LOCUS       NM_197978               2084 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens hemogen (HEMGN), transcript variant 1, mRNA.
ACCESSION   NM_197978
VERSION     NM_197978.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2084)
  AUTHORS   Jiang,Y., Yu,L., Hu,Q., Kang,Y., You,J., Huang,C., Xu,X. and
            Chen,L.
  TITLE     Cancer/testis antigen HEMGN correlated with immune infiltration
            serves as a prognostic biomarker in lung adenocarcinoma
  JOURNAL   Mol Immunol 153, 226-237 (2023)
   PUBMED   36563642
  REMARK    GeneRIF: Cancer/testis antigen HEMGN correlated with immune
            infiltration serves as a prognostic biomarker in lung
            adenocarcinoma.
REFERENCE   2  (bases 1 to 2084)
  AUTHORS   Wu,Z., Wen,Y., Fan,G., He,H., Zhou,S. and Chen,L.
  TITLE     HEMGN and SLC2A1 might be potential diagnostic biomarkers of
            steroid-induced osteonecrosis of femoral head: study based on WGCNA
            and DEGs screening
  JOURNAL   BMC Musculoskelet Disord 22 (1), 85 (2021)
   PUBMED   33451334
  REMARK    GeneRIF: HEMGN and SLC2A1 might be potential diagnostic biomarkers
            of steroid-induced osteonecrosis of femoral head: study based on
            WGCNA and DEGs screening.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2084)
  AUTHORS   Li,Z., Huang,X., Liu,A., Xu,J., Lai,J., Guan,H. and Ma,J.
  TITLE     Circ_PSD3 promotes the progression of papillary thyroid carcinoma
            via the miR-637/HEMGN axis
  JOURNAL   Life Sci 264, 118622 (2021)
   PUBMED   33203523
  REMARK    GeneRIF: Circ_PSD3 promotes the progression of papillary thyroid
            carcinoma via the miR-637/HEMGN axis.
REFERENCE   4  (bases 1 to 2084)
  AUTHORS   Dong,X.M., Zhao,K., Zheng,W.W., Xu,C.W., Zhang,M.J., Yin,R.H.,
            Gao,R., Tang,L.J., Liu,J.F., Chen,H., Zhan,Y.Q., Yu,M., Ge,C.H.,
            Gao,H.Y., Li,X., Luo,T., Ning,H.M., Yang,X.M. and Li,C.Y.
  TITLE     EDAG mediates Hsp70 nuclear localization in erythroblasts and
            rescues dyserythropoiesis in myelodysplastic syndrome
  JOURNAL   FASEB J 34 (6), 8416-8427 (2020)
   PUBMED   32350948
  REMARK    GeneRIF: EDAG mediates Hsp70 nuclear localization in erythroblasts
            and rescues dyserythropoiesis in myelodysplastic syndrome.
REFERENCE   5  (bases 1 to 2084)
  AUTHORS   Zhao,K., Zheng,W.W., Dong,X.M., Yin,R.H., Gao,R., Li,X., Liu,J.F.,
            Zhan,Y.Q., Yu,M., Chen,H., Ge,C.H., Ning,H.M., Yang,X.M. and
            Li,C.Y.
  TITLE     EDAG promotes the expansion and survival of human CD34+ cells
  JOURNAL   PLoS One 13 (1), e0190794 (2018)
   PUBMED   29324880
  REMARK    GeneRIF: Using ex vivo culture and HSC transplantation models,
            study finds that EDAG enhances proliferative potential of human
            cord blood CD34+ cells, increases survival, prevents cell apoptosis
            and promotes their repopulating capacity. EDAG overexpression
            induces rapid entry of CD34+ cells into the cell cycle. Gene
            expression profile analysis shows that EDAG knockdown leads to
            down-regulation of positive cell cycle regulators.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2084)
  AUTHORS   Li,C.Y., Zhan,Y.Q., Xu,C.W., Xu,W.X., Wang,S.Y., Lv,J., Zhou,Y.,
            Yue,P.B., Chen,B. and Yang,X.M.
  TITLE     EDAG regulates the proliferation and differentiation of
            hematopoietic cells and resists cell apoptosis through the
            activation of nuclear factor-kappa B
  JOURNAL   Cell Death Differ 11 (12), 1299-1308 (2004)
   PUBMED   15332117
  REMARK    GeneRIF: These results suggest that EDAG regulates the
            proliferation and differentiation of hematopoietic cells and
            resists cell apoptosis through the activation of NF-kappa B.
REFERENCE   7  (bases 1 to 2084)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 2084)
  AUTHORS   Liu,C.C., Chou,Y.L. and Ch'ang,L.Y.
  TITLE     Down-regulation of human NDR gene in megakaryocytic differentiation
            of erythroleukemia K562 cells
  JOURNAL   J Biomed Sci 11 (1), 104-116 (2004)
   PUBMED   14730214
  REMARK    GeneRIF: results suggest a novel function of nuclear negative
            differentiation regulator (NDR) protein in regulating hematopoietic
            cell development [NDR]
REFERENCE   9  (bases 1 to 2084)
  AUTHORS   Yang,L.V., Heng,H.H., Wan,J., Southwood,C.M., Gow,A. and Li,L.
  TITLE     Alternative promoters and polyadenylation regulate tissue-specific
            expression of Hemogen isoforms during hematopoiesis and
            spermatogenesis
  JOURNAL   Dev Dyn 228 (4), 606-616 (2003)
   PUBMED   14648837
REFERENCE   10 (bases 1 to 2084)
  AUTHORS   Yang,L.V., Nicholson,R.H., Kaplan,J., Galy,A. and Li,L.
  TITLE     Hemogen is a novel nuclear factor specifically expressed in mouse
            hematopoietic development and its human homologue EDAG maps to
            chromosome 9q22, a region containing breakpoints of hematological
            neoplasms
  JOURNAL   Mech Dev 104 (1-2), 105-111 (2001)
   PUBMED   11404085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF306682.1.
            
            On Nov 23, 2018 this sequence version replaced NM_197978.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF306682.1, AY255672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616898.2/ ENSP00000480020.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2084              AF306682.1         4-2087
FEATURES             Location/Qualifiers
     source          1..2084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..2084
                     /gene="HEMGN"
                     /gene_synonym="CT155; EDAG; EDAG-1; NDR"
                     /note="hemogen"
                     /db_xref="GeneID:55363"
                     /db_xref="HGNC:HGNC:17509"
                     /db_xref="MIM:610715"
     exon            1..115
                     /gene="HEMGN"
                     /gene_synonym="CT155; EDAG; EDAG-1; NDR"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1491
                     /gene="HEMGN"
                     /gene_synonym="CT155; EDAG; EDAG-1; NDR"
                     /note="hemopoietic gene protein; negative differentiation
                     regulator protein; erythroid differentiation-associated
                     gene protein"
                     /codon_start=1
                     /product="hemogen"
                     /protein_id="NP_932095.1"
                     /db_xref="CCDS:CCDS6731.1"
                     /db_xref="GeneID:55363"
                     /db_xref="HGNC:HGNC:17509"
                     /db_xref="MIM:610715"
                     /translation="MDLGKDQSHLKHHQTPDPHQEENHSPEVIGTWSLRNRELLRKRK
                     AEVHEKETSQWLFGEQKKRKQQRTGKGNRRGRKRQQNTELKVEPQPQIEKEIVEKALA
                     PIEKKTEPPGSITKVFPSVASPQKVVPEEHFSEICQESNIYQENFSEYQEIAVQNHSS
                     ETCQHVSEPEDLSPKMYQEISVLQDNSSKICQDMKEPEDNSPNTCQVISVIQDHPFKM
                     YQDMAKREDLAPKMCQEAAVPKILPCPTSEDTADLAGCSLQAYPKPDVPKGYILDTDQ
                     NPAEPEEYNETDQGIAETEGLFPKIQEIAEPKDLSTKTHQESAEPKYLPHKTCNEIIV
                     PKAPSHKTIQETPHSEDYSIEINQETPGSEKYSPETYQEIPGLEEYSPEIYQETSQLE
                     EYSPEIYQETPGPEDLSTETYKNKDVPKECFPEPHQETGGPQGQDPKAHQEDAKDAYT
                     FPQEMKEKPKEEPGIPAILNESHPENDVYSYVLF"
     exon            116..209
                     /gene="HEMGN"
                     /gene_synonym="CT155; EDAG; EDAG-1; NDR"
                     /inference="alignment:Splign:2.1.0"
     exon            210..1396
                     /gene="HEMGN"
                     /gene_synonym="CT155; EDAG; EDAG-1; NDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..2084
                     /gene="HEMGN"
                     /gene_synonym="CT155; EDAG; EDAG-1; NDR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HEMGN"
                     /gene_synonym="CT155; EDAG; EDAG-1; NDR"
                     /note="hexamer: ATTAAA"
     polyA_site      2084
                     /gene="HEMGN"
                     /gene_synonym="CT155; EDAG; EDAG-1; NDR"
                     /note="major polyA site"
ORIGIN      
        1 agtcagacca aaatagcagg aaggtattgc agcaagatgg atttgggaaa ggaccaatct
       61 catttgaagc accatcagac acctgaccct catcaagaag agaaccattc tccagaagtc
      121 attggaacct ggagtttgag aaacagagaa ctacttagaa aaagaaaagc tgaagtgcat
      181 gaaaaggaaa catcacaatg gctatttgga gaacagaaaa aacgcaagca gcagagaaca
      241 ggaaaaggaa atcgaagagg cagaaagaga caacaaaaca cagaattgaa ggtggagcct
      301 cagccacaga tagaaaagga aatagtggag aaagcactgg cacctataga gaaaaaaact
      361 gagccacctg ggagcataac caaagtattt ccttcagtag cctccccgca aaaagttgtg
      421 cctgaggaac acttttctga aatatgtcaa gaaagtaaca tatatcagga gaatttttct
      481 gagtaccaag aaatagcagt acaaaaccat tcttctgaaa catgccaaca tgtgtctgaa
      541 cctgaagacc tctctcctaa aatgtaccaa gaaatatctg tacttcaaga caattcttcc
      601 aaaatatgcc aagacatgaa ggaacctgaa gacaactctc ctaacacatg ccaagtaata
      661 tctgtaattc aagaccatcc tttcaaaatg taccaagata tggctaaacg agaagatctg
      721 gctcctaaaa tgtgccaaga agctgctgta cccaaaatcc ttccttgtcc aacatctgaa
      781 gacacagctg atctggcagg atgctctctt caagcatatc caaaaccaga tgtgcctaaa
      841 ggctatattc ttgacacaga ccaaaatcca gcagaaccag aggaatacaa tgaaacagat
      901 caaggaatag ctgagacaga aggccttttt cctaaaatac aagaaatagc tgagcctaaa
      961 gacctttcta caaaaacaca ccaagaatca gctgaaccta aataccttcc tcataaaaca
     1021 tgtaacgaaa ttattgtgcc taaagccccc tctcataaaa caatccaaga aacacctcat
     1081 tctgaagact attcaattga aataaaccaa gaaactcctg ggtctgaaaa atattcacct
     1141 gaaacgtatc aagaaatacc tgggcttgaa gaatattcac ctgaaatata ccaagaaaca
     1201 tcccagcttg aagaatattc acctgaaata taccaagaaa caccggggcc tgaagacctc
     1261 tctactgaga catataaaaa taaggatgtg cctaaagaat gctttccaga accacaccaa
     1321 gaaacaggtg ggccccaagg ccaggatcct aaagcacacc aggaagatgc taaagatgct
     1381 tatacttttc ctcaagaaat gaaagaaaaa cccaaagaag agccaggaat accagcaatt
     1441 ctgaatgaga gtcatccaga aaatgatgtc tatagttatg ttttgtttta acaatgctca
     1501 accataaagt tgtggtccaa tggaacatac agcttaatag tttatgcgtg attttctcaa
     1561 aatattgtaa aacttttgac aatgctcatt aatattattt tttctatttg tagaccatat
     1621 ctgaaagaaa taacattttt taaggctcta ccacatagac aatatcatgc tagaatgtgt
     1681 gtgtgtgtgt gtgtgtgtgt gtgtgtatgt atgtataggt cggggagagg atagtggtgg
     1741 gaacagacaa ataaggaagc ggggaggact ggataattgg ttttcccccc taagaacatt
     1801 tatttacgtc ttaagagcag ataagtgact aagactgaac acatacattt tgtggagtat
     1861 atagttttct tgtaaatgct gttcaattat taatgtaaca gtagcatcaa aattttattc
     1921 aggctttagt tgactctttt ggtcagtttt aacaattctc cttaaaagat attttggagt
     1981 gatgaatgta gtttactttt gtatttgaat tttgattttc tatttttatt ttttaaatat
     2041 tgtatttgtg cacaatgtac attaaatcat tattacatgc ttaa
//
