LOCUS       NM_004667              15364 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens HECT and RLD domain containing E3 ubiquitin protein
            ligase 2 (HERC2), mRNA.
ACCESSION   NM_004667
VERSION     NM_004667.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15364)
  AUTHORS   Yagita,Y., Zavodszky,E., Peak-Chew,S.Y. and Hegde,R.S.
  TITLE     Mechanism of orphan subunit recognition during assembly quality
            control
  JOURNAL   Cell 186 (16), 3443-3459 (2023)
   PUBMED   37480851
  REMARK    GeneRIF: Mechanism of orphan subunit recognition during assembly
            quality control.
REFERENCE   2  (bases 1 to 15364)
  AUTHORS   Xie,S., Naslavsky,N. and Caplan,S.
  TITLE     EHD1 promotes CP110 ubiquitination by centriolar satellite delivery
            of HERC2 to the mother centriole
  JOURNAL   EMBO Rep 24 (6), e56317 (2023)
   PUBMED   37074924
  REMARK    GeneRIF: EHD1 promotes CP110 ubiquitination by centriolar satellite
            delivery of HERC2 to the mother centriole.
REFERENCE   3  (bases 1 to 15364)
  AUTHORS   Liu,Y., Xu,Q., Deng,F., Zheng,Z., Luo,J., Wang,P., Zhou,J., Lu,X.,
            Zhang,L., Chen,Z., Zhang,Q., Chen,Q. and Zuo,D.
  TITLE     HERC2 promotes inflammation-driven cancer stemness and immune
            evasion in hepatocellular carcinoma by activating STAT3 pathway
  JOURNAL   J Exp Clin Cancer Res 42 (1), 38 (2023)
   PUBMED   36721234
  REMARK    GeneRIF: HERC2 promotes inflammation-driven cancer stemness and
            immune evasion in hepatocellular carcinoma by activating STAT3
            pathway.
            Erratum:[J Exp Clin Cancer Res. 2024 Nov 13;43(1):300. doi:
            10.1186/s13046-024-03223-4.. PMID: 39538344]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 15364)
  AUTHORS   Calbet-Llopart,N., Combalia,M., Kiroglu,A., Potrony,M.,
            Tell-Marti,G., Combalia,A., Brugues,A., Podlipnik,S., Carrera,C.,
            Puig,S., Malvehy,J. and Puig-Butille,J.A.
  TITLE     Common genetic variants associated with melanoma risk or naevus
            count in patients with wildtype MC1R melanoma
  JOURNAL   Br J Dermatol 187 (5), 753-764 (2022)
   PUBMED   35701387
  REMARK    GeneRIF: Common genetic variants associated with melanoma risk or
            naevus count in patients with wildtype MC1R melanoma.
REFERENCE   5  (bases 1 to 15364)
  AUTHORS   Sala-Gaston,J., Pedrazza,L., Ramirez,J., Martinez-Martinez,A.,
            Rawlins,L.E., Baple,E.L., Crosby,A.H., Mayor,U., Ventura,F. and
            Rosa,J.L.
  TITLE     HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway
            altering the cellular response to oxidative stress
  JOURNAL   Cell Mol Life Sci 79 (11), 548 (2022)
   PUBMED   36241744
  REMARK    GeneRIF: HERC2 deficiency activates C-RAF/MKK3/p38 signalling
            pathway altering the cellular response to oxidative stress.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 15364)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   7  (bases 1 to 15364)
  AUTHORS   Suzuki,Y., Tsunoda,T., Sese,J., Taira,H., Mizushima-Sugano,J.,
            Hata,H., Ota,T., Isogai,T., Tanaka,T., Nakamura,Y., Suyama,A.,
            Sakaki,Y., Morishita,S., Okubo,K. and Sugano,S.
  TITLE     Identification and characterization of the potential promoter
            regions of 1031 kinds of human genes
  JOURNAL   Genome Res 11 (5), 677-684 (2001)
   PUBMED   11337467
REFERENCE   8  (bases 1 to 15364)
  AUTHORS   Ji,Y., Rebert,N.A., Joslin,J.M., Higgins,M.J., Schultz,R.A. and
            Nicholls,R.D.
  TITLE     Structure of the highly conserved HERC2 gene and of multiple
            partially duplicated paralogs in human
  JOURNAL   Genome Res 10 (3), 319-329 (2000)
   PUBMED   10720573
REFERENCE   9  (bases 1 to 15364)
  AUTHORS   Walkowicz,M., Ji,Y., Ren,X., Horsthemke,B., Russell,L.B.,
            Johnson,D., Rinchik,E.M., Nicholls,R.D. and Stubbs,L.
  TITLE     Molecular characterization of radiation- and chemically induced
            mutations associated with neuromuscular tremors, runting, juvenile
            lethality, and sperm defects in jdf2 mice
  JOURNAL   Mamm Genome 10 (9), 870-878 (1999)
   PUBMED   10441737
REFERENCE   10 (bases 1 to 15364)
  AUTHORS   Ji,Y., Walkowicz,M.J., Buiting,K., Johnson,D.K., Tarvin,R.E.,
            Rinchik,E.M., Horsthemke,B., Stubbs,L. and Nicholls,R.D.
  TITLE     The ancestral gene for transcribed, low-copy repeats in the
            Prader-Willi/Angelman region encodes a large protein implicated in
            protein trafficking, which is deficient in mice with neuromuscular
            and spermiogenic abnormalities
  JOURNAL   Hum Mol Genet 8 (3), 533-542 (1999)
   PUBMED   9949213
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091304.15, AU100235.1,
            AF071172.3, AC126332.9, AW897649.1, DA868501.1, AK122977.1,
            BC148318.2, CX784863.1, AI820017.1, CF135750.1, BX440995.2 and
            AC135329.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2019 this sequence version replaced NM_004667.5.
            
            Summary: This gene belongs to the HERC gene family that encodes a
            group of unusually large proteins, which contain multiple
            structural domains. All members have at least 1 copy of an
            N-terminal region showing homology to the cell cycle regulator RCC1
            and a C-terminal HECT (homologous to E6-AP C terminus) domain found
            in a number of E3 ubiquitin protein ligases. Genetic variations in
            this gene are associated with skin/hair/eye pigmentation
            variability. Multiple pseudogenes of this gene are located on
            chromosomes 15 and 16. [provided by RefSeq, Mar 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF071172.3, SRR14038192.446025.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261609.13/ ENSP00000261609.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC091304.15        41366-41392         c
            28-75               AU100235.1         1-48
            76-2541             AF071172.3         1-2466
            2542-2581           AC126332.9         106192-106231       c
            2582-3192           AF071172.3         2507-3117
            3193-3441           AW897649.1         107-355
            3442-3584           AF071172.3         3367-3509
            3585-3585           AC126332.9         95068-95068         c
            3586-4197           AF071172.3         3511-4122
            4198-4198           AC126332.9         83285-83285         c
            4199-4832           AF071172.3         4124-4757
            4833-4833           AC126332.9         79538-79538         c
            4834-5393           AF071172.3         4759-5318
            5394-5715           DA868501.1         180-501
            5716-7466           AF071172.3         5641-7391
            7467-8472           AK122977.1         1441-2446
            8473-9822           BC148318.2         740-2089
            9823-10329          CX784863.1         111-617
            10330-10461         AI820017.1         302-433             c
            10462-10941         CF135750.1         192-671
            10942-11685         AF071172.3         10867-11610
            11686-12327         BX440995.2         37-678
            12328-14690         AF071172.3         12253-14615
            14691-15364         AC135329.12        64393-65066
FEATURES             Location/Qualifiers
     source          1..15364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.1"
     gene            1..15364
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /note="HECT and RLD domain containing E3 ubiquitin protein
                     ligase 2"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
     exon            1..105
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            106..208
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..14641
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /EC_number="2.3.2.26"
                     /note="probable E3 ubiquitin-protein ligase HERC2; hect
                     domain and RCC1-like domain-containing protein 2; hect
                     domain and RLD 2; HECT-type E3 ubiquitin transferase
                     HERC2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase HERC2"
                     /protein_id="NP_004658.3"
                     /db_xref="CCDS:CCDS10021.1"
                     /db_xref="GeneID:8924"
                     /db_xref="HGNC:HGNC:4868"
                     /db_xref="MIM:605837"
                     /translation="MPSESFCLAAQARLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGE
                     IVYTGTESTQNGELPPRKDDSVEPSGTKKEDLNDKEKKDEEETPAPIYRAKSILDSWV
                     WGKQPDVNELKECLSVLVKEQQALAVQSATTTLSALRLKQRLVILERYFIALNRTVFQ
                     ENVKVKWKSSGISLPPVDKKSSRPAGKGVEGLARVGSRAALSFAFAFLRRAWRSGEDA
                     DLCSELLQESLDALRALPEASLFDESTVSSVWLEVVERATRFLRSVVTGDVHGTPATK
                     GPGSIPLQDQHLALAILLELAVQRGTLSQMLSAILLLLQLWDSGAQETDNERSAQGTS
                     APLLPLLQRFQSIICRKDAPHSEGDMHLLSGPLSPNESFLRYLTLPQDNELAIDLRQT
                     AVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLAN
                     LGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLVQGLASRNIVKIAAHSDGHHYL
                     ALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAI
                     TAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENG
                     QVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWG
                     KGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ
                     HFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSEWSIGLRVPFVVDICSMT
                     FEQLDLLLRQVSEGMDGSADWPPPQEKECVAVATLNLLRLQLHAAISHQVDPEFLGLG
                     LGSILLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPTAEERARALSALLPC
                     AVSGNEVNISPGRRFMIDLLVGSLMADGGLESALHAAITAEIQDIEAKKEAQKEKEID
                     EQEANASTFHRSRTPLDKDLINTGICESSGKQCLPLVQLIQQLLRNIASQTVARLKDV
                     ARRISSCLDFEQHSRERSASLDLLLRFQRLLISKLYPGESIGQTSDISSPELMGVGSL
                     LKKYTALLCTHIGDILPVAASIASTSWRHFAEVAYIVEGDFTGVLLPELVVSIVLLLS
                     KNAGLMQEAGAVPLLGGLLEHLDRFNHLAPGKERDDHEELAWPGIMESFFTGQNCRNN
                     EEVTLIRKADLENHNKDGGFWTVIDGKVYDIKDFQTQSLTGNSILAQFAGEDPVVALE
                     AALQFEDTRESMHAFCVGQYLEPDQEIVTIPDLGSLSSPLIDTERNLGLLLGLHASYL
                     AMSTPLSPVEIECAKWLQSSIFSGGLQTSQIHYSYNEEKDEDHCSSPGGTPASKSRLC
                     SHRRALGDHSQAFLQAIADNNIQDHNVKDFLCQIERYCRQCHLTTPIMFPPEHPVEEV
                     GRLLLCCLLKHEDLGHVALSLVHAGALGIEQVKHRTLPKSVVDVCRVVYQAKCSLIKT
                     HQEQGRSYKEVCAPVIERLRFLFNELRPAVCNDLSIMSKFKLLSSLPRWRRIAQKIIR
                     ERRKKRVPKKPESTDDEEKIGNEESDLEEACILPHSPINVDKRPIAIKSPKDKWQPLL
                     STVTGVHKYKWLKQNVQGLYPQSPLLSTIAEFALKEEPVDVEKMRKCLLKQLERAEVR
                     LEGIDTILKLASKNFLLPSVQYAMFCGWQRLIPEGIDIGEPLTDCLKDVDLIPPFNRM
                     LLEVTFGKLYAWAVQNIRNVLMDASAKFKELGIQPVPLQTITNENPSGPSLGTIPQAR
                     FLLVMLSMLTLQHGANNLDLLLNSGMLALTQTALRLIGPSCDNVEEDMNASAQGASAT
                     VLEETRKETAPVQLPVSGPELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGE
                     DGWIRVQWDTGSTNSYRMGKEGKYDLKLAELPAAAQPSAEDSDTEDDSEAEQTERNIH
                     PTAMMFTSTINLLQTLCLSAGVHAEIMQSEATKTLCGLLRMLVESGTTDKTSSPNRLV
                     YREQHRSWCTLGFVRSIALTPQVCGALSSPQWITLLMKVVEGHAPFTATSLQRQILAV
                     HLLQAVLPSWDKTERARDMKCLVEKLFDFLGSLLTTCSSDVPLLRESTLRRRRVRPQA
                     SLTATHSSTLAEEVVALLRTLHSLTQWNGLINKYINSQLRSITHSFVGRPSEGAQLED
                     YFPDSENPEVGGLMAVLAVIGGIDGRLRLGGQVMHDEFGEGTVTRITPKGKITVQFSD
                     MRTCRVCPLNQLKPLPAVAFNVNNLPFTEPMLSVWAQLVNLAGSKLEKHKIKKSTKQA
                     FAGQVDLDLLRCQQLKLYILKAGRALLSHQDKLRQILSQPAVQETGTVHTDDGAVVSP
                     DLGDMSPEGPQPPMILLQQLLASATQPSPVKAIFDKQELEAAALAVCQCLAVESTHPS
                     SPGFEDCSSSEATTPVAVQHIRPARVKRRKQSPVPALPIVVQLMEMGFSRRNIEFALK
                     SLTGASGNASSLPGVEALVGWLLDHSDIQVTELSDADTVSDEYSDEEVVEDVDDAAYS
                     MSTGAVVTESQTYKKRADFLSNDDYAVYVRENIQVGMMVRCCRAYEEVCEGDVGKVIK
                     LDRDGLHDLNVQCDWQQKGGTYWVRYIHVELIGYPPPSSSSHIKIGDKVRVKASVTTP
                     KYKWGSVTHQSVGVVKAFSANGKDIIVDFPQQSHWTGLLSEMELVPSIHPGVTCDGCQ
                     MFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRINEPGQSAVFCGRSGKQLKRC
                     HSSQPGMLLDSWSRMVKSLNVSSSVNQASRLIDGSEPCWQSSGSQGKHWIRLEIFPDV
                     LVHRLKMIVDPADSSYMPSLVVVSGGNSLNNLIELKTININPSDTTVPLLNDCTEYHR
                     YIEIAIKQCRSSGIDCKIHGLILLGRIRAEEEDLAAVPFLASDNEEEEDEKGNSGSLI
                     RKKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSK
                     SLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHAT
                     ALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSG
                     ELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFS
                     WGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDY
                     FRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNG
                     TTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGAS
                     YLGVPSDADSSAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMY
                     ARDAVVGALMPAAMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPW
                     QEKREIVSSEDAVTPSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKEDVESQN
                     KAAGPEPQALDEFTSLLIADDTRVVVDLLKLSVCSRAGDRGRDVLSAVLSGMGTAYPQ
                     VADMLLELCVTELEDVATDSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRV
                     EFDRQCSTERRHDPLTVMDGVNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVN
                     GWGWRFTVYPIMPAAGPKELLSDRCVLSCPSMDLVTCLLDFRLNLASNRSIVPRLAAS
                     LAACAQLSALAASHRMWALQRLRKLLTTEFGQSININRLLGENDGETRALSFTGSALA
                     ALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLELDTLPCCAETHKWA
                     WFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSENMDVLHESHDIFKREQD
                     EQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPV
                     QLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNS
                     GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSA
                     CVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTD
                     DDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYT
                     WGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDE
                     GQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYN
                     HLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDETGLGPSVGFDTLRGILISQ
                     GKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMS
                     SFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDE
                     SGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLT
                     IADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDN
                     RAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHL
                     LKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFV
                     IQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIA
                     LTGEPAADDSSDDSDNEDVDSFASDSTQDYLTGH"
     exon            209..323
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..458
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..678
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..779
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..936
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1047
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1219
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1393
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1582
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1734
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1892
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2006
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2258
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2452
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2653
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2882
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3007
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3186
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3371
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..3527
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3528..3713
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3714..3884
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3885..3988
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3989..4139
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4140..4354
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4355..4487
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4488..4615
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4616..4811
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4812..4945
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4946..5119
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5120..5256
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5257..5408
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5409..5600
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5601..5788
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5789..5981
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            5982..6164
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6165..6346
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6347..6494
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6495..6691
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6692..6922
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            6923..7061
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            7062..7205
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            7206..7348
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            7349..7616
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            7617..7753
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            7754..7852
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            7853..8021
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            8022..8147
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            8148..8256
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            8257..8396
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            8397..8587
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            8588..8693
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            8694..8785
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            8786..8961
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            8962..9073
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            9074..9155
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            9156..9299
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            9300..9390
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            9391..9568
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            9569..9650
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            9651..9822
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            9823..9967
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            9968..10193
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            10194..10365
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            10366..10549
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            10550..10690
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            10691..10882
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            10883..11036
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            11037..11144
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            11145..11276
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            11277..11435
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            11436..11554
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            11555..11680
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            11681..11836
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            11837..11952
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            11953..12151
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            12152..12366
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            12367..12544
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            12545..12706
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            12707..12798
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            12799..12938
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            12939..13126
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            13127..13324
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            13325..13408
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            13409..13550
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            13551..13745
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            13746..13858
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            13859..14049
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            14050..14155
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            14156..14368
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            14369..15364
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15102..15107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /note="hexamer: ATTAAA"
     polyA_site      15125
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
     regulatory      15344..15349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /note="hexamer: AATAAA"
     polyA_site      15364
                     /gene="HERC2"
                     /gene_synonym="D15F37S1; jdf2; MRT38; p528; SHEP1"
                     /note="major polyA site"
ORIGIN      
        1 gggccgcgag aggcgccggg atcgcgggcg ccggctgagc cagcggctct tgggaggctg
       61 cgtccgcgcg ccggcgaggc gaggcggccg ggccctgcgc gtcaggcctg agacctggga
      121 ggaagctgga gaaaagatgc cctctgaatc tttctgtttg gctgcccagg ctcgcctcga
      181 ctccaaatgg ttgaaaacag atatacagct tgcattcaca agagatgggc tctgtggtct
      241 gtggaatgaa atggttaaag atggagaaat tgtatacact ggaacagaat caacccagaa
      301 cggagagctc cctcctagaa aagatgatag tgtcgaacca agtggaacaa agaaagaaga
      361 tctgaatgac aaagagaaaa aagatgaaga agaaactcct gcacctatat atagggccaa
      421 gtcaattctg gacagctggg tatggggcaa gcaaccagat gtgaatgaac tgaaggagtg
      481 tctttctgtg ctggttaaag agcagcaggc cctggccgtc cagtcagcca ccaccaccct
      541 ctcagccctg cgactcaagc agaggctggt gatcttggag cgctatttca ttgccttgaa
      601 tagaaccgtt tttcaggaga atgtcaaagt taagtggaaa agcagcggta tttctctgcc
      661 tcctgtggac aaaaaaagtt cccggcctgc gggcaaaggt gtggaggggc tcgccagagt
      721 gggatcccga gcggcgctgt cttttgcctt tgccttcctg cgcagggcct ggcgatcagg
      781 cgaggatgcg gacctctgca gtgagctgtt gcaggagtcc ctggacgccc tgcgagcact
      841 tcccgaggcc tcgctctttg acgagagcac cgtgtcctct gtgtggctgg aggtggtgga
      901 gagagcgacc aggttcctca ggtccgtcgt gacgggggat gttcacggaa cgccagccac
      961 caaagggcca ggaagcatcc ccctgcagga ccagcacttg gccctggcca tcctgctgga
     1021 gctggctgtg cagagaggca cgctgagcca aatgttgtct gccatcctgt tgttgcttca
     1081 gctgtgggac agcggggcac aggagactga caatgagcgt tccgcccagg gcaccagcgc
     1141 cccacttttg cccttgctgc aaaggttcca gagcatcatt tgcaggaagg atgcacccca
     1201 ctccgagggc gacatgcacc ttttgtctgg ccctctgagc cccaatgaga gtttcctgag
     1261 gtacctcacc cttccacaag acaacgagct tgccattgat ctgcgacaaa cggcggttgt
     1321 tgtcatggcc catttagacc gtctggctac gccctgtatg cctccgctgt gtagctctcc
     1381 gacatctcat aagggatcat tgcaagaggt cataggttgg gggttaatag gatggaaata
     1441 ctatgccaat gtgattggtc caatccagtg cgaaggcctg gccaacctgg gagtcacaca
     1501 gattgcctgt gcagagaagc gtttcctgat tctgtcacgc aatggccgcg tgtacacaca
     1561 ggcctataat agtgacacgc tggccccaca gctggtccaa ggccttgcct ccagaaacat
     1621 tgtaaaaatt gctgcccatt ctgatggtca ccactaccta gccttggctg ctactggaga
     1681 ggtgtactcc tggggctgtg gggacggcgg acggctgggc catggggaca ctgtgccttt
     1741 ggaggagcct aaggtgatct ccgccttctc tggaaagcag gccgggaagc acgtggtgca
     1801 catcgcttgc gggagcactt acagtgcggc catcactgcc gagggggagc tgtacacctg
     1861 gggccgcggg aactacggcc ggctgggcca tggctccagt gaggacgagg ccattccgat
     1921 gctggtagcc gggcttaaag gactgaaggt catcgatgtg gcgtgtggga gtggggatgc
     1981 tcaaaccctg gctgtcactg agaacgggca agtgtggtct tggggagatg gtgactatgg
     2041 gaaattgggc agaggtggta gtgatggctg caaaacccca aagctgattg aaaagcttca
     2101 agacttggat gtggtcaaag tccgctgtgg aagtcagttt tccattgctt tgacgaaaga
     2161 tggccaagtt tattcatggg gaaaaggtga caaccagaga cttggacatg gaacagagga
     2221 acatgttcgt tatccaaaac tcttagaagg cttgcaaggg aagaaggtga ttgatgtggc
     2281 tgcaggctcc acccactgcc tggctctgac tgaggacagc gaggtccaca gctgggggag
     2341 caacgaccag tgccagcact ttgacacctt gcgcgtgacc aagccagaac ctgcagcatt
     2401 gccaggactg gacaccaaac acatagtggg aattgcctgt gggcctgccc agagctttgc
     2461 ttggtcatca tgttctgagt ggtccattgg cctccgtgtc ccttttgtgg tggacatctg
     2521 ctcaatgact tttgagcagc tggatctcct gcttcggcag gtgagtgagg ggatggatgg
     2581 ttccgcggac tggcccccgc cccaggagaa agagtgtgtg gccgtggcaa cgctgaatct
     2641 tctacgactt cagttgcatg ctgccattag tcaccaggtt gacccggaat tccttggttt
     2701 aggtctgggc agcatcctcc tgaacagcct gaagcagacg gtggtgaccc tggccagcag
     2761 tgcgggcgtg ctgagcaccg tgcagtcggc cgcccaggcc gtgctgcaga gtggctggtc
     2821 cgtgctgctg cccaccgcgg aggagcgggc ccgggcactc tctgctctcc tgccctgcgc
     2881 agtttcaggc aatgaagtga acataagtcc aggtcgtcga ttcatgattg atcttctggt
     2941 gggcagcttg atggctgatg gagggttgga gtcagcctta cacgcagcca ttactgcaga
     3001 gatccaggat attgaagcca aaaaagaagc acagaaggaa aaagaaattg atgaacagga
     3061 agcgaatgcc tcaacatttc atagaagcag gactccactg gataaagacc ttattaatac
     3121 ggggatctgt gagtcttctg gcaaacagtg tttgcctctg gttcagctca tacaacagct
     3181 tcttagaaac attgcttctc agactgtagc cagattgaaa gatgttgccc gtcggatttc
     3241 atcatgtctg gactttgagc aacacagtcg tgaaagatct gcttcattgg atttgttact
     3301 gcgttttcaa cgtttgctta ttagtaaact ttatccagga gaaagtattg gtcagacctc
     3361 agatatttct agtccagagc taatgggtgt tggttccttg ctgaagaagt acacagccct
     3421 cctgtgcacg cacattggag atatactgcc tgtggccgcc agcattgctt ctaccagctg
     3481 gcggcacttc gcggaggtgg cttacattgt ggaaggggac tttactggtg ttctccttcc
     3541 agaactagta gtttctatag tgcttctgct cagtaaaaat gctggtctca tgcaagaggc
     3601 tggagctgta cctctgctgg gtggcctgtt ggaacatctg gatcggttca accatctggc
     3661 accaggaaag gaacgggatg atcatgaaga gttagcctgg cctggcataa tggagtcatt
     3721 ttttacaggt cagaactgta gaaataatga ggaagtgaca cttatacgca aagctgattt
     3781 ggagaaccat aataaagatg gaggcttctg gactgtgatt gacgggaagg tgtatgatat
     3841 aaaggacttc cagacacagt cgttaacagg aaatagtatt cttgctcagt ttgcagggga
     3901 agacccagtg gtagctttgg aagctgcttt gcagtttgaa gacacccggg aatccatgca
     3961 cgcgttttgt gttggccagt atttggagcc tgaccaagaa atcgtcacca taccagatct
     4021 ggggagtctc tcttcacctc tgatagacac agagaggaat ctgggcctgc ttctcggatt
     4081 acacgcttcg tatttggcaa tgagcacacc gctgtctcct gtcgagattg aatgtgccaa
     4141 atggcttcag tcatccatct tctctggagg cctgcagacc agccagatcc actacagcta
     4201 caacgaggag aaagacgagg accactgcag ctccccaggg ggcacacctg ccagcaaatc
     4261 tcgactctgc tcccacagac gggccctggg ggaccattcc caggcatttc tgcaagccat
     4321 tgcagacaac aacattcagg atcacaacgt gaaggacttt ttgtgtcaaa tagaaaggta
     4381 ctgtaggcag tgccatttga ccacaccgat catgtttccc cccgagcatc ccgtggaaga
     4441 ggtcggtcgc ttgttgttat gttgcctctt aaaacatgaa gatttaggtc atgtggcatt
     4501 atctttagtt catgcaggtg cacttggtat tgagcaagta aagcacagaa cgttgcctaa
     4561 gtcagtggtg gatgtttgta gagttgtcta ccaagcaaaa tgttcgctca ttaagactca
     4621 tcaagaacag ggccgttctt acaaggaggt ctgcgctcct gtcatcgaac gtttgagatt
     4681 cctctttaat gaattgagac ctgctgtttg taatgacctc tctataatgt ctaagtttaa
     4741 attgttaagt tctttgcccc gttggaggag gatagctcaa aagataattc gagaacgaag
     4801 gaaaaagaga gttcctaaga agccagaatc tacggatgat gaagaaaaaa ttggaaacga
     4861 agagagtgat ttagaagaag cttgcatttt gcctcatagt ccaataaatg tggacaagag
     4921 acccattgca attaaatcac ccaaggacaa atggcagccg ctgttgagta ctgttacagg
     4981 tgttcacaaa tacaagtggt tgaagcagaa tgtgcagggt ctttatccgc agtctccact
     5041 cctcagtaca attgctgaat ttgcccttaa agaagagcca gtggatgtgg aaaaaatgag
     5101 aaagtgccta ctaaaacagt tggagagagc agaggttcgc ctggaaggga tagatacaat
     5161 tttaaaactg gcgagcaaga atttcttact tccatctgtg cagtatgcga tgttttgtgg
     5221 atggcaaaga cttattcctg agggaatcga tataggggaa cctcttactg attgtttaaa
     5281 ggatgttgat ttgatcccgc cttttaatcg gatgctgctg gaagtcacct ttggcaagct
     5341 gtacgcttgg gctgtacaga acattcgaaa tgttttgatg gatgccagtg ccaaatttaa
     5401 agagcttggt atccagccgg ttcccctgca aaccatcacc aatgagaacc cgtcaggacc
     5461 gagcctgggg accatcccgc aagcccgctt cctcctggtg atgctcagca tgctcaccct
     5521 gcagcacggc gcaaacaacc tcgaccttct gctcaattcc ggcatgctgg ccctcacgca
     5581 gacggcactg cgcctgattg gccccagttg tgacaacgtt gaggaagata tgaatgcttc
     5641 tgctcaaggt gcttctgcca cagttttgga agaaacaagg aaggaaacgg ctcctgtgca
     5701 gctccctgtt tcaggaccag aactggctgc catgatgaag attggaacaa gggtcatgag
     5761 aggtgtggac tggaaatggg gcgatcagga tgggcctcct ccaggcctag gccgcgtgat
     5821 tggtgagctg ggagaggacg gatggataag agtccagtgg gacacaggca gcaccaactc
     5881 ctacaggatg gggaaagaag gaaaatacga cctcaagctg gcagagctgc cggctgctgc
     5941 acagccctca gcagaggatt cggacacaga ggatgactct gaagccgaac aaactgaaag
     6001 gaacattcac cccactgcaa tgatgtttac cagcactatt aacttactgc agactctttg
     6061 tctgtctgct ggagttcatg ctgagatcat gcagagcgaa gccaccaaga ctttatgcgg
     6121 actgctgcga atgttagtgg aaagcggaac gacggacaag acatcttctc caaacaggct
     6181 ggtgtacagg gagcaacacc ggagctggtg cacgctgggg tttgtgcgga gcatcgctct
     6241 cacgccgcag gtatgcggcg ccctcagctc cccgcagtgg atcacgctgc tcatgaaggt
     6301 cgtggaaggg cacgcaccct tcactgccac ctcgctgcag aggcagatct tagctgtgca
     6361 tttgttgcaa gcagtccttc catcatggga caagaccgaa agggcgaggg acatgaaatg
     6421 cctcgtggag aagctgtttg acttcttggg aagcttgctc actacctgct cctctgacgt
     6481 gccattactc agagagtcca cgctgaggcg gcgcagggtg cgcccgcagg cctcgctgac
     6541 tgccacccac agcagcacac tggcggagga ggtggtggca ctgctgcgca cgctgcactc
     6601 cctgactcag tggaatgggc tcatcaacaa gtacatcaac tcccagctcc gctccatcac
     6661 ccacagcttt gtgggaaggc cttccgaagg ggcccagtta gaggactact tccccgactc
     6721 cgagaaccct gaagtggggg gcctcatggc agtcctggct gtgattggag gcatcgatgg
     6781 tcgcctgcgc ctgggcggtc aagttatgca cgatgagttt ggagaaggca ctgtgactcg
     6841 catcacccca aagggcaaaa tcaccgtgca gttctctgac atgcggacgt gtcgcgtttg
     6901 cccattgaat cagctgaaac cactccctgc cgtggccttt aatgtgaaca acctgccctt
     6961 cacagagccc atgctgtctg tctgggctca gttggtgaac ctcgctggaa gcaagttaga
     7021 aaagcacaaa ataaagaaat cgactaaaca ggcctttgca ggacaagtgg acctggacct
     7081 gctgcggtgc cagcagttga agctatacat cctgaaagca ggtcgggcgc tgctctccca
     7141 ccaggataaa ctgcggcaga tcctgtctca gccagctgtt caggagactg gaactgttca
     7201 cacagatgat ggagcagtgg tatcacctga ccttggggac atgtctcctg aagggccgca
     7261 gccccccatg atcctcttgc agcagctgct ggcctcggcc acccagccgt ctcctgtgaa
     7321 ggccatattt gataaacagg aacttgaggc tgctgcactg gccgtttgcc agtgcttggc
     7381 tgtggagtcc actcaccctt cgagcccagg atttgaagac tgcagctcca gtgaggccac
     7441 cacgcctgtc gccgtgcagc acatccgccc tgccagagtg aagaggcgca agcagtcgcc
     7501 cgttcccgct ctgccgatcg tggtgcagct catggagatg ggattttcca gaaggaacat
     7561 cgagtttgcc ctgaagtctc tcactggtgc ttccgggaat gcatccagct tgcctggtgt
     7621 ggaagccttg gtcgggtggc tgctggacca ctccgacata caggtcacgg agctctcaga
     7681 tgcagacacg gtgtccgacg agtattctga cgaggaggtg gtggaggacg tggatgatgc
     7741 cgcctactcc atgtctactg gtgctgttgt gacggagagc cagacgtaca aaaaacgagc
     7801 tgatttcttg agtaatgatg attatgctgt atatgtgaga gagaatattc aggtgggaat
     7861 gatggttaga tgctgccgag cgtatgaaga agtgtgcgaa ggtgatgttg gcaaagtcat
     7921 caagctggac agagatggat tgcatgatct caatgtgcag tgtgactggc agcagaaagg
     7981 gggcacctac tgggttaggt acattcatgt ggaacttata ggctatcctc caccaagttc
     8041 ttcttctcac atcaagattg gtgataaagt gcgggtcaaa gcctctgtca ccacaccaaa
     8101 atacaaatgg ggatctgtga ctcatcagag tgtgggggtt gtgaaagctt tcagtgccaa
     8161 tggaaaagat atcattgtcg actttcccca gcagtctcac tggactgggt tgctatcaga
     8221 aatggagttg gtacccagta ttcatcctgg ggttacgtgt gatggatgtc agatgtttcc
     8281 tatcaatgga tccagattca aatgcagaaa ctgtgatgac tttgattttt gtgaaacgtg
     8341 tttcaagacc aaaaaacaca ataccaggca tacatttggc agaataaatg aaccaggtca
     8401 gtctgcggta ttttgtggcc gttctggaaa acagctgaag cgttgccaca gcagccagcc
     8461 aggcatgctg ctggacagct ggtcccgcat ggtgaagagc ctgaatgtgt cgtcctccgt
     8521 gaaccaggca tcccgtctca ttgacggcag cgagccctgc tggcagtcat cggggtcgca
     8581 aggaaagcac tggattcgtt tggagatttt cccagatgtt cttgttcata gattaaaaat
     8641 gatcgtagat cctgctgaca gtagctacat gccgtccctg gttgtagtgt caggtggaaa
     8701 ttccctgaat aaccttattg aactaaagac aatcaatatt aacccttctg acaccacagt
     8761 gccccttctg aatgactgca cagagtatca caggtatatt gaaattgcta taaagcagtg
     8821 caggagctca ggaatcgatt gtaaaatcca tggtctcatc ctgctgggac ggatccgtgc
     8881 agaagaggaa gatttggctg cagttccttt cttagcttcg gataatgaag aggaggagga
     8941 tgagaaaggc aacagcggaa gcctcattag aaagaaggct gctgggctgg aatcagcagc
     9001 tacgataaga accaaggtgt ttgtgtgggg cctgaatgac aaggaccagc tgggcgggct
     9061 gaaaggctcc aagataaagg ttccttcgtt ctctgagaca ctgtcagctt tgaatgtggt
     9121 acaggtggct ggtggatcta aaagtttgtt tgcagtgact gtggaaggga aggtgtatgc
     9181 ctgtggagaa gccacgaatg gccggctggg gctgggcatt tccagcggga cggtgcccat
     9241 cccacggcag atcacagctc tcagcagcta cgtggtcaag aaggtggctg ttcactcagg
     9301 tggccggcac gcgacggctt taactgtcga tggaaaagtg ttttcgtggg gcgaaggtga
     9361 cgatggaaaa cttggacact tcagcagaat gaactgtgac aaaccaaggc tgatcgaggc
     9421 cctgaaaacc aagcgtatcc gggatatcgc ctgtgggagc tcgcacagcg cagccctcac
     9481 atccagcgga gaactgtaca cctggggcct cggcgagtac ggccggctgg gacatgggga
     9541 taatacgaca cagctaaagc ccaaaatggt gaaagtcctt ctcggtcaca gagtaatcca
     9601 ggttgcatgt gggagtagag acgcgcagac cctggctctg accgatgaag gtttggtatt
     9661 ttcctggggt gatggtgact ttggaaaact gggccggggc ggaagtgaag gctgtaacat
     9721 tccccagaac attgagagac taaatggaca gggggtgtgc cagattgagt gtggagctca
     9781 gttctccctg gcgctcacca agtctggagt ggtgtggaca tggggaaagg gggattactt
     9841 cagattgggc cacggctctg acgtgcacgt gcggaaacca caggtggtgg aagggctgag
     9901 agggaagaag atcgtgcatg tggctgtcgg ggccctgcac tgcctggcgg tcacggactc
     9961 ggggcaggtg tatgcttggg gtgacaacga ccacggccag cagggcaatg gcacgaccac
    10021 ggttaacagg aagcccacac tcgtgcaagg cttagaaggc cagaagatca cacgcgtggc
    10081 ttgtgggtcg tcccacagtg tggcgtggac aactgtggat gtggccacgc cctctgtcca
    10141 cgagcccgtc ctcttccaga ctgcaagaga ccctttaggt gcttcctatt taggcgtgcc
    10201 ttcagatgct gattcttctg ctgccagtaa taaaataagt ggtgcaagta attctaagcc
    10261 aaatcgccct tctcttgcca agattctctt gtcattggat ggaaatctgg ccaaacagca
    10321 ggccttatca catattctta cagcattgca aatcatgtat gccagagatg ctgttgtcgg
    10381 ggccctgatg ccggccgcca tgatcgcccc ggtggagtgc ccctcgttct cctcggcggc
    10441 cccttccgac gcatctgcga tggctagtcc catgaatgga gaagaatgca tgctggctgt
    10501 tgatatcgaa gacagactga gtccaaatcc atggcaagaa aagagagaga ttgtttcctc
    10561 tgaggacgca gtgaccccct ctgcagtgac tccgtcggcc ccctcagcct ccgctcggcc
    10621 ttttatccca gtgacggatg acctgggagc cgcaagcatc attgcagaaa ccatgaccaa
    10681 aaccaaagag gatgttgaaa gccaaaataa agcagcaggt ccggagcctc aggccttgga
    10741 tgagttcacc agtctgctga ttgcggatga cactcgtgtg gtggtagacc tgctcaagct
    10801 gtcagtgtgc agccgggccg gggacagggg cagggatgtg ctctccgcgg tgctttccgg
    10861 catggggacc gcctacccac aggtggcaga tatgctgttg gagctctgtg tcaccgagtt
    10921 ggaggatgtg gccacagact cgcagagcgg ccgcctctct tctcagcctg tggtggtgga
    10981 gagtagccac ccttacaccg acgacacctc caccagtggc acagtgaaga taccaggtgc
    11041 agaaggactc agggtagaat ttgaccggca gtgctccaca gagaggcgcc acgaccctct
    11101 cacagtcatg gacggcgtca acaggatcgt ctccgtgcgg tcaggccgag agtggtccga
    11161 ctggtccagc gagctgcgca tcccagggga tgagttaaag tggaagttca tcagcgatgg
    11221 gtctgtgaat ggctggggct ggcgcttcac cgtctatccc atcatgccag ctgctggccc
    11281 taaagaactc ctctctgacc gctgcgtcct ctcctgtcca tccatggact tggtgacgtg
    11341 tctgttagac ttccgactca accttgcctc taacagaagc atcgtccctc gccttgcggc
    11401 ctcgctggca gcttgtgcac agctgagtgc cctagctgcc agtcacagaa tgtgggccct
    11461 tcagagactg aggaagctgc ttacaactga atttgggcag tcaattaaca taaataggct
    11521 gcttggagaa aatgatgggg aaacaagagc tttgagtttt acaggtagtg ctcttgctgc
    11581 tttggtgaaa ggtcttccag aagctttgca aaggcagttt gaatatgaag atcctattgt
    11641 gaggggtggc aaacagctgc tccacagccc attctttaag gtactggtag ctcttgcttg
    11701 tgacctggag ctggacactc tgccttgctg tgccgagacg cacaagtggg cctggttccg
    11761 gaggtactgc atggcctccc gtgttgctgt ggcccttgac aaaagaacac cgttgccccg
    11821 tctgtttctt gatgaggtgg ctaagaaaat tcgtgaatta atggcagaca gcgaaaacat
    11881 ggatgttctg catgagagcc atgacatttt taaaagagag caagacgaac aacttgtgca
    11941 gtggatgaac aggcgaccag atgactggac tctctctgct ggtggcagtg gaacaattta
    12001 tggatgggga cataatcaca ggggccagct cgggggcatt gaaggcgcaa aagtcaaagt
    12061 tcccactccc tgtgaagccc ttgcaactct cagacccgtg cagttaatcg gaggggaaca
    12121 gaccctcttt gctgtgacgg ctgatgggaa gctgtatgcc actgggtatg gtgcaggtgg
    12181 cagactaggc attggaggga cagagtcggt gtccacccca acattgcttg aatccattca
    12241 gcatgtgttt attaagaaag tagctgtgaa ctctggagga aagcactgcc ttgccctgtc
    12301 ttcagaagga gaagtttact cttggggtga ggcagaagat gggaagttgg ggcatggcaa
    12361 cagaagtccg tgtgaccgcc ctcgtgtcat cgagtctctg agaggaattg aagtggtcga
    12421 tgttgctgct ggcggagccc acagcgcctg tgtcacagca gccggggacc tctacacatg
    12481 gggcaaaggc cgctacggcc ggctggggca cagcgacagt gaggaccagc tgaagccgaa
    12541 gctggtggag gcgctgcagg gccaccgtgt ggttgacatc gcctgtggca gtggagatgc
    12601 ccagaccctc tgcctcacag atgacgacac tgtctggtcc tggggggacg gggactacgg
    12661 caagctcggc cggggaggca gcgatggctg taaagtgcct atgaagattg attctcttac
    12721 tggtcttgga gtagttaaag tggaatgcgg atcccagttt tctgttgccc ttaccaaatc
    12781 tggagctgtt tatacctggg gcaaaggcga ttatcacagg ttgggccatg gatcagatga
    12841 ccatgttcga aggcctcggc aggtccaagg gttgcagggg aagaaagtca tcgccatcgc
    12901 cactggctcc ctgcactgtg tgtgctgcac agaggatggt gaggtttata catggggcga
    12961 caatgatgag ggacaactgg gagacggaac caccaatgcc atccagaggc ctcggttggt
    13021 agctgccctt cagggtaaga aggtcaaccg tgtggcctgt ggctcagcac ataccctcgc
    13081 ctggtcgacc agcaagcccg ccagtgctgg caaactccct gcacaggtcc ccatggagta
    13141 caatcacctg caggagatcc ccatcattgc gctgaggaac cgtctgctgc tgctgcacca
    13201 cctctccgag ctcttctgcc cctgcatccc catgttcgac ctggaaggct cgctcgacga
    13261 aactggactc gggccttctg ttgggttcga cactctccga ggaattctga tatcccaggg
    13321 aaaggaggcg gctttccgga aagtagtaca agcaactatg gtacgcgatc gtcagcatgg
    13381 ccccgtcgtg gagctgaacc gcatccaggt caaacgatca aggagcaaag gcgggctggc
    13441 cggccccgac ggcaccaagt ctgtctttgg gcagatgtgt gctaagatga gctcgtttgg
    13501 tcccgacagc ctcctccttc ctcaccgtgt ctggaaagtc aagtttgtgg gtgaatctgt
    13561 ggatgactgt gggggcggct acagcgagtc catagctgag atctgtgagg agctgcagaa
    13621 cggactcacg cccctgctga tcgtgacacc caacgggagg gatgagtctg gggccaaccg
    13681 agactgctac ctgctcagcc cggccgccag agcacccgtg cacagcagca tgttccgctt
    13741 cctgggtgtg ttgctgggca ttgccatccg aaccgggagt cccctgagcc tcaaccttgc
    13801 cgagcctgtc tggaagcagc tggctgggat gagcctcacc atcgcggacc tcagtgaggt
    13861 tgataaggat tttattcctg gactcatgta catccgagac aatgaagcca cctcagagga
    13921 gtttgaagcc atgagcctgc ccttcacagt gccaagtgcc agtggccagg acattcagtt
    13981 gagctccaag cacacacaca tcaccctgga caaccgcgcg gagtacgtgc ggctggcgat
    14041 aaactataga ctccatgaat ttgatgagca ggtggctgct gttcgggaag gaatggcccg
    14101 cgttgtgcct gttcccctcc tctctctgtt caccggctac gaactggaga cgatggtgtg
    14161 tggcagccct gacatcccgc tgcaccttct caagtcggtg gccacctata aaggcatcga
    14221 gccttccgca tcgctgatcc agtggttctg ggaggtgatg gagtccttct ccaacacaga
    14281 gcgctctctt ttccttcgct tcgtctgggg ccggacgagg ctgcccagga ccatcgccga
    14341 cttccggggc cgagacttcg tcatccaggt gttggataaa tacaaccctc cagaccactt
    14401 cctccctgag tcctacacct gtttcttctt gctgaagctg cccaggtatt cctgcaagca
    14461 ggtgctggag gagaagctca agtacgccat ccacttctgc aagtccatag acacagatga
    14521 ctacgctcgc atcgcactta caggagagcc agccgccgac gacagcagcg acgattcaga
    14581 taacgaggat gtcgactcct ttgcttcgga ctctacacaa gattatttaa caggacacta
    14641 agatggggaa acgtcctcgt gagatgagag cctgagccag gcagcagagc gctcgctgct
    14701 gtgtagactg taggctgcct ggtgtgtctg atgagaagcg tccgtcctcg agccaggcgg
    14761 gaggagggag tggagagact gactggccgt gatgggaatg acagtgagaa ggtccgcctg
    14821 tgcgcgtgga acactgtgga cgctcgactt ccaagggtct tctcacccgt aatgctgcat
    14881 tacatgtagg actgtgttta ctaaagtgtg taaatgttta tataaatacc aaattgcagc
    14941 atccccaaaa tgaataaagc ctttttactt gtgggtgcaa tcgatttttt ttctttctcc
    15001 tttctttcaa gtgtcgtgag tcgtcttgat tgtatattgg aaataactgt gtaacaaatc
    15061 gtattataaa tatttcaatt aattttactc tgaatttgtt tattaaaaga cttttgaaca
    15121 tgaaatgatt agtattactt gaatgcatcc agaggatatt taaaccaaaa tgaaaaacca
    15181 gaaggccatt tggtgtcccc cctcccaggt gtccccttgt agcatatgca ttatgtcatc
    15241 tgaattgagg cctttctgtg aacagcatca taacttctat catggaaagt gtactatata
    15301 taatgtttgt gtcatgtata tgcctaaatt ttaattatct ataaataaaa catctgacat
    15361 aaaa
//
