="MIM:620829"
                     /translation="MDQSGMEIPVTLIIKAPNQKYSDQTISCFLNWTVGKLKTHLSNV
                     YPSKPLTKDQRLVYSGRLLPDHLQLKDILRKQDEYHMVHLVCTSRTPPSSPKSSTNRE
                     SHEALASSSNSSSDHSGSTTPSSGQETLSLAVGSSSEGLRQRTLPQAQTDQAQSHQFP
                     YVMQGNVDNQFPGQAAPPGFPVYPAFSPLQMLWWQQMYAHQYYMQYQAAVSAQATSNV
                     NPTQPTTSQPLNLAHVPGEEPPPAPNLVAQENRPMNENVQMNAQGGPVLNEEDFNRDW
                     LDWMYTFSRAAILLSIVYFYSSFSRFIMVMGAMLLVYLHQAGWFPFRQEGGHQQAPNN
                     NAEVNNDGQNANNLELEEMERLMDDGLEDESGEDGGEDASAIQRPGLMASAWSFITTF
                     FTSLIPEGPPQVAN"
     exon            780..857
                     /gene="HERPUD2"
                     /inference="alignment:Splign:2.1.0"
     exon            858..971
                     /gene="HERPUD2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1126
                     /gene="HERPUD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1249
                     /gene="HERPUD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1573
                     /gene="HERPUD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1691
                     /gene="HERPUD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..2884
                     /gene="HERPUD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2862..2867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HERPUD2"
                     /note="hexamer: AATAAA"
     polyA_site      2884
                     /gene="HERPUD2"
                     /note="major polyA site"
ORIGIN      
        1 aacaacaaaa ccggcgcgcc agcggtggcg caacggctct cgtccccgcc ctcctgctac
       61 ctgtagtcgc ctgggccgcc cccggcccag ccctgccttg ccgccaccct gcgctgtcca
      121 gactgagggg tcaggcggag agccgggccg cgccttcggt cagcttctct ccctttcacc
      181 cgcgcctcct cgcgagaccc ggggctgggc cgtgccggtc gccgcgcagc aggaagggag
      241 cggctgccac ggaaaacgcc tggccggacg gtgtggctgg cggccctgcc tgggcgcgga
      301 gggcggcggt ggcgggcccc gcggccttct ctcagcttcc tttctcctca cgacggcctc
      361 cacagtccgg agcccggcgg agcccggacc tggcggggag agctgcctcc acggccgggc
      421 acccagaccc caccgtcgca gtcgccacca cctcagtcca tccttggtac cggcaatggg
      481 cttcgtatcc tccagtgcac ttgtaactga cttggacacg gaatactaag aactcacttc
      541 tgtcctcatc ccagtcgcgc cggcggtgac catctcggct cttttgggct taactgccgc
      601 tcctctggac tctgtctgac tttgggggca ccatggacca aagtgggatg gagattcctg
      661 tgaccctcat cattaaagca ccgaatcaga aatacagtga ccagactatt agctgcttct
      721 tgaactggac cgtggggaaa ctaaaaacgc atctatctaa cgtttaccct agcaaaccat
      781 tgacgaagga tcagagattg gtgtattcgg gcagactgct tcccgatcat ctgcagctga
      841 aagacattct cagaaaacaa gatgagtatc atatggttca tctagtatgt acttctcgga
      901 ctcctcccag ttctccaaaa tccagcacca atagagaaag tcatgaagca ttggcatcca
      961 gcagcaattc tagttcagat cattcaggat caacaactcc atcatctggt caagaaacct
     1021 tgtctttagc tgtgggttct tcctcagaag gattgaggca gcgtaccctt ccacaagcac
     1081 aaactgacca agcacagagt caccagtttc catatgtaat gcaaggaaat gtagacaacc
     1141 aatttcctgg gcaagctgct ccacctggat tcccagtgta tcccgcgttt agcccactgc
     1201 agatgctatg gtggcaacag atgtatgctc atcagtatta tatgcagtat caagctgcag
     1261 tttcagctca ggccacatca aatgtcaacc caacccagcc tactacttca cagcctctaa
     1321 atttggcaca tgttcctgga gaagaacccc caccagctcc aaacctagtg gcccaagaaa
     1381 atcgacccat gaatgagaat gttcaaatga atgcacaggg aggtccagta ctaaatgaag
     1441 aagacttcaa tcgagactgg ctagactgga tgtacacgtt ctcacgagct gcgattctcc
     1501 ttagcattgt atacttctat tcttctttta gtcggtttat catggtaatg ggagccatgc
     1561 tactggttta tttacaccaa gctggatggt ttccttttag gcaagaagga ggtcatcagc
     1621 aggctcccaa caataatgcc gaagttaaca atgatgggca aaatgcaaac aacttggaac
     1681 ttgaagaaat ggagcgtctt atggatgatg ggcttgaaga tgagagtgga gaagatggag
     1741 gtgaagatgc cagtgcaatt caaaggcctg gattaatggc ttcagcttgg tctttcatca
     1801 ccaccttctt tacttcacta ataccagagg ggcctcccca ggttgccaat tgacctgaaa
     1861 aactgtgcca gctacaagga gggtctgact tcaggaaagt ggtttaaata acagtgcaat
     1921 ttcaaaaaaa tttataactt tcttttgatc atcatgtaca gaggtgtttt ttttctttag
     1981 gcttctcatg catatgaata ttttaagcac gaatggacta ctaaatatct gagttttttt
     2041 tttttttttt taaagatcct aacagaacat agcgtaacaa tattggtctt ccaggtgtta
     2101 ctcatttcaa ttatgtgtag tataccagga cagacctatt ttcatgtctt atttctttaa
     2161 agagctgctt cattggccgg gcgccatggc tcacgtctgt aatcccagca ctttgggagg
     2221 ccgaggcggg tgggttactt gaggtcagga gttcgagacc agcctggcaa acatggcgaa
     2281 accccatctt aactaaaaat acaaaaaaat tagccgggtg tggtgtcacg cgcctgtaat
     2341 cccagctact tggggggctc aggcaggaga attgcctgaa cccaggaggc ggaggttgca
     2401 gtgagctgag attgggccac tgcactccac cctgggcgac agagtgagac tcggtctcag
     2461 aaaaaaaaaa aaaagagctg cttcacatat aaatgtctat agctagtagc ctggcccttt
     2521 aatgtttaat ttgaatagat atatctgttt tccgtgaatt atcttgaaag ttttaaacag
     2581 aatgacctca tagtttttaa taaagaatat tatttaccta aaatgtgcta gtagcatctt
     2641 gcccagccat aaagcaataa acttctcaat aatcttaatt ttgatatttg aataaataat
     2701 ggaaactttc tgtattaagg gcatgtatcc catcaattgg aatcagtacc ttaacagaaa
     2761 aaggcagctc ttcaatggaa ttaacgtgat ataaaatgtt tgatataggc agtactttta
     2821 taaaaaaaga taagctggaa attgctccgt gtaatttttt aaataaaaag tcaattatgg
     2881 taaa
//
