LOCUS       XM_047433241           15239 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens HECT and RLD domain containing E3 ubiquitin
            protein ligase family member 1 (HERC1), transcript variant X32,
            mRNA.
ACCESSION   XM_047433241
VERSION     XM_047433241.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     gene            1..15239
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /note="HECT and RLD domain containing E3 ubiquitin protein
                     ligase family member 1; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 2 mRNAs, 103 ESTs, 2634
                     long SRA reads, 2 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     11 samples with support for all annotated introns"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
     CDS             149..14776
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HERC1
                     isoform X23"
                     /protein_id="XP_047289197.1"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
                     /translation="MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSN
                     KEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALAKMVCSDSPFAGA
                     LRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEM
                     GVRTGLSLLFALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMG
                     LDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEMALGASA
                     VVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYE
                     AALCLFEEVCRMASDYSRTCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEK
                     ILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
                     FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPL
                     QGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEV
                     SCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQ
                     SSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSH
                     DNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDR
                     QVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLL
                     SNHLALALAGGVATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPP
                     LRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADL
                     SSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLL
                     GTSSSENSQPAHLHELLCSLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIY
                     SRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARPLLSYLLDL
                     LPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIA
                     LLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGN
                     EEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLLDT
                     VSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRS
                     SSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEGHPEPEDEEEEREHE
                     VMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQD
                     VYTAACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTA
                     ESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSGRRNVDLDLAASHRKRGPMHSQL
                     ESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFK
                     EPEESMSTSPQASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGF
                     QSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQDGIRAAKRNIQIEIQVAVH
                     KIYQQLSATLERALQANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLSQ
                     LCGTDTMLGQPLQLLPKTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLL
                     DLLCSQLKNLLSQTGVLHMASFGEGEQEDGEEEEKKVDSSGETEKKDFRAALRKQHAA
                     ELHLGDFLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLAL
                     HVLEAVLPACESGVEDDQMAQIVERLFSLLSDCMWETPIAQAKHAIQIKEKEQEIKLQ
                     KQGELEEEDENLPIQEVSFDPEKAQCCLVENGQILTHGSGGKGYGLASTGVTSGCYQW
                     KFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFT
                     QGDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCVMFYSSNPGEKVKICDMQ
                     MRGTPRDLLPGDPICSPVAAVLAEATIQLIRILHRTDRWTYCINKKMMERLHKIKICI
                     KESGQKLKKSRSVQSREENEMREEKESKEEEKGKHTRHGLADLSELQLRTLCIEVWPV
                     LAVIGGVDAGLRVGGRCVHKQTGRHATLLGVVKEGSTSAKVQWDEAEITISDTPLYNL
                     EPCEPLPFDVARFRGLTASVLLDLTYLTGVHEDMGKQSTKRHEKKHRHESEEKGDVEQ
                     KPESESALDMRTGLTSDDVKSQSTTSSKSENEIASFSLDPTLPSVESQHQITEGKRKN
                     HEHMSKNHDVAQSEIRAVQLSYLYLGAMKSLSALLGCSKYAELLLIPKVLAENGHNSD
                     CASSPVVHEDVEMRAALQFLMRHMVKRAVMRSPIKRALGLADLERAQAMIYKLVVHGL
                     LEDQFGGKIKQEIDQQAEESDPAQQAQTPVTTSPSASSTTSFMSSSLEDTTTATTPVT
                     DTETVPASESPGVMPLSLLRQMFSSYPTTTVLPTRRAQTPPISSLPTSPSDEVGRRQS
                     LTSPDSQSARPANRTALSDPSSRLSTSPPPPAIAVPLLEMGFSLRQIAKAMEATGARG
                     EADAQNITVLAMWMIEHPGHEDEEEPQSGSTADSRPGAAVLGSGGKSNDPCYLQSPGD
                     IPSADAAEMEEGFSESPDNLDHTENAASGSGPSARGRSAVTRRHKFDLAARTLLARAA
                     GLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFGQDLTSDND
                     ILGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHPGCGRSANRQG
                     YRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPDLIGK
                     QDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDSDPLGASVA
                     MVTATNSMEETLMQIELCFSGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTA
                     AAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLST
                     SPSAMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISA
                     ATGVNLTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNY
                     DKSEVEKKGLIAQLYAHPSYDPSAVGPLELANALAACCLSSRLSSQHRQWAAQQLVRT
                     LAAHDRDNQTTLQTLADMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTI
                     RVWNVTKKQYSLQQTCVFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALEKMVN
                     IWQVNGGKGLVDIQPHWVSALAWPEEGPATAWSGESPELLLVGRMDGSLGLIEVVDVS
                     TMHRRELEHCYRKDVSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHK
                     DTLISMKWDPTGHILMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKG
                     SKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQESNCQDGYRKSSGAKCVYQ
                     LRGHITPVRTVAFSSDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPE
                     VGVAACSNRSKDVLVVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLP
                     MMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDP
                     ASWNPNEWAWLECFSTTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLMDNSKWIN
                     GMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQV
                     ICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGS
                     DGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAV
                     VTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGS
                     MVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFG
                     QDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQ
                     LGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPD
                     TVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGI
                     VQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQ
                     VVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNAT
                     AEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVP
                     LTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGG
                     NSIPLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVC
                     GMPEISVEVLKKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANT
                     ADISQRFQIMKVDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDN
                     YMLSRNVDNAEGSDTDY"
ORIGIN      
        1 gtctttccct ttgacaagtc gctgctgctg cagcaaaaat aaaggacgcg accgccgcag
       61 cctctgcgga gccgggctcg ggtcgccgga gccgcgcccc accccgccag ctccagagcc
      121 acgactaatg gctgaaggat aaatcaacat ggcaactatg attccaccag tgaagctgaa
      181 atggcttgaa cacttgaaca gctcctggat tacagaggac agtgaatcta ttgctacaag
      241 agagggagtt gctgttctgt attctaaact ggttagcaat aaggaagtag tacctttgcc
      301 ccaacaagtt ttatgcctca aaggaccaca gttgccagac tttgaacgtg agtctctttc
      361 aagtgatgag caggaccact atttggatgc ccttcttagc agccagctag cattggcaaa
      421 gatggtatgt tcagattccc catttgccgg ggcacttaga aaacgactgc ttgtactcca
      481 gcgtgtcttt tatgcacttt ctaataaata ccatgacaaa ggcaaggtga agcagcagca
      541 gcattctccg gagagcagtt ctggttcagc agatgtccat tctgttagtg aacgcccccg
      601 gtcaagcact gatgcactta tagaaatggg tgttcgaact ggtctaagtt tattatttgc
      661 gcttctaaga caaagttgga tgatgcctgt gtcaggacct ggtctcagtc tttgcaacga
      721 tgtcattcat actgcaattg aagttgtgag ctctttgcca ccattatcat tagcaaatga
      781 aagcaagatt cctcctatgg gcttggactg cttatcgcaa gtaacaacat ttcttaaagg
      841 agtcactatt cctaattctg gggcagacac tttaggtcgt agattagctt ctgagttgct
      901 gcttggtttg gcagctcaac gaggctcatt gcgatatctt cttgaatgga tagaaatggc
      961 tttgggggct tcggcagttg tacacaccat ggagaaaggc aaactactct caagccagga
     1021 aggaatgatc agctttgact gctttatgac catattaatg cagatgaggc gttctttggg
     1081 ttcatctgct gatcggagtc agtggagaga accaaccaga acatcggatg gcttgtgctc
     1141 cctttacgag gcagcattat gtctctttga agaggtttgc agaatggctt ctgattattc
     1201 gagaacatgt gctagcccag atagcattca gactggtgat gctcccattg tctccgaaac
     1261 ctgtgaggtt tatgtttggg ggagcaatag cagccatcag ttggtagaag gtacacagga
     1321 gaaaatactg caacccaaac tggctcctag tttctctgat gcacagacca ttgaagctgg
     1381 acagtactgc acttttgtca tttctacgga tggctctgtt agagcttgcg ggaaaggcag
     1441 ctatgggaga ctgggccttg gagactccaa taatcagtca actttaaaaa agttaacatt
     1501 cgagcctcac agatccatta aaaaggtttc atcttctaaa ggatctgatg gtcacacttt
     1561 agcctttacg acagaaggag aagtcttcag ttggggagat ggtgattatg ggaaactggg
     1621 gcatggaaat agttcaacac agaaatatcc caagcttatt cagggacctc tacaaggaaa
     1681 ggtagttgtt tgtgtgtcag ctggatacag acatagtgct gctgtcacag aggatgggga
     1741 attatacaca tggggtgaag gagactttgg aagattaggt catggtgaca gcaatagtcg
     1801 taacattcca acattagtaa aagacatcag caatgtagga gaggtttctt gtggcagttc
     1861 acatactatt gctctgtcta aagatgggag aactgtatgg tcttttggag gaggagacaa
     1921 tggtaaactt ggtcatggtg ataccaacag agtgtataaa cctaaagtta ttgaagcttt
     1981 acaaggaatg ttcattcgca aagtttgtgc tgggagccag tcttcacttg ctttgacatc
     2041 aacagggcag gtctatgctt ggggctgtgg agcttgtcta ggttgtggtt cttcagaagc
     2101 tactgctttg agacccaagc ttattgaaga actggctgcc acaagaatag ttgatgtttc
     2161 tattggagac agtcattgtt tggctctttc tcatgataat gaagtttatg cctggggcaa
     2221 taactcaatg gggcaatgtg gtcagggaaa ttccacaggt cctattacta aaccaaagaa
     2281 agtgagtggc ttagatggca tagctattca gcagatttcg gctggaacat cacatagtct
     2341 ggcatggact gctcttccta gggacagaca agttgttgca tggcaccgac cttattgtgt
     2401 agatcttgaa gagagtacct tctcacacct gcgttctttt cttgagagat actgtgataa
     2461 aataaacagt gagattcccc cactcccttt cccttcatca agagaacacc acagttttct
     2521 caagctgtgc ctgaagctac tttcaaatca ccttgctctt gcacttgcgg gaggggtagc
     2581 taccagcatt ctcgggaggc aggcaggtcc acttcgaaat ttgctcttca gactgatgga
     2641 ctcaactgtc ccagatgaaa tccaagaggt ggtaattgaa actttatcag tgggagcaac
     2701 catgctgtta cctccattac gagaacggat ggaattactt cattctcttt tacctcaagg
     2761 acctgataga tgggaaagct tatctaaagg acagagaatg caactggata tcatcctgac
     2821 aagtttgcaa gatcataccc acgtagcctc cctacttggc tatagttcac cctctgatgc
     2881 tgctgaccta tcttctgtgt gtactggcta cggaaatctg tcagatcaac cttacggcac
     2941 tcagagctgc catccagata cccacctggc tgaaattttg atgaagaccc tcttaagaaa
     3001 tttaggattt tatacagatc aagcatttgg agagctagaa aagaatagtg ataaatttct
     3061 acttggaaca tcatcatcag aaaacagtca gcctgctcat cttcatgaac tgctatgttc
     3121 actacagaaa cagctgctgg cattttgcca tatcaataac attagtgaga actcaagcag
     3181 tgtggcattg cttcataaac atcttcagct tttgttgcct catgccacag atatttattc
     3241 acgttctgca aatttgctca aagaaagtcc ttggaatggc agtgttggag aaaaattaag
     3301 agatgtgata tacgtctcag ctgctggcag tatgctctgc cagattgtta actccctgct
     3361 gttactccct gtgtcagtgg ctcggccttt attgagttac ctcctcgact tgttgccacc
     3421 tcttgattgc cttaatagac tcctgccagc tgctgatctt ttagaagacc aggagttaca
     3481 gtggcctctt catggagggc cagaactaat tgatcctgct ggtctgccat tacctcagcc
     3541 agctcagtcc tgggtatggc ttgtggatct agaaagaaca attgctctcc ttattgggcg
     3601 gtgtcttggt ggcatgcttc agggctcccc tgtgtctcca gaggaacagg acactgcata
     3661 ttggatgaaa acgccactgt tcagtgacgg tgtagaaatg gacactcctc aattggataa
     3721 atgtatgagt tgcctgttag aagtagcact ttctggaaat gaagaacaga agccttttga
     3781 ttataaattg cggcctgaaa ttgctgtcta tgtagacttg gcattgggtt gttctaaaga
     3841 gcctgcccga agcctttgga tcagcatgca ggactatgct gttagtaaag attgggacag
     3901 tgcaacttta agtaatgagt cactcttgga cactgtgtct agatttgttc ttgcagctct
     3961 tctgaaacac acaaatttac ttagtcaagc atgtggagaa agccgatatc aacctggtaa
     4021 acacttatca gaagtgtacc gttgtgtata caaagttcga agtcgtttac ttgcttgcaa
     4081 gaaccttgaa cttattcaaa caaggtcatc atcacgggac agatggatat cagaaaacca
     4141 ggactctgca gatgttgatc ctcaggagca ttcatttact cgaactattg atgaagaagc
     4201 tgaaatggaa gaacaggctg agagagaccg ggaagagggg catccggagc cagaggatga
     4261 agaggaggaa cgggaacatg aagtgatgac agctggcaaa atctttcagt gtttcctctc
     4321 agcccgtgaa gtagctcgta gccgagaccg agatagaatg aacagtgggg cagggtctgg
     4381 ggctcgagct gatgatccac ctcctcagtc tcagcaagag cgaagggtca gcacagacct
     4441 tcctgagggt caggatgtgt acactgctgc atgcaactcc gtgatccatc ggtgtgccct
     4501 gttaatatta ggagtaagtc ctgtgataga tgagcttcag aagcgaagag aagaaggaca
     4561 gttgcagcaa ccttcaacaa gtgcctctga agggggtgga cttatgacca ggagtgaaag
     4621 tcttactgca gagagccggc tagtccacac aagcccaaat tatagactga tcaaatcgag
     4681 gagtgaatct gatttgtctc agcctgaatc agatgaagag ggttacgcac tgagtggcag
     4741 acgaaatgtt gatttggatt tggcagcatc tcacagaaag agaggtccta tgcacagtca
     4801 attggaatcc ctgagtgact cttgggctcg cctgaaacat agcagagact ggttatgcaa
     4861 ctcctcctat tcctttgagt cagattttga tcttaccaag tctttgggag ttcacacttt
     4921 gattgaaaat gttgtaagct ttgtgagtgg agatgtgggg aatgccccag gttttaaaga
     4981 gccagaggaa agtatgtcta caagtcccca ggcctccatc attgcaatgg aacagcagca
     5041 gttaagggca gaacttcgtt tagaggcact tcatcagatc ctcgttctat tgtctgggat
     5101 ggaagaaaaa ggtagcatct cactggcagg aagcagattg agttcaggct tccagtcctc
     5161 cacactactc acgtctgtga ggctgcagtt cctagcaggg tgttttggtt taggcactgt
     5221 tggacacaca ggaggcaagg gagagagtgg ccgattgcat cactatcagg atgggatcag
     5281 agcagctaag agaaatattc agattgaaat ccaggtagct gtgcataaaa tttatcaaca
     5341 gttgtctgct accctggaaa gagccctgca agcaaacaag catcacattg aagcccagca
     5401 acgtctgctt ctggttacag tttttgccct aagtgttcat tatcaaccag tagatgtttc
     5461 tttggcaatt tccactggtc tgctaaacgt attgtcacag ttgtgtggta cagacaccat
     5521 gctaggacag cccctgcagt tgttgccaaa gacgggtgtt tcccagctta gcacagcttt
     5581 gaaagtggcc agtacaaggt tgctccagat tctagccatc actactggga cctatgctga
     5641 taaactgagt cccaaagtag ttcaatcctt gttggatcta ctctgtagtc agttgaagaa
     5701 tttattgtcc caaactggtg tactacatat ggcctctttc ggagaagggg agcaagaaga
     5761 cggtgaagaa gaagaaaaaa aagttgactc cagtggagaa actgagaaga aagatttcag
     5821 agctgctctt aggaaacaac atgcagccga actccatcta ggggattttt tagtttttct
     5881 tcgcagagtt gtatcttcaa aagcaattca atcaaaaatg gcttccccaa agtggaccga
     5941 agtgcttcta aatatagcat ctcagaaatg ttcttcaggt atccctctgg ttggtaactt
     6001 aagaacaagg ctccttgcac ttcatgtcct tgaagctgtg ctgccagctt gtgaatctgg
     6061 tgtagaagat gatcaaatgg cccagattgt tgagcgctta ttttcccttc tctctgattg
     6121 tatgtgggag acacccattg ctcaggccaa acatgctatt cagataaagg aaaaagaaca
     6181 agaaataaaa ctacagaagc agggcgagtt ggaagaagaa gatgagaatc ttcctatcca
     6241 agaagtatcc tttgacccgg agaaagctca gtgttgccta gtggagaatg gacagatttt
     6301 aactcacggc agtggaggga aaggatatgg attggcatct acaggagtaa cttctgggtg
     6361 ctatcagtgg aagttttata ttgtgaagga aaacagaggt aatgaaggca cgtgtgttgg
     6421 agtttctcgc tggccagtac atgactttaa tcaccgcact acctcggata tgtggctcta
     6481 tagggcctac agtggtaacc tctatcacaa tggagaacag actctcacat tgtccagctt
     6541 tactcaagga gatttcatta cctgtgtgtt agacatggaa gccaggacca tttcttttgg
     6601 gaaaaatgga gaggaaccca aattagcttt tgaagatgtg gatgcagcag agttgtaccc
     6661 atgtgtgatg ttctatagta gcaatccagg ggaaaaggtg aaaatttgtg atatgcagat
     6721 gcgtggcaca ccccgagact tacttccagg agaccctatt tgtagtccag tagcagcagt
     6781 gctggctgag gccactattc agctcatccg tatccttcac cgaacagacc gttggactta
     6841 ctgcattaac aaaaaaatga tggaaaggct tcacaaaatt aagatatgta ttaaagagtc
     6901 aggtcagaag ctaaagaaaa gccgctcggt tcagagccga gaggaaaatg aaatgagaga
     6961 ggagaaggag agcaaagagg aagagaaagg taaacatact aggcatggcc tcgctgacct
     7021 ctcagagctg cagctgagga ctctttgcat agaggtgtgg cccgtgctgg ctgtgatagg
     7081 aggagttgat gctggtctta gagttggagg tcggtgtgtt cacaagcaaa ctgggcgcca
     7141 tgccacgctg ctgggagtgg tcaaagaggg cagcacgtct gccaaggtcc aatgggatga
     7201 agcagaaatt actatcagtg atactccatt gtataatctg gaaccctgtg aaccattgcc
     7261 gtttgatgtg gcgcgattcc gaggcctgac ggcttctgtg ctgctggacc taacatatct
     7321 cactggcgtt catgaagaca tgggcaaaca gagcaccaaa cgacatgaaa agaaacaccg
     7381 acatgaatcc gaggagaaag gggatgttga gcagaaacct gagagtgaat ccgctttaga
     7441 tatgcgaaca ggcctaacat ctgatgacgt caaaagtcag agtaccacaa gctccaaatc
     7501 agaaaatgaa atcgcttcat tttctttaga tccaacactg ccaagtgtgg aatcccaaca
     7561 tcaaataaca gaagggaaaa gaaaaaatca tgaacacatg tccaaaaacc atgatgtagc
     7621 ccagtcagaa atcagagcag tccagctgtc ctatctttac ctcggtgcta tgaagtcact
     7681 tagtgccctt cttggctgta gtaaatatgc tgagctgttg ctgataccaa aagttctggc
     7741 tgaaaatggc cacaactcag actgtgcaag ttctccagtt gttcatgaag acgtggagat
     7801 gcgagcagcc ctgcagttct tgatgcgaca catggtgaag cgagcagtca tgcggtcacc
     7861 cataaagaga gcattgggat tagctgatct ggaacgagcg caagccatga tctataaatt
     7921 agtggttcat gggcttttgg aagaccagtt tgggggcaaa attaagcaag agattgatca
     7981 acaagctgaa gaaagtgacc ctgcccagca ggcacagaca ccagttacta ctagcccatc
     8041 agcctcaagc acgacctcct ttatgagcag ctctctggag gacaccacaa ctgccaccac
     8101 tccagtcact gacacagaaa cagtgcctgc atccgagtcc ccgggagtga tgcctcttag
     8161 tcttctcagg caaatgttct ctagttaccc aactaccact gtacttccca cacgtcgggc
     8221 acagactcct ccaatatctt cgttaccaac ctctccttct gatgaagtag gaaggaggca
     8281 aagtttaact tctcctgatt cccagtcagc aaggccagct aaccgcacag ccttgtcaga
     8341 cccaagcagt agactttcaa cttctcctcc tcctccagca attgcagttc ccttgctgga
     8401 aatggggttc tctcttcggc agattgccaa agccatggaa gctacaggtg ctaggggaga
     8461 ggctgatgcc cagaatatca ctgtccttgc catgtggatg atagagcacc ctgggcatga
     8521 ggatgaagag gagccccagt cgggcagcac agcagactct aggcctggag cagccgttct
     8581 aggcagtggc gggaagtcaa atgatccctg ttatttgcag tcacctggag acataccatc
     8641 agctgatgct gctgaaatgg aggaaggttt tagtgaaagc cctgataatt tggatcatac
     8701 agagaatgca gcttctggaa gtggaccatc agctagaggt cgctcagcgg taacaagaag
     8761 acacaagttt gacttagctg ctcgcacact gctagcaaga gcagcgggat tataccgctc
     8821 tgtgcaggcc cacaggaatc aaagtcggag agaaggaata tctttgcagc aagacccagg
     8881 ggcgttgtat gactttaatt tagatgagga attggaaatt gatcttgatg atgaggcgat
     8941 ggaagctatg tttggacaag acctgaccag tgacaatgat attctgggaa tgtggatccc
     9001 agaggtactg gattggccta cctggcatgt ttgtgagtct gaagacaggg aagaagtggt
     9061 ggtgtgtgaa ctgtgtgaat gcagcgtcgt cagcttcaat cagcacatga agagaaacca
     9121 tccaggctgt gggcgcagtg caaaccgcca gggctatcgc agcaatggtt cctatgtgga
     9181 tggctggttt ggcggtgaat gtgggagtgg aaatccgtac tacctgttat gtggcacctg
     9241 cagggagaag tacttagcca tgaagaccaa atctaagtca acaagttctg aaaggtacaa
     9301 gggacaagct ccagatctaa ttggcaagca agacagtgtg tatgaagaag actgggacat
     9361 gttggatgtt gatgaagatg aaaagctaac tggtgaagaa gaatttgaat tacttgctgg
     9421 accgcttggt ttaaatgacc ggcgcattgt accagaacca gttcagttcc ctgacagcga
     9481 tccactggga gcatcagtag caatggtcac agccaccaac agtatggaag agactctgat
     9541 gcaaatagaa ttatgttttt caggttgcca tggctccgta gaaaagagct cctctgggag
     9601 aataacgtta ggagagcagg cagctgccct agcaaaccct catgaccgtg tggtggcttt
     9661 aaggagagtg actgctgctg ctcaggttct tctggccaga accatggtca tgagagcgct
     9721 gtctcttctc tcagtcagtg gttccagttg tagcctggct gctggtcttg agtctctggg
     9781 gctaacagat atccgaacgc tagttcgatt aatgtgcttg gcagcagcag ggagagctgg
     9841 cctctccacc agcccttctg ccatggctag cacctcagaa cgatcacgag gtgggcatag
     9901 caaggctaac aagcctatct cttgcctggc ctatttgagc acagcagtgg gatgtctggc
     9961 atcaaatgct cctagtgctg ccaaactgct tgtacagttg tgtacacaga acttgatttc
    10021 tgctgcaaca ggtgtaaatc taaccacagt tgatgactca attcagcgaa agtttctacc
    10081 cagctttctc cgaggaattg ctgaagagaa caagcttgtg acctccccaa actttgttgt
    10141 aacacaggcc cttgtggcat tgctagcaga caaaggggcc aaactaagac ctaactatga
    10201 taagtcagaa gttgaaaaga aaggtttaat tgcccaattg tatgcccatc cttcctatga
    10261 tccttctgct gtaggccctc tggagttggc taatgccctg gcagcctgct gcctctcctc
    10321 caggctgtcc tcacagcatc ggcaatgggc agctcagcaa ctcgtgcgca ctcttgctgc
    10381 acacgaccgt gacaaccaaa ctactctgca gacacttgct gatatgggag gagatcttag
    10441 aaaatgctcc tttatcaaat tggaggctca tcagaacaga gtaatgacat gtgtttggtg
    10501 taataaaaaa ggtcttttgg ctacaagtgg caatgatggc accatccgcg tatggaatgt
    10561 taccaagaag caatattcac tgcaacagac ctgtgtgttc aacagattgg aaggggatgc
    10621 tgaggaaagc ctgggatcac ccagtgatcc aagtttctca ccagtttcct ggagtatcag
    10681 tggcaaatat ctagcaggcg ctttggaaaa gatggtgaat atctggcaag ttaatggagg
    10741 aaaaggatta gtagatattc agcctcattg ggtatctgcc ctggcttggc cagaagaggg
    10801 tccggctaca gcctggtcag gagagtctcc agaattgttg ttggtgggac ggatggatgg
    10861 atctctggga ctgattgaag ttgttgatgt gtccaccatg caccgtcgag aattggagca
    10921 ttgctatcga aaggatgtgt ctgttacttg cattgcatgg ttcagtgaag acagaccatt
    10981 tgcagtggga tattttgatg gaaaactgtt actgggaaca aaggaaccac ttgagaaagg
    11041 aggcattgtt ctaattgatg cacataagga tactcttatt agcatgaagt gggaccctac
    11101 aggtcatatt cttatgacat gtgccaaaga agacagtgtg aaactctggg gctctatttc
    11161 gggatgctgg tgctgtctac attcactctg ccatccatct attgtaaatg gcattgcttg
    11221 gtgccgcctt ccagggaaag gatccaagtt gcagttactg atggctactg gctgtcagag
    11281 tggcttagta tgtgtttggc gcattcctca agatactaca cagaccaatg tgactagtgc
    11341 agaaggatgg tgggagcagg aatcaaattg ccaggatgga tataggaaat catcaggagc
    11401 caagtgtgtt tatcagctgc ggggacacat cactcctgtt cggactgttg cctttagttc
    11461 tgatgggttg gccctggtgt ctggtggact aggtgggctc atgaacattt ggtctttaag
    11521 ggatggctct gtcttgcaaa ctgttgtgat aggctctgga gctattcaga ccacagtatg
    11581 gattccagaa gttggagtag ctgcttgctc aaatagatca aaggatgttt tggtcgtgaa
    11641 ttgtacagca gaatgggcag ctgccaatca tgttttggca acctgtagga cagcattgaa
    11701 acagcagggt gttctgggat tgaacatggc tccctgcatg agagcatttt tggagcggct
    11761 ccccatgatg cttcaggagc agtatgccta tgaaaagcct catgtggttt gtggtgacca
    11821 acttgttcat agcccctata tgcaatgctt ggcttccctt gctgtgggac ttcatctgga
    11881 tcagctgttg tgtaaccctc cagtgccacc acaccaccag aactgtctcc ctgaccctgc
    11941 atcctggaat ccaaatgaat gggcctggtt agaatgtttc tcaaccacta taaaagctgc
    12001 cgaagccctg accaatggag cccagtttcc agaatctttt accgttccag atctagaacc
    12061 tgttccagag gatgaacttg tatttctaat ggataacagt aaatggatta acggcatgga
    12121 tgaacaaatt atgtcttggg caacttccag acctgaggac tggcacctgg gaggtaaatg
    12181 tgatgtctac ttatggggtg ctggtaggca tggacagctg gcagaagctg gaagaaatgt
    12241 aatggtacct gcagcagctc cctcattctc acaggcccaa caggtcattt gtggtcagaa
    12301 ttgtaccttt gtcatccagg ccaatggcac agtgttggct tgtggggaag gaagttatgg
    12361 cagattagga caaggaaatt cagatgacct tcatgtgctg acagttattt cagccttaca
    12421 aggctttgtg gtgacccagc tggtgacttc ctgtggttct gatgggcact ctatggccct
    12481 aactgaaagt ggtgaggtct ttagctgggg agatggtgac tatggtaaac ttggccatgg
    12541 gaacagcgac aggcagcggc ggcccaggca gatcgaggcc ttacaaggag aagaagtggt
    12601 gcagatgtct tgtggcttca agcactcagc agtggtcact tcagatggca aactgttcac
    12661 ctttgggaat ggtgactatg gtcgtctggg tcttggaaat acctctaaca aaaaacttcc
    12721 agagagagtg actgcactgg agggatatca gattggacag gtggcctgtg gattaaacca
    12781 cactttggca gtgtcagcag atggttccat ggtgtgggct tttggagatg gagactatgg
    12841 aaaactaggc ttaggaaatt ccactgcaaa atcttcacct cagaaaattg acgtcctttg
    12901 tggaattgga ataaaaaagg ttgcttgtgg aactcagttt tctgttgctt tgaccaaaga
    12961 tggtcatgtg tatacctttg gtcaagatcg cctgataggc ttgccagagg ggcgtgctcg
    13021 caatcacaat cgaccgcaac aaatccctgt cctggctgga gtaatcatag aagatgtggc
    13081 agttggagct gaacacacac ttgctttggc atcaaatgga gatgtgtatg cctgggggag
    13141 caattcagaa gggcagctcg gcttaggcca taccaaccat gttcgagaac caaccctggt
    13201 aacaggtctg caagggaaaa atgttcggca gatctcggct ggccgctgcc acagtgctgc
    13261 atggacagca ccacctgtcc caccaagagc accaggtgtg tcagtacctc tgcagctggg
    13321 cctgcctgac acagtgcccc cccagtatgg ggcgctgaga gaagtcagca ttcacacggt
    13381 gcgggccagg ctccggctgc tctaccactt ctctgacctc atgtactcat cctggagact
    13441 gctgaacctt agccccaaca accagaacag cacatcccat tataatgctg gaacttgggg
    13501 cattgtacag ggacaacttc ggcctttgtt agccccaaga gtctacactc tgccaatggt
    13561 gcgctccata ggaaaaacca tggttcaagg caaaaactat ggacctcaga taactgtaaa
    13621 gaggatatca accagaggac ggaagtgtaa gcctattttt gtccaaatag cgagacaagt
    13681 agttaagctg aatgcttcag acctccgcct gccttcccga gcgtggaagg ttaagctggt
    13741 tggagaaggg gctgatgatg ctggaggagt gtttgatgac accatcacag agatgtgcca
    13801 ggaacttgaa actggtattg ttgaccttct tataccctct cccaatgcca ccgcagaagt
    13861 gggttacaat agggacaggt tcctttttaa cccttctgcc tgcctcgatg aacacttaat
    13921 gcagtttaag tttttaggaa ttttaatggg ggttgccatt cgcacaaaga agcctctgga
    13981 cctccacttg gcccctctgg tgtggaagca gctgtgctgt gtcccactca ccctagagga
    14041 cctggaggag gtggatctgc tctacgtgca gactctcaac agcattcttc acattgaaga
    14101 cagtgggatt accgaggaga gtttccatga gatgattcct cttgattctt ttgttggcca
    14161 gagtgctgat ggcaaaatgg ttcctataat ccctggtgga aatagtatcc cactcacatt
    14221 ttccaacagg aaggaatatg tggagagggc cattgaatat cgacttcatg agatggacag
    14281 acaggtggct gcagtccgag aagggatgtc ctggattgtt cctgtgccgc tgctgtccct
    14341 cctcacagca aaacaactgg agcagatggt gtgtgggatg cccgagatct ctgtggaagt
    14401 cttgaagaaa gtggtgcggt accgtgaggt ggatgagcag catcagctgg tgcagtggtt
    14461 ctggcacacg ctggaagagt tctccaatga ggagcgggtg cttttcatga ggtttgtgtc
    14521 aggaagatct cgactaccag ccaacactgc tgacatttct cagagatttc aaatcatgaa
    14581 ggttgatagg ccttacgaca gtctgcctac ctcacagacc tgcttcttcc agctgaggct
    14641 gcccccgtac tccagccagc tggtcatggc cgagcgcctg cgctatgcca tcaacaactg
    14701 ccgctcaatc gacatggaca actacatgct ctcgagaaac gtggacaacg ccgagggctc
    14761 cgacactgac tactgaccgt gcgggtgctc tcaccctccc ttctctccct caataatgct
    14821 cacttctgat ttgatgttga tatactttta tggtaactac atagatgtta taagaacata
    14881 aaccaacatt ataaacaatg gccacattta gttactctaa atgtaacaaa gaaattagat
    14941 gtttttattt ttctgtgatt gtacaaaaac aacaaaaacg aagtgctctc agtcaggttt
    15001 ttccctccat atttttggtc acttttgata agtttgcatg aaaccatttt ggtgcatttt
    15061 tagttgggaa tggtacattt ttgtaaatcc acccagtgaa catgaaattg tacattgtgt
    15121 ataattgttc attagaaagg acagttttac atgaatattc atatatttat tttgttttaa
    15181 tttgaattgc ctgttcaggg ttccttatgc agagaaataa agcagattca ggaattgga
//
