LOCUS       NM_017912               3776 bp    mRNA    linear   PRI 16-FEB-2024
DEFINITION  Homo sapiens HECT and RLD domain containing E3 ubiquitin protein
            ligase family member 6 (HERC6), transcript variant 1, mRNA.
ACCESSION   NM_017912 XM_496710
VERSION     NM_017912.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3776)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   2  (bases 1 to 3776)
  AUTHORS   Hochrainer,K., Mayer,H., Baranyi,U., Binder,B., Lipp,J. and
            Kroismayr,R.
  TITLE     The human HERC family of ubiquitin ligases: novel members, genomic
            organization, expression profiling, and evolutionary aspects
  JOURNAL   Genomics 85 (2), 153-164 (2005)
   PUBMED   15676274
  REMARK    GeneRIF: HERC6 ancestor emerged in nematodes and that the family
            expanded throughout evolution. The mRNA expression pattern was
            found to be diverse in selected tissues and cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083829.5 and FJ695209.1.
            
            On Nov 30, 2019 this sequence version replaced NM_017912.3.
            
            Summary: HERC6 belongs to the HERC family of ubiquitin ligases, all
            of which contain a HECT domain and at least 1 RCC1 (MIM
            179710)-like domain (RLD). The 350-amino acid HECT domain is
            predicted to catalyze the formation of a thioester with ubiquitin
            before transferring it to a substrate, and the RLD is predicted to
            act as a guanine nucleotide exchange factor for small G proteins
            (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042047.1, BX647121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264346.12/ ENSP00000264346.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC083829.5         5451-5535
            86-269              FJ695209.1         1-184
            270-429             AC083829.5         9819-9978
            430-506             AC083829.5         12097-12173
            507-734             AC083829.5         17250-17477
            735-829             AC083829.5         20086-20180
            830-957             AC083829.5         22613-22740
            958-1094            AC083829.5         23449-23585
            1095-1162           AC083829.5         24740-24807
            1163-1284           AC083829.5         31474-31595
            1285-1344           AC083829.5         32152-32211
            1345-1438           AC083829.5         35122-35215
            1439-1628           AC083829.5         39675-39864
            1629-1783           AC083829.5         44023-44177
            1784-1897           AC083829.5         50458-50571
            1898-2005           AC083829.5         51193-51300
            2006-2176           AC083829.5         55178-55348
            2177-2320           AC083829.5         57760-57903
            2321-2487           AC083829.5         62323-62489
            2488-2554           AC083829.5         63503-63569
            2555-2625           AC083829.5         64309-64379
            2626-2809           AC083829.5         66472-66655
            2810-2912           AC083829.5         66746-66848
            2913-3776           AC083829.5         68832-69695
FEATURES             Location/Qualifiers
     source          1..3776
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..3776
                     /gene="HERC6"
                     /note="HECT and RLD domain containing E3 ubiquitin protein
                     ligase family member 6"
                     /db_xref="GeneID:55008"
                     /db_xref="HGNC:HGNC:26072"
                     /db_xref="MIM:609249"
     exon            1..269
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..3139
                     /gene="HERC6"
                     /EC_number="2.3.2.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable E3 ubiquitin-protein ligase HERC6; potential
                     ubiquitin ligase; HECT domain and RCC1-like
                     domain-containing protein 6; hect domain and RLD 6;
                     HECT-type E3 ubiquitin transferase HERC6"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HERC6
                     isoform 1"
                     /protein_id="NP_060382.3"
                     /db_xref="CCDS:CCDS47098.1"
                     /db_xref="GeneID:55008"
                     /db_xref="HGNC:HGNC:26072"
                     /db_xref="MIM:609249"
                     /translation="MYFCWGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRV
                     LSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAG
                     SEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQL
                     GLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGR
                     NVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEK
                     RGPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTSKPTHPEALTENFDI
                     SCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPGKTLPEISRISQSMAEKWIA
                     VKRRSTEHEMAKSEIRMIFSSPACLTASFLKKRGTGETTSIDVDLEMARDTFKKLTKK
                     EWISSMITTCLEDDLLRALPCHSPHQEALSVFLLLPECPVMHDSKNWKNLVVPFAKAV
                     CEMSKQSLQVLKKCWAFLQESSLNPLIQMLKAAIISQLLHQTKTEQDHCNVKALLGMM
                     KELHKVNKANCRLPENTFNINELSNLLNFYIDRGRQLFRDNHLIPAETPSPVIFSDFP
                     FIFNSLSKIKLLQADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRVRRSRLV
                     KDALRQLSQAEATDFCKVLVVEFINEICPESGGVSSEFFHCMFEEMTKPEYGMFMYPE
                     MGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSLEDLK
                     ELSPRLGKSLQEVLDDAADDIGDALCIRFSIHWDQNDVDLIPNGISIPVDQTNKRDYV
                     SKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIGNTDYDWKQFEQN
                     SKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPE
                     TFSERDHPTSITCHNILSLPKYSTMERMEEALQVAINNNRGFVSPMLTQS"
     exon            270..429
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            430..506
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            507..734
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            735..829
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            830..957
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1094
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1162
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1284
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1344
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1438
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1628
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1783
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1897
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2005
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2176
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2320
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2487
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2554
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2625
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2809
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2912
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3776
                     /gene="HERC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3752..3757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HERC6"
                     /note="hexamer: AATAAA"
     polyA_site      3776
                     /gene="HERC6"
                     /note="major polyA site"
ORIGIN      
        1 accagcgttc gggagcctgt cgcagcggga ccgacggaat ccggagcagg cgacagggcg
       61 cagaagcggg atgtacttct gttggggcgc cgactccagg gagctgcagc gccggaggac
      121 ggcgggcagc cccggggctg agctactgca ggcggccagc ggggagcgcc actctctgct
      181 gctgctgacc aaccacaggg tcctctcgtg cggagacaac agcaggggtc agctgggccg
      241 caggggcgcg cagcgcgggg agctgccaga accaattcag gcattggaaa ccctaattgt
      301 tgatctcgtg agctgcggga aggagcactc cctggctgtg tgccacaaag gaagggtctt
      361 cgcatgggga gctggttctg aagggcagct ggggattgga gaattcaagg aaataagttt
      421 cacacctaag aaaataatga ctctgaatga tataaaaata atacaagttt cctgtggaca
      481 ctaccactcc ctggcattat caaaagatag ccaagtgttt tcgtggggaa agaacagcca
      541 tgggcagctg ggcttgggga aggagttccc ctcccaagcc agcccgcaga gggtgaggtc
      601 cctggagggg atcccactgg ctcaggtggc tgccggaggg gctcacagct ttgccctgtc
      661 tctctgtggg acttcgtttg gctggggaag taacagtgcc gggcagctgg ccctcagtgg
      721 gcgtaatgtc ccagtgcaaa gcaacaagcc tctctcagtc ggtgcactga agaatctagg
      781 tgtggtttat atcagctgtg gtgatgcaca cactgcggtg cttacccagg acgggaaagt
      841 gttcacattt ggagacaatc gctctggaca gctgggatac agccccactc ctgagaagag
      901 aggtccacaa cttgtggaaa gaattgatgg cctagtttcg cagatagatt gtggaagtta
      961 tcacaccctg gcatatgtgc acaccactgg tcaggtggta tcttttggtc atggaccaag
     1021 tgacacaagc aagccaactc atccggaggc cctgacagag aactttgaca ttagctgcct
     1081 gatttctgct gaagacttcg tggatgttca agtcaaacac atttttgctg gaacatatgc
     1141 caactttgtg acaactcatc aggatactag ttccacacgt gctcccggga aaaccctgcc
     1201 agaaataagc cgaattagcc agtccatggc agaaaaatgg atagcagtga aaagaagaag
     1261 tactgaacat gaaatggcta aaagtgaaat tagaatgata ttttcatctc ctgcttgtct
     1321 gactgcaagt tttttaaaga aaagaggaac tggagaaacg acttccattg atgtggactt
     1381 agaaatggca agagatacct tcaagaagtt aacaaaaaag gaatggattt cttccatgat
     1441 aactacgtgt ctcgaggatg atctgctcag agctcttcca tgccattctc cacaccaaga
     1501 agctttatca gttttcctcc tgctcccaga atgtcctgtg atgcatgatt ctaagaactg
     1561 gaagaacctg gtggttccat ttgcaaaggc tgtgtgtgaa atgagtaaac aatctttgca
     1621 agtcctaaag aagtgttggg catttttgca agaatcttct ctgaatccgc tgatccagat
     1681 gcttaaagca gccatcatct ctcagctgct tcatcagact aaaaccgaac aggatcactg
     1741 taatgttaaa gctcttttag gaatgatgaa agaactgcat aaggtaaaca aagctaactg
     1801 tcgactacca gaaaatactt tcaacataaa tgaactctcc aacttattaa acttttatat
     1861 agatagagga agacagctct ttcgggataa ccacctgata cctgcagaaa cccccagtcc
     1921 tgttattttc agtgattttc catttatctt taattcgcta tccaaaatta aattattgca
     1981 agctgattca catataaaga tgcagatgtc agaaaagaaa gcatacatgc ttatgcatga
     2041 aacaattctg caaaaaaagg atgaatttcc tccatcaccc agatttatac ttagagtcag
     2101 acgaagtcgc ctggttaaag atgctctgcg tcaattaagt caagctgaag ctactgactt
     2161 ctgcaaagta ttagtggttg aatttattaa tgaaatttgt cctgagtctg gaggggttag
     2221 ttcagagttc ttccactgta tgtttgaaga gatgaccaag ccagaatatg gaatgttcat
     2281 gtatcctgaa atgggttcct gcatgtggtt tcctgccaag cctaaacctg agaagaaaag
     2341 atatttcctc tttggaatgc tgtgtggact ctccttattc aatttaaatg ttgctaacct
     2401 tcctttccca ctggctctgt ataaaaaact tctggaccaa aagccatcat tggaagattt
     2461 aaaagaactc agtcctcggt tggggaagag tttgcaagaa gttctagatg atgctgctga
     2521 tgacattgga gatgcgctct gcatacgctt ttctatacac tgggaccaaa atgatgttga
     2581 cttaattcca aatgggatct ccatacctgt ggaccaaacc aacaagagag actatgtttc
     2641 taagtatatt gattacattt tcaacgtctc tgtaaaagca gtttatgagg aatttcagag
     2701 aggattttat agagtctgtg agaaggagat acttagacat ttctaccctg aagaactaat
     2761 gacagcaatc attggaaata ctgattatga ctggaaacag tttgaacaga attcaaagta
     2821 tgagcaagga taccaaaaat cacatcctac tatacagttg ttttggaagg ctttccacaa
     2881 actaaccttg gatgaaaaga aaaaattcct ctttttcctt acaggacgtg ataggctgca
     2941 tgcaagaggc atacagaaaa tggaaatagt atttcgctgt cctgaaactt tcagtgaaag
     3001 agatcaccca acatcaataa cttgtcataa tattctctcc ctccctaagt attctacaat
     3061 ggaaagaatg gaggaagcac ttcaagtagc catcaacaac aacagaggat ttgtctcacc
     3121 catgctcaca cagtcataat cacctctgag agactcaggg tgggctttct cacacttgga
     3181 tccttctgtt cttccttaca cctaaataat acaagagatt aatgaatagt ggttagaagt
     3241 agttgaggga gagattgggg gaatggggag atgatgatga tggtcaaagg gtgcaaaatc
     3301 tcacacaaga ctgaggcagg agaatagggt acagagatag ggatctaagg atgacttgga
     3361 cacactccct ggcactgaag agtctgaaca ctggcctgtg attggtccat tccaggacct
     3421 tcatttgcat aaggtatcaa accacatcag cctctgattg gccatgggcc agacctgcac
     3481 tctggccaat gattggttca ttccaggaca ttcatttgca taaggagtca aaccacacca
     3541 gtcttggatt ggctgtgagc caattcacct cagtctctaa ttggctgtga gtcagtcttt
     3601 catttacata gggtgtaacc atcaagaaac ctctacaggg tacttaagcc ccagaagatt
     3661 ttgctaccag ggctcttgag ccacttgctc tagcccactc ccaccctgtg gaatgtactt
     3721 tcacttttgc tgcttcactg ccttgtgctc caataaatcc actccttcac caccca
//
