LOCUS       NM_014606               4914 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens HECT and RLD domain containing E3 ubiquitin protein
            ligase 3 (HERC3), transcript variant 1, mRNA.
ACCESSION   NM_014606
VERSION     NM_014606.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4914)
  AUTHORS   Kamada,Y., Ohnishi,Y., Nakashima,C., Fujii,A., Terakawa,M.,
            Hamano,I., Nakayamada,U., Katoh,S., Hirata,N., Tateishi,H.,
            Fukuda,R., Takahashi,H., Lukacs,G.L. and Okiyoneda,T.
  TITLE     HERC3 facilitates ERAD of select membrane proteins by recognizing
            membrane-spanning domains
  JOURNAL   J Cell Biol 223 (7) (2024)
   PUBMED   38722278
  REMARK    GeneRIF: HERC3 facilitates ERAD of select membrane proteins by
            recognizing membrane-spanning domains.
REFERENCE   2  (bases 1 to 4914)
  AUTHORS   Yuan,B., Liu,J., Shi,A., Cao,J., Yu,Y., Zhu,Y., Zhang,C., Qiu,Y.,
            Luo,H., Shi,J., Cao,X., Xu,P., Shen,L., Liang,T., Zhao,B. and
            Feng,X.H.
  TITLE     HERC3 promotes YAP/TAZ stability and tumorigenesis independently of
            its ubiquitin ligase activity
  JOURNAL   EMBO J 42 (4), e111549 (2023)
   PUBMED   36598329
  REMARK    GeneRIF: HERC3 promotes YAP/TAZ stability and tumorigenesis
            independently of its ubiquitin ligase activity.
REFERENCE   3  (bases 1 to 4914)
  AUTHORS   Zhang,Z., Wu,Q., Fang,M., Liu,Y., Jiang,J., Feng,Q., Hu,R. and
            Xu,J.
  TITLE     HERC3 directly targets RPL23A for ubiquitination degradation and
            further regulates Colorectal Cancer proliferation and the cell
            cycle
  JOURNAL   Int J Biol Sci 18 (8), 3282-3297 (2022)
   PUBMED   35637966
  REMARK    GeneRIF: HERC3 directly targets RPL23A for ubiquitination
            degradation and further regulates Colorectal Cancer proliferation
            and the cell cycle.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4914)
  AUTHORS   Zhang,Z., He,G., Lv,Y., Liu,Y., Niu,Z., Feng,Q., Hu,R. and Xu,J.
  TITLE     HERC3 regulates epithelial-mesenchymal transition by directly
            ubiquitination degradation EIF5A2 and inhibits metastasis of
            colorectal cancer
  JOURNAL   Cell Death Dis 13 (1), 74 (2022)
   PUBMED   35064108
  REMARK    GeneRIF: HERC3 regulates epithelial-mesenchymal transition by
            directly ubiquitination degradation EIF5A2 and inhibits metastasis
            of colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4914)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4914)
  AUTHORS   Hochrainer,K., Pejanovic,N., Olaseun,V.A., Zhang,S., Iadecola,C.
            and Anrather,J.
  TITLE     The ubiquitin ligase HERC3 attenuates NF-kappaB-dependent
            transcription independently of its enzymatic activity by delivering
            the RelA subunit for degradation
  JOURNAL   Nucleic Acids Res 43 (20), 9889-9904 (2015)
   PUBMED   26476452
  REMARK    GeneRIF: HERC3 negatively regulates NF-kappaB signaling by
            enhancing RelA subunit degradation.
REFERENCE   7  (bases 1 to 4914)
  AUTHORS   Yoo,N.J., Park,S.W. and Lee,S.H.
  TITLE     Frameshift mutations of ubiquitination-related genes HERC2, HERC3,
            TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with
            microsatellite instability
  JOURNAL   Pathology 43 (7), 753-755 (2011)
   PUBMED   22124266
  REMARK    GeneRIF: we found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1
            and UBE4B genes in gastric carcinoma and colorectal carcinomas with
            microsatellite instability
REFERENCE   8  (bases 1 to 4914)
  AUTHORS   Hochrainer,K., Mayer,H., Baranyi,U., Binder,B., Lipp,J. and
            Kroismayr,R.
  TITLE     The human HERC family of ubiquitin ligases: novel members, genomic
            organization, expression profiling, and evolutionary aspects
  JOURNAL   Genomics 85 (2), 153-164 (2005)
   PUBMED   15676274
REFERENCE   9  (bases 1 to 4914)
  AUTHORS   Cruz,C., Ventura,F., Bartrons,R. and Rosa,J.L.
  TITLE     HERC3 binding to and regulation by ubiquitin
  JOURNAL   FEBS Lett 488 (1-2), 74-80 (2001)
   PUBMED   11163799
REFERENCE   10 (bases 1 to 4914)
  AUTHORS   Cruz,C., Nadal,M., Ventura,F., Bartrons,R., Estivill,X. and
            Rosa,J.L.
  TITLE     The human HERC3 gene maps to chromosome 4q21 by fluorescence in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 263-264 (1999)
   PUBMED   10702688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA333248.1, AK289990.1,
            D25215.1 and BE044624.1.
            
            On Nov 24, 2018 this sequence version replaced NM_014606.2.
            
            Summary: This gene encodes a member the HERC ubiquitin ligase
            family. The encoded protein is located in the cytosol and binds
            ubiquitin via a HECT domain. Mutations in this gene have been
            associated with colorectal and gastric carcinomas. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Oct 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.214354.1,
                                           SRR1660805.133528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402738.6/ ENSP00000385684.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DA333248.1         58-58
            2-16                AK289990.1         2-16
            17-4910             D25215.1           1-4894
            4911-4914           BE044624.1         15-18               c
FEATURES             Location/Qualifiers
     source          1..4914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..4914
                     /gene="HERC3"
                     /note="HECT and RLD domain containing E3 ubiquitin protein
                     ligase 3"
                     /db_xref="GeneID:8916"
                     /db_xref="HGNC:HGNC:4876"
                     /db_xref="MIM:605200"
     exon            1..95
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            96..153
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            154..408
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..3335
                     /gene="HERC3"
                     /EC_number="2.3.2.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable E3 ubiquitin-protein ligase HERC3; HECT domain
                     and RCC1-like domain-containing protein 3; hect domain and
                     RLD 3; HECT-type E3 ubiquitin transferase HERC3"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HERC3
                     isoform 1"
                     /protein_id="NP_055421.1"
                     /db_xref="CCDS:CCDS34028.1"
                     /db_xref="GeneID:8916"
                     /db_xref="HGNC:HGNC:4876"
                     /db_xref="MIM:605200"
                     /translation="MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGN
                     HSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDR
                     GQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFT
                     WGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNN
                     AGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH
                     DSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHTCN
                     VKCPSPVKGYWAAHSGQLSARADRFKYHIVKQIFSGGDQTFVLCSKYENYSPAVDFRT
                     MNQAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHFK
                     TSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYL
                     ILPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGA
                     VLYLLRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQ
                     EDYLMWFLHQAGMKARPSIIQDTVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGAN
                     LQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEA
                     VDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLA
                     IYNSTVVDLHFPLALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLN
                     FTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFL
                     KVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEF
                     PLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEYLPVAHTCYNLLDLPKYSSK
                     EILSARLTQALDNYEGFSLA"
     exon            409..568
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..645
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            646..867
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            868..959
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1090
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1251
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1328
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1453
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1513
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1625
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1815
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1979
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2093
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2117
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2207
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2378
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2522
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2689
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2756
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2839
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2840..3023
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..3126
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..4914
                     /gene="HERC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4889..4894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HERC3"
                     /note="hexamer: AATAAA"
     polyA_site      4914
                     /gene="HERC3"
                     /note="major polyA site"
ORIGIN      
        1 cttattattg tgacgccgaa aacggagaaa ccccgggtcc ggcgagaggg gctgtgacag
       61 tcggagtccc aagctgcggt tcggctgctg ccgagaactg caaggtgtgg aatatttctg
      121 gcttctagtc caatgccaag tgtgtgacct gtggctacat gattccctga aagataagaa
      181 caatgttatg ttggggatat tggtctctgg gccaacctgg tatcagcacc aacctgcagg
      241 gaattgtggc tgagccccag gtgtgtgggt tcatatctga cagaagtgtc aaggaagtgg
      301 cctgtggggg aaaccactct gtgttcctgc tggaagatgg ggaagtttac acatgtggtt
      361 tgaacaccaa ggggcaactg ggccatgaga gggaaggaaa caagccagaa caaattggag
      421 ctctggcaga tcagcatatc attcatgtgg catgtggcga gtcccacagt ctggccctca
      481 gtgaccgagg ccagctgttt tcttggggtg cagggagtga tggtcagcta ggactcatga
      541 ctactgagga ttctgtggca gtgcccaggt taatacaaaa gctgaaccag caaacaatat
      601 tacaagtttc ctgtggcaac tggcattgct tggctcttgc ggctgatggc cagttcttca
      661 cctggggaaa gaacagccat gggcagcttg gcttagggaa ggagttcccc tcccaagcca
      721 gcccacagag ggtgaggtcc ctggagggga tcccactggc tcaggtggct gccggagggg
      781 ctcacagctt tgccctgtct ctctcaggag ctgtttttgg ctgggggatg aataatgccg
      841 ggcagctagg gctcagtgat gaaaaagatc gagaatctcc atgccatgta aaactcttac
      901 gcacgcaaaa agttgtctat attagttgtg gagaagaaca cacagcagtt ctcacaaaga
      961 gtggaggtgt gtttaccttt ggcgctggtt cctgtgggca acttggacac gactccatga
     1021 atgatgaggt taaccctaga agagttctag agctgatggg tagtgaagta actcaaattg
     1081 cttgtggcag acaacatacc ctagccttcg tgccttcttc tggactcatc tatgcatttg
     1141 gttgtggagc aagaggtcaa ttaggaactg ggcacacttg taatgttaag tgcccatctc
     1201 ctgtcaaggg ttactgggct gcccacagtg gccagctttc agcccgagct gatcgcttta
     1261 aatatcatat cgttaagcag atcttctctg gaggagacca gacttttgta ctttgctcca
     1321 aatacgagaa ttattctcct gctgttgact tcaggactat gaaccaagca cattatacca
     1381 gtttaataaa tgatgaaacc atagcagttt ggagacaaaa actctcagaa cacaacaatg
     1441 caaatacaat caatggtgtt gttcagatat tatcttctgc agcctgttgg aatggaagtt
     1501 ttcttgaaaa aaaaattgat gaacatttta aaacgagtcc caaaatccct gggattgacc
     1561 tgaactcaac tagggtgtta tttgagaagt taatgaactc tcagcactcc atgattctag
     1621 aacagatttt gaacagtttt gaaagttgtc tgattcccca gttgtcaagc tcaccaccag
     1681 atgttgaagc catgagaatc tatttaatac tacctgagtt tcccctactc caggattcca
     1741 agtattatat aacattgact attcccttgg ctatggccat tcttcggctg gatacaaacc
     1801 ccagcaaagt actagataac tggtggtctc aggtatgccc gaaatatttc atgaagctgg
     1861 taaacctcta taaaggtgca gtcctttatc tactgagggg aagaaagaca ttcttaattc
     1921 ccgtactgtt taacaattat atcacagcag ctctcaaact cttggagaag ttatataagg
     1981 taaatcttaa agtgaagcat gtggaatatg atacatttta cattcctgag atttccaatc
     2041 tcgtggacat tcaggaagac tacctcatgt ggttcttgca tcaagcaggg atgaaggcta
     2101 gaccatcaat aatacaggat actgtaacac tttgttccta ccctttcatc tttgatgccc
     2161 aagccaagac caaaatgtta cagacagatg ctgaactaca gatgcaggtg gcagtcaatg
     2221 gagccaacct gcagaatgtc ttcatgcttc tcaccctgga gcctctgctg gccagaagcc
     2281 ccttcctggt ccttcacgtt cgcaggaaca accttgttgg agatgcccta agagagctga
     2341 gcattcattc tgatattgat ttgaaaaagc ctctcaaagt aatctttgat ggtgaagaag
     2401 cagtggatgc cggtggtgtt acaaaggaat tttttctttt gctgttaaaa gaacttttga
     2461 atcccatcta tggaatgttt acctactatc aagattcaaa tctcttgtgg ttttcagaca
     2521 cgtgttttgt agagcacaac tggtttcact tgattggtat aacctgtgga ctagctatct
     2581 acaactccac tgtggtcgat ctccacttcc cattggctct ctacaagaag ttactcaatg
     2641 taaagcctgg cttggaagac ttaaaggagt tgtcacccac tgaaggaagg agtctccaag
     2701 agcttttaga ttaccccggg gaggatgtgg aggagacttt ctgcctcaac ttcacgatct
     2761 gccgagaaag ctatggagtg attgaacaga agaagctgat acctggggga gataatgtaa
     2821 ctgtgtgcaa ggataacagg caggaatttg tggatgctta tgtgaattat gtcttccaaa
     2881 tctcagttca tgaatggtac acagccttct ctagtggctt cctaaaggtg tgtggtggca
     2941 aagtacttga gctcttccag ccttcagaac tgagggctat gatggtgggg aacagcaact
     3001 acaactggga agaactggaa gagactgcca tctacaaggg agattactcg gccacacatc
     3061 ccactgtaaa actattttgg gaaacatttc atgagtttcc attggaaaag aagaagaagt
     3121 ttctcttgtt cctgacaggc agcgatcgga ttcccatcta cggcatggcc agtctgcaga
     3181 ttgtcatcca gtccacagcc agcggggagg agtacttgcc ggtggcccac acttgctaca
     3241 accttcttga cctccccaag tacagcagca aagagattct gagtgcccgg ctgacccagg
     3301 cccttgacaa ctatgaaggg tttagtttgg cctgaggctt ctcagcttgt ccagtatttc
     3361 ccttcgttcc tcagtgtcca cattgaggcc tatacagaaa atcatgggga gtgatttcta
     3421 tttttttatt gtctaagtgg gttgggactt ttaaatactg agcctggttg atgtgtttct
     3481 gggattgtat agcagtaaac aacctttttg aaaaattaga ggttggggat ggggtgaaaa
     3541 attggccctt gtatgggagg tgtttttgtt tttgttttaa accaaactac ccagtattcc
     3601 ttgcacttgt gaatgtgttg cactctgctg gatgaaatgg cagtggattt ttaaacttta
     3661 atttcccaaa tgtctctctc agccctgatg ttttctcaca gtgcttcctt gtccttctct
     3721 taacttctca ttcctctata agaatgattt agactgacct gtcctttttt atctgcgcat
     3781 gcgagaacat caccttcctc tgtacacttg gaaatgcctc tggcttgttg cagccctcct
     3841 ttaacccaaa ggaggaaagg actgcttcag aaactcccaa ttccaaaaag ctgagtctgg
     3901 gtccattatt ttggcagaac tcctaagaat ttatgggagc ctatataaac atatcttgct
     3961 tttaaaaagt tcttgaggga atagcaactt tcccatggct gtgcctattt cctagacctt
     4021 ttaaaagatg tgcagagcag cttagcattc gttgcagctg agcctaattt tttcttgctc
     4081 atccttgtcc ctttgacaat aaggttaatt gatagaccca ccacctcttg cactctcgct
     4141 tttggagcaa gttgcattaa ctattttgag tctctatatt gtccaagaaa agtagaaata
     4201 ataaatttac tttccctttt tctatcacct tatgtcctct accattttct ccttcctccc
     4261 ttcccttatt ttctcctttt cgtaccctgt gtcctccctg attttccttt cgtttcttct
     4321 ttattttatc ccattctctg ttacttgact cagtgctccc ttcctctcct ctccttctag
     4381 tggatgcatg cagccttttt ttcaattttt atttaaattg caaaattttt actcagattt
     4441 tttttcctct tccctaattg ctaagattta aggacgttct ttattatgaa actttatcac
     4501 attcgaaatg tttgtttaca gtgggatttt aggggggatt gtgtttaaat caaatatatg
     4561 tattttaaaa ataatgacat gctcaacctt cctcatcatg gagtaagaaa attctacatg
     4621 attaaagaat ccatgtaagt ctaattttaa attcctagta actagagaaa agacttattt
     4681 atataaaatg aagtatttat gaactgtgat aaagcatcaa atcttgatga aggattgtag
     4741 atttttgctt tttctttttg tttttaaaac ttattccaat tgctaaattg gtagtttttc
     4801 agtctttata aatacaggat taaaaatata tatacagtta tatgaaatgt ttattttcta
     4861 tgtgtgtgca tatagttcaa tattatgcaa taaatttggt gttttaactt aaaa
//
