LOCUS       NM_003922              15197 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens HECT and RLD domain containing E3 ubiquitin protein
            ligase family member 1 (HERC1), mRNA.
ACCESSION   NM_003922
VERSION     NM_003922.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15197)
  AUTHORS   Jankovic,M., Poon,W.W.L., Gonzales-Losada,C., Vazquez,G.G.,
            Sharif-Askari,B., Ding,Y., Craplet-Desombre,C., Ilie,A., Shi,J.,
            Wang,Y., Jayavelu,A.K., Orthwein,A. and Mercier,F.E.
  TITLE     The E3 ubiquitin ligase Herc1 modulates the response to nucleoside
            analogs in acute myeloid leukemia
  JOURNAL   Blood Adv 8 (20), 5315-5329 (2024)
   PUBMED   39093953
  REMARK    GeneRIF: The E3 ubiquitin ligase Herc1 modulates the response to
            nucleoside analogs in acute myeloid leukemia.
REFERENCE   2  (bases 1 to 15197)
  AUTHORS   Cui,Y., Wu,X., Jin,J., Man,W., Li,J., Li,X., Li,Y., Yao,H.,
            Zhong,R., Chen,S., Wu,J., Zhu,T., Lin,Y., Xu,J. and Wang,Y.
  TITLE     CircHERC1 promotes non-small cell lung cancer cell progression by
            sequestering FOXO1 in the cytoplasm and regulating the
            miR-142-3p-HMGB1 axis
  JOURNAL   Mol Cancer 22 (1), 179 (2023)
   PUBMED   37932766
  REMARK    GeneRIF: CircHERC1 promotes non-small cell lung cancer cell
            progression by sequestering FOXO1 in the cytoplasm and regulating
            the miR-142-3p-HMGB1 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 15197)
  AUTHORS   Lalonde,R. and Strazielle,C.
  TITLE     The Herc1 gene in neurobiology
  JOURNAL   Gene 814, 146144 (2022)
   PUBMED   34990797
  REMARK    GeneRIF: The Herc1 gene in neurobiology.
            Review article
REFERENCE   4  (bases 1 to 15197)
  AUTHORS   Zavodszky,E., Peak-Chew,S.Y., Juszkiewicz,S., Narvaez,A.J. and
            Hegde,R.S.
  TITLE     Identification of a quality-control factor that monitors failures
            during proteasome assembly
  JOURNAL   Science 373 (6558), 998-1004 (2021)
   PUBMED   34446601
  REMARK    GeneRIF: Identification of a quality-control factor that monitors
            failures during proteasome assembly.
REFERENCE   5  (bases 1 to 15197)
  AUTHORS   Garcia-Gonzalo,F.R., Munoz,P., Gonzalez,E., Casaroli-Marano,R.P.,
            Vilaro,S., Bartrons,R., Ventura,F. and Rosa,J.L.
  TITLE     The giant protein HERC1 is recruited to aluminum fluoride-induced
            actin-rich surface protrusions in HeLa cells
  JOURNAL   FEBS Lett 559 (1-3), 77-83 (2004)
   PUBMED   14960311
  REMARK    GeneRIF: HERC1 overexpression does not stimulate protrusion
            formation in the absence of AlF(4)(-), in conditions where ARNO
            does, indicating that HERC1 is not acting as an ARF6-GEF, but
            instead its recruitment takes place downstream of ARF6 activation
REFERENCE   6  (bases 1 to 15197)
  AUTHORS   Garcia-Gonzalo,F.R., Cruz,C., Munoz,P., Mazurek,S., Eigenbrodt,E.,
            Ventura,F., Bartrons,R. and Rosa,J.L.
  TITLE     Interaction between HERC1 and M2-type pyruvate kinase
  JOURNAL   FEBS Lett 539 (1-3), 78-84 (2003)
   PUBMED   12650930
  REMARK    GeneRIF: physical interaction between the HECT domain of HERC1, a
            giant protein involved in intracellular membrane traffic, and the
            M2 isoform of glycolytic enzyme pyruvate kinase (M2-PK)
REFERENCE   7  (bases 1 to 15197)
  AUTHORS   Ji,Y., Walkowicz,M.J., Buiting,K., Johnson,D.K., Tarvin,R.E.,
            Rinchik,E.M., Horsthemke,B., Stubbs,L. and Nicholls,R.D.
  TITLE     The ancestral gene for transcribed, low-copy repeats in the
            Prader-Willi/Angelman region encodes a large protein implicated in
            protein trafficking, which is deficient in mice with neuromuscular
            and spermiogenic abnormalities
  JOURNAL   Hum Mol Genet 8 (3), 533-542 (1999)
   PUBMED   9949213
REFERENCE   8  (bases 1 to 15197)
  AUTHORS   Cruz,C., Paladugu,A., Ventura,F., Bartrons,R., Aldaz,C.M. and
            Rosa,J.L.
  TITLE     Assignment of the human P532 gene (HERC1) to chromosome 15q22 by
            fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 86 (1), 68-69 (1999)
   PUBMED   10516438
REFERENCE   9  (bases 1 to 15197)
  AUTHORS   Rosa,J.L. and Barbacid,M.
  TITLE     A giant protein that stimulates guanine nucleotide exchange on ARF1
            and Rab proteins forms a cytosolic ternary complex with clathrin
            and Hsp70
  JOURNAL   Oncogene 15 (1), 1-6 (1997)
   PUBMED   9233772
REFERENCE   10 (bases 1 to 15197)
  AUTHORS   Rosa,J.L., Casaroli-Marano,R.P., Buckler,A.J., Vilaro,S. and
            Barbacid,M.
  TITLE     p619, a giant protein related to the chromosome condensation
            regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and
            Rab proteins
  JOURNAL   EMBO J 15 (16), 4262-4273 (1996)
   PUBMED   8861955
  REMARK    Erratum:[EMBO J 1996 Oct 15;15(20):5738]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB117652.1, U50078.1,
            BQ216911.1 and AK226162.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003922.3.
            
            Summary: This gen encodes a member of the HERC protein family. This
            protein stimulates guanine nucleotide exchange on ARF1 and Rab
            proteins. This protein may be involved in membrane transport
            processes. [provided by RefSeq, Mar 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U50078.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443617.7/ ENSP00000390158.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                DB117652.1         1-60
            61-1416             U50078.1           9-1364
            1417-1519           BQ216911.1         666-768
            1520-2937           U50078.1           1468-2885
            2938-15196          AK226162.1         1-12259
            15197-15197         U50078.1           15145-15145
FEATURES             Location/Qualifiers
     source          1..15197
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..15197
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /note="HECT and RLD domain containing E3 ubiquitin protein
                     ligase family member 1"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
     exon            1..122
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            123..1078
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..14734
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /EC_number="2.3.2.26"
                     /note="guanine nucleotide exchange factor p532; HECT
                     domain and RCC1-like domain-containing protein 1; hect
                     (homologous to the E6-AP (UBE3A) carboxyl terminus) domain
                     and RCC1 (CHC1)-like domain (RLD) 1; HECT-type E3
                     ubiquitin transferase HERC1"
                     /codon_start=1
                     /product="probable E3 ubiquitin-protein ligase HERC1"
                     /protein_id="NP_003913.3"
                     /db_xref="CCDS:CCDS45277.1"
                     /db_xref="GeneID:8925"
                     /db_xref="HGNC:HGNC:4867"
                     /db_xref="MIM:605109"
                     /translation="MATMIPPVKLKWLEHLNSSWITEDSESIATREGVAVLYSKLVSN
                     KEVVPLPQQVLCLKGPQLPDFERESLSSDEQDHYLDALLSSQLALAKMVCSDSPFAGA
                     LRKRLLVLQRVFYALSNKYHDKGKVKQQQHSPESSSGSADVHSVSERPRSSTDALIEM
                     GVRTGLSLLFALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMG
                     LDCLSQVTTFLKGVTIPNSGADTLGRRLASELLLGLAAQRGSLRYLLEWIEMALGASA
                     VVHTMEKGKLLSSQEGMISFDCFMTILMQMRRSLGSSADRSQWREPTRTSDGLCSLYE
                     AALCLFEEVCRMASDYSRTCASPDSIQTGDAPIVSETCEVYVWGSNSSHQLVEGTQEK
                     ILQPKLAPSFSDAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLT
                     FEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPL
                     QGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEV
                     SCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQ
                     SSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSH
                     DNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDR
                     QVVAWHRPYCVDLEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLL
                     SNHLALALAGGVATSILGRQAGPLRNLLFRLMDSTVPDEIQEVVIETLSVGATMLLPP
                     LRERMELLHSLLPQGPDRWESLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADL
                     SSVCTGYGNLSDQPYGTQSCHPDTHLAEILMKTLLRNLGFYTDQAFGELEKNSDKFLL
                     GTSSSENSQPAHLHELLCSLQKQLLAFCHINNISENSSSVALLHKHLQLLLPHATDIY
                     SRSANLLKESPWNGSVGEKLRDVIYVSAAGSMLCQIVNSLLLLPVSVARPLLSYLLDL
                     LPPLDCLNRLLPAADLLEDQELQWPLHGGPELIDPAGLPLPQPAQSWVWLVDLERTIA
                     LLIGRCLGGMLQGSPVSPEEQDTAYWMKTPLFSDGVEMDTPQLDKCMSCLLEVALSGN
                     EEQKPFDYKLRPEIAVYVDLALGCSKEPARSLWISMQDYAVSKDWDSATLSNESLLDT
                     VSRFVLAALLKHTNLLSQACGESRYQPGKHLSEVYRCVYKVRSRLLACKNLELIQTRS
                     SSRDRWISENQDSADVDPQEHSFTRTIDEEAEMEEQAERDREEGHPEPEDEEEEREHE
                     VMTAGKIFQCFLSAREVARSRDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQD
                     VYTAACNSVIHRCALLILGVSPVIDELQKRREEGQLQQPSTSASEGGGLMTRSESLTA
                     ESRLVHTSPNYRLIKSRSESDLSQPESDEEGYALSGRRNVDLDLAASHRKRGPMHSQL
                     ESLSDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVHTLIENVVSFVSGDVGNAPGFK
                     EPEESMSTSPQASIIAMEQQQLRAELRLEALHQILVLLSGMEEKGSISLAGSRLSSGF
                     QSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLHHYQDGIRAAKRNIQIEIQVAVH
                     KIYQQLSATLERALQANKHHIEAQQRLLLVTVFALSVHYQPVDVSLAISTGLLNVLSQ
                     LCGTDTMLGQPLQLLPKTGVSQLSTALKVASTRLLQILAITTGTYADKLSPKVVQSLL
                     DLLCSQLKNLLSQTGVLHMASFGEGEQEDGEEEEKKVDSSGETEKKDFRAALRKQHAA
                     ELHLGDFLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKCSSGIPLVGNLRTRLLAL
                     HVLEAVLPACESGVEDDQMAQIVERLFSLLSDCMWETPIAQAKHAIQIKEKEQEIKLQ
                     KQGELEEEDENLPIQEVSFDPEKAQCCLVENGQILTHGSGGKGYGLASTGVTSGCYQW
                     KFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQTLTLSSFT
                     QGDFITCVLDMEARTISFGKNGEEPKLAFEDVDAAELYPCVMFYSSNPGEKVKICDMQ
                     MRGTPRDLLPGDPICSPVAAVLAEATIQLIRILHRTDRWTYCINKKMMERLHKIKICI
                     KESGQKLKKSRSVQSREENEMREEKESKEEEKGKHTRHGLADLSELQLRTLCIEVWPV
                     LAVIGGVDAGLRVGGRCVHKQTGRHATLLGVVKEGSTSAKVQWDEAEITISFPTFWSP
                     SDTPLYNLEPCEPLPFDVARFRGLTASVLLDLTYLTGVHEDMGKQSTKRHEKKHRHES
                     EEKGDVEQKPESESALDMRTGLTSDDVKSQSTTSSKSENEIASFSLDPTLPSVESQHQ
                     ITEGKRKNHEHMSKNHDVAQSEIRAVQLSYLYLGAMKSLSALLGCSKYAELLLIPKVL
                     AENGHNSDCASSPVVHEDVEMRAALQFLMRHMVKRAVMRSPIKRALGLADLERAQAMI
                     YKLVVHGLLEDQFGGKIKQEIDQQAEESDPAQQAQTPVTTSPSASSTTSFMSSSLEDT
                     TTATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTTVLPTRRAQTPPISSLPTSPS
                     DEVGRRQSLTSPDSQSARPANRTALSDPSSRLSTSPPPPAIAVPLLEMGFSLRQIAKA
                     MEATGARGEADAQNITVLAMWMIEHPGHEDEEEPQSGSTADSRPGAAVLGSGGKSNDP
                     CYLQSPGDIPSADAAEMEEGFSESPDNLDHTENAASGSGPSARGRSAVTRRHKFDLAA
                     RTLLARAAGLYRSVQAHRNQSRREGISLQQDPGALYDFNLDEELEIDLDDEAMEAMFG
                     QDLTSDNDILGMWIPEVLDWPTWHVCESEDREEVVVCELCECSVVSFNQHMKRNHPGC
                     GRSANRQGYRSNGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKG
                     QAPDLIGKQDSVYEEDWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDS
                     DPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRR
                     VTAAAQVLLARTMVMRALSLLSVSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAG
                     LSTSPSAMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNL
                     ISAATGVNLTTVDDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLR
                     PNYDKSEVEKKGPLELANALAACCLSSRLSSQHRQWAAQQLVRTLAAHDRDNQTTLQT
                     LADMGGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQ
                     TCVFNRLEGDAEESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQ
                     PHWVSALAWPEEGPATAWSGESPELLLVGRMDGSLGLIEVVDVSTMHRRELEHCYRKD
                     VSVTCIAWFSEDRPFAVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDPTGHI
                     LMTCAKEDSVKLWGSISGCWCCLHSLCHPSIVNGIAWCRLPGKGSKLQLLMATGCQSG
                     LVCVWRIPQDTTQTNVTSAEGWWEQESNCQDGYRKSSGAKCVYQLRGHITPVRTVAFS
                     SDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGSGAIQTTVWIPEVGVAACSNRSKDVL
                     VVNCTAEWAAANHVLATCRTALKQQGVLGLNMAPCMRAFLERLPMMLQEQYAYEKPHV
                     VCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDPASWNPNEWAWLECF
                     STTIKAAEALTNGAQFPESFTVPDLEPVPEDELVFLMDNSKWINGMDEQIMSWATSRP
                     EDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQAQQVICGQNCTFVIQANG
                     TVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF
                     SWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGD
                     YGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLG
                     LGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARN
                     HNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTL
                     VTGLQGKNVRQISAGRCHSAAWTAPPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSI
                     HTVRARLRLLYHFSDLMYSSWRLLNLSPNNQNSTSHYNAGTWGIVQGQLRPLLAPRVY
                     TLPMVRSIGKTMVQGKNYGPQITVKRISTRGRKCKPIFVQIARQVVKLNASDLRLPSR
                     AWKVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNP
                     SACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQLCCVPLTLEDLEEVDLLYV
                     QTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSIPLTFSNRKEYV
                     ERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVV
                     RYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQRFQIMKVDR
                     PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNYMLSRNVDNAEGSD
                     TDY"
     exon            1079..1174
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1369
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1681
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1778
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1922
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2050
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2195
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2367
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2502
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2668
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2794
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..3016
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3169
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3302
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3494
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..3716
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..3890
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4005
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            4006..4126
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            4127..4298
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            4299..4611
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            4612..4732
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            4733..4784
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            4785..5053
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            5054..5269
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            5270..5390
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            5391..5628
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            5629..5822
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            5823..5978
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            5979..6085
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            6086..6196
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            6197..6373
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            6374..6613
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            6614..6697
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            6698..7218
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            7219..7994
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            7995..8193
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            8194..8354
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            8355..8471
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            8472..8703
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            8704..8828
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            8829..9049
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            9050..9318
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            9319..9371
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            9372..9572
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            9573..9747
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            9748..10018
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            10019..10232
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            10233..10438
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            10439..10566
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            10567..10694
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            10695..10895
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            10896..11026
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            11027..11226
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            11227..11332
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            11333..11479
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            11480..11581
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            11582..11755
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            11756..12049
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            12050..12115
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            12116..12241
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            12242..12380
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            12381..12562
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            12563..12718
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            12719..12841
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            12842..12944
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            12945..13114
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            13115..13253
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            13254..13423
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            13424..13593
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            13594..13759
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            13760..13836
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            13837..14089
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            14090..14242
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            14243..14548
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     exon            14549..15197
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15174..15179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /note="hexamer: AATAAA"
     polyA_site      15197
                     /gene="HERC1"
                     /gene_synonym="MDFPMR; p532; p619"
                     /note="major polyA site"
ORIGIN      
        1 gtctttccct ttgacaagtc gctgctgctg cagcaaaaat aaaggacgcg accgccgcag
       61 cctctgcgga gccgggctcg ggtcgccgga gccgcgcccc accccgccag ctccagagcc
      121 acgactaatg gctgaaggat aaatcaacat ggcaactatg attccaccag tgaagctgaa
      181 atggcttgaa cacttgaaca gctcctggat tacagaggac agtgaatcta ttgctacaag
      241 agagggagtt gctgttctgt attctaaact ggttagcaat aaggaagtag tacctttgcc
      301 ccaacaagtt ttatgcctca aaggaccaca gttgccagac tttgaacgtg agtctctttc
      361 aagtgatgag caggaccact atttggatgc ccttcttagc agccagctag cattggcaaa
      421 gatggtatgt tcagattccc catttgccgg ggcacttaga aaacgactgc ttgtactcca
      481 gcgtgtcttt tatgcacttt ctaataaata ccatgacaaa ggcaaggtga agcagcagca
      541 gcattctccg gagagcagtt ctggttcagc agatgtccat tctgttagtg aacgcccccg
      601 gtcaagcact gatgcactta tagaaatggg tgttcgaact ggtctaagtt tattatttgc
      661 gcttctaaga caaagttgga tgatgcctgt gtcaggacct ggtctcagtc tttgcaacga
      721 tgtcattcat actgcaattg aagttgtgag ctctttgcca ccattatcat tagcaaatga
      781 aagcaagatt cctcctatgg gcttggactg cttatcgcaa gtaacaacat ttcttaaagg
      841 agtcactatt cctaattctg gggcagacac tttaggtcgt agattagctt ctgagttgct
      901 gcttggtttg gcagctcaac gaggctcatt gcgatatctt cttgaatgga tagaaatggc
      961 tttgggggct tcggcagttg tacacaccat ggagaaaggc aaactactct caagccagga
     1021 aggaatgatc agctttgact gctttatgac catattaatg cagatgaggc gttctttggg
     1081 ttcatctgct gatcggagtc agtggagaga accaaccaga acatcggatg gcttgtgctc
     1141 cctttacgag gcagcattat gtctctttga agaggtttgc agaatggctt ctgattattc
     1201 gagaacatgt gctagcccag atagcattca gactggtgat gctcccattg tctccgaaac
     1261 ctgtgaggtt tatgtttggg ggagcaatag cagccatcag ttggtagaag gtacacagga
     1321 gaaaatactg caacccaaac tggctcctag tttctctgat gcacagacca ttgaagctgg
     1381 acagtactgc acttttgtca tttctacgga tggctctgtt agagcttgcg ggaaaggcag
     1441 ctatgggaga ctgggccttg gagactccaa taatcagtca actttaaaaa agttaacatt
     1501 cgagcctcac agatccatta aaaaggtttc atcttctaaa ggatctgatg gtcacacttt
     1561 agcctttacg acagaaggag aagtcttcag ttggggagat ggtgattatg ggaaactggg
     1621 gcatggaaat agttcaacac agaaatatcc caagcttatt cagggacctc tacaaggaaa
     1681 ggtagttgtt tgtgtgtcag ctggatacag acatagtgct gctgtcacag aggatgggga
     1741 attatacaca tggggtgaag gagactttgg aagattaggt catggtgaca gcaatagtcg
     1801 taacattcca acattagtaa aagacatcag caatgtagga gaggtttctt gtggcagttc
     1861 acatactatt gctctgtcta aagatgggag aactgtatgg tcttttggag gaggagacaa
     1921 tggtaaactt ggtcatggtg ataccaacag agtgtataaa cctaaagtta ttgaagcttt
     1981 acaaggaatg ttcattcgca aagtttgtgc tgggagccag tcttcacttg ctttgacatc
     2041 aacagggcag gtctatgctt ggggctgtgg agcttgtcta ggttgtggtt cttcagaagc
     2101 tactgctttg agacccaagc ttattgaaga actggctgcc acaagaatag ttgatgtttc
     2161 tattggagac agtcattgtt tggctctttc tcatgataat gaagtttatg cctggggcaa
     2221 taactcaatg gggcaatgtg gtcagggaaa ttccacaggt cctattacta aaccaaagaa
     2281 agtgagtggc ttagatggca tagctattca gcagatttcg gctggaacat cacatagtct
     2341 ggcatggact gctcttccta gggacagaca agttgttgca tggcaccgac cttattgtgt
     2401 agatcttgaa gagagtacct tctcacacct gcgttctttt cttgagagat actgtgataa
     2461 aataaacagt gagattcccc cactcccttt cccttcatca agagaacacc acagttttct
     2521 caagctgtgc ctgaagctac tttcaaatca ccttgctctt gcacttgcgg gaggggtagc
     2581 taccagcatt ctcgggaggc aggcaggtcc acttcgaaat ttgctcttca gactgatgga
     2641 ctcaactgtc ccagatgaaa tccaagaggt ggtaattgaa actttatcag tgggagcaac
     2701 catgctgtta cctccattac gagaacggat ggaattactt cattctcttt tacctcaagg
     2761 acctgataga tgggaaagct tatctaaagg acagagaatg caactggata tcatcctgac
     2821 aagtttgcaa gatcataccc acgtagcctc cctacttggc tatagttcac cctctgatgc
     2881 tgctgaccta tcttctgtgt gtactggcta cggaaatctg tcagatcaac cttacggcac
     2941 tcagagctgc catccagata cccacctggc tgaaattttg atgaagaccc tcttaagaaa
     3001 tttaggattt tatacagatc aagcatttgg agagctagaa aagaatagtg ataaatttct
     3061 acttggaaca tcatcatcag aaaacagtca gcctgctcat cttcatgaac tgctatgttc
     3121 actacagaaa cagctgctgg cattttgcca tatcaataac attagtgaga actcaagcag
     3181 tgtggcattg cttcataaac atcttcagct tttgttgcct catgccacag atatttattc
     3241 acgttctgca aatttgctca aagaaagtcc ttggaatggc agtgttggag aaaaattaag
     3301 agatgtgata tacgtctcag ctgctggcag tatgctctgc cagattgtta actccctgct
     3361 gttactccct gtgtcagtgg ctcggccttt attgagttac ctcctcgact tgttgccacc
     3421 tcttgattgc cttaatagac tcctgccagc tgctgatctt ttagaagacc aggagttaca
     3481 gtggcctctt catggagggc cagaactaat tgatcctgct ggtctgccat tacctcagcc
     3541 agctcagtcc tgggtatggc ttgtggatct agaaagaaca attgctctcc ttattgggcg
     3601 gtgtcttggt ggcatgcttc agggctcccc tgtgtctcca gaggaacagg acactgcata
     3661 ttggatgaaa acgccactgt tcagtgacgg tgtagaaatg gacactcctc aattggataa
     3721 atgtatgagt tgcctgttag aagtagcact ttctggaaat gaagaacaga agccttttga
     3781 ttataaattg cggcctgaaa ttgctgtcta tgtagacttg gcattgggtt gttctaaaga
     3841 gcctgcccga agcctttgga tcagcatgca ggactatgct gttagtaaag attgggacag
     3901 tgcaacttta agtaatgagt cactcttgga cactgtgtct agatttgttc ttgcagctct
     3961 tctgaaacac acaaatttac ttagtcaagc atgtggagaa agccgatatc aacctggtaa
     4021 acacttatca gaagtgtacc gttgtgtata caaagttcga agtcgtttac ttgcttgcaa
     4081 gaaccttgaa cttattcaaa caaggtcatc atcacgggac agatggatat cagaaaacca
     4141 ggactctgca gatgttgatc ctcaggagca ttcatttact cgaactattg atgaagaagc
     4201 tgaaatggaa gaacaggctg agagagaccg ggaagagggg catccggagc cagaggatga
     4261 agaggaggaa cgggaacatg aagtgatgac agctggcaaa atctttcagt gtttcctctc
     4321 agcccgtgaa gtagctcgta gccgagaccg agatagaatg aacagtgggg cagggtctgg
     4381 ggctcgagct gatgatccac ctcctcagtc tcagcaagag cgaagggtca gcacagacct
     4441 tcctgagggt caggatgtgt acactgctgc atgcaactcc gtgatccatc ggtgtgccct
     4501 gttaatatta ggagtaagtc ctgtgataga tgagcttcag aagcgaagag aagaaggaca
     4561 gttgcagcaa ccttcaacaa gtgcctctga agggggtgga cttatgacca ggagtgaaag
     4621 tcttactgca gagagccggc tagtccacac aagcccaaat tatagactga tcaaatcgag
     4681 gagtgaatct gatttgtctc agcctgaatc agatgaagag ggttacgcac tgagtggcag
     4741 acgaaatgtt gatttggatt tggcagcatc tcacagaaag agaggtccta tgcacagtca
     4801 attggaatcc ctgagtgact cttgggctcg cctgaaacat agcagagact ggttatgcaa
     4861 ctcctcctat tcctttgagt cagattttga tcttaccaag tctttgggag ttcacacttt
     4921 gattgaaaat gttgtaagct ttgtgagtgg agatgtgggg aatgccccag gttttaaaga
     4981 gccagaggaa agtatgtcta caagtcccca ggcctccatc attgcaatgg aacagcagca
     5041 gttaagggca gaacttcgtt tagaggcact tcatcagatc ctcgttctat tgtctgggat
     5101 ggaagaaaaa ggtagcatct cactggcagg aagcagattg agttcaggct tccagtcctc
     5161 cacactactc acgtctgtga ggctgcagtt cctagcaggg tgttttggtt taggcactgt
     5221 tggacacaca ggaggcaagg gagagagtgg ccgattgcat cactatcagg atgggatcag
     5281 agcagctaag agaaatattc agattgaaat ccaggtagct gtgcataaaa tttatcaaca
     5341 gttgtctgct accctggaaa gagccctgca agcaaacaag catcacattg aagcccagca
     5401 acgtctgctt ctggttacag tttttgccct aagtgttcat tatcaaccag tagatgtttc
     5461 tttggcaatt tccactggtc tgctaaacgt attgtcacag ttgtgtggta cagacaccat
     5521 gctaggacag cccctgcagt tgttgccaaa gacgggtgtt tcccagctta gcacagcttt
     5581 gaaagtggcc agtacaaggt tgctccagat tctagccatc actactggga cctatgctga
     5641 taaactgagt cccaaagtag ttcaatcctt gttggatcta ctctgtagtc agttgaagaa
     5701 tttattgtcc caaactggtg tactacatat ggcctctttc ggagaagggg agcaagaaga
     5761 cggtgaagaa gaagaaaaaa aagttgactc cagtggagaa actgagaaga aagatttcag
     5821 agctgctctt aggaaacaac atgcagccga actccatcta ggggattttt tagtttttct
     5881 tcgcagagtt gtatcttcaa aagcaattca atcaaaaatg gcttccccaa agtggaccga
     5941 agtgcttcta aatatagcat ctcagaaatg ttcttcaggt atccctctgg ttggtaactt
     6001 aagaacaagg ctccttgcac ttcatgtcct tgaagctgtg ctgccagctt gtgaatctgg
     6061 tgtagaagat gatcaaatgg cccagattgt tgagcgctta ttttcccttc tctctgattg
     6121 tatgtgggag acacccattg ctcaggccaa acatgctatt cagataaagg aaaaagaaca
     6181 agaaataaaa ctacagaagc agggcgagtt ggaagaagaa gatgagaatc ttcctatcca
     6241 agaagtatcc tttgacccgg agaaagctca gtgttgccta gtggagaatg gacagatttt
     6301 aactcacggc agtggaggga aaggatatgg attggcatct acaggagtaa cttctgggtg
     6361 ctatcagtgg aagttttata ttgtgaagga aaacagaggt aatgaaggca cgtgtgttgg
     6421 agtttctcgc tggccagtac atgactttaa tcaccgcact acctcggata tgtggctcta
     6481 tagggcctac agtggtaacc tctatcacaa tggagaacag actctcacat tgtccagctt
     6541 tactcaagga gatttcatta cctgtgtgtt agacatggaa gccaggacca tttcttttgg
     6601 gaaaaatgga gaggaaccca aattagcttt tgaagatgtg gatgcagcag agttgtaccc
     6661 atgtgtgatg ttctatagta gcaatccagg ggaaaaggtg aaaatttgtg atatgcagat
     6721 gcgtggcaca ccccgagact tacttccagg agaccctatt tgtagtccag tagcagcagt
     6781 gctggctgag gccactattc agctcatccg tatccttcac cgaacagacc gttggactta
     6841 ctgcattaac aaaaaaatga tggaaaggct tcacaaaatt aagatatgta ttaaagagtc
     6901 aggtcagaag ctaaagaaaa gccgctcggt tcagagccga gaggaaaatg aaatgagaga
     6961 ggagaaggag agcaaagagg aagagaaagg taaacatact aggcatggcc tcgctgacct
     7021 ctcagagctg cagctgagga ctctttgcat agaggtgtgg cccgtgctgg ctgtgatagg
     7081 aggagttgat gctggtctta gagttggagg tcggtgtgtt cacaagcaaa ctgggcgcca
     7141 tgccacgctg ctgggagtgg tcaaagaggg cagcacgtct gccaaggtcc aatgggatga
     7201 agcagaaatt actatcagct tcccaacttt ttggtcgcct agtgatactc cattgtataa
     7261 tctggaaccc tgtgaaccat tgccgtttga tgtggcgcga ttccgaggcc tgacggcttc
     7321 tgtgctgctg gacctaacat atctcactgg cgttcatgaa gacatgggca aacagagcac
     7381 caaacgacat gaaaagaaac accgacatga atccgaggag aaaggggatg ttgagcagaa
     7441 acctgagagt gaatccgctt tagatatgcg aacaggccta acatctgatg acgtcaaaag
     7501 tcagagtacc acaagctcca aatcagaaaa tgaaatcgct tcattttctt tagatccaac
     7561 actgccaagt gtggaatccc aacatcaaat aacagaaggg aaaagaaaaa atcatgaaca
     7621 catgtccaaa aaccatgatg tagcccagtc agaaatcaga gcagtccagc tgtcctatct
     7681 ttacctcggt gctatgaagt cacttagtgc ccttcttggc tgtagtaaat atgctgagct
     7741 gttgctgata ccaaaagttc tggctgaaaa tggccacaac tcagactgtg caagttctcc
     7801 agttgttcat gaagacgtgg agatgcgagc agccctgcag ttcttgatgc gacacatggt
     7861 gaagcgagca gtcatgcggt cacccataaa gagagcattg ggattagctg atctggaacg
     7921 agcgcaagcc atgatctata aattagtggt tcatgggctt ttggaagacc agtttggggg
     7981 caaaattaag caagagattg atcaacaagc tgaagaaagt gaccctgccc agcaggcaca
     8041 gacaccagtt actactagcc catcagcctc aagcacgacc tcctttatga gcagctctct
     8101 ggaggacacc acaactgcca ccactccagt cactgacaca gaaacagtgc ctgcatccga
     8161 gtccccggga gtgatgcctc ttagtcttct caggcaaatg ttctctagtt acccaactac
     8221 cactgtactt cccacacgtc gggcacagac tcctccaata tcttcgttac caacctctcc
     8281 ttctgatgaa gtaggaagga ggcaaagttt aacttctcct gattcccagt cagcaaggcc
     8341 agctaaccgc acagccttgt cagacccaag cagtagactt tcaacttctc ctcctcctcc
     8401 agcaattgca gttcccttgc tggaaatggg gttctctctt cggcagattg ccaaagccat
     8461 ggaagctaca ggtgctaggg gagaggctga tgcccagaat atcactgtcc ttgccatgtg
     8521 gatgatagag caccctgggc atgaggatga agaggagccc cagtcgggca gcacagcaga
     8581 ctctaggcct ggagcagccg ttctaggcag tggcgggaag tcaaatgatc cctgttattt
     8641 gcagtcacct ggagacatac catcagctga tgctgctgaa atggaggaag gttttagtga
     8701 aagccctgat aatttggatc atacagagaa tgcagcttct ggaagtggac catcagctag
     8761 aggtcgctca gcggtaacaa gaagacacaa gtttgactta gctgctcgca cactgctagc
     8821 aagagcagcg ggattatacc gctctgtgca ggcccacagg aatcaaagtc ggagagaagg
     8881 aatatctttg cagcaagacc caggggcgtt gtatgacttt aatttagatg aggaattgga
     8941 aattgatctt gatgatgagg cgatggaagc tatgtttgga caagacctga ccagtgacaa
     9001 tgatattctg ggaatgtgga tcccagaggt actggattgg cctacctggc atgtttgtga
     9061 gtctgaagac agggaagaag tggtggtgtg tgaactgtgt gaatgcagcg tcgtcagctt
     9121 caatcagcac atgaagagaa accatccagg ctgtgggcgc agtgcaaacc gccagggcta
     9181 tcgcagcaat ggttcctatg tggatggctg gtttggcggt gaatgtggga gtggaaatcc
     9241 gtactacctg ttatgtggca cctgcaggga gaagtactta gccatgaaga ccaaatctaa
     9301 gtcaacaagt tctgaaaggt acaagggaca agctccagat ctaattggca agcaagacag
     9361 tgtgtatgaa gaagactggg acatgttgga tgttgatgaa gatgaaaagc taactggtga
     9421 agaagaattt gaattacttg ctggaccgct tggtttaaat gaccggcgca ttgtaccaga
     9481 accagttcag ttccctgaca gcgatccact gggagcatca gtagcaatgg tcacagccac
     9541 caacagtatg gaagagactc tgatgcaaat aggttgccat ggctccgtag aaaagagctc
     9601 ctctgggaga ataacgttag gagagcaggc agctgcccta gcaaaccctc atgaccgtgt
     9661 ggtggcttta aggagagtga ctgctgctgc tcaggttctt ctggccagaa ccatggtcat
     9721 gagagcgctg tctcttctct cagtcagtgg ttccagttgt agcctggctg ctggtcttga
     9781 gtctctgggg ctaacagata tccgaacgct agttcgatta atgtgcttgg cagcagcagg
     9841 gagagctggc ctctccacca gcccttctgc catggctagc acctcagaac gatcacgagg
     9901 tgggcatagc aaggctaaca agcctatctc ttgcctggcc tatttgagca cagcagtggg
     9961 atgtctggca tcaaatgctc ctagtgctgc caaactgctt gtacagttgt gtacacagaa
    10021 cttgatttct gctgcaacag gtgtaaatct aaccacagtt gatgactcaa ttcagcgaaa
    10081 gtttctaccc agctttctcc gaggaattgc tgaagagaac aagcttgtga cctccccaaa
    10141 ctttgttgta acacaggccc ttgtggcatt gctagcagac aaaggggcca aactaagacc
    10201 taactatgat aagtcagaag ttgaaaagaa aggccctctg gagttggcta atgccctggc
    10261 agcctgctgc ctctcctcca ggctgtcctc acagcatcgg caatgggcag ctcagcaact
    10321 cgtgcgcact cttgctgcac acgaccgtga caaccaaact actctgcaga cacttgctga
    10381 tatgggagga gatcttagaa aatgctcctt tatcaaattg gaggctcatc agaacagagt
    10441 aatgacatgt gtttggtgta ataaaaaagg tcttttggct acaagtggca atgatggcac
    10501 catccgcgta tggaatgtta ccaagaagca atattcactg caacagacct gtgtgttcaa
    10561 cagattggaa ggggatgctg aggaaagcct gggatcaccc agtgatccaa gtttctcacc
    10621 agtttcctgg agtatcagtg gcaaatatct agcaggcgct ttggaaaaga tggtgaatat
    10681 ctggcaagtt aatggaggaa aaggattagt agatattcag cctcattggg tatctgccct
    10741 ggcttggcca gaagagggtc cggctacagc ctggtcagga gagtctccag aattgttgtt
    10801 ggtgggacgg atggatggat ctctgggact gattgaagtt gttgatgtgt ccaccatgca
    10861 ccgtcgagaa ttggagcatt gctatcgaaa ggatgtgtct gttacttgca ttgcatggtt
    10921 cagtgaagac agaccatttg cagtgggata ttttgatgga aaactgttac tgggaacaaa
    10981 ggaaccactt gagaaaggag gcattgttct aattgatgca cataaggata ctcttattag
    11041 catgaagtgg gaccctacag gtcatattct tatgacatgt gccaaagaag acagtgtgaa
    11101 actctggggc tctatttcgg gatgctggtg ctgtctacat tcactctgcc atccatctat
    11161 tgtaaatggc attgcttggt gccgccttcc agggaaagga tccaagttgc agttactgat
    11221 ggctactggc tgtcagagtg gcttagtatg tgtttggcgc attcctcaag atactacaca
    11281 gaccaatgtg actagtgcag aaggatggtg ggagcaggaa tcaaattgcc aggatggata
    11341 taggaaatca tcaggagcca agtgtgttta tcagctgcgg ggacacatca ctcctgttcg
    11401 gactgttgcc tttagttctg atgggttggc cctggtgtct ggtggactag gtgggctcat
    11461 gaacatttgg tctttaaggg atggctctgt cttgcaaact gttgtgatag gctctggagc
    11521 tattcagacc acagtatgga ttccagaagt tggagtagct gcttgctcaa atagatcaaa
    11581 ggatgttttg gtcgtgaatt gtacagcaga atgggcagct gccaatcatg ttttggcaac
    11641 ctgtaggaca gcattgaaac agcagggtgt tctgggattg aacatggctc cctgcatgag
    11701 agcatttttg gagcggctcc ccatgatgct tcaggagcag tatgcctatg aaaagcctca
    11761 tgtggtttgt ggtgaccaac ttgttcatag cccctatatg caatgcttgg cttcccttgc
    11821 tgtgggactt catctggatc agctgttgtg taaccctcca gtgccaccac accaccagaa
    11881 ctgtctccct gaccctgcat cctggaatcc aaatgaatgg gcctggttag aatgtttctc
    11941 aaccactata aaagctgccg aagccctgac caatggagcc cagtttccag aatcttttac
    12001 cgttccagat ctagaacctg ttccagagga tgaacttgta tttctaatgg ataacagtaa
    12061 atggattaac ggcatggatg aacaaattat gtcttgggca acttccagac ctgaggactg
    12121 gcacctggga ggtaaatgtg atgtctactt atggggtgct ggtaggcatg gacagctggc
    12181 agaagctgga agaaatgtaa tggtacctgc agcagctccc tcattctcac aggcccaaca
    12241 ggtcatttgt ggtcagaatt gtacctttgt catccaggcc aatggcacag tgttggcttg
    12301 tggggaagga agttatggca gattaggaca aggaaattca gatgaccttc atgtgctgac
    12361 agttatttca gccttacaag gctttgtggt gacccagctg gtgacttcct gtggttctga
    12421 tgggcactct atggccctaa ctgaaagtgg tgaggtcttt agctggggag atggtgacta
    12481 tggtaaactt ggccatggga acagcgacag gcagcggcgg cccaggcaga tcgaggcctt
    12541 acaaggagaa gaagtggtgc agatgtcttg tggcttcaag cactcagcag tggtcacttc
    12601 agatggcaaa ctgttcacct ttgggaatgg tgactatggt cgtctgggtc ttggaaatac
    12661 ctctaacaaa aaacttccag agagagtgac tgcactggag ggatatcaga ttggacaggt
    12721 ggcctgtgga ttaaaccaca ctttggcagt gtcagcagat ggttccatgg tgtgggcttt
    12781 tggagatgga gactatggaa aactaggctt aggaaattcc actgcaaaat cttcacctca
    12841 gaaaattgac gtcctttgtg gaattggaat aaaaaaggtt gcttgtggaa ctcagttttc
    12901 tgttgctttg accaaagatg gtcatgtgta tacctttggt caagatcgcc tgataggctt
    12961 gccagagggg cgtgctcgca atcacaatcg accgcaacaa atccctgtcc tggctggagt
    13021 aatcatagaa gatgtggcag ttggagctga acacacactt gctttggcat caaatggaga
    13081 tgtgtatgcc tgggggagca attcagaagg gcagctcggc ttaggccata ccaaccatgt
    13141 tcgagaacca accctggtaa caggtctgca agggaaaaat gttcggcaga tctcggctgg
    13201 ccgctgccac agtgctgcat ggacagcacc acctgtccca ccaagagcac caggtgtgtc
    13261 agtacctctg cagctgggcc tgcctgacac agtgcccccc cagtatgggg cgctgagaga
    13321 agtcagcatt cacacggtgc gggccaggct ccggctgctc taccacttct ctgacctcat
    13381 gtactcatcc tggagactgc tgaaccttag ccccaacaac cagaacagca catcccatta
    13441 taatgctgga acttggggca ttgtacaggg acaacttcgg cctttgttag ccccaagagt
    13501 ctacactctg ccaatggtgc gctccatagg aaaaaccatg gttcaaggca aaaactatgg
    13561 acctcagata actgtaaaga ggatatcaac cagaggacgg aagtgtaagc ctatttttgt
    13621 ccaaatagcg agacaagtag ttaagctgaa tgcttcagac ctccgcctgc cttcccgagc
    13681 gtggaaggtt aagctggttg gagaaggggc tgatgatgct ggaggagtgt ttgatgacac
    13741 catcacagag atgtgccagg aacttgaaac tggtattgtt gaccttctta taccctctcc
    13801 caatgccacc gcagaagtgg gttacaatag ggacaggttc ctttttaacc cttctgcctg
    13861 cctcgatgaa cacttaatgc agtttaagtt tttaggaatt ttaatggggg ttgccattcg
    13921 cacaaagaag cctctggacc tccacttggc ccctctggtg tggaagcagc tgtgctgtgt
    13981 cccactcacc ctagaggacc tggaggaggt ggatctgctc tacgtgcaga ctctcaacag
    14041 cattcttcac attgaagaca gtgggattac cgaggagagt ttccatgaga tgattcctct
    14101 tgattctttt gttggccaga gtgctgatgg caaaatggtt cctataatcc ctggtggaaa
    14161 tagtatccca ctcacatttt ccaacaggaa ggaatatgtg gagagggcca ttgaatatcg
    14221 acttcatgag atggacagac aggtggctgc agtccgagaa gggatgtcct ggattgttcc
    14281 tgtgccgctg ctgtccctcc tcacagcaaa acaactggag cagatggtgt gtgggatgcc
    14341 cgagatctct gtggaagtct tgaagaaagt ggtgcggtac cgtgaggtgg atgagcagca
    14401 tcagctggtg cagtggttct ggcacacgct ggaagagttc tccaatgagg agcgggtgct
    14461 tttcatgagg tttgtgtcag gaagatctcg actaccagcc aacactgctg acatttctca
    14521 gagatttcaa atcatgaagg ttgataggcc ttacgacagt ctgcctacct cacagacctg
    14581 cttcttccag ctgaggctgc ccccgtactc cagccagctg gtcatggccg agcgcctgcg
    14641 ctatgccatc aacaactgcc gctcaatcga catggacaac tacatgctct cgagaaacgt
    14701 ggacaacgcc gagggctccg acactgacta ctgaccgtgc gggtgctctc accctccctt
    14761 ctctccctca ataatgctca cttctgattt gatgttgata tacttttatg gtaactacat
    14821 agatgttata agaacataaa ccaacattat aaacaatggc cacatttagt tactctaaat
    14881 gtaacaaaga aattagatgt ttttattttt ctgtgattgt acaaaaacaa caaaaacgaa
    14941 gtgctctcag tcaggttttt ccctccatat ttttggtcac ttttgataag tttgcatgaa
    15001 accattttgg tgcattttta gttgggaatg gtacattttt gtaaatccac ccagtgaaca
    15061 tgaaattgta cattgtgtat aattgttcat tagaaaggac agttttacat gaatattcat
    15121 atatttattt tgttttaatt tgaattgcct gttcagggtt ccttatgcag agaaataaag
    15181 cagattcagg aattgga
//
