LOCUS       NM_018063               3128 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens helicase, lymphoid specific (HELLS), transcript
            variant 1, mRNA.
ACCESSION   NM_018063
VERSION     NM_018063.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3128)
  AUTHORS   Consiglio,A., Venturin,M., Briguglio,S., Rossi,C., Grillo,G.,
            Bellosta,S., Cattaneo,M.G., Licciulli,F. and Battaglia,C.
  TITLE     Lost in HELLS: Disentangling the mystery of SALNR existence in
            senescence cellular models
  JOURNAL   PLoS One 18 (5), e0286104 (2023)
   PUBMED   37252915
  REMARK    GeneRIF: Lost in HELLS: Disentangling the mystery of SALNR
            existence in senescence cellular models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3128)
  AUTHORS   Peixoto,E., Khan,A., Lewis,Z.A., Contreras-Galindo,R. and Czaja,W.
  TITLE     The Chromatin Remodeler HELLS: A New Regulator in DNA Repair,
            Genome Maintenance, and Cancer
  JOURNAL   Int J Mol Sci 23 (16), 9313 (2022)
   PUBMED   36012581
  REMARK    GeneRIF: The Chromatin Remodeler HELLS: A New Regulator in DNA
            Repair, Genome Maintenance, and Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3128)
  AUTHORS   Liang,X., Li,L. and Fan,Y.
  TITLE     Diagnostic, Prognostic, and Immunological Roles of HELLS in
            Pan-Cancer: A Bioinformatics Analysis
  JOURNAL   Front Immunol 13, 870726 (2022)
   PUBMED   35774795
  REMARK    GeneRIF: Diagnostic, Prognostic, and Immunological Roles of HELLS
            in Pan-Cancer: A Bioinformatics Analysis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3128)
  AUTHORS   He,C. and Liu,L.
  TITLE     Hsa_circ_0072008 regulates cell proliferation, migration, and
            invasion in cervical squamous cell carcinoma via miR-1305/helicase,
            lymphoid specific (HELLS) axis
  JOURNAL   Bioengineered 13 (4), 8311-8322 (2022)
   PUBMED   35311456
  REMARK    GeneRIF: Hsa_circ_0072008 regulates cell proliferation, migration,
            and invasion in cervical squamous cell carcinoma via
            miR-1305/helicase, lymphoid specific (HELLS) axis.
REFERENCE   5  (bases 1 to 3128)
  AUTHORS   Chen,X., Li,Y., Rubio,K., Deng,B., Li,Y., Tang,Q., Mao,C., Liu,S.,
            Xiao,D., Barreto,G. and Tao,Y.
  TITLE     Lymphoid-specific helicase in epigenetics, DNA repair and cancer
  JOURNAL   Br J Cancer 126 (2), 165-173 (2022)
   PUBMED   34493821
  REMARK    GeneRIF: Lymphoid-specific helicase in epigenetics, DNA repair and
            cancer.
            Review article
REFERENCE   6  (bases 1 to 3128)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 3128)
  AUTHORS   Sun,L.Q., Lee,D.W., Zhang,Q., Xiao,W., Raabe,E.H., Meeker,A.,
            Miao,D., Huso,D.L. and Arceci,R.J.
  TITLE     Growth retardation and premature aging phenotypes in mice with
            disruption of the SNF2-like gene, PASG
  JOURNAL   Genes Dev 18 (9), 1035-1046 (2004)
   PUBMED   15105378
REFERENCE   8  (bases 1 to 3128)
  AUTHORS   Ohira,M., Morohashi,A., Nakamura,Y., Isogai,E., Furuya,K.,
            Hamano,S., Machida,T., Aoyama,M., Fukumura,M., Miyazaki,K.,
            Suzuki,Y., Sugano,S., Hirato,J. and Nakagawara,A.
  TITLE     Neuroblastoma oligo-capping cDNA project: toward the understanding
            of the genesis and biology of neuroblastoma
  JOURNAL   Cancer Lett 197 (1-2), 63-68 (2003)
   PUBMED   12880961
  REMARK    Review article
REFERENCE   9  (bases 1 to 3128)
  AUTHORS   Lee,D.W., Zhang,K., Ning,Z.Q., Raabe,E.H., Tintner,S., Wieland,R.,
            Wilkins,B.J., Kim,J.M., Blough,R.I. and Arceci,R.J.
  TITLE     Proliferation-associated SNF2-like gene (PASG): a SNF2 family
            member altered in leukemia
  JOURNAL   Cancer Res 60 (13), 3612-3622 (2000)
   PUBMED   10910076
REFERENCE   10 (bases 1 to 3128)
  AUTHORS   Geiman,T.M., Durum,S.K. and Muegge,K.
  TITLE     Characterization of gene expression, genomic structure, and
            chromosomal localization of Hells (Lsh)
  JOURNAL   Genomics 54 (3), 477-483 (1998)
   PUBMED   9878251
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314485.1, AF155827.1,
            BC111789.1 and BC015477.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018063.4.
            
            Summary: This gene encodes a lymphoid-specific helicase. Other
            helicases function in processes involving DNA strand separation,
            including replication, repair, recombination, and transcription.
            This protein is thought to be involved with cellular proliferation
            and may play a role in leukemogenesis. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF155827.1, SRR1660805.237081.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN03267750,
                                           SAMN03267752 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000348459.10/ ENSP00000239027.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK314485.1         11-39
            30-364              AF155827.1         1-335
            365-594             BC111789.1         310-539
            595-3047            AF155827.1         566-3018
            3048-3128           BC015477.1         1352-1432
FEATURES             Location/Qualifiers
     source          1..3128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..3128
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="helicase, lymphoid specific"
                     /db_xref="GeneID:3070"
                     /db_xref="HGNC:HGNC:4861"
                     /db_xref="MIM:603946"
     exon            1..165
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2651
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SWI/SNF2-related, matrix-associated, actin-dependent
                     regulator of chromatin, subfamily A, member 6;
                     proliferation-associated SNF2-like protein; Senescence
                     Associated Long Non-coding RNA"
                     /codon_start=1
                     /product="lymphoid-specific helicase isoform 1"
                     /protein_id="NP_060533.2"
                     /db_xref="CCDS:CCDS7434.1"
                     /db_xref="GeneID:3070"
                     /db_xref="HGNC:HGNC:4861"
                     /db_xref="MIM:603946"
                     /translation="MPAERPAGSGGSEAPAMVEQLDTAVITPAMLEEEEQLEAAGLER
                     ERKMLEKARMSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLER
                     KKESLKVKKGKNSIDASEEKPVMRKKRGREDESYNISEVMSKEEILSVAKKNKKENED
                     ENSSSTNLCVEDLQKNKDSNSIIKDRLSETVRQNTKFFFDPVRKCNGQPVPFQQPKHF
                     TGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLV
                     CGPLSTLPNWMAEFKRFTPDIPTMLYHGTQEERQKLVRNIYKRKGTLQIHPVVITSFE
                     IAMRDRNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSE
                     LWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLR
                     RLKSDVALEVPPKREVVVYAPLSKKQEIFYTAIVNRTIANMFGSSEKETIELSPTGRP
                     KRRTRKSINYSKIDDFPNELEKLISQIQPEVDRERAVVEVNIPVESEVNLKLQNIMML
                     LRKCCNHPYLIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLLFSQM
                     TSMLDILMDYCHLRDFNFSRLDGSMSYSEREKNMHSFNTDPEVFIFLVSTRAGGLGIN
                     LTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKR
                     KLEKLIIHKNHFKGGQSGLNLSKNFLDPKELMELLKSRDYEREIKGSREKVISDKDLE
                     LLLDRSDLIDQMNASGPIKEKMGIFKILENSEDSSPECLF"
     exon            166..287
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            288..410
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            411..467
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            468..504
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            505..569
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            570..611
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            612..839
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1022
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1166
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1363
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1460
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1622
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1762
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1901
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1985
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2105
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2222
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2382
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2479
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2556
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..3128
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3106..3111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="hexamer: AATAAA"
     polyA_site      3128
                     /gene="HELLS"
                     /gene_synonym="ICF4; LSH; Nbla10143; PASG; SALNR; SMARCA6"
                     /note="major polyA site"
ORIGIN      
        1 gaaggagaag cgcgcttttt tccctggcgg gggatttggc tagaaggctg ggccggcagc
       61 ggttgtgagg agttagctcg cggcattgca ggctctgaga ggaggggacc cggttcccgg
      121 gtgagtgtcc aggcatgcca gcggaacggc ccgcgggcag cggcggctcg gaggctccag
      181 caatggttga acaactggac actgctgtga ttaccccggc catgctagaa gaggaagaac
      241 agcttgaagc tgctggacta gagagagagc ggaagatgct ggaaaaggct cgcatgtctt
      301 gggatagaga gtcgacagaa attcggtacc gtagacttca acatttgctt gaaaaaagca
      361 atatatactc caaattttta ttgacgaaaa tggaacagca acaattagag gaacagaaga
      421 agaaagaaaa attggagaga aaaaaggagt ctttaaaagt taaaaagggt aaaaattcaa
      481 ttgatgcaag tgaagagaag ccagttatga ggaaaaaaag aggaagagaa gatgaatcat
      541 acaatatttc agaggtcatg tcaaaagagg aaattttgtc tgtggctaaa aaaaataaaa
      601 aggagaatga ggatgaaaac tcctcctcta ctaatctctg tgtggaagat cttcagaaaa
      661 ataaagattc gaatagtata attaaagata gattgtctga aacggttagg cagaatacta
      721 aattcttttt tgacccagtc cggaagtgta atggtcagcc agtacctttt caacaaccaa
      781 agcacttcac tggaggagtg atgcgatggt accaagtaga aggcatggaa tggcttagga
      841 tgctttggga aaatggaatt aatggcattt tagcagatga aatgggattg ggtaagacag
      901 ttcagtgcat tgctactatt gcattgatga ttcagagagg agtaccagga ccttttcttg
      961 tctgtggccc tttgtctaca cttcctaact ggatggctga attcaaaaga tttacaccag
     1021 atatccctac aatgttatat catggaaccc aggaggaacg tcaaaaattg gtaagaaata
     1081 tttacaaacg gaaagggact ttgcagattc atcctgtggt aatcacgtca tttgaaatag
     1141 ccatgagaga ccgaaatgcg ttacagcatt gctattggaa atacttaata gtagatgaag
     1201 gacacaggat taagaatatg aagtgccgtc taatcaggga gttaaaacga ttcaatgctg
     1261 ataacaaact tcttttgact ggtactccct tgcaaaacaa tttatcagaa ctttggtcat
     1321 tgctaaactt tttgttgcca gatgtatttg atgacttgaa aagctttgag tcttggtttg
     1381 acatcactag tctttctgaa actgctgaag atattattgc taaagaaaga gaacagaatg
     1441 tattgcatat gctgcaccag attttaacac ctttcttatt gagaagactg aagtctgatg
     1501 ttgctcttga agttcctcct aaacgagaag tagtcgttta tgctccactt tcaaagaagc
     1561 aggagatctt ttatacagcc attgtgaacc gtacaattgc aaacatgttt ggatccagtg
     1621 agaaagaaac aattgagtta agtcctactg gtcgaccaaa acgacgaact agaaaatcaa
     1681 taaattacag caaaatagat gatttcccta atgaattgga aaaactgatc agtcaaatac
     1741 agccagaggt ggaccgagaa agagctgttg tggaagtgaa tatccctgta gaatctgaag
     1801 ttaatctgaa gctgcagaat ataatgatgc tacttcgtaa atgttgtaat catccatatt
     1861 tgattgaata tcctatagac cctgttacac aagaatttaa gatcgatgaa gaattggtaa
     1921 caaattctgg gaagttcttg attttggatc gaatgctgcc agaactaaaa aaaagaggtc
     1981 acaaggtgct gcttttttca caaatgacaa gcatgttgga cattttgatg gattactgcc
     2041 atctcagaga tttcaacttc agcaggcttg atgggtccat gtcttactca gagagagaaa
     2101 aaaacatgca cagcttcaac acggatccag aggtgtttat cttcttagtg agtacacgag
     2161 ctggtggcct gggcattaat ctgactgcag cagatacagt tatcatttat gatagtgatt
     2221 ggaaccccca gtcggatctt caggcccagg atagatgtca tagaattggt cagacaaagc
     2281 cagttgttgt ttatcgcctt gttacagcaa atactatcga tcagaaaatt gtggaaagag
     2341 cagctgctaa aaggaaactg gaaaagttga tcatccataa aaatcatttc aaaggtggtc
     2401 agtctggatt aaatctgtct aagaatttct tagatcctaa ggaattaatg gaattattaa
     2461 aatctagaga ttatgaaagg gaaataaaag gatcaagaga gaaggtcatt agtgataaag
     2521 atctagagtt gttgttagat cgaagtgatc ttattgatca aatgaatgct tcaggaccaa
     2581 ttaaagagaa gatggggata ttcaagatat tagaaaattc tgaagattcc agtcctgaat
     2641 gtttgtttta aagtggagct caagaatagc ttttaaaagt tcttatttac atctagtgat
     2701 ttccctgtat tgggtttgaa atactgattg tccacttcac cttttttatt atatcagttg
     2761 acatgtaact agtaccatgc gtacttaaat agatggtaat tttctgagcc ttaccaagaa
     2821 caaagaagta tccatattaa gtttagattt tcagttaatt tttgagactg agtagtattc
     2881 ttggatacag gctgatgtgt acttaaccac ttccagattt atacagtctt cctgtggaag
     2941 tttagtaaat gtctttttcc ctcctttctt ctagtaatgc agttcatggg ctttaggtac
     3001 ttcagttatg aagtaggctt ttcatgggga gagattggga ttatgctctc tgttgtttaa
     3061 gaaactgttt gattttagag tctatttcta tgagatagtt taccaaataa atgttcctta
     3121 taagatga
//
