LOCUS       NM_001037558            1428 bp    mRNA    linear   PRI 25-SEP-2023
DEFINITION  Homo sapiens hepatocellular carcinoma, down-regulated 1 (HEPN1),
            mRNA.
ACCESSION   NM_001037558
VERSION     NM_001037558.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1428)
  AUTHORS   Hu S, Tao R, Wang S, Wang C, Zhao X, Zhao H, Li L, Zhu S, He Y,
            Jiang X and Gao Y.
  TITLE     MicroRNA-21 promotes cell proliferation in human hepatocellular
            carcinoma partly by targeting HEPN1
  JOURNAL   Tumour Biol 36 (7), 5467-5472 (2015)
   PUBMED   25687183
  REMARK    GeneRIF: the current study suggested an underlying mechanism that
            miR-21 directly target HEPN1 and inhibit its expression during the
            carcinogenesis of HCC. HEPN1 may thus be a candidate as a
            therapeutic target for patients with HCC.
REFERENCE   2  (bases 1 to 1428)
  AUTHORS   Kim HS and Jung G.
  TITLE     Reactive oxygen species increase HEPN1 expression via activation of
            the XBP1 transcription factor
  JOURNAL   FEBS Lett 588 (23), 4413-4421 (2014)
   PUBMED   25448679
  REMARK    GeneRIF: ROS increase production of an alternately spliced form of
            X-box binding protein 1 (XBP1s) and XBP1s increases HEPN1
            expression by binding to the HEPN1 promoter
REFERENCE   3  (bases 1 to 1428)
  AUTHORS   Moh MC, Zhang C, Luo C, Lee LH and Shen S.
  TITLE     Structural and functional analyses of a novel ig-like cell adhesion
            molecule, hepaCAM, in the human breast carcinoma MCF7 cells
  JOURNAL   J Biol Chem 280 (29), 27366-27374 (2005)
   PUBMED   15917256
REFERENCE   4  (bases 1 to 1428)
  AUTHORS   Chung Moh M, Hoon Lee L and Shen S.
  TITLE     Cloning and characterization of hepaCAM, a novel Ig-like cell
            adhesion molecule suppressed in human hepatocellular carcinoma
  JOURNAL   J Hepatol 42 (6), 833-841 (2005)
   PUBMED   15885354
REFERENCE   5  (bases 1 to 1428)
  AUTHORS   Moh MC, Lee LH, Yang X and Shen S.
  TITLE     HEPN1, a novel gene that is frequently down-regulated in
            hepatocellular carcinoma, suppresses cell growth and induces
            apoptosis in HepG2 cells
  JOURNAL   J Hepatol 39 (4), 580-586 (2003)
   PUBMED   12971969
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003501.2.
            
            On May 13, 2022 this sequence version replaced NM_001037558.3.
            
            Summary: This gene is expressed predominantly in the liver.
            Transient transfection studies show the expression of this gene
            significantly inhibits cell growth, suggesting a role for this gene
            in apoptosis. Expression of this gene is down-regulated or lost in
            hepatocellular carcinomas (HCC), suggesting that loss of this gene
            is involved in carcinogenesis of hepatocytes (PMID:12971969). This
            gene maps to the 3'-noncoding region of the HEPACAM gene
            (GeneID:220296) on the antisense strand. [provided by RefSeq, Aug
            2020].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY275431.1, SRR14038191.1832721.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408930.7/ ENSP00000386143.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1428              AP003501.2         54330-55757
FEATURES             Location/Qualifiers
     source          1..1428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..1428
                     /gene="HEPN1"
                     /note="hepatocellular carcinoma, down-regulated 1"
                     /db_xref="GeneID:641654"
                     /db_xref="HGNC:HGNC:34400"
                     /db_xref="MIM:611641"
     exon            1..1428
                     /gene="HEPN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             502..768
                     /gene="HEPN1"
                     /note="HEPACAM opposite strand 1; cancer susceptibility
                     gene HEPN1"
                     /codon_start=1
                     /product="putative cancer susceptibility gene HEPN1
                     protein"
                     /protein_id="NP_001032647.2"
                     /db_xref="GeneID:641654"
                     /db_xref="HGNC:HGNC:34400"
                     /db_xref="MIM:611641"
                     /translation="MGNWGLGIAPWVDGESELEFRRLGMQGPLEALRRREWNTQRASF
                     SFSFLIALSPHTVDYCHSYELFNRRWHGHVLATQRPSLFILMLV"
ORIGIN      
        1 ttcatcaaaa gtttattgag catccagtat gtgctaggca ctctgctgga tgctagtaat
       61 acaaagatga agatgaaaac aacacaaaaa caaaccccac ttccttactt acccctcccc
      121 acccccaatt taaggcagat ttggcttaag cctggcaagc tggcccctca gggattcagc
      181 accagggtat ggcatgttct catctcaccc taaccttcac ctgtgcatct caaggctgac
      241 cagcaggtac tccttatcca agtcctgctg cctcttccac cttcttgaga aacttttccc
      301 ctacatgcat tatctcatta tggatgaggc acctgggaag tttaggggag ctgcgaaggc
      361 acacctgctc aaatgagcct ggggaagtgc cgagggacag ggagctgaga caggcatgct
      421 gtggggttca gggcagaggg ggcaaactag aaatgtcagt gcctttgggg ctgagacaaa
      481 acttgacctg gtgtggaggt gatgggtaac tggggccttg gaattgctcc atgggttgat
      541 ggcgaatcag agctggagtt taggagacta gggatgcaag gacccttgga ggcattaagg
      601 aggagggaat ggaatacaca gagggcctcc ttctctttca gctttttaat tgccctctct
      661 cctcacacag tagattactg ccactcctat gaactgttca ataggcggtg gcatgggcat
      721 gtcctggcta cacagcggcc cagcctcttt attttgatgt tagtgtgatt agggagtctg
      781 ccctttttct gtgccctggg acctgagcat gtgggagcag ggcagatggg tggcaggagg
      841 ccaggggttg gatcatgttc cccccaaatg ctgggaagca ataagcctcc tcctcccccc
      901 accatttctc tggagattag gacttattct cacagctgga ggaagctcaa caactttcct
      961 gaggacaatg attgtttgaa aggcttgttt tgtaaggaag ccaggaggaa tatatgagtt
     1021 tgatgagcta aaacagttcc tcatttggtc tagttttcgg gccaggggag taagtgaaat
     1081 tcacttctct ataagaataa gcccatccat ctcttttatt catgaacaga gacagaaaga
     1141 gtgcttggca tggcatgcct ccgagggagg ctgtgggagg aggccaagct ggcaggctcg
     1201 ggttctttgc ccttgctagc gcccaggtca gagggaaaag gaatgtactc gtacccttcc
     1261 ctcaccacct tgtaggtccc caggtaccag gtgcccaggg aagaaggcct tcacaatgat
     1321 ccccccagct cagaacagcc cctgcacacc cagtaaccgg catctggctt ctccttagct
     1381 tagtgcagct gtggattctg ggaaagtggc ctctctaatc tgaacttg
//
